Martin Lepage
PhD

Division: 
Clinical Research

Martin Lepage, PhD
 

Office: 
F-1143, Frank B. Common Pavilion

6875 Boulevard LaSalle
Montréal, QC
H4H 1R3


(514) 761-6131 x4393

Fax: 
(514) 888-4099


Research area: 
Clinical Research / Human Research

Research Theme: 
Psychosis and Neurodevelopmental Disorders


FRQS Research Chair in cognitive neuroscience and schizophrenia

​Researcher, Douglas Research Centre
Deputy Scientific Director, Douglas Research Centre
Clinical Psychologist, Douglas Mental Health University Institute
James McGill Professor, Department of Psychiatry, McGill University
Associate Professor, Department of Psychology, McGill University



CRISP group: Comprehensive research into schizophrenia and psychosis


The CRISP group is currently exploring several inter-related dimensions of schizophrenia and psychosis through the use of various clinical, neurocognitive and neuroimaging techniques, such as:

  • MRI and fMRI
  • Neuropsychological testing
  • Cognitive behavioural therapy
  • Cognitive remediation

Our approach is motivated by a desire to better understand negative and cognitive symptoms that often characterize schizophrenia (e.g. memory difficulties, avolition, anhedonia, poor insight, etc.) and to develop research programs that will have significant clinical applications.

More specifically, the laboratory studies:

  • Neurocognitive and neuroimaging markers of remission in first episode psychosis
  • Biological and psychological determinants of insight in schizophrenia
  • Cognitive behavioural therapy for social anxiety in psychosis
  • Cognitive remediation therapy in schizophrenia
  • Cognitive neuroscience of episodic memory in schizophrenia

All publications

2019

  1. *Baer, L., Shah, J., & Lepage, M. (2019). Anxiety in youth at clinical high risk of psychosis: A case study and conceptual model. Schizophrenia Research, 208: 441-446.
  2. *Béland, S., *Makowski, C., *Konsztowicz, S., Buchy, L., Chakravarty, M., & Lepage, M.   (2019). Clarifying associations between cortical thickness, subcortical structures, and a comprehensive assessment of clinical insight in enduring schizophrenia. Schizophrenia Research, 204: 245-252.
  3. Daneault, J.-G., Maraj, A., Lepage, M., Malla, A. Schmitz, N., Iyer, S.N., Joober, R., & Shah, J.L. (2019). Medication adherence in first episode psychosis: The role of pre-onset sub-threshold symptoms. Acta Psychiatrica Scandinavica, 139(4): 336-347.
  4. Hansen, M., Jones, B.D., Eack, S.H., Glenthøj B.L., Ikezawa, S., Iwane, T., Kidd, S.A. Lepage, M., Lindenmayer, J.-P., Ljuri, I., Maida, K. Matsuda, Y. Nakagome, K., Nordentoft, M., Ozog, V., *Penney, D., Saperstein, A.M. Sunaga, A., Vinogradov, S., Virdee, G., Wojtalik, J.A., & Medalia, A. (2019). Validation of the MUSIC Model of Motivation Inventory for use with cognitive training for schizophrenia spectrum disorders: A multinational study. Schizophrenia Research, 206: 142-148.
  5. *Konsztowicz, S., & Lepage, M. (2019). The role of illness engulfment in the association between insight and depressive symptomatology in schizophrenia. Journal of Psychiatric Research, 111: 1-7.  
  6. *Makowski, C., Lepage, M., & Evans, A.C. (2019). Head motion: The dirty little secret of neuroimaging in psychiatry. Journal of Psychiatry & Neuroscience, 44(1): 62-68.
  7. *Penney, D., *Sauvé, G., Joober, R., Malla, A.K., & Lepage, M. (2019). Establishing clinical cutoff values for the Beck Cognitive Insight Scale. Cognitive Therapy and Research, 43(2): 324-334.
  8. Plitman, E., Guma, E., Lepage, M., Near, J., & Chakravarty, M. (2019). Using proton magnetic resonance spectroscopic imaging to study glutamatergic alterations in patients with schizophrenia: A systematic review. Schizophrenia Research, 210: 13-20.
  9. *Rosengard, R.J., Malla, A., Mustafa, S., Iyer, S.N., Joober, R., *Bodnar, M., Lepage, M., & Shah, J. (2019). Association of pre-onset subthreshold psychotic symptoms with longitudinal outcomes during treatment of a first episode of psychosis. JAMA Psychiatry, 76(1): 61-70.
  10. *Sauvé, G., *Brodeur, M., Shah, J., & Lepage, M. (2019). The prevalence of negative symptoms across the stages of the psychosis continuum. Harvard Review of Psychiatry, 27(1): 15-32.
  11. *Sauvé, G., Kline, R.B., Shah, J.L., Joober, R., Malla, A.K., *Brodeur, M.B., & Lepage, M. (2019). Cognitive capacity similarly predicts insight into symptoms in
    first- and multiple-episode psychosis. Schizophrenia Research, 206: 236-243.
  12. *Sauvé, G., Lepage, M., & Corbière, M. (2019). Impacts de la combinaison de programmes de soutien à l’emploi et de remédiation cognitive sur le maintien en emploi de personnes souffrant de schizophrénie: Une méta-analyse. Annales médico-psychologiques, 177(6) : 534-543.

2018

  1. *Buchy, L., *Makowski, C., Malla, A., Joober, R., & Lepage, M. (2018). A longitudinal study of cognitive insight and cortical thickness in first-episode psychosis. Schizophrenia Research, 193: 251-260.
  2. *Guimond, S., *Béland, S., & Lepage, M. (2018). Strategy for semantic association memory (SESAME) training: Effects on brain functioning in schizophrenia. Psychiatric Research: Neuroimaging, 271: 50-58.
  3. Iyer, S., Mustafa, S., Gariepy, G., Shah, J., Joober, R., Lepage, M., & Malla, A. (2018). A NEET distinction: Youths not in employment, education or training follow different pathways to illness and care in psychosis. Social Psychiatry and Psychiatric Epidemiology, 53(12): 1401-1411.
  4. Jordan, G., Veru, F., Lepage, M., Joober, R., Malla, A.K., & Iyer, S. (2018). Pathways to functional outcomes following a first episode of psychosis: The roles of premorbid adjustment, verbal memory and symptom remission. Australian and New Zealand Journal of Psychiatry, 52(8): 793-803.
  5. *Konsztowicz, S., Schmitz, N., & Lepage, M. (2018). Dimensions of insight in schizophrenia: Exploratory factor analysis of items from multiple self- and interviewer-rated measures of insight. Schizophrenia Research, 199: 319-325.
  6. Lutgens, D., Joober, R., Iyer, S., Lepage, M., Norman, R., Schmitz, N., Mustafa, S., Abadi, S., & Malla, A.K. (2018). Progress of negative symptoms over the initial five years of a first episode of psychosis. Psychological Medicine, 49(1): 66-74.
  7. *Makowski, C., *Béland, S., Kostopoulos, P., Bhagwat, N., Devenyi, G.A., Malla, A.K., Joober, R., Lepage, M., & Chakravarty, M.M. (2018). Evaluating accuracy of striatal, pallidal, and thalamic segmentation methods: Comparing automated approaches to manual delineation. NeuroImage, 170:182-198.
  8. Mustafa, S., Joober, R., Lepage, M., Iyer, S., Shah, J., & Malla, A. (2018). Predictors of ‘all cause discontinuation’ of initial oral antipsychotic medication in first episode psychosis. Schizophrenia Research, 201: 287-293.
  9. *Sauvé, G. Malla, A.K., Joober, R., *Brodeur, M.B., & Lepage, M. (2018). Comparing cognitive clusters across first- and multiple-episode of psychosis. Psychiatry Research, 269: 707-718.

 

2017

  1. *Béland, S., & Lepage, M. (2017). The relative contributions of social cognition and self-reflectiveness to clinical insight in enduring schizophrenia. Psychiatry Research, 258: 116-123.
  2. *Benoit, A., Bowie, C.R., & Lepage, M. (2017). Is cognitive insight relevant to functional capacity in schizophrenia? Schizophrenia Research, 184:150-151.
  3. *Buchy, L., *Makowski, C., Malla, A.K., Joober, R., & Lepage, M. (2017). Longitudinal trajectory of clinical insight and covariation with cortical thickness in first-episode psychosis. Journal of Psychiatric Research, 86:46-54.
  4. Ding, Y., Pereira, F., Hoehne, A., Beaulieu, M.M., Lepage, M., Turecki, G., & F. Jollant (2017). Altered brain processing of decision-making in healthy first-degree biological relatives of suicide completers. Molecular Psychiatry, 22:1149-1154.
  5. Grossman, M., Bowie, C., Lepage, M. Malla, A., Iyer, S. & Joober, R. (2017). Smoking status and its relationship to demographic and clinical characteristics in first episode psychosis. Journal of Psychiatric Research, 85:83-89.
  6. *Guimond, S., *Hawco, C., & Lepage, M. (2017). Prefrontal activity and impaired memory encoding strategies in schizophrenia. Journal of Psychiatric Research, 91:64-73.
  7. *Hawco, C., Armony, J.L., Daskalakis, Z.J., Berlim, M.T., Chakravarty, M.M., Pike, G.B., & Lepage, M. (2017). Differing Time of Onset of Concurrent TMS-fMRI during Associative Memory Encoding: A measure of dynamic connectivity. Frontiers in Human Neuroscience, 11:404.
  8. Lyne, J., Joober, R., Schmitz, N., Lepage, M., & Malla, A. (2017). Duration of active psychosis and first-episode psychosis negative symptoms. Early Intervention in Psychiatry,11(1), 63-71.
  9. *Makowski, C., *Bodnar, M., *Shenker, J., Malla, A. K., Joober, R., Chakravarty, M. M., & Lepage, M. (2017). Linking Early Persistent Negative Symptoms to Amygdala-Hippocampus Structure in First Episode Psychosis. Translational Psychiatry, 7(8), e1195.
  10. Sengupta S.M., McDonald, K., Fathalli, F., Yim, A., Lepage, M., Iyer, S., Malla, A.K., & Joober, R. (2017). Polygenic Risk Score associated with specific symptom dimensions in first episode psychosis. Schizophrenia Research, 184:116-121.
  11. *Shenker, J., Sengupta, S., Joober, R., Malla, A., Chakravarty, M., & Lepage, M. (2017). Bipolar disorder risk gene FOXO6 modulates negative symptoms in schizophrenia: A neuroimaging genetics study. Journal of Psychiatry and Neuroscience, 42(3), 172.

 

2016

 

  1. *Auclair, V., *Harvey, P.-O., & Lepage, M. (2016). La thérapie cognitive-comportementale dans le traitement du TDAH chez l’adulte. Santé Mentale au Québec, 41:291-312.
  2. *Azar, M., Pruessner, M., Baer, L., Iyer, S., Malla, A.K., & Lepage, M. (2016). A study on negative and depressive symptom prevalence in individuals at ultra-high risk for psychosis. Early Intervention in Psychiatry, 12(5): 900-906.
  3. *Benoit, A., *Harvey, P.-O., *Bherer, L., & Lepage, M. (2016). Does the Beck Cognitive Insight Scale predict response to cognitive remediation in schizophrenia? Schizophrenia Research and Treatment 2016, doi:10.1155/2016/6371856.
  4. Bhagwat, N., Pipitone, J., Winterburn, J.L., Guo, T., Duerden, E.G., Voineskos, A.N., Lepage, M., Miller, S.P., Pruessner, J.C., Chakravarty, M.M., the Alzheimer’s Disease Neuroimaging Initiative. (2016). Manual-protocol inspired technique for Improving automated MR image segmentation during label-fusion. Frontiers in Neuroscience, Brain Imaging Methods, 10: 325.
  5. *Bodnar, M., Malla, A., *Makowski, C., Chakravarty, M.M., Joober, R., & Lepage, M. (2016). The effect of second-generation antipsychotics on hippocampal volume in first episode psychosis: A longitudinal study. British Journal of Psychiatry Open, 2:139-146.
  6. Dedovic, K., Pruessner, J., Tremblay, J., Nadeau, L., Ouimet, M.-C., Lepage, M., & Brown, T.G. (2016). Examining cortical thickness in male and female DWI offenders. Neuroscience Letters, 619:189-195.
  7. *Emami, S., *Guimond, S., Chakravarty, M.M., & Lepage, M. (2016). Cortical thickness and low insight into symptoms in enduring schizophrenia. Schizophrenia Research, 170(1): 66-72.
  8. *Guimond, S., Chakravarty, M.M., *Bergeron-Gagnon, L., Patel, R., & Lepage, M. (2016). Verbal memory impairments in schizophrenia associated with cortical thinning. NeuroImage: Clinical, 11:20-29.
  9. *Guimond, S., & Lepage, M. (2016). Cognitive training of self-initiation of semantic encoding strategies in schizophrenia. A pilot study. Neuropsychological Rehabilitation, 26:464-479.
  10. *Guimond, S., Lepage, M., *Benoit, A., *Charbonneau, G., *Hawco, C., Malla, A.K., Joober, R., & *Brodeur, M. (2016). Recollection rejection of new items in individuals with first-episode psychosis. Journal of Abnormal Psychology, 125(1):104-113.
  11. Jollant, F., Ding, Y., Pereira, F., Hoehne, A., Beaulieu, M.M., Lepage, M., & Turecki, G. (2016). Altered brain processing of decision-making in healthy first-degree biological relatives of suicide completers. Molecular Psychiatry, doi:10.1038/mp.2016.221.
  12. *Luck, D., Joober, R., Malla, A., & Lepage, M. (2016). Altered emotional modulation of associative memory in first episode schizophrenia: An fMRI study. Schizophrenia Research: Cognition, 3:26-32.
  13. Malla, A.K., Mustafa, S., Rho, A., Abadi, S., Lepage, M., & Joober, R. (2016). Therapeutic effectiveness and tolerability of aripiprazole as initial choice of treatment in first episode psychosis in an early intervention service: A one-year outcome study. Schizophrenia Research, 174:120-125.
  14. *Makowski, C.*, Bodnar, M.*, Malla, A.K., Joober, R., Lepage, M. (2016). Age-related cortical thickness trajectories in first episode psychosis patients presenting with persistent negative symptoms. Npj Schizophrenia, 2:16029
  15. *Makowski, C., Lepage, M., & *Harvey, P.-O. (2016). Functional neural correlates of social approval in schizophrenia. Social, Cognitive and Affective Neuroscience, 11(3):445-457.
  16. *Montreuil, T., Malla, A.K., Joober, R., Bélanger, C., Myhr, G., & Lepage, M. (2016). Manualized group cognitive behavioral intervention for social anxiety in First Episode Psychosis. International Journal of Group Psychotherapy, 66(2):225-245.
  17. Richard-Devantoy, S., Ding, Y., Lepage, M., Turecki, G., & Jollant, F. (2016). Cognitive inhibition in depression and suicidal behaviour: A neuroimaging study.
    Psychological Medicine. 46(05):933-944.
  18. Shah, J.L., Chakravarty, M.M. Joober, R., & Lepage, M. (2016). Dynamic endophenotypes and longitudinal trajectories: Capturing changing aspects of development in early psychosis. Journal of Psychiatry and Neuroscience, 41:148-151.

 

2015

  1. *Benoit, A., Malla, A.K., Joober, R., Bherer, L., & Lepage, M. (2015). Cognitive deficits characterization using the CogState Research Battery in first-episode psychosis patients. Schizophrenia Research: Cognition, 2(3): 140-145.
  2. *Buchy, L., Hawco, C., Joober, R., Malla, A., & Lepage, M. (2015). Cognitive insight in first-episode psychosis: Further evidence for a role of the ventrolateral prefrontal cortex. Schizophrenia Research, 166:65-68.
  3. *Buchy, L., & Lepage, M. (2015). Modeling the neurocognitive and neuroanatomical mechanisms of cognitive insight in non-clinical subjects. Cognitive Research & Therapy, 39:415-423.
  4. *Hawco, C., *Buchy, L., *Bodnar, M., Izadi, S., Dell’Elce, J., Messina, K., Joober, R., Malla, A., & Lepage, M. (2015). Source retrieval is not properly differentiated from object retrieval in early schizophrenia: an fMRI study using virtual reality. NeuroImage Clinical, 7:336-346.
  5. *Hovington, C.L., *Bodnar, M., Chakravarty, M.M., Joober, R., Malla, A., & Lepage, M. (2015). Investigation of white matter abnormalities in first episode psychosis patients with persistent negative symptoms. Psychiatry Research: Neuroimaging, 233:402-408.
  6. Lepage, M., Hawco, C., & *Bodnar M. (2015). Relational memory as a possible neurocognitive marker of schizophrenia. JAMA Psychiatry, 72(9): 946-947. doi:10.1001/jamapsychiatry.2015.0488.
  7. *Ouellet, J., McGirr, A., Van Den Eynde, F., Jollant, F., Lepage, M., & Berlim, M., (2015). Enhancing decision-making and cognitive impulse control with transcranial direct current stimulation (tDCS) applied over the orbitofrontal cortex (OFC): A randomized and sham-controlled exploratory study. Journal of Psychiatric Research, 69:27-34.
  8. Prevost, M., *Brodeur, M., Onishi, K.H., Lepage, M., & Gold, I. (2015). Judging strangers’ trustworthiness is associated with theory of mind skills. Frontiers in Psychiatry, 6:52.
  9. Pruessner, M., Lepage, M., Collins, L., Pruessner, J.C., Joober, R., & Malla, A. (2015). Reduced hippocampal volume and hypothalamus-pituitary-adrenal axis function in first episode psychosis: Evidence for sex differences.  NeuroImage Clinical, 7:195-202.
  10. Rho, A., Traicu, A., Lepage, M., Iyer, S., Malla, A., & Joober, R. (2015). Clinical and functional implications of a history of childhood ADHD in first-episode psychosis. Schizophrenia Research, 165:128-133.

2014

  1. Albanna, A., Choudhry, Z., *Harvey, P.-O., Fathalli, F., *Cassidy, C., Sengupta, S., Rho, A., Lepage, M., Malla, A., & Joober, R. (2014). TCF4 gene polymorphism and cognitive performance in patients with first episode psychosis. Schizophrenia Research,152:124-129.
  2. *Benoit, A., *Bodnar, M., Malla, A.K., Joober, R., Bherer, L., & Lepage, M. (2014). Changes in memory performance over a 12-month period in relation to achieving symptomatic remission after a first episode psychosis. Schizophrenia Research, 153:103-108.
  3. *Bodnar, M., *Hovington, C.L., *Buchy, L., Malla, A.K., Joober, R., & Lepage, M. (2014). Cortical thinning in temporo-parietal junction in non-affective first-episode of psychosis patients with persistent negative symptoms. PlosOne, 9(6):e101372.
  4. *Buchy, L., *Hawco, C., *Bodnar, M., Izadi, S., Dell’Elce, J., Messina, K., & Lepage, M. (2014). Functional Magnetic Resonance Imaging study of external source memory and its relation to cognitive insight in non-clinical subjects. Psychiatry and Clinical Neurosciences, 68:683–691.
  5. *Cassidy, C.M., *Brodeur, M., Lepage, M., & Malla, A. (2014). Do reward-processing deficits in schizophrenia-spectrum disorders promote cannabis use? An investigation of physiological response to natural rewards and drug cues. Journal of Psychiatry and Neuroscience, 39(5):339-347.
  6. *Cassidy, C., *Buchy, L., *Bodnar, M., Dell’Elce, Choudry, Z., Fathalli, F., Fox, R., Sengupta, S., Iyer, S., Ad-Dab’bagh, Y., Evans, A., Malla, A., Lepage, M., & Joober, R. (2014). Association of a risk allele of ANK3 with lower cognitive performance and cortical thinning in patients with first episode psychosis. Journal of Psychiatry & Neuroscience, 39:31-39.
  7. *Cassidy, C.M., Lepage, M., & Malla, A. (2014). Do motivation deficits in schizophrenia-spectrum disorders promote cannabis use? An investigation of behavioural response to natural rewards and drug cues. Psychiatry Research, 215:522-527.
  8. *Harvey, P., & Lepage, M. (2014). Neural correlates of recognition memory of social information in people with schizophrenia. Journal of Psychiatry & Neuroscience, 39:97-109.
  9. *Hawco, C., & Lepage, M. (2014). Overlapping neural activity for different forms of novelty in fMRI. Frontiers in Neuroscience, 8:699.
  10. Jordan, G., Lutgens, D., Iyer, S., Joober, R., Lepage, M., & Malla, A. (2014). The relative contribution of cognition and symptomatic remission to functional outcome following treatment of a first episode of psychosis. Journal of Clinical Psychiatry, 75:e566-e572.
  11. Lepage, M., *Bodnar M., & Bowie, C. (2014). Neurocognition: Clinical and Functional Outcomes in Schizophrenia. Canadian Journal of Psychiatry, 59:5-12.
  12. Luck, D., Leclerc, M.-E., & Lepage, M. (2014). The Potentiation of Associative Memory by Emotions: An Event-Related FMRI Study. Advances in Neuroscience, 2014: doi:10.1155/2014/964024.
  13. Lutgens, D., Lepage, M., Iyer, S., & Malla, A. (2014). Predictors of cognition in first episode psychosis. Schizophrenia Research, 152:164-169.
  14. Pipitone, J., Park, M.T., Winterburn, J., Lett, T.A., Lerch, J.P., Pruessner, J.C., Lepage, M., Voineskos, A., & Chakravarty, M.M. (2014). Multi-atlas segmentation of the whole hippocampus and subfields using multiple automatically generated templates. NeuroImage, 101:494-512.

2013

  1. *Hawco, C., Berlim, M.T., & Lepage, M. (2013). The dorsolateral prefrontal cortex plays a role in self-initiated elaborative cognitive processing during episodic memory encoding: rTMS evidence. PlosOne, 8(9):e73789.
  2. *Hawco, C., Armony, J., & Lepage, M. (2013). Neural activity related to self-initiating elaborative semantic encoding in associative memory. NeuroImage, 67:273-282.
  3. *Hovington, C.L., *Bodnar, M, Joober, R., Malla, A., & Lepage, M. (2013). Impairment in verbal memory in first episode psychosis patients with persistent negative symptoms. Schizophrenia Research, 147:223-229.
  4. *Hovington, C.L., McGirr, A., Lepage, M., & Berlim, M. (2013). Repetitive transcranial magnetic stimulation (rTMS) for treating unipolar major depression and schizophrenia: a systematic review of recent meta-analyses. Annals of Medicine, 45:308-321.
  5. Lutgens, D., Lepage, M., Machanda, R., & Malla, A. (2013). Persistent negative symptoms in schizophrenia: Survey of Canadian psychiatrists. International Psychiatry, 10:69-72.
  6. *Montreuil, T.C., Malla, A., Joober, R., Bélanger, C., & Lepage, M. (2013). Anxiety symptoms severity and short-term clinical outcome in first-episode psychosis. Early Intervention in Psychiatry, 7:5-11.

2012

  1. *Benoit, A., *Bodnar, M., Czechowska, Y., *Mostert, J., Malla, A., Joober, R., & Lepage, M. (2012). The structural neural substrates of persistent negative symptoms in first-episode of non-affective psychosis: A voxel-based morphometry study. Frontiers in Psychiatry, 3 :42. doi: 10.3389/fpsyt.2012.00042.
  2. *Bodnar, M., *Achim, A.M., Malla, A., Joober, R., *Benoit, A., Sutton, H., & Lepage, M. (2012). Functional magnetic resonance imaging correlates of memory encoding in relation to achieving remission in first-episode schizophrenia. British Journal of Psychiatry, 200:300-307.
  3. *Bodnar, Malla, A., Joober, R., Lord, C., *Smith, E., & Lepage, M. (2012). Neural markers of early remission in first-episode schizophrenia: a volumetric neuroimaging study of the parahippocampus. Psychiatry Research: Neuroimaging, 201(1):40-47.
  4. *Brodeur, M., Kehayia, E., *Dion-Lessard, G., *Chauret, M., *Dionne-Dostie, E., *Montreuil, T., Smith, L., & Lepage, M. (2012). The Bank of Standardized Stimuli (BOSS): Comparison between French and English norms. Behavior Research Methods, 44:961-970.
  5. *Buchy, L., Ad-Dab’bagh, Y., Malla, A., Lepage, C., Joober, R., Evans, A., & Lepage, M. (2012). Symptom attribution in first-episode psychosis: A cortical thickness study. Psychiatry Research: Neuroimaging, 203:6-13.
  6. *Buchy, L., *Luck, D., Malla, A., Joober, R., Czechowska, Y., & Lepage, M. (2012). Diffusion tensor imaging tractography of the fornix and belief confidence in beliefs in first-episode psychosis. Schizophrenia Research, 137:80-84.
  7. *Buchy, L., *Brodeur, M., & Lepage, M. (2012). The Beck Cognitive Insight Scale: Psychometric properties in a Canadian community sample. Schizophrenia Research, 137:254-255.
  8. *Cassidy, C.M., Lepage, M., *Harvey, P.-O., & Malla, A. (2012). Cannabis use and anticipatory pleasure as reported by subjects with early psychosis and community controls. Schizophrenia Research, 137:39-44.
  9. *Hovington, C.L., & Lepage, M. (2012). Neurocognition and neuroimaging of persistent negative symptoms of schizophrenia. Expert Review of Neurotherapeutics, 12(1):53-69.
  10. *Hovington, C.L., *Bodnar, M, Joober, R., Malla, A., & Lepage, M. (2012). Identifying persistent negative symptoms in first episode psychosis. BMC Psychiatry, 12(1):224. doi:10.1186/1471-244X-12-224.
  11. *Hovington, CL., McGirr, A., Lepage, M., & Berlim, MT. (2013). Repetitive transcranial magnetic stimulation (rTMS) for treating major depression and schizophrenia: a systematic review of recent meta-analyses. Annals of medicine, 45:308-321.
  12. O'Sullivan, M., Lepage, M., Bouras, M., *Montreuil, T., & *Brodeur, M.B. (2012). North-American Norms for Name Disagreement: Pictorial Stimuli Naming Discrepancies. PLoS ONE, 7(10), e47802.

2011

  1. *Bodnar, M.D., *Harvey, P.-O., Malla, A.K., Joober, R., & Lepage, M. (2011). The parahippocampal gyrus as a neural marker of early remission in first-episode psychosis: a voxel-based morphometry study. Clinical Schizophrenia & Related Psychoses, 4:217-228.
  2. **Brodeur, M., Chauret, M., Dion-Lessard, G., & Lepage, M. (2011). Symmetry brings an impression of familiarity but does not improve recognition memory. Acta Psychologica, 137:359-370.
  3. **Brodeur, M., Debruille, J.B., Renoult, L., Prévost, M., *Dionne-Dostie, E., *Buchy, L., & Lepage, M. (2011). The influence of contour fragmentation on recognition memory: an event-related potential study. Brain & Cognition, 76:115-122.
  4. *Buchy, L., Ad-Dab’bagh, Y., Malla, A., Lepage, C., *Bodnar, M., Joober, R., *Sergerie, K., Evans, A., & Lepage, M. (2011). Cortical thickness is associated with poor insight in first-episode psychosis. Journal of Psychiatric Research, 45:781-787.
  5. Lepage, M., *Sergerie, K., *Benoit, A., Czechowska, Y., Dickie, E., & Armony, J.L. (2011). Emotional face processing and flat affect in schizophrenia: Functional and structural neural correlates. Psychological Medicine, 41:1833-1844.
  6. *Luck, D., *Buchy, L., Czechowska, Y., *Bodnar, M., *Achim, A., Campbell, J., Pike, B., Malla, A., Joober, R., & Lepage, M. (2011). Fronto-temporal disconnectivity and clinical short-term outcome in first episode psychosis: A DTI-tractography study. Journal of Psychiatric Research, 45:369-377.
  7. Malla, A.K., *Bodnar, M., Joober, R., & Lepage, M. (2011). Duration of untreated psychosis is associated with orbital-frontal grey matter volume reductions in first episode psychosis. Schizophrenia Research, 125:13-20.

2010

  1. Béchard-Evans, L., Iyer, S., Lepage, M., Joober, R., & Malla, A. (2010). Investigating cognitive deficits and symptomatology across premorbid adjustment patterns in first-episode psychosis. Psychological Medicine, 40:749-759.
  2. *Buchy, L., *Bodnar, M.D., Malla, A.K., Joober, R., & Lepage, M. (2010). A 12-month outcome study of insight and symptom change in first-episode psychosis. Early Intervention in Psychiatry, 4:79-88.
  3. *Buchy, L., Czechowska, Y., Chocol, C., Malla, A.K., Joober, R., Pruessner, J., & Lepage, M. (2010). Toward a model of cognitive insight in psychosis: Verbal memory and hippocampal structure. Schizophrenia Bulletin, 36:1040-1049.
  4. *Bodnar, M.D., Malla, A.K., Czechowska, Y., *Benoit, A., Fathalli, F., Joober, R., Pruessner, M., Pruessner, J., & Lepage, M. (2010). Neural markers of remission in first-episode schizophrenia: a volumetric neuroimaging study of the hippocampus and amygdala. Schizophrenia Research, 122:72-80.
  5. **Brodeur, M., *Dionne-Dostie, E., *Montreuil, T., & Lepage, M. (2010). The Bank of Standardized Stimuli (BOSS), a new set of 480 normalive photos of objects to be used as visual stimuli in cognitive research. PLoS One, 5(5):e10773.
  6. **Brodeur, M., *Pelletier, M., *Bodnar, M., & Lepage, M. (2010). The effect of viewpoint on visual stimuli: a study of episodic memory in schizophrenia. Psychiatry Research, 176:126-131.
  7. *Harvey, P.-O., Malla, A.K., Armony, J., & Lepage, M. (2010). Functional neural substrates of self-reported physical anhedonia in non-clinical individuals and in patients with schizophrenia. Journal of Psychiatric Research, 44:707-716.
  8. Lepage, M., *Pelletier, M., *Achim, A.M., *Montoya, A., Menear, M., & Lal, S. (2010). Parietal cortex and episodic memory retrieval in schizophrenia. Psychiatry Research: Neuroimaging, 182:191-199.
  9. Lepage, M., *Bodnar, M., Joober, R., & Malla, A.K. (2010). Is there an association between neurocognitive performance and medication adherence in first episode psychosis? Early Intervention in Psychiatry, 4:189-195.
  10. Lepage, M., *Bodnar, M., *Buchy, L., Joober, R., & Malla, A.K. (2010). Early medication adherence and insight change in first-episode psychosis. Clinical Schizophrenia & Related Psychoses, 3:201-208.
  11. *Luck, D., Malla, A., Joober, R., & Lepage, M. (2010). Disrupted integrity of the fornix in first-episode schizophrenia. Schizophrenia Research, 119:61-64.
  12. *Montreuil, T., *Bodnar, M., *Bertrand, M.-C., Malla, A.K., Joober, R., & Lepage, M. (2010). Social cognitive markers of short-term clinical outcome in first-episode psychosis. Clinical Schizophrenia & Related Psychoses, 4:105-114.
  13. *Roy, M., *Harvey, P.-O., Berlim, M.T., Mamdani, F., Beaulieu, M.M., Turecki, G., & Lepage, M. (2010). Medial prefrontal cortex activity during memory encoding of pictures and its relation to symptomatic improvement after citalopram treatment in patients with major depression. Journal of Psychiatry & Neuroscience, 35:152-162.
  14. *Sergerie, K., Armony, J.L., Menear, M., Sutton, H., & Lepage, M. (2010). Influence of emotional expression on memory recognition bias in schizophrenia as revealed by fMRI. Schizophrenia Bulletin, 36:800-810.

2009

  1. Bergouignan, L., Chupin, M., Czechowska, Y., Kinkingnéhun, S., Lemogne, C., Le Bastard, G., Lepage, M., Garnero, L., Colliot, O., & Fossati, P. (2009). Can voxel based morphometry, manual segmentation, and automated segmentation equally detect hippocampal volume differences in acute depression? NeuroImage, 45:29-37.
  2. *Brodeur, M., *Pelletier, M., & Lepage, M. (2009). Memory for everyday actions in schizophrenia. Schizophrenia Research, 114:71-78.
  3. Brown, T.G., Ouimet, M.-C., Nadeau, L., Gianoulakis, C., Lepage, M., Tremblay, J., & Dongier, M. (2009). From the brain to bad behaviour and back again: Neurocognitive and psychobiological mechanisms of driving while impaired by alcohol. Drug and Alcohol Review, 28(4): 406-418.
  4. *Buchy, L., Malla, A.K., Joober, R., & Lepage, M. (2009). Delusions are associated with low self-reflectiveness in first-episode psychosis. Schizophrenia Research, 112:187-191.
  5. *Buchy, L., Czechowska, Y., Chochol C., Malla, A., Joober, R., Pruessner, J., & Lepage, M. (2009). Toward a model of cognitive insight in first-episode psychosis: verbal memory and hippocampal structure. Schizophrenia Bulletin, sbp015.
  6. *Harvey, P.-O., *Bodnar, M.D., *Sergerie, K., Armony, J., & Lepage, M. (2009). Relation between emotional face memory and social anhedonia in schizophrenia. Journal of Psychiatry & Neuroscience, 34:102-110.
  7. *Luck, D., Lepage, M., *Buchy, L., & Danion, J.-M. (2009). Examining the effects of two factors on working memory maintenance of bound information in schizophrenia. Journal of the International Neuropsychological Society, 15:597-605.
  8. *Luck, D., *Montoya, A., Menear, M., *Achim, A.M., Lal, S., & Lepage, M. (2009). Selective pair recognition memory impairment with no response bias in schizophrenia. Psychiatry Research, 169:39-42.

2008

  1. *Bertrand, M.-C., *Achim, A., *Harvey, P.-O., Sutton, H., Malla, A.K., & Lepage, M. (2008). Structural neural correlates of impairments in social cognition in first episode psychosis. Social Neuroscience, 3:79-88.
  2. *Blondin, F., & Lepage, M. (2008). An fMRI study on memory discriminability for complex visual scenes. Human Brain Mapping, 29(10):1159-1169.
  3. *Bodnar, M.D., Malla, A.K., Joober, R., & Lepage, M. (2008). Cognitive markers of short-term clinical outcome in first-episode psychosis. British Journal of Psychiatry, 193:297-304.
  4. *Brodeur, M., Bacon, B.A., Renoult, L., Prévost, M., Lepage, M., & Debruille, J.B. (2008). On the functional significance of the P1 and N1 effects to illusory figures in the notch mode of presentation. PLoS ONE. 3(10):e3505.
  5. *Brodeur, M., Lepore, F., Lepage, M., Bacon, B.A., Jemel, B., & Debruille, J.B. (2008). Alternative mode of presentation of Kanizsa figures sheds new light on the chronometry of the neural mechanisms underlying the perception of illusory figures. Neuropsychologia, 46:554-566.
  6. *Brodeur, M., *Pelletier, M., & Lepage, M. (2008). Seeing is remembering: Do deficits in closure affect visual memory recognition in schizophrenia? Cognitive Neuropsychiatry, 13(5):385-405.
  7. Brown, T.G., Ouimet, M.-C., Nadeau, L., Lepage, M., Tremblay, J., Dongier, M., & Ng Ying Kin, N.M.K. (2008). DUI offenders who delay relicensing: A quantitative and qualitative investigation. Traffic Injury Prevention, 9:109-118.
  8. Lepage, M., *Buchy, L., *Bodnar, M.D., *Bertrand, M.-C., Joober, R., & Malla, A.K. (2008). Cognitive insight and verbal memory in first episode of psychosis. European Psychiatry, 23:368-374.
  9. *Luck, D., Foucher, J., Offerlin-Meyer, I., Lepage, M., & Danion, J.-M. (2008). Assessment of single and bound features in a working memory task in schizophrenia. Schizophrenia Research, 100:153-160.
  10. *Montoya, A., Lal, S., Menear M., *Duplessis, E., Thavundayil, J., Schmitz, N., & Lepage, M. (2008). Apomorphine effects on episodic memory in young healthy volunteers. Neuropsychologia, 46:292-300.
  11. *Pelletier, M., *Luck, D., *Harvey, P.-O., & Lepage, M. (2008). Apports de la neuro-imagerie fonctionnelle dans la physiopathologie des symptômes positifs de la schizophrénie. Revue Québécoise de Psychologie, 29:25-36.
  12. Tranulis, C., Lepage, M., & Malla, A.K. (2008). Insight in first episode psychosis: who is measuring what? Early Intervention in Psychiatry, 2:34-41.

2007

  1. *Achim, A.M., *Bertrand, M.-C., *Montoya, A., Malla, A.K., & Lepage, M. (2007). Medial temporal lobe activations during associative memory encoding for arbitrary and semantically related object pairs. Brain Research, 1161:46-55.
  2. *Achim, A.M., *Bertrand, M.-C., Sutton, H., *Montoya, A., Czechowska, Y., Malla, A.K., Joober, R., Pruessner, J.C., & Lepage, M. (2007). Selective abnormal modulation of hippocampal activity during memory formation in first-episode psychosis. Archives of General Psychiatry, 64:999-1014.
  3. *Bertrand, M.-C., Sutton, H., *Achim, A.M., Malla, A.K., & Lepage, M. (2007). Social cognitive impairments in first episode of psychosis. Schizophrenia Research, 95:124-133.
  4. *Harvey, P.-O., Fossati, P., & Lepage, M. (2007). Modulation of memory formation by stimulus content: specific role of the medial prefrontal cortex in the successful encoding of social pictures. Journal of Cognitive Neuroscience, 19(2):351-362.
  5. *Harvey, P.-O., & Lepage, M. (2007). Corrélats neuronaux de la capacité hédonique: Un marqueur potentiel de vulnérabilité aux maladies psychiatriques? Médecine/Sciences, 23(12):1096-1098.
  6. *Harvey, P.-O., Lepage, M., & Malla, A.K. (2007). Benefits of enriched intervention compared with standard care for patients with a recent-onset psychosis: a meta-analytic approach. Canadian Journal of Psychiatry, 52(7):464-472.
  7. *Harvey, P.-O., Pruessner, J.C., Czechowska, Y., & Lepage, M. (2007). Individual differences in trait anhedonia: a structural and functional magnetic resonance imaging study in non-clinical subjects. Molecular Psychiatry, 12:767-775.
  8. Lepage, M. (2007). Memory and schizophrenia. (Guest editorial). Canadian Journal of Psychiatry, 52:691-692.
  9. Lepage, M., *Sergerie, K., *Pelletier, M., & *Harvey, P.-O. (2007). Episodic memory bias and the symptoms of schizophrenia. Canadian Journal of Psychiatry, 52(11):702-709.
  10. *Montoya, A., *Pelletier, M., *Achim, A.M., Menear, M., Lal, S., & Lepage, M. (2007). Disfunción prefrontal en esquizofrenia: implicación en el reconocimiento de asociaciones (Prefrontal dysfunction and associative recognition in schizophrenia) Actas Españolas de Psiquiatría, 35:176-181.
  11. Ouimet, M.-C., Brown, T.G., Nadeau, L., Lepage, M., *Pelletier, M., Couture, S., Tremblay, J., Legault, L., Dongier, M., Gianoulakis, C., & Ng Ying Kin, N.M. (2007). Neurocognitive characteristics of DUI recidivists. Accident Analysis & Prevention, 39:743-750.
  12. Pellerin, M., Yankeelov, T.E., & Lepage, M. (2007). Incorporating contrast agent diffusion into the analysis of DCE-MRI data. Magnetic resonance in medicine, 58(6): 1124-1134.
  13. *Sergerie, K., Lepage, M., & Armony, J.L. (2007). Influence of emotional expression on memory recognition bias: a functional magnetic resonance imaging study. Biological Psychiatry, 62(10):1126-1133.

2006

  1. Lepage, M., *Montoya, A., *Pelletier, M., *Achim, A.M., Menear, M., & Lal, S. (2006) Associative memory encoding and recognition in schizophrenia: an event-related fMRI study. Biological Psychiatry, 60:1215-1223.
  2. *Montoya, A., *Achim, A.M., Menear, M., Chouinard, S., Richer, F., Lepage, M., & Ruiz-Lopez, I. (2006). Disfunción de la memoria episódica en la enfermedad de Huntington (Memory dysfunction in Huntington's disease). Archivos de neurosciencias, 11(1):11-17.
  3. *Montoya, A., *Pelletier, M., Menear, M., *Duplessis, E., Richer, F., & Lepage, M. (2006). Episodic Memory impairment in Huntington's Disease: A Meta-Analysis. Neuropsychologia, 44(10):1984-1994.
  4. *Montoya, A., Price, B.H., Menear, M., & Lepage, M. (2006). Brain imaging and cognitive dysfunctions in Huntington's Disease. Journal of Psychiatry & Neuroscience, 31:21-29.
  5. *Montoya, A., Price, B.H., & Lepage, M. (2006). Neural correlates of ‘functional’ symptoms in neurology. Functional Neurology, 21(4):193-197.
  6. *Sergerie, K., Lepage, M., & Armony, J.L. (2006). A process-specific functional dissociation of the amygdala in emotional memory. Journal of Cognitive Neuroscience, 18(8):1359-1367.

2005

  1. *Achim, A.M., & Lepage, M. (2005). Episodic memory-related activation in schizophrenia: meta-analysis. British Journal of Psychiatry, 187:500-509.
  2. *Achim, A.M., & Lepage, M. (2005). Dorsolateral prefrontal cortex involvement in memory post-retrieval monitoring revealed in both item and associative recognition tests. NeuroImage, 24(4), 1113-1121.
  3. *Achim, A.M., & Lepage, M. (2005). Neural correlates of memory for items and for associations: An event-related functional Magnetic Resonance Imaging study. Journal of Cognitive Neuroscience, 17(4):652-667.
  4. *Blondin, F., & Lepage, M. (2005). Decrease and increase in brain activity during visual perceptual priming: an fMRI study on similar but perceptually different complex visual scenes. Neuropsychologia, 43:1887-1900.
  5. Lepage, M., *Blondin, F., *Achim, A.M, Menear, M., & *Brodeur, M. (2005). The interfering effect of related events on recognition memory discriminability: a functional magnetic resonance imaging study. Cognitive Brain Research, 22(3):429-437.
  6. Lepage, M., Menear, M., *Montoya, A., & *Achim, A.M. (2005). Associative interference does not affect recognition memory in schizophrenia. Schizophrenia Research, 80:185-196.
  7. *Montoya, A., Lepage, M., & Malla, A. (2005). Disfunción estructural del lóbulo temporal en pacientes con un primer episodio psicótico de esquizofrenia (Temporal lobe dysfunction in patients with first-episode schizophrenia). Salud Mental, 28(2):33-39.
  8. *Pelletier, M., *Achim, A., *Montoya, A., Lal, S., & Lepage, M. (2005). Cognitive and clinical moderators of recognition memory in schizophrenia: A meta-analysis. Schizophrenia Research, 74:233-252.
  9. *Sergerie, K., Lepage, M., & Armony, J.L. (2005). A face to remember: Emotional expression modulates prefrontal activity during memory formation. NeuroImage, 24:580-585.

2004

  1. Fossati, P., Hevenor, S.J., Lepage, M., Graham, S.J., Grady, C., Keightley, M.L., Craik, F., & Mayberg, H. (2004). Distributed self in episodic memory: neural correlates of successful retrieval of self-encoded positive and negative personality traits. NeuroImage, 22(4):1596-1604.
  2. Lepage, M. (2004). Differential contribution of left and right prefrontal cortex to associative cued-recall memory: A parametric PET study. Neuroscience Research, 48(3):297-304.

2003

  1. *Achim, A.M., & Lepage, M. (2003). Is associative recognition more impaired than item recognition memory in schizophrenia? A meta-analysis. Brain & Cognition, 53(2):121-124.
  2. Lepage, M., *Brodeur, M., & Bourgouin, P. (2003). Prefrontal cortex contribution to associative recognition memory in humans: An event-related functional Magnetic Resonance Imaging study. Neuroscience Letters, 346:73-76.
  3. Marcantoni, W.S., Lepage, M., Beaudoin, G., Bourgouin P., & Richer, F. (2003). Neural correlates of dual task interference in rapid visual streams: an fMRI study. Brain & Cognition, 53(2): 318-321.

2002

  1. Lepage, M., & *Achim, A (2002). Le lobe frontal et la mémoire épisodique: Une perspective cognitive neuroscientifique. Revue Québécoise de Psychologie, 23:147-163.

2001

  1. Lepage, M., McIntosh, A.R., & Tulving, E. (2001). Transperceptual encoding and retrieval processes in memory: A PET study of visual and haptic objects. NeuroImage, 14(3):572-584.
  2. Lupien, S.J., & Lepage, M. (2001). Stress, memory and the hippocampus: can’t live with it, can’t live without it. Behavioral Brain Research, 127(1-2):137-158.

2000

  1. Lepage, M., Ghaffar, O., Nyberg, L., & Tulving, E. (2000). Prefrontal cortex and episodic memory retrieval mode. Proceedings of the National Academy of Sciences of the United States of America, 97(1):506-511.
  2. Lepage, M., Habib, R., Cormier, H., Houle, S., & McIntosh, A.R. (2000). Neural correlates of semantic associative encoding in episodic memory. Cognitive Brain Research, 9(3):271-280.
  3. Lepage, M., & Richer, F. (2000). Frontal brain lesions affect the use of advance information during response planning. Behavioral Neuroscience, 114(6):1034-1040.

1999-1996

  1. Lepage, M., Beaudoin, G., Boulet, C., O’Brien, I., Marcantoni, W., Bourgouin, P., & Richer, F. (1999). Frontal cortex and the programming of repetitive tapping movements in man: Lesion effects and functional neuroimaging. Cognitive Brain Research, 8(1):17-25.
  2. Lepage, M., Décary, A., & Richer, F. (1996). Contributions of decisional control processes to frontal executive deficit. Brain & Cognition, 30:346-348.
  3. Lepage, M., Habib, R., & Tulving, E. (1998). Hippocampal PET activations of memory encoding and retrieval: The HIPER model. Hippocampus, 8(4):313-322.
  4. Lepage, M., & Richer, F. (1996). Inter-response interference contributes to the sequencing deficit in frontal lobe lesions. Brain, 119:1289-1295.
  5. Lepage, M., Stuss, D.T., & Richer, F. (1999). Attention and the frontal lobes: A comparison between normal aging and lesion effects. Brain & Cognition, 39:63-66.
  6. Richer, F., Bédard, S., Lepage, M., & Chouinard, M.-J. (1998). Frontal lesions produce a dual-task deficit in simple rapid choices.  Brain & Cognition, 37:173-175.
  7. Richer, F., Décary, A., Chouinard, M.-J., & Lepage, M. (1996). Working memory is not preferentially affected by frontal excisions. Brain & Cognition, 30:422-425.
  8. Richer, F., & Lepage, M. (1996). Frontal lesions increase post-target interference in rapid stimulus streams. Neuropsychologia, 34(6):509-514.
  9. Tulving, E., Habib, R., Nyberg, L., Lepage, M., & McIntosh, A.R. (1999). Positron emission tomography correlations in and beyond the medial temporal lobes. Hippocampus, 9(1):71-82.

 


James McGill Professor Award (2013-2020)
FRQS Senior Research Scholar (2010-2014)
Clinical Scholarship, Beck Institute for Cognitive Therapy & Research (2010)
Dr. Heinz Lehmann Award, Douglas Institute Foundation (2010)
Diplomé émérite: Department of Psychology, Université du Quebec à Montreal (2010)
Canadian College of Neuropsychopharmacology (CCNP) - Young Investigator Award (2007)
Dean’s Research Recognition Award, Faculty of Medicine, McGill University (2006)
FRQS Research Scholar Junior 2 (2006 - 2010)
FRQS Research Scholar Junior 1(2002 - 2006)
National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award (2002)


Lab Manager:

Karyne Anselmo, M.Sc; ext. 3296; karyne.anselmo@douglas.mcgill.ca

Research Coordinators:

Danielle Penney, B.A.; ext. 3485;  danielle.penney@douglas.mcgill.ca
Lucile Rapin, Ph.D.; ext. 3478; lucile.rapin@douglas.mcgill.ca

Research Assistant: 

Casandra Roy Gelencser, B.A.; ext. 3386; casandra.roy-gelencser@douglas.mcgill.ca

Graduate Students:

 


Recent publications