6875 Boulevard Lasalle
Researcher, Douglas Institute
Assistant Professor, Department of Psychiatry, McGill University
Study and prevention of psychiatric and neuro-degenerative diseases
Xiangfei has broad research interests in population health and neuro-psychiatric epidemiology in general and aging populations, using a wide range of techniques to research the roles of genetic, psycho-socio environmental risk factors and their interactions of common mental disorders across the life span, especially focusing on the importance of prevention strategies in diverse ethno-cultural environment.
The etiology of mental disorders remains unclear. It is widely accepted that a complex interplay of genetic and psycho-socio environmental risk factors, and their interactions cause mental disorders.
Even through psychotropic medications, psychotherapy, and alternative therapies have been widely used in the clinical practice, their population impact is limited due to the rising treatment demands and limited resources for mental health care services. There is a lack of population initiatives or large-scale trials for the prevention of mental disorders.
Because of the nature of mental disorders, people with different genetic backgrounds maybe associated to varying degrees of vulnerabilities for mental disorders and thus respond differently when faced with similar psycho-socio environmental risks.
Mental disorder prevention strategies should embody a life course approach, that draws attention to the powerful connection between experiences/events early on and their consequences over time.
Evidence-based prevention strategies for common mental disorders specific to the Canadian population and Quebecers are needed, with special attention given to logical links throughout the life course.
Her research applies evidence-based epidemiological approaches to strengthen evidence and strategies for the prevention of mental disorders, will advance the understanding of the etiology and prevention of mental disorders, maximize "translational" component in which knowledge is used in a joint effort to translate discoveries into clinical and public health actions, and perhaps set an example for the prevention of other complex diseases.
Meng X, D'Arcy C. Comorbidity between lifetime eating problems and mood and anxiety disorders: results from the Canadian Community Health Survey of Mental Health and Well-being. Eur Eat Disord Rev. 2015;23(2):156-62. http://www.ncbi.nlm.nih.gov/pubmed/?term=25604862
D'Arcy C, Meng X. Prevention of common mental disorders: conceptual framework and effective interventions. Curr Opin Psychiatry. 2014;27(4):294-301.
Meng X, D'Arcy C. The projected effect of risk factor reduction on major depression incidence: a 16-year longitudinal Canadian cohort of the National Population Health Survey. J Affect Disord. 2014;158:56-61.
Meng X, D'Arcy C, Tempier R. Long-term trend in pediatric antidepressant use, 1983-2007: a population-based study. Can J Psychiatry. 2014;59(2):89-97.
Meng X, D'Arcy C. Successful aging in Canada: prevalence and predictors from a population-based sample of older adults. Gerontology. 2014; 60(1):65-72.
Meng X, D'Arcy C. Apolipoprotein E gene, environmental risk factors, and their interactions in dementia among seniors. Int J Geriatr Psychiatry. 2013; 28(10):1005-14.
Meng X, D'Arcy C. Mortality and morbidity hazards associated with cognitive status in seniors: a Canadian population prospective cohort study. Asia Pac Psychiatry. 2013;5(3):175-82.
Meng X, Yu Y, Kou C, D'Arcy C, Shi J. No genetic association between single-nucleotide polymorphisms in the coding region of the SLC6A4 gene and internalizing disorders in mainland Chinese university students. Psychiatr Genet. 2013;23(1):36-7.
Meng X, D'Arcy C, Morgan D, Mousseau DD. Predicting the risk of dementia among Canadian seniors: a useable practice-friendly diagnostic algorithm. Alzheimer Dis Assoc Disord. 2013;27(1):23-9.
Meng X, D'Arcy C. The projected effect of increasing physical activity on reducing the prevalence of common mental disorders among Canadian men and women: a national population-based community study. Prev Med. 2013;56(1):59-63.
Meng X, D'Arcy C. Common and unique risk factors and comorbidity for 12-month mood and anxiety disorders among Canadians. Can J Psychiatry. 2012;57(8):479-87.
Meng X, D'Arcy C, Tempier R, Kou C, Morgan D, Mousseau DD. Survival of patients with incident dementia who had a pre-existing psychiatric disorder: a population-based 7-year follow-up study. Int J Geriatr Psychiatry. 2012;27(7):683-91.
Meng X, D'Arcy C. Education and dementia in the context of the cognitive reserve hypothesis: a systematic review with meta-analyses and qualitative analyses. PLoS One. 2012;7(6):e38268.
Meng X, Kou C, Shi J, Yu Y, Huang Y. Susceptibility genes, social environmental risk factors and their interactions in internalizing disorders among mainland Chinese undergraduates. J Affect Disord. 2011;132(1-2):254-9.
Meng X, Kou C, Yu Q, Shi J, Yu Y. Schizophrenia: an association study targets phospholipase A2 genes as potential sites of susceptible genes. Psychiatry Res. 2010;175(1-2):186-7. http://www.ncbi.nlm.nih.gov/pubmed/?term=19892409
Xiangfei Meng was trained in multiple disciplines. Her previous training consists of a Bachelor degree in Preventive Medicine, a Master Degree in Epidemiology & Biostatistics and a Doctor degree in Medical Genomics (Genetic Epidemiology direction). She then successfully completed her postdoctoral training, which was funded by CIHR-PHARE (Public Health and the Agricultural Rural Ecosystem) and SHRF (Saskatchewan Health Research Foundation).
The poster by Xiangfei Meng et al., “Does More Education Protect Against Alzheimer’s Disease and Vascular Dementia? A Systematic Review With Meta-Analysis” received First Prize awarded to posters at 2008 World Psychiatric Association Epidemiology and Public Health Section Meeting, Saskatoon, Saskatchewan, Canada, May 11-14, 2008.
Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis. Hum Psychopharmacol. 2016;31(4):286-95.
When social anxiety and depression go together: A population study of comorbidity and associated consequences. J Affect Disord. 2016;206:48-54.
Prevalence, correlates of major depression: A mental health survey among undergraduates at a mainland Chinese university. Asia Pac Psychiatry. 2016;8(3):206-14.
Associations between adult attachment style and mental health care utilization: Findings from a large-scale national survey. Psychiatry Res. 2015;229(1-2):454-61.