Treatment Options for the Cardinal Symptoms of Disruptive Mood Dysregulation Disorder.
Title | Treatment Options for the Cardinal Symptoms of Disruptive Mood Dysregulation Disorder. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Tourian L, LeBoeuf A, Breton J-J, Cohen D, Gignac M, Labelle R, Guilé J-M, Renaud J |
Journal | J Can Acad Child Adolesc Psychiatry |
Volume | 24 |
Issue | 1 |
Pagination | 41-54 |
Date Published | 2015 Winter |
ISSN | 1719-8429 |
Abstract | OBJECTIVE: DSM-5 has added a new developmentally appropriate child and adolescent mood disorder subtype called disruptive mood dysregulation disorder (DMDD). The core features of DMDD are temper outbursts (manifested by either verbal rages and/or physical aggression) and unrelenting irritability or anger. Currently, the literature is lacking a thorough review of the possible treatment options for the cardinal symptoms constituting DMDD. The objective of this article is to provide a thorough review of peer-reviewed studies on the subject of pharmacological treatment options for children and adolescents with the cardinal symptoms of DMDD.METHODS: Relevant articles for this study were obtained through Pubmed, Medline, PsychINFO and PsychINDEXplus using the key words: "adolescents," "children," "paediatric," "youth," "irritability," "temper outbursts," "aggression," "rage," "disruptive behaviour," "treatment," "dysphoria," "autism," "mental retardation/intellectual disability," "impulsivity," "ADHD," "oppositional defiant disorder," and "conduct disorder." A total of 823 studies were generated; only English studies focusing on pharmacological treatment were retained.RESULTS: Currently there are no established guidelines or thorough reviews summarizing the treatment of DMDD. Pharmacotherapeutic treatment options of both aggression and chronic irritability include: antidepressants/selective norepinephrine reuptake inhibitors, mood stabilizers, psychostimulants, antipsychotics, and alpha-2 agonists.CONCLUSION: Treatment options of severe, persistent irritability in youth are numerous, and a consensual treatment algorithm has not yet emerged from the literature. Further studies and clinical trials are warranted to determine efficacious and safe treatment modalities. |
Alternate Journal | J Can Acad Child Adolesc Psychiatry |
PubMed ID | 26336379 |
PubMed Central ID | PMC4357333 |