Transcriptomic and epigenomic biomarkers of antidepressant response.

TitleTranscriptomic and epigenomic biomarkers of antidepressant response.
Publication TypeJournal Article
Year of Publication2017
AuthorsBelzeaux R, Lin R, Ju C, Chay M-A, Fiori LM, Lutz P-E, Turecki G
JournalJ Affect Disord
Date Published2017 Sep 08
ISSN1573-2517
Abstract

BACKGROUND: Antidepressant treatment is associated with a high rate of poor response, and thus, biomarker development is warranted.METHODS: We aimed to synthesize studies investigating gene expression, small RNAs, and epigenomic biomarkers of antidepressant response. We conducted a narrative review of the literature.RESULTS: Firstly, we detailed the challenges involved, in terms of biological tissues, relevant study time frames, and mandatory statistical tools. Secondly we synthesized results obtained in gene expression studies, focusing mainly on genome-wide studies, particularly small non-coding RNA, including micro-RNA and other small RNA species. In addition, we reviewed the potential biomarkers of antidepressant response arising from studies investigating DNA methylation variation and histone modifications.LIMITATIONS: We did not conduct a meta-analysis due to the heterogeneity of the study.CONCLUSION: Although promising, the field of gene expression and epigenomic biomarkers of antidepressant response is still in its infancy, and needs further development to define useful biomarkers in clinical practice.

DOI10.1016/j.jad.2017.08.087
Alternate JournalJ Affect Disord
PubMed ID28918100

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