Tracking neuroinflammation in Alzheimer's disease: the role of positron emission tomography imaging.

TitleTracking neuroinflammation in Alzheimer's disease: the role of positron emission tomography imaging.
Publication TypeJournal Article
Year of Publication2014
AuthorsZimmer ERigon, Leuzy A, Benedet ALessa, Breitner JCS, Gauthier S, Rosa-Neto P
JournalJ Neuroinflammation
Volume11
Pagination120
Date Published2014
ISSN1742-2094
KeywordsAlzheimer Disease, Anti-Inflammatory Agents, Encephalitis, Humans, Positron-Emission Tomography
Abstract

Alzheimer's disease (AD) has been reconceptualized as a dynamic pathophysiological process, where the accumulation of amyloid-beta (Aβ) is thought to trigger a cascade of neurodegenerative events resulting in cognitive impairment and, eventually, dementia. In addition to Aβ pathology, various lines of research have implicated neuroinflammation as an important participant in AD pathophysiology. Currently, neuroinflammation can be measured in vivo using positron emission tomography (PET) with ligands targeting diverse biological processes such as microglial activation, reactive astrocytes and phospholipase A2 activity. In terms of therapeutic strategies, despite a strong rationale and epidemiological studies suggesting that the use of non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the prevalence of AD, clinical trials conducted to date have proven inconclusive. In this respect, it has been hypothesized that NSAIDs may only prove protective if administered early on in the disease course, prior to the accumulation of significant AD pathology. In order to test various hypotheses pertaining to the exact role of neuroinflammation in AD, studies in asymptomatic carriers of mutations deterministic for early-onset familial AD may prove of use. In this respect, PET ligands for neuroinflammation may act as surrogate markers of disease progression, allowing for the development of more integrative models of AD, as well as for the measuring of target engagement in the context of clinical trials using NSAIDs. In this review, we address the biological basis of neuroinflammatory changes in AD, underscore therapeutic strategies using anti-inflammatory compounds, and shed light on the possibility of tracking neuroinflammation in vivo using PET imaging ligands.

DOI10.1186/1742-2094-11-120
Alternate JournalJ Neuroinflammation
PubMed ID25005532
PubMed Central IDPMC4099095
Grant ListMOP-11-51-31 / / Canadian Institutes of Health Research / Canada