Tieyuan Zhang

Tieyuan Zhang

Room E-4131.01, Perry Pavilion

6875 Boulevard Lasalle
Montréal, QC 
H4H 1R3

(514) 761-6131 x6178

Research area: 
Basic Neuroscience / Animal Research

Research Theme: 
Stress, mood and impulsivity disorders

Assistant professor.
MD., PhD.

Optoneuroepigenetics lab

Variations in maternal care profoundly influence multiple aspects of offspring development. These maternal effects are observed across a wide range of species yet we have a limited understanding of the neurobiological basis of maternal care and its effects on offspring neurodevelopment. 
The lab uses optogenetic manipulations paired with next generation sequencing to characterize the critical brain circuits and transcriptional pathways required for the induction and maintenance of maternal behavior.
The lab is also affiliated with the Ludmer Centre for Neuroinformatics and Mental Health. The Centre provides an internationally unique research platform integrating neuroscience, computational biology, mathematics/statistics, genetics, epigenetics, bioinformatics, and epidemiology, together with advanced computing capacity and IT technology. 

1. Zhang, T. Y., Labonte, B., Wen, X. L., Turecki, G., & Meaney, M. J. (2013). Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans. Neuropsychopharmacology, 38(1), 111-123. doi:10.1038/npp.2012.149.
2. Bagot, R. C., Zhang, T. Y., Wen, X., Nguyen, T. T., Nguyen, H. B., Diorio, J., . . . Meaney, M. J. (2012). Variations in postnatal maternal care and the epigenetic regulation of metabotropic glutamate receptor 1 expression and hippocampal function in the rat. Proc Natl Acad Sci U S A, 109 Suppl 2, 17200-17207. doi:10.1073/pnas.1204599109.
3. Shahrokh, D. K., Zhang, T. Y., Diorio, J., Gratton, A., & Meaney, M. J. (2010). Oxytocin-dopamine interactions mediate variations in maternal behavior in the rat. Endocrinology, 151(5), 2276-2286. doi:10.1210/en.2009-1271.
4. Zhang, T. Y., & Meaney, M. J. (2010). Epigenetics and the environmental regulation of the genome and its function. Annu Rev Psychol, 61, 439-466, C431-433. doi:10.1146/annurev.psych.60.110707.163625.
5. Zhang, T. Y., Hellstrom, I. C., Bagot, R. C., Wen, X., Diorio, J., & Meaney, M. J. (2010). Maternal care and DNA methylation of a glutamic acid decarboxylase 1 promoter in rat hippocampus. J Neurosci, 30(39), 13130-13137. doi:10.1523/JNEUROSCI.1039-10.2010.
6. Zhang, T. Y., Chretien, P., Meaney, M. J., & Gratton, A. (2005). Influence of naturally occurring variations in maternal care on prepulse inhibition of acoustic startle and the medial prefrontal cortical dopamine response to stress in adult rats. J Neurosci, 25(6), 1493-1502. doi:10.1523/JNEUROSCI.3293-04.2005.

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