Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer's disease.

TitleTest-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer's disease.
Publication TypeJournal Article
Year of Publication2015
AuthorsOrban P, Madjar C, Savard M, Dansereau C, Tam A, Das S, Evans AC, Rosa-Neto P, Breitner JCS, Bellec P
Corporate AuthorsPREVENT-AD Research Group
JournalSci Data
Date Published2015
KeywordsAged, Alzheimer Disease, Cohort Studies, Dementia, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Randomized Controlled Trials as Topic, Reproducibility of Results

We present a test-retest dataset of resting-state fMRI data obtained in 80 cognitively normal elderly volunteers enrolled in the "Pre-symptomatic Evaluation of Novel or Experimental Treatments for Alzheimer's Disease" (PREVENT-AD) Cohort. Subjects with a family history of Alzheimer's disease in first-degree relatives were recruited as part of an on-going double blind randomized clinical trial of Naproxen or placebo. Two pairs of scans were acquired ~3 months apart, allowing the assessment of both intra- and inter-session reliability, with the possible caveat of treatment effects as a source of inter-session variation. Using the NeuroImaging Analysis Kit (NIAK), we report on the standard quality of co-registration and motion parameters of the data, and assess their validity based on the spatial distribution of seed-based connectivity maps as well as intra- and inter-session reliability metrics in the default-mode network. This resource, released publicly as sample UM1 of the Consortium for Reliability and Reproducibility (CoRR), will benefit future studies focusing on the preclinical period preceding the appearance of dementia in Alzheimer's disease.

Alternate JournalSci Data
PubMed ID26504522
PubMed Central IDPMC4603392
Grant ListP50 AG005134 / AG / NIA NIH HHS / United States