TCF4 gene polymorphism and cognitive performance in patients with first episode psychosis.

TitleTCF4 gene polymorphism and cognitive performance in patients with first episode psychosis.
Publication TypeJournal Article
Year of Publication2014
AuthorsAlbanna A, Choudhry Z, Harvey P-O, Fathalli F, Cassidy C, Sengupta SM, Iyer SN, Rho A, Lepage M, Malla A, Joober R
JournalSchizophr Res
Date Published2014 Jan

BACKGROUND: Single nucleotide polymorphisms in TCF4 gene have been consistently associated with schizophrenia in genome wide association studies, including the C allele of rs9960767. However, its exact role in modulating the schizophrenia phenotype is not known.AIMS: To comprehensively investigate the relationship between rs9960767 risk allele (C) of TCF4 and cognitive performance in patients with first episode psychosis (FEP).METHODS: 173 patients with FEP received a comprehensive neurocognitive evaluation and were genotyped for rs9960767. Carriers of the risk allele (CA/CC) were compared to non-carriers (AA) using Multivariate Analysis of Covariance MANCOVA. Ethnicity, negative symptoms and substance abuse were included as covariates.RESULTS: Carriers of the risk allele had a statistically significant lower performance in the cognitive domain of Reasoning/Problem-Solving compared to non-carriers (F1,172=4.4, p=.038). There were no significant genotype effects on the other cognitive domains or general cognition. This effect on the Reasoning/Problem-Solving domain remained significant even when controlling for IQ (F1,172=4.3, p=.039).CONCLUSIONS: rs9960767 (C) of TCF4 appears to be associated with neurocognitive deficits in the Reasoning/Problem-Solving cognitive domain, in patients with FEP. A confirmation of this finding in a larger sample and including other TCF4 polymorphisms will be needed to gain further validity of this result.

Alternate JournalSchizophr. Res.
PubMed ID24275585
Grant List / / Canadian Institutes of Health Research / Canada