Targeting Alzheimer's Disease at the Right Time and the Right Place: Validation of a Personalized Approach to Diagnosis and Treatment.

TitleTargeting Alzheimer's Disease at the Right Time and the Right Place: Validation of a Personalized Approach to Diagnosis and Treatment.
Publication TypeJournal Article
Year of Publication2018
AuthorsGauthier S, Ng KPin, Pascoal TA, Zhang H, Rosa-Neto P
JournalJ Alzheimers Dis
Date Published2018 Mar 01
ISSN1875-8908
Abstract

Cautious optimism is appropriate for a near future (five years) time frame for a number of drugs acting on the different pathophysiological components of Alzheimer's disease (amyloid deposition, tau hyperphosphorylation, neuroinflammation, vascular changes, to name the most important known so far). Since the relative weight of these components will be different between individuals and will even change over time for each individual, a 'one drug fit for all' approach is no longer defensible. Precision medicine using biomarkers in the diagnosis and treatment of Alzheimer's disease is the new strategy.

DOI10.3233/JAD-179924
Alternate JournalJ. Alzheimers Dis.
PubMed ID29504543