Synergistic interaction between amyloid and tau predicts the progression to dementia.
Title | Synergistic interaction between amyloid and tau predicts the progression to dementia. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Pascoal TA, Mathotaarachchi S, Shin M, Benedet AL, Mohades S, Wang S, Beaudry T, Kang MSu, Soucy J-P, Labbe A, Gauthier S, Rosa-Neto P |
Corporate Authors | Alzheimer's Disease Neuroimaging Initiative |
Journal | Alzheimers Dement |
Volume | 13 |
Issue | 6 |
Pagination | 644-653 |
Date Published | 2017 Jun |
ISSN | 1552-5279 |
Abstract | INTRODUCTION: Recent literature proposes that amyloid β (Aβ) and phosphorylated tau (p-tau) synergism accelerates biomarker abnormalities in controls. Yet, it remains to be answered whether this synergism is the driving force behind Alzheimer disease (AD) dementia.METHODS: We stratified 314 mild cognitive impairment individuals using [(18)F]florbetapir positron emission tomography Aβ imaging and cerebrospinal fluid p-tau. Regression and voxel-based logistic regression models with interaction terms evaluated 2-year changes in cognition and clinical status as a function of baseline biomarkers.RESULTS: We found that the synergism between [(18)F]florbetapir and p-tau, rather than their additive effects, was associated with the cognitive decline and progression to AD. Furthermore, voxel-based analysis revealed that temporal and inferior parietal were the regions where the synergism determined an increased likelihood of developing AD.DISCUSSION: Together, the present results support that progression to AD dementia is driven by the synergistic rather than a mere additive effect between Aβ and p-tau proteins. |
DOI | 10.1016/j.jalz.2016.11.005 |
Alternate Journal | Alzheimers Dement |
PubMed ID | 28024995 |