Superficial white matter as a novel substrate of age-related cognitive decline.
|Title||Superficial white matter as a novel substrate of age-related cognitive decline.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Nazeri A, Chakravarty MM, Rajji TK, Felsky D, Rotenberg DJ, Mason M, Xu LN, Lobaugh NJ, Mulsant BH, Voineskos AN|
|Date Published||2015 Jun|
Studies of diffusion tensor imaging have focused mainly on the role of deep white matter tract microstructural abnormalities associated with aging and age-related cognitive decline. However, the potential role of superficial white matter (SWM) in aging and, by extension, cognitive-aging, is less clear. Healthy individuals (n = 141; F/M: 66/75 years) across the adult lifespan (18-86 years) underwent diffusion tensor imaging and a battery of cognitive testing. SWM was assessed via a combination of probabilistic tractography and tract-based spatial statistics (TBSS). A widespread inverse relationship of fractional anisotropy (FA) values in SWM with age was observed. SWM-FA adjacent to the precentral gyri was associated with fine-motor-speed, whereas performance in visuomotor-attention/processing speed correlated with SWM-FA in all 4 lobes of the left-hemisphere and in right parieto-occipital SWM-FA (family-wise error corrected p < 0.05). Independent of deep white matter-FA, right frontal and right occipital SWM-FA-mediated age effects on motor-speed and visuomotor-attention/processing speed, respectively. Altogether, our results indicate that SWM-FA contributes uniquely to age-related cognitive performance, and should be considered as a novel biomarker of cognitive-aging.
|Alternate Journal||Neurobiol. Aging|
|Grant List||R01MH099167 / MH / NIMH NIH HHS / United States |
R01MH102324 / MH / NIMH NIH HHS / United States
/ / Canadian Institutes of Health Research / Canada