Superficial white matter as a novel substrate of age-related cognitive decline.

TitleSuperficial white matter as a novel substrate of age-related cognitive decline.
Publication TypeJournal Article
Year of Publication2015
AuthorsNazeri A, Chakravarty MM, Rajji TK, Felsky D, Rotenberg DJ, Mason M, Xu LN, Lobaugh NJ, Mulsant BH, Voineskos AN
JournalNeurobiol Aging
Volume36
Issue6
Pagination2094-106
Date Published2015 Jun
ISSN1558-1497
Abstract

Studies of diffusion tensor imaging have focused mainly on the role of deep white matter tract microstructural abnormalities associated with aging and age-related cognitive decline. However, the potential role of superficial white matter (SWM) in aging and, by extension, cognitive-aging, is less clear. Healthy individuals (n = 141; F/M: 66/75 years) across the adult lifespan (18-86 years) underwent diffusion tensor imaging and a battery of cognitive testing. SWM was assessed via a combination of probabilistic tractography and tract-based spatial statistics (TBSS). A widespread inverse relationship of fractional anisotropy (FA) values in SWM with age was observed. SWM-FA adjacent to the precentral gyri was associated with fine-motor-speed, whereas performance in visuomotor-attention/processing speed correlated with SWM-FA in all 4 lobes of the left-hemisphere and in right parieto-occipital SWM-FA (family-wise error corrected p < 0.05). Independent of deep white matter-FA, right frontal and right occipital SWM-FA-mediated age effects on motor-speed and visuomotor-attention/processing speed, respectively. Altogether, our results indicate that SWM-FA contributes uniquely to age-related cognitive performance, and should be considered as a novel biomarker of cognitive-aging.

DOI10.1016/j.neurobiolaging.2015.02.022
Alternate JournalNeurobiol. Aging
PubMed ID25834938
Grant ListR01MH099167 / MH / NIMH NIH HHS / United States
R01MH102324 / MH / NIMH NIH HHS / United States
/ / Canadian Institutes of Health Research / Canada