Spontaneous spatial navigation circuitry in schizophrenia spectrum disorders.

TitleSpontaneous spatial navigation circuitry in schizophrenia spectrum disorders.
Publication TypeJournal Article
Year of Publication2019
AuthorsWilkins LK, Girard TA, Christensen BK, King J, Kiang M, Bohbot VD
JournalPsychiatry Res
Date Published2019 Aug

Spatial memory is core to wayfinding and everyday memory. Interestingly, individuals with schizophrenia using spatial navigation strategies (cognitive mapping) are impaired, whereas those using response-based (e.g., single-landmark) strategies show relatively intact memory performance. We observed abnormal brain communication in schizophrenia participants who used a spatial strategy during a virtual-reality navigation task, particularly between temporal and frontal brain regions. In contrast, schizophrenia participants using a response strategy recruited similar brain systems to healthy participants, but to a greater extent to support memory performance. These findings highlight that strategy use is an important consideration for understanding memory systems and navigation in schizophrenia.

Alternate JournalPsychiatry Res
PubMed ID31174032