Spatial working memory and attention skills are predicted by maternal stress during pregnancy.

TitleSpatial working memory and attention skills are predicted by maternal stress during pregnancy.
Publication TypeJournal Article
Year of Publication2015
AuthorsPlamondon A, Akbari E, Atkinson L, Steiner M, Meaney MJ, Fleming AS
Corporate AuthorsMAVAN Research Team
JournalEarly Hum Dev
Volume91
Issue1
Pagination23-9
Date Published2015 Jan
ISSN1872-6232
KeywordsAdult, Anxiety, Attention, Child Development, Female, Humans, Infant, Male, Memory, Short-Term, Pregnancy, Pregnancy Complications, Stress, Psychological
Abstract

INTRODUCTION: Experimental evidence in rodents shows that maternal stress during pregnancy (MSDP) negatively impacts spatial learning and memory in the offspring. We aim to investigate the association between MSDP (i.e., life events) and spatial working memory, as well as attention skills (attention shifting and attention focusing), in humans. The moderating roles of child sex, maternal anxiety during pregnancy and postnatal care are also investigated.METHODS: Participants were 236 mother-child dyads that were followed from the second trimester of pregnancy until 4 years postpartum. Measurements included questionnaires and independent observations.RESULTS: MSDP was negatively associated with attention shifting at 18 months when concurrent maternal anxiety was low. MSDP was associated with poorer spatial working memory at 4 years of age, but only for boys who experienced poorer postnatal care.CONCLUSION: Consistent with results observed in rodents, MSDP was found to be associated with spatial working memory and attention skills. These results point to postnatal care and maternal anxiety during pregnancy as potential targets for interventions that aim to buffer children from the detrimental effects of MSDP.

DOI10.1016/j.earlhumdev.2014.11.004
Alternate JournalEarly Hum. Dev.
PubMed ID25460253
Grant List / / Canadian Institutes of Health Research / Canada

  • Douglas Hospital
  • Dobell Pavillion
  • Brain imaging centre