@article{pmid34027016,

title = {Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study},

author = {Jackie M Poos and Lucy L Russell and Georgia Peakman and Martina Bocchetta and Caroline V Greaves and Lize C Jiskoot and Emma L van der Ende and Harro Seelaar and Janne M Papma and Esther van den Berg and Yolande A L Pijnenburg and Barbara Borroni and Raquel Sanchez-Valle and Fermin Moreno and Robert Laforce and Caroline Graff and Matthias Synofzik and Daniela Galimberti and James B Rowe and Mario Masellis and Carmela Tartaglia and Elizabeth Finger and Rik Vandenberghe and Alexandre de Medonça and Fabrizio Tagliavini and Chris R Butler and Isabel Santana and Isabelle Le Ber and Alex Gerhard and Simon Ducharme and Johannes Levin and Adrian Danek and Markus Otto and Sandro Sorbi and Florence Pasquier and John C van Swieten and Jonathan D Rohrer and },

doi = {10.1002/dad2.12185},

issn = {2352-8729},

year  = {2021},

date = {2021-01-01},

journal = {Alzheimers Dement (Amst)},

volume = {13},

number = {1},

pages = {e12185},

abstract = {INTRODUCTION: We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT).nnMETHODS: The FCSRT was administered in 417 presymptomatic and symptomatic mutation carriers (181 chromosome 9 open reading frame 72 [], 163 progranulin [], and 73 microtubule-associated protein tau []) and 290 controls. Group differences and correlations with other neuropsychological tests were examined. We performed voxel-based morphometry to investigate the underlying neural substrates of the FCSRT.nnRESULTS: All symptomatic mutation carrier groups and presymptomatic  mutation carriers performed significantly worse on all FCSRT scores compared to controls. In the presymptomatic  group, deficits were found on all scores except for the delayed total recall task, while no deficits were found in presymptomatic  mutation carriers. Performance on the FCSRT correlated with executive function, particularly in  mutation carriers, but also with memory and naming tasks in the  group. FCSRT performance also correlated with gray matter volumes of frontal, temporal, and subcortical regions in  and , but mainly temporal areas in  mutation carriers.nnDISCUSSION: The FCSRT detects presymptomatic deficits in - and -associated FTD and provides important insight into the underlying cause of memory impairment in different forms of FTD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid30776161,

title = {Age-specific associations between oestradiol, cortico-amygdalar structural covariance, and verbal and spatial skills},

author = {Tuong-Vi Nguyen and Sherri Lee Jones and Tricia Gower and Jimin Lew and Matthew D Albaugh and Kelly N Botteron and James J Hudziak and Vladimir S Fonov and D Louis Collins and Benjamin C Campbell and Linda Booij and Catherine M Herba and Patricia Monnier and Simon Ducharme and Deborah Waber and James T McCracken},

doi = {10.1111/jne.12698},

issn = {1365-2826},

year  = {2019},

date = {2019-04-01},

journal = {J Neuroendocrinol},

volume = {31},

number = {4},

pages = {e12698},

abstract = {Oestradiol is known to play an important role in the developing human brain, although little is known about the entire network of potential regions that might be affected and how these effects may vary from childhood to early adulthood, which in turn can explain sexually differentiated behaviours. In the present study, we examined the relationships between oestradiol, cortico-amygdalar structural covariance, and cognitive or behavioural measures typically showing sex differences (verbal/spatial skills, anxious-depressed symptomatology) in 152 children and adolescents (aged 6-22 years). Cortico-amygdalar structural covariance shifted from positive to negative across the age range. Oestradiol was found to diminish the impact of age on cortico-amygdalar covariance for the pre-supplementary motor area/frontal eye field and retrosplenial cortex (across the age range), as well as for the posterior cingulate cortex (in older children). Moreover, the influence of oestradiol on age-related cortico-amygdalar networks was associated with higher word identification and spatial working memory (across the age range), as well as higher reading comprehension (in older children), although it did not impact anxious-depressed symptoms. There were no significant sex effects on any of the above relationships. These findings confirm the importance of developmental timing on oestradiol-related effects and hint at the non-sexually dimorphic role of oestradiol-related cortico-amygdalar structural networks in aspects of cognition distinct from emotional processes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid30179274,

title = {Association between carotid atheroma and cerebral cortex structure at age 73 years},

author = {Saud Alhusaini and Sherif Karama and Tuong-Vi Nguyen and Alexander Thiel and Boris C Bernhardt and Simon R Cox and Janie Corley and Adele Taylor and Alan C Evans and John M Star and Mark E Bastin and Joanna M Wardlaw and Ian J Deary and Simon Ducharme},

doi = {10.1002/ana.25324},

issn = {1531-8249},

year  = {2018},

date = {2018-10-01},

journal = {Ann Neurol},

volume = {84},

number = {4},

pages = {576--587},

abstract = {OBJECTIVE: To examine the relationship between carotid atherosclerosis and cerebral cortical thickness and investigate whether cortical thickness mediates the association between carotid atheroma and relative cognitive decline.nnMETHODS: We assessed 554 community-dwelling subjects (male/female: 296/258) from the Lothian Birth Cohort 1936 who underwent brain magnetic resonance imaging and carotid Doppler ultrasound studies at age 73 years. The relationship between carotid atherosclerosis markers (internal carotid artery stenosis, intima-media thickness, velocity, pulsatility, and resistivity indexes) and vertex-wide cerebral cortical thickness was examined cross-sectionally, controlling for gender, extensive vascular risk factors (VRFs), and intelligence quotient at age 11 (IQ-11). We also determined the association between carotid stenosis and a composite measure of fluid intelligence at age 73 years. A mediation model was applied to examine whether cortical thickness mediated the relationship between carotid stenosis and cognitive function.nnRESULTS: A widespread negative association was identified between carotid stenosis (median = 15%) and cerebral cortical thickness at age 73 years, independent of the side of carotid stenosis, other carotid measures, VRFs, and IQ-11. This association increased in an almost dose-response relationship from mild to severe degrees of carotid stenosis, across the anterior and posterior circulation territories. A negative association was also noted between carotid stenosis and fluid intelligence (standardized beta coefficient = -0.151, p = 0.001), which appeared partly (approximately 22%) mediated by carotid stenosis-related thinning of the cerebral cortex.nnINTERPRETATION: The findings suggest that carotid stenosis represents a marker of processes that accelerate aging of the cerebral cortex and cognition that is in part independent of measurable VRFs. Cortical thinning within the anterior and posterior circulation territories partially mediated the relationship between carotid atheroma and fluid intelligence. Ann Neurol 2018;84:576-587.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}