The role of maternal immune activation in altering the neurodevelopmental trajectories of offspring: A translational review of neuroimaging studies with implications for autism spectrum disorder and schizophrenia.

TitleThe role of maternal immune activation in altering the neurodevelopmental trajectories of offspring: A translational review of neuroimaging studies with implications for autism spectrum disorder and schizophrenia.
Publication TypeJournal Article
Year of Publication2019
AuthorsGuma E, Plitman E, M Chakravarty M
JournalNeurosci Biobehav Rev
Volume104
Pagination141-157
Date Published2019 Sep
ISSN1873-7528
Abstract

Exposure to maternal infection in utero increases the risk that offspring will develop neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. Research in animal models has confirmed this link and demonstrated that maternal immune activation (MIA) is sufficient to induce alterations in offspring neurodevelopment. Building homology between observations made in humans and animal models is a challenge; however, neuroimaging allows for homologous characterization of developmental trajectories across species. This systematic review aims to discuss findings from human and animal studies that performed neuroimaging in offspring exposed to maternal infection, inflammation, or MIA, in the context of neurodevelopmental disorders.

DOI10.1016/j.neubiorev.2019.06.020
Alternate JournalNeurosci Biobehav Rev
PubMed ID31265870