Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases.

TitleResting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases.
Publication TypeJournal Article
Year of Publication2014
AuthorsFox MD, Buckner RL, Liu H, M Chakravarty M, Lozano AM, Pascual-Leone A
JournalProc Natl Acad Sci U S A
Volume111
Issue41
PaginationE4367-75
Date Published2014 Oct 14
ISSN1091-6490
KeywordsBrain, Deep Brain Stimulation, Humans, Mental Disorders, Nerve Net, Nervous System Diseases, Rest
Abstract

Brain stimulation, a therapy increasingly used for neurological and psychiatric disease, traditionally is divided into invasive approaches, such as deep brain stimulation (DBS), and noninvasive approaches, such as transcranial magnetic stimulation. The relationship between these approaches is unknown, therapeutic mechanisms remain unclear, and the ideal stimulation site for a given technique is often ambiguous, limiting optimization of the stimulation and its application in further disorders. In this article, we identify diseases treated with both types of stimulation, list the stimulation sites thought to be most effective in each disease, and test the hypothesis that these sites are different nodes within the same brain network as defined by resting-state functional-connectivity MRI. Sites where DBS was effective were functionally connected to sites where noninvasive brain stimulation was effective across diseases including depression, Parkinson's disease, obsessive-compulsive disorder, essential tremor, addiction, pain, minimally conscious states, and Alzheimer's disease. A lack of functional connectivity identified sites where stimulation was ineffective, and the sign of the correlation related to whether excitatory or inhibitory noninvasive stimulation was found clinically effective. These results suggest that resting-state functional connectivity may be useful for translating therapy between stimulation modalities, optimizing treatment, and identifying new stimulation targets. More broadly, this work supports a network perspective toward understanding and treating neuropsychiatric disease, highlighting the therapeutic potential of targeted brain network modulation.

DOI10.1073/pnas.1405003111
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID25267639
PubMed Central IDPMC4205651
Grant ListK23 NS083741 / NS / NINDS NIH HHS / United States
K23NS083741 / NS / NINDS NIH HHS / United States
K25 NS069805 / NS / NINDS NIH HHS / United States
P50 AG005134 / AG / NIA NIH HHS / United States
R01HD069776 / HD / NICHD NIH HHS / United States
R01NS073601 / NS / NINDS NIH HHS / United States
R21HD07616 / HD / NICHD NIH HHS / United States
R21MH099196 / MH / NIMH NIH HHS / United States
R21NS082870 / NS / NINDS NIH HHS / United States
R21NS085491 / NS / NINDS NIH HHS / United States
UL1 RR025758 / RR / NCRR NIH HHS / United States
UL1 RR025758 / RR / NCRR NIH HHS / United States