Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons.

TitleResilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons.
Publication TypeJournal Article
Year of Publication2016
AuthorsIsingrini E, Perret L, Rainer Q, Amilhon B, Guma E, Tanti A, Martin G, Robinson J, Moquin L, Marti F, Mechawar N, Williams S, Gratton A, Giros B
JournalNat Neurosci
Volume19
Issue4
Pagination560-3
Date Published2016 Apr
ISSN1546-1726
KeywordsAdrenergic Neurons, Animals, Chronic Disease, Dopaminergic Neurons, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Neural Inhibition, Norepinephrine, Resilience, Psychological, Stress, Psychological, Ventral Tegmental Area, Vesicular Monoamine Transport Proteins
Abstract

Dopamine (DA) neurons in the ventral tegmental area (VTA) help mediate stress susceptibility and resilience. However, upstream mechanisms controlling these neurons remain unknown. Noradrenergic (NE) neurons in the locus coeruleus, implicated in the pathophysiology of depression, have direct connections within the VTA. Here we demonstrate that NE neurons regulate vulnerability to social defeat through inhibitory control of VTA DA neurons.

DOI10.1038/nn.4245
Alternate JournalNat. Neurosci.
PubMed ID26878672

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