Research from the Flores lab shows teens’ brains make them more vulnerable to suicide

A paper published by the Flores laboratory sheds some light on the role of gene, called DCC, which controls dopamine connectivity in the prefrontal cortex during adolescence, and show that dysfunction of the gene — through stress and drug abuse, for example — can lead to long-term mental health consequences.

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Manitt C, Eng C, Pokinko M, Ryan R, Torres-Berrio A, Lopez J P, Yogendran S, Daubaras M, Grant A, Ewoud R E, Krimpenfort P, Cooper H, Pasterkamp J, Kolb B, Turecki G, Wong T-P, Nestler E J, Giros B, Flores C (2013) dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients Translational Psychiatry, 3,e338; doi:10.1038/tp.2013.105  PMID:24346136

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