Relationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study.

TitleRelationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study.
Publication TypeJournal Article
Year of Publication2014
AuthorsChong MFF, X Y Wong J, Colega M, Chen L-W, van Dam RM, Tan CSeng, Lim ALin, Cai S, Broekman BFP, Lee YSeng, Saw SMei, Kwek K, Godfrey KM, Chong YSeng, Gluckman P, Meaney MJ, Chen H
Corporate Authorsgroup Gstudy
JournalJ Psychiatr Res
Date Published2014 Aug
KeywordsAdult, Cohort Studies, Depression, Postpartum, Depressive Disorder, Female, Folic Acid, Humans, Multivariate Analysis, Odds Ratio, Pregnancy, Pregnancy Complications, Psychiatric Status Rating Scales, Regression Analysis, Singapore, Vitamin B 12

UNLABELLED: Studies in the general population have proposed links between nutrition and depression, but less is known about the perinatal period. Depletion of nutrient reserves throughout pregnancy and delayed postpartum repletion could increase the risk of perinatal depression. We examined the relationships of plasma folate and vitamin B12 concentrations during pregnancy with perinatal depression. At 26th-28th weeks of gestation, plasma folate and vitamin B12 were measured in women from the GUSTO mother-offspring cohort study in Singapore. Depressive symptoms were measured with the Edinburgh Postnatal Depression Scale (EPDS) during the same period and at 3-month postpartum. EPDS scores of ≥15 during pregnancy or ≥13 at postpartum were indicative of probable depression. Of 709 women, 7.2% (n = 51) were identified with probable antenatal depression and 10.4% (n = 74) with probable postnatal depression. Plasma folate concentrations were significantly lower in those with probable antenatal depression than those without (mean ± SD; 27.3 ± 13.8 vs 40.4 ± 36.5 nmol/L; p = 0.011). No difference in folate concentrations was observed in those with and without probable postnatal depression. In adjusted regression models, the likelihood of probable antenatal depression decreases by 0.69 for every unit variation (increase) in folate (OR = 0.69 per SD increase in folate; 95% CI: 0.52, 0.94). Plasma vitamin B12 concentrations were not associated with perinatal depression. Lower plasma folate status during pregnancy was associated with antenatal depression, but not with postnatal depression. Replication in other studies is needed to determine the direction of causality between low folate and antenatal depression.CLINICAL TRIAL REGISTRY: NCT01174875.

Alternate JournalJ Psychiatr Res
PubMed ID24774647
Grant ListMC_UP_A620_1017 / / Medical Research Council / United Kingdom