Publications
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Evaluation of Amide Bioisosteres Leading to 1,2,3-Triazole Containing Compounds as GPR88 Agonists: Design, Synthesis, and Structure-Activity Relationship Studies.. J Med Chem. 64(16):12397-12413.
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2021. Emotional Impairment and Persistent Upregulation of mGlu5 Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction.. Int J Neuropsychopharmacol. 19(7)
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2016. Drug discovery: Designing the ideal opioid.. Nature. 537(7619):170-171.
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2016. Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence.. Neuropsychopharmacology. 39(11):2694-705.
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2014. Dissociation of heroin-induced emotional dysfunction from psychomotor activation and physical dependence among inbred mouse strains.. Psychopharmacology (Berl). 232(11):1957-71.
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2015. Dissecting the spinal NOP receptor distribution under a chronic pain model using NOP-eGFP knock-in mice.. Br J Pharmacol.
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2018. Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake.. J Med Chem. 61(15):6748-6758.
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2016. Developmental and adult expression patterns of the G-protein-coupled receptor GPR88 in the rat: Establishment of a dual nuclear-cytoplasmic localization.. J Comp Neurol. 524(14):2776-802.
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2016. Design, Synthesis, and Structure-Activity Relationship Studies of (4-Alkoxyphenyl)glycinamides and Bioisosteric 1,3,4-Oxadiazoles as GPR88 Agonists.. J Med Chem. 63(23):14989-15012.
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2020. Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn.. Neuron. 81(6):1312-27.
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2014. Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures.. Behav Brain Res. 278:429-34.
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2015. Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome.. Proc Natl Acad Sci U S A. 113(41):11603-11608.
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2018. The Control of Reward Seeking.. Biol Psychiatry. 83(12):981-983.
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2018. Chronic generalized pain disrupts whole brain functional connectivity in mice.. Brain Imaging Behav. 15(5):2406-2416.
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2017. BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone.. Front Neurosci. 10:471.
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2016. Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons.. iScience. 14:47-57.
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2019. Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity.. Neuropsychopharmacology. 39(9):2049-60.
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2014. An Anti-Opioid System, Courtesy of a Worm Model.. N Engl J Med. 381(21):2067-2069.
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2019. Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function.. J Neurosci. 36(12):3541-51.
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