Publications

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Chen GG, Gross JA, Lutz P-E, Vaillancourt K, Maussion G, Bramoulle A, Théroux J-F, Gardini ES, Ehlert U, Bourret G et al..  2017.  Medium throughput bisulfite sequencing for accurate detection of 5-methylcytosine and 5-hydroxymethylcytosine.. BMC Genomics. 18(1):96.
Pidsley R, Viana J, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk LC, Bray NJ et al..  2014.  Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.. Genome Biol. 15(10):483.
Salamanca L, Mechawar N, Murai KK, Balling R, Bouvier DS, Skupin A.  2019.  MIC-MAC: An automated pipeline for high-throughput characterization and classification of three-dimensional microglia morphologies in mouse and human postmortem brain samples.. Glia. 67(8):1496-1509.
Maheu M, Lopez JP, Crapper L, Davoli MA, Turecki G, Mechawar N.  2015.  MicroRNA regulation of central glial cell line-derived neurotrophic factor (GDNF) signalling in depression.. Transl Psychiatry. 5:e511.
Lopez JPablo, Fiori LM, Cruceanu C, Lin R, Labonte B, Cates HM, Heller EA, Vialou V, Ku SM, Gerald C et al..  2017.  MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes.. Nat Commun. 8:15497.
Lopez JPablo, Lim R, Cruceanu C, Crapper L, Fasano C, Labonte B, Maussion G, Yang JP, Yerko V, Vigneault E et al..  2014.  miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment.. Nat Med. 20(7):764-8.
Poirel O, Mella S, Videau C, Ramet L, Davoli MAntonietta, Herzog E, Katsel P, Mechawar N, Haroutunian V, Epelbaum J et al..  2018.  Moderate decline in select synaptic markers in the prefrontal cortex (BA9) of patients with Alzheimer's disease at various cognitive stages.. Sci Rep. 8(1):938.
Torres-Platas SG, Comeau S, Rachalski A, Dal Bo G, Cruceanu C, Turecki G, Giros B, Mechawar N.  2014.  Morphometric characterization of microglial phenotypes in human cerebral cortex.. J Neuroinflammation. 11:12.
Bell S, Rousseau J, Peng H, Aouabed Z, Priam P, Théroux J-F, Jefri M, Tanti A, Wu H, Kolobova I et al..  2019.  Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons. The American Journal of Human Genetics.
Bell S, Rousseau J, Peng H, Aouabed Z, Priam P, Théroux J-F, Jefri M, Tanti A, Wu H, Kolobova I et al..  2019.  Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons.. Am J Hum Genet. 104(5):815-834.
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Kelaï S, Ramoz N, Moalic J-M, Noble F, Mechawar N, Imbeaud S, Turecki G, Simonneau M, Gorwood P, Maussion G.  2017.  Netrin G1: its downregulation in the nucleus accumbens of cocaine-conditioned mice and genetic association in human cocaine dependence.. Addict Biol.
Mechawar N, Savitz J.  2016.  Neuropathology of mood disorders: do we see the stigmata of inflammation? Transl Psychiatry. 6(11):e946.
Hökfelt T, Barde S, Xu Z-QDavid, Kuteeva E, Rüegg J, Le Maitre E, Risling M, Kehr J, Ihnatko R, Theodorsson E et al..  2018.  Neuropeptide and Small Transmitter Coexistence: Fundamental Studies and Relevance to Mental Illness.. Front Neural Circuits. 12:106.
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Cyr M, Parent MJ, Mechawar N, Rosa-Neto P, Soucy J-P, Aliaga A, Kostikov A, Maclaren DAA, Clark SD, Bedard M-A.  2014.  PET imaging with [¹⁸F]fluoroethoxybenzovesamicol ([¹⁸F]FEOBV) following selective lesion of cholinergic pedunculopontine tegmental neurons in rat.. Nucl Med Biol. 41(1):96-101.
Mahar I, Albuquerque MSilva, Mondragon-Rodriguez S, Cavanagh C, Davoli MAntonietta, Chabot J-G, Williams S, Mechawar N, Quirion R, Krantic S.  2016.  Phenotypic Alterations in Hippocampal NPY- and PV-Expressing Interneurons in a Presymptomatic Transgenic Mouse Model of Alzheimer's Disease.. Front Aging Neurosci. 8:327.
Trépanier MO, Hopperton KE, Mizrahi R, Mechawar N, Bazinet RP.  2016.  Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review.. Mol Psychiatry. 21(8):1009-26.
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Albuquerque MS, Mahar I, Davoli MAntonietta, Chabot J-G, Mechawar N, Quirion R, Krantic S.  2015.  Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer's disease.. Front Aging Neurosci. 7:30.
Guma E, Rocchetti J, Devenyi GA, Tanti A, Mathieu A, Lerch JP, Elgbeili G, Courcot B, Mechawar N, M Chakravarty M et al..  2018.  Regional brain volume changes following chronic antipsychotic administration are mediated by the dopamine D2 receptor.. Neuroimage. 176:226-238.
Lopez JPablo, Fiori LM, Gross JA, Labonte B, Yerko V, Mechawar N, Turecki G.  2014.  Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers.. Int J Neuropsychopharmacol. 17(1):23-32.
Nagy C, Torres-Platas SG, Mechawar N, Turecki G.  2016.  Repression of Astrocytic Connexins in Cortical and Subcortical Brain Regions and Prefrontal Enrichment of H3K9me3 in Depression and Suicide.. Int J Neuropsychopharmacol.
Isingrini E, Perret L, Rainer Q, Amilhon B, Guma E, Tanti A, Martin G, Robinson J, Moquin L, Marti F et al..  2016.  Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons.. Nat Neurosci. 19(4):560-3.
Pabba M, Scifo E, Kapadia F, Nikolova YS, Ma T, Mechawar N, Tseng GC, Sibille E.  2017.  Resilient protein co-expression network in male orbitofrontal cortex layer 2/3 during human aging.. Neurobiol Aging. 58:180-190.
Guma E, Rocchetti J, Devenyi GA, Tanti A, Mathieu AP, Lerch JP, Elgbeili G, Courcot B, Mechawar N, M Chakravarty M et al..  2019.  Role of D3 dopamine receptors in modulating neuroanatomical changes in response to antipsychotic administration.. Sci Rep. 9(1):7850.
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Labonte B, Engmann O, Purushothaman I, Ménard C, Wang J, Tan C, Scarpa JR, Moy G, Loh Y-HE, Cahill M et al..  2017.  Sex-specific transcriptional signatures in human depression.. Nat Med. 23(9):1102-1111.
Mahar I, Bambico FRodriguez, Mechawar N, Nobrega JN.  2014.  Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects.. Neurosci Biobehav Rev. 38:173-92.

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