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2025
Salles, Juliette; Lin, Rixing; Turecki, Gustavo
Small Nucleolar RNAs and the Brain: Growing Evidence Supporting Their Role in Psychiatric Disorders Journal Article
In: Biol Psychiatry Glob Open Sci, vol. 5, no. 2, pp. 100415, 2025, ISSN: 2667-1743.
@article{pmid39867567,
title = {Small Nucleolar RNAs and the Brain: Growing Evidence Supporting Their Role in Psychiatric Disorders},
author = {Juliette Salles and Rixing Lin and Gustavo Turecki},
doi = {10.1016/j.bpsgos.2024.100415},
issn = {2667-1743},
year = {2025},
date = {2025-03-01},
journal = {Biol Psychiatry Glob Open Sci},
volume = {5},
number = {2},
pages = {100415},
abstract = {Noncoding RNAs comprise most of the transcriptome and represent an emerging area of research. Among them, small nucleolar RNAs (snoRNAs) have emerged as a promising target because they have been associated with the development and evolution of several diseases, including psychiatric disorders. snoRNAs are expressed in the brain, with some showing brain-specific expression that indicates specific roles in brain development, function, and dysfunction. However, the role of snoRNAs in conditions that affect the brain needs further investigation to be better understood. This scoping review summarizes existing literature on studies that have investigated snoRNAs in psychiatry and offers insight into potential pathophysiological mechanisms to be further investigated in future research.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Dalal, Tyler C; Liang, Liangbing; Silva, Angelica M; Mackinley, Michael; Voppel, Alban; Palaniyappan, Lena
Speech based natural language profile before, during and after the onset of psychosis: A cluster analysis Journal Article
In: Acta Psychiatr Scand, vol. 151, no. 3, pp. 332–347, 2025, ISSN: 1600-0447.
@article{pmid38600593,
title = {Speech based natural language profile before, during and after the onset of psychosis: A cluster analysis},
author = {Tyler C Dalal and Liangbing Liang and Angelica M Silva and Michael Mackinley and Alban Voppel and Lena Palaniyappan},
doi = {10.1111/acps.13685},
issn = {1600-0447},
year = {2025},
date = {2025-03-01},
journal = {Acta Psychiatr Scand},
volume = {151},
number = {3},
pages = {332--347},
abstract = {BACKGROUND AND HYPOTHESIS: Speech markers are digitally acquired, computationally derived, quantifiable set of measures that reflect the state of neurocognitive processes relevant for social functioning. "Oddities" in language and communication have historically been seen as a core feature of schizophrenia. The application of natural language processing (NLP) to speech samples can elucidate even the most subtle deviations in language. We aim to determine if NLP based profiles that are distinctive of schizophrenia can be observed across the various clinical phases of psychosis.nnDESIGN: Our sample consisted of 147 participants and included 39 healthy controls (HC), 72 with first-episode psychosis (FEP), 18 in a clinical high-risk state (CHR), 18 with schizophrenia (SZ). A structured task elicited 3 minutes of speech, which was then transformed into quantitative measures on 12 linguistic variables (lexical, syntactic, and semantic). Cluster analysis that leveraged healthy variations was then applied to determine language-based subgroups.nnRESULTS: We observed a three-cluster solution. The largest cluster included most HC and the majority of patients, indicating a 'typical linguistic profile (TLP)'. One of the atypical clusters had notably high semantic similarity in word choices with less perceptual words, lower cohesion and analytical structure; this cluster was almost entirely composed of patients in early stages of psychosis (EPP - early phase profile). The second atypical cluster had more patients with established schizophrenia (SPP - stable phase profile), with more perceptual but less cognitive/emotional word classes, simpler syntactic structure, and a lack of sufficient reference to prior information (reduced givenness).nnCONCLUSION: The patterns of speech deviations in early and established stages of schizophrenia are distinguishable from each other and detectable when lexical, semantic and syntactic aspects are assessed in the pursuit of 'formal thought disorder'.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Richard-Devantoy, Stéphane; Inja, Ayla; Dicker, Marina; Bertrand, Josie-Anne; Turecki, Gustavo; Orri, M; Keilp, John G
Cognitive control impairment in suicide behaviors: what do we know? A systematic review and meta-analysis of Stroop in suicide behaviors Journal Article
In: J Affect Disord, vol. 372, pp. 358–369, 2025, ISSN: 1573-2517.
@article{pmid39644928,
title = {Cognitive control impairment in suicide behaviors: what do we know? A systematic review and meta-analysis of Stroop in suicide behaviors},
author = {Stéphane Richard-Devantoy and Ayla Inja and Marina Dicker and Josie-Anne Bertrand and Gustavo Turecki and M Orri and John G Keilp},
doi = {10.1016/j.jad.2024.12.009},
issn = {1573-2517},
year = {2025},
date = {2025-03-01},
journal = {J Affect Disord},
volume = {372},
pages = {358--369},
abstract = {BACKGROUND: Suicidal behavior results from a complex interplay between stressful events and vulnerability factors, including cognitive deficits. Poorer performance on the Stroop task, a measure of cognitive control, has been associated with suicidal behavior in numerous studies. The objective was to conduct an updated systematic review of the literature on the Stroop task as a neuropsychological test of vulnerability to suicidal acts in patients with mood and other psychiatric disorders, while also looking at how the type (classic versus emotional) or the version (paper or computerized) of the Stroop task, as well as the characteristics of the patient (clinical population, age, sex) moderated the Stroop effect.nnMETHODS: A search on Medline, Embase, PsycInfo databases, and article references was performed. 53 studies (6781 participants) met the selection criteria. Interference time and errors of the Stroop Test were assessed in at least 3 studies to be analyzed. Moderators, such as the type (classic versus emotional) of the Stroop task and the characteristics of the patient (clinical population, age, sex) were also assessed.nnRESULTS: Interference time on Stroop performance was lower in suicide attempters than in patient controls (g = 0.20; 95%CI [0.10-0.30]) and healthy controls (g = 0.79; 95 % CI [0.29-1.29]), with patient controls scoring lower than healthy controls (g = -0.63; 95%CI [-1.01-0.25]). This was moderated by age and having a mood disorder. In terms of interference errors, suicide attempters performed worse than healthy controls (g = 0.57; 95%CI [0.01-1.15]) but did not perform differently from patient controls (g = 0.20; 95 % CI [-0.06-0.45]). Patient controls also did not score differently than healthy controls (g = -0.18; 95 % CI [-0.54-0.18]). There was a significant moderation effect for the type (i.e., original Stroop task) and version (i.e., paper format) of the Stroop task, and for some characteristics of the patient (i.e., older patients and having a mood disorder).nnCONCLUSIONS: Cognitive control impairment was associated with a history of suicidal behavior in patients, especially in older populations and those with mood disorders, however this result was moderated by outcome measure (interference time vs. errors), the type (i.e., original Stroop task) and the version (i.e., paper format) of the Stroop task. Cognitive control processes may be an important factor of suicidal vulnerability. Choosing the right neurocognitive test in the right population to detect suicide vulnerability is important direction for future research.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Meng, Xiangfei; Li, Muzi; Su, Yingying; Caron, Jean; Xiang, Yu-Tao
In: J Affect Disord, vol. 372, pp. 643–652, 2025, ISSN: 1573-2517.
@article{pmid39706485,
title = {Longitudinal analysis of lifetime stressors and depression: Exploring intersectionality and tailoring social support for better mental health in a community population cohort},
author = {Xiangfei Meng and Muzi Li and Yingying Su and Jean Caron and Yu-Tao Xiang},
doi = {10.1016/j.jad.2024.12.066},
issn = {1573-2517},
year = {2025},
date = {2025-03-01},
journal = {J Affect Disord},
volume = {372},
pages = {643--652},
abstract = {AIMS: Health inequalities studies need to understand how individuals simultaneously defined by several socioeconomic factors differ from others when facing a series of stressors across the lifespan in the risk of major depression (MD). Theoretical efforts, as well as empirical studies, have suggested a pertinent role of social support in mental health outcomes. However, little is known about which forms of social support would alleviate the negative impact of MD vulnerability in self-rated mental health (SRMH) across different socioeconomic groups. We investigated 1) differential associations between lifetime stressors and MD across social groups and 2) explored diverse social support forms mediating the associations between MD vulnerability and SRMH.nnMETHODS: Data analyzed were from a large longitudinal population-based cohort. Multilevel analysis of individual heterogeneity and discriminatory accuracy was used to articulate MD vulnerability in different social groups defined by ethnicity, gender, and socioeconomic status (SES). Genetic predispositions were also included in the modeling process. These social groups were then regrouped based on their vulnerability level of MD. Mediation analyses were then applied to identify which social support forms mediate the effect of MD vulnerability on SRMH.nnRESULTS: Higher levels of stressors were associated with higher risks of MD, and their associations varied by different social groups. The social groups (White men with medium SES or White women with high SES) had the lowest predicted incidence of MD, whereas White women with low SES reported the highest predicted incidence of MD. Two social support forms (guidance and opportunity for nurturance) significantly mediated the indirect paths between MD vulnerability and SRMH.nnCONCLUSIONS: By applying an intersectional lens, the present study provides a novel quantitative instrument for documenting the associations of stress and depression in various social identities. The findings of the study suggest more focused intervention programs and strategies for risk reduction should focus on identified characteristics and pay particular attention to the combined effect of lifetime stressors and discovered social identities.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Ros, Lucas U Da; Borelli, Wyllians Vendramini; Aguzzoli, Cristiano Schaffer; Bastiani, Marco Antônio De; Schilling, Lucas Porcello; Santamaria-Garcia, Hernando; Pascoal, Tharick A; Rosa-Neto, Pedro; Souza, Diogo O; da Costa, Jaderson Costa; Ibañez, Agustin; Suemoto, Claudia Kimie; Zimmer, Eduardo R
Social and health disparities associated with healthy brain ageing in Brazil and in other Latin American countries Journal Article
In: Lancet Glob Health, vol. 13, no. 2, pp. e277–e284, 2025, ISSN: 2214-109X.
@article{pmid39890228,
title = {Social and health disparities associated with healthy brain ageing in Brazil and in other Latin American countries},
author = {Lucas U Da Ros and Wyllians Vendramini Borelli and Cristiano Schaffer Aguzzoli and Marco Antônio De Bastiani and Lucas Porcello Schilling and Hernando Santamaria-Garcia and Tharick A Pascoal and Pedro Rosa-Neto and Diogo O Souza and Jaderson Costa da Costa and Agustin Ibañez and Claudia Kimie Suemoto and Eduardo R Zimmer},
doi = {10.1016/S2214-109X(24)00451-0},
issn = {2214-109X},
year = {2025},
date = {2025-02-01},
journal = {Lancet Glob Health},
volume = {13},
number = {2},
pages = {e277--e284},
abstract = {BACKGROUND: Latin American countries present major health-related inequities due to historical, cultural, and social aspects. Recent evidence highlights that factors related to social and health disparities outweigh classic demographic factors in determining healthy brain aging in these populations. However, these analyses have not been conducted with the Brazilian population, the largest and most ethnically diverse population in Latin America.nnMETHODS: Here, we evaluated demographic, social, and health factors for healthy brain ageing using a machine learning model in a Brazilian population-based cohort (n=9412) and in additional cohorts from other Latin American countries, including Colombia (n=23 694), Chile (n=1301), Ecuador (n=5235), and Uruguay (n=1450).nnFINDINGS: In the Brazilian population and other Latin American countries, social and health disparities were more influential than demographic factors for cognition and functional ability. Uniquely in Brazil, education emerged as the primary risk factor impacting cognitive outcomes, diverging from other Latin American countries where mental health symptoms played more prominent roles. In terms of functional ability, Brazil displayed a distinct pattern, with mental health symptoms identified as the primary contributing factor.nnINTERPRETATION: Our findings indicate that Brazil converges with other Latin American countries to show that heterogeneous factors impacted more than demographic factors, but also showed a unique set of health factors when compared with other Latin American countries. Therefore, our study emphasises that social and health disparity factors are relevant predictors of healthy brain ageing in Latin America, but population-specific analyses are necessary to identify the specific risk profiles of each country.nnFUNDING: None.nnTRANSLATIONS: For the Portuguese and Spanish translations of the abstract see Supplementary Materials section.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Morneau-Vaillancourt, Geneviève; Orri, Massimiliano; Ouellet-Morin, Isabelle; Geoffroy, Marie-Claude; Boivin, Michel
A longitudinal study of adolescent pathways differentiating suicide ideation and attempt in early adulthood Journal Article
In: J Adolesc, vol. 97, no. 2, pp. 395–408, 2025, ISSN: 1095-9254.
@article{pmid39428944,
title = {A longitudinal study of adolescent pathways differentiating suicide ideation and attempt in early adulthood},
author = {Geneviève Morneau-Vaillancourt and Massimiliano Orri and Isabelle Ouellet-Morin and Marie-Claude Geoffroy and Michel Boivin},
doi = {10.1002/jad.12427},
issn = {1095-9254},
year = {2025},
date = {2025-02-01},
journal = {J Adolesc},
volume = {97},
number = {2},
pages = {395--408},
abstract = {OBJECTIVE: Suicide ideation and attempt are leading risk factors for mortality in young adults. However, the adolescent risk factors distinguishing suicide ideation from attempt in young adults remain unclear. The present study aimed to examine the extent to which within-person stability and change in depressive symptoms, school difficulties, and peer victimization from ages 12 to 17 were differentially associated with later suicide ideation and attempt from ages 20 to 23.nnMETHOD: The study included 1647 participants from the Quebec Longitudinal Study of Child Development (QLSCD; 52% female). Participants reported on their depressive symptoms, school difficulties, and peer victimization at ages 12, 13, 15, and 17, and on suicide ideation and attempt at ages 20 and 23. Data were collected in the Province of Quebec, Canada, between 2010 and 2021.nnRESULTS: Results indicated that 11% (N = 121) and 8% (N = 86) reported suicide ideation and attempt, respectively, between ages 20 and 23. A random-intercept cross-lagged panel model showed that within-person increases in depressive symptoms during adolescence were related to both suicide ideation and attempt, whereas within-person increases in school difficulties and peer victimization were for the most part related to suicide attempt only. Within-person stability in depressive symptoms from ages 12 to 17 years were also related to suicide attempt, and not ideation. However, this association was only marginally significant.nnCONCLUSION: Findings suggest that experiencing unusual rises in school difficulties and peer victimization during adolescence, as well as depressive symptoms persisting over time, may distinguish young adults who think about suicide from those who attempt suicide.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Langevin, Rachel; Ouellet-Morin, Isabelle; Kay, Sebastian; Chartrand, Elise; Castellanos-Ryan, Natalie; Collin-Vezina, Delphine; Geoffroy, Marie-Claude
In: Child Abuse Negl, vol. 161, pp. 107300, 2025, ISSN: 1873-7757.
@article{pmid39893761,
title = {Construct validity of probable child maltreatment indicators using prospectively recorded information in a longitudinal cohort of Canadian children},
author = {Rachel Langevin and Isabelle Ouellet-Morin and Sebastian Kay and Elise Chartrand and Natalie Castellanos-Ryan and Delphine Collin-Vezina and Marie-Claude Geoffroy},
doi = {10.1016/j.chiabu.2025.107300},
issn = {1873-7757},
year = {2025},
date = {2025-02-01},
journal = {Child Abuse Negl},
volume = {161},
pages = {107300},
abstract = {BACKGROUND: Officially reported and self-reported measures of child maltreatment show poor agreement and may differentially predict psychosocial problems in adulthood. However, research remains primarily based on retrospective self-reports, warranting examination of the validity of prospective assessments of maltreatment.nnOBJECTIVE: To assess the construct validity of prospective indicators of child maltreatment using a longitudinal cohort of Canadian children.nnPARTICIPANTS AND SETTING: The population-based cohort comprises 2120 participants born between 1997 and 1998 in Quebec, Canada.nnMETHODS: Maternal and familial risk factors (maternal age, depressive symptoms, and antisocial behaviors, socioeconomic status, and single-parent home) and early adulthood functioning difficulties (depression, anxiety, suicidality, alcohol misuse, and unemployment status) were assessed across various time points (0-23 years). Associations between factors and prospective and retrospective maltreatment indicators were appraised.nnRESULTS: Most maternal and familial risk factors (80 %) showed associations with indicators of prospective maltreatment (ΔM = +/-0.04 to 0.72; p < 0.05). Several early adulthood functioning difficulties (30 %) showed associations with physical (ΔM = 0.05 to 0.22; p < 0.05) and sexual abuse (ΔM = 0.33 to 0.34; p < 0.05), while emotional, supervisory, and physical neglect were only associated with educational/employment status (ΔM = 0.04 to 0.10; p < 0.05). Cumulatively assessed maltreatment also showed a dose-response relationship with maternal and familial risk factors/functioning difficulties.nnCONCLUSIONS: The strong construct validity exhibited by our prospective indicators highlights the need to assess child maltreatment multi-modally. Our findings further contribute to the wider discussion surrounding the measurement of child maltreatment.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Fleury, Marie-Josée; Ferland, Francine; Farand, Lambert; Grenier, Guy; Imboua, Armelle; Gaida, Firas
Reasons Explaining High Emergency Department Use in Patients With Mental Illnesses: Different Staff Perspectives Journal Article
In: Int J Ment Health Nurs, vol. 34, no. 1, pp. e13442, 2025, ISSN: 1447-0349.
@article{pmid39334334,
title = {Reasons Explaining High Emergency Department Use in Patients With Mental Illnesses: Different Staff Perspectives},
author = {Marie-Josée Fleury and Francine Ferland and Lambert Farand and Guy Grenier and Armelle Imboua and Firas Gaida},
doi = {10.1111/inm.13442},
issn = {1447-0349},
year = {2025},
date = {2025-02-01},
journal = {Int J Ment Health Nurs},
volume = {34},
number = {1},
pages = {e13442},
abstract = {For patients with mental illnesses (MIs), emergency departments (EDs) are often the entry point into the healthcare system, or their only resort for quickly accessing mental health treatment. A better understanding of the various barriers justifying high ED use among patients with MIs may help recommend targeted interventions that better meet their needs. This explorative qualitative study aimed to identify such barriers and the solutions brought forth to reduce ED use based on the perspectives of clinicians and managers working in EDs, other hospital departments or the community sector. Interviews were conducted between April 2021 and February 2022; 86 mental health professionals (22% were nurses) from four large urban ED sites in Quebec (Canada) were interviewed. Barriers were identified in relation to patient profiles, healthcare system and organisational features and professional characteristics. The key barriers that were found to explain high ED use were patients having serious MIs (e.g., psychotic disorders) or social issues (e.g., poverty), lack of coordination and patient referrals between EDs and other health services, insufficient access to mental health and addiction services and inadequacy of care. Very few solutions were implemented to improve care for high ED users. Better deployment of ED interventions in collaboration with outpatient care may be prioritised to reduce high ED use for patients with MIs. Improvements to the referral and transfer processes to outpatient care, particularly through care plans and case management programs, may be implemented to reduce high ED use and improve outpatient care among patients with multiple health and social needs.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Clément, Myriam; Ahun, Marilyn N; Orri, Massimiliano; Montreuil, Tina C; St-André, Martin; Herba, Catherine M; Moullec, Gregory; Côté, Sylvana M
In: J Child Psychol Psychiatry, vol. 66, no. 2, pp. 225–240, 2025, ISSN: 1469-7610.
@article{pmid39255831,
title = {The interplay of maternal and paternal postpartum depressive symptoms with children's internalizing and externalizing symptoms from childhood to adolescence: does socioeconomic status matter? A longitudinal cohort study},
author = {Myriam Clément and Marilyn N Ahun and Massimiliano Orri and Tina C Montreuil and Martin St-André and Catherine M Herba and Gregory Moullec and Sylvana M Côté},
doi = {10.1111/jcpp.14051},
issn = {1469-7610},
year = {2025},
date = {2025-02-01},
journal = {J Child Psychol Psychiatry},
volume = {66},
number = {2},
pages = {225--240},
abstract = {BACKGROUND: Maternal postpartum depression is an important risk factor for internalizing and externalizing problems in children. The role of concurrent paternal depression remains unclear, especially by socioeconomic status. This study examined independent and interactive associations of postpartum maternal and paternal depression with children's internalizing/externalizing symptoms throughout childhood and adolescence (ages 3.5-17 years).nnMETHODS: We used data from the Québec Longitudinal Study of Child Development, a representative birth cohort (1997-1998) in Canada. Data included self-reported maternal and paternal depressive symptoms at 5 months' postpartum using the Center for Epidemiologic Studies Depression Scale. Internalizing and externalizing symptoms in children were reported by parents, teachers and children/adolescents using the Social Behaviour Questionnaire (ages 3.5-13 years) and the Mental Health and Social Inadaptation Assessment for Adolescents (ages 15-17 years). We used three-level mixed effects modelling to test associations after adjusting for confounding factors.nnRESULTS: With 168 single-parent families excluded, our sample consisted of 1,700 families with useable data. Of these, 275 (16.2%) families reported maternal depression (clinically elevated symptoms), 135 (7.9%) paternal depression and 39 (2.3%) both. In families with high socioeconomic status, maternal depression was associated with greater child internalizing (β = .34; p < .001) and externalizing symptoms (β = .22; p = .002), regardless of the presence/absence of paternal depression. In families with low socioeconomic status, associations with symptoms were stronger with concurrent paternal depression (internalizing, β = .84, p < .001; externalizing, β = .71, p = .003) than without (internalizing, β = .30, p < .001; externalizing, β = .24, p = .002).nnCONCLUSIONS: Maternal depression increases the risk for children's internalizing/externalizing problems in all socioeconomic contexts. In families with low socioeconomic status, risks were exacerbated by concurrent paternal depression. Postpartum depression, especially in low socioeconomic environments, should be a primary focus to optimize mental health across generations.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Blasco, M Belen; Aji, Kankana Nisha; Ramos-Jiménez, Christian; Leppert, Ilana Ruth; Tardif, Christine Lucas; Cohen, Johan; Rusjan, Pablo M; Mizrahi, Romina
Synaptic Density in Early Stages of Psychosis and Clinical High Risk Journal Article
In: JAMA Psychiatry, vol. 82, no. 2, pp. 171–180, 2025, ISSN: 2168-6238.
@article{pmid39535765,
title = {Synaptic Density in Early Stages of Psychosis and Clinical High Risk},
author = {M Belen Blasco and Kankana Nisha Aji and Christian Ramos-Jiménez and Ilana Ruth Leppert and Christine Lucas Tardif and Johan Cohen and Pablo M Rusjan and Romina Mizrahi},
doi = {10.1001/jamapsychiatry.2024.3608},
issn = {2168-6238},
year = {2025},
date = {2025-02-01},
journal = {JAMA Psychiatry},
volume = {82},
number = {2},
pages = {171--180},
abstract = {IMPORTANCE: Synaptic dysfunction is involved in schizophrenia pathophysiology. However, whether in vivo synaptic density is reduced in early stages of psychosis, including its high-risk states, remains unclear.nnOBJECTIVE: To investigate whether synaptic density (synaptic vesicle glycoprotein 2A [SV2A] binding potential) is reduced in first-episode psychosis (FEP) and in clinical high risk (CHR) and investigate the effect of cannabis use on synaptic density and examine its relationship with psychotic symptoms and gray matter microstructure across groups.nnDESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study was performed in a tertiary care psychiatric hospital from July 2021 to October 2023. Participants were patients with antipsychotic-free or minimally exposed FEP or CHR and healthy controls with a clean urine drug screen (except cannabis).nnMAIN OUTCOMES AND MEASURES: Synaptic density was quantified with dynamic 90-minute [18F]SynVesT-1 positron emission tomography (PET) scans across prioritized brain regions of interest (ROIs) delineated in individual magnetic resonance images (MRIs). Cannabis use was confirmed with urine drug screens. Gray matter microstructure was assessed using diffusion-weighted MRI to estimate neurite density.nnRESULTS: A total of 49 participants were included, including 16 patients with FEP (mean [SD] age, 26.1 [4.6] years; 9 males and 7 females), 17 patients at CHR (mean [SD] age, 21.2 [3.5] years; 8 males and 9 females), and 16 healthy controls (mean [SD] age, 23.4 [3.6] years; 7 males and 9 females). Synaptic density was significantly different between groups (F2,273 = 4.02, P = .02, Cohen F = 0.17; ROI: F5,273 = 360.18, P < .01, Cohen F = 2.55) with a group × ROI interaction (F10,273 = 2.67, P < .01, Cohen F = 0.32). Synaptic density was lower in cannabis users (F1,272 = 5.31, P = .02, Cohen F = 0.14). Lower synaptic density across groups was associated with more negative symptoms (Positive and Negative Syndrome Scale negative scores: F1,81 = 4.31, P = .04, Cohen F = 0.23; Scale of Psychosis-Risk Symptoms negative scores: F1,90 = 4.12, P = .04, Cohen F = 0.21). SV2A binding potential was significantly associated with neurite density index (F1,138 = 6.76, P = .01, Cohen F = 0.22).nnCONCLUSIONS AND RELEVANCE: This study found that synaptic density reductions were present during the early stages of psychosis and its risk states and associated with negative symptoms. The implications of SV2A for negative symptoms in psychosis and CHR warrant further investigation. Future studies should investigate the impact of cannabis use on synaptic density in CHR longitudinally.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Hammond, Nicole G; Gravel, Christopher; Ferro, Mark A; Landry, Hannah; Geoffroy, Marie-Claude; Racine, Nicole; Colman, Ian
In: Can J Psychiatry, pp. 7067437251315526, 2025, ISSN: 1497-0015.
@article{pmid39901502,
title = {The Relationship Between Family Dynamics and Help-Seeking and Disclosure of Adolescent Self-Harm and Suicidality: A Population-Representative Study: Relation entre dynamique familiale et recherche d'aide, et dévoilement des actes d'automutilation et de la suicidalité chez les adolescents : étude représentative de la population},
author = {Nicole G Hammond and Christopher Gravel and Mark A Ferro and Hannah Landry and Marie-Claude Geoffroy and Nicole Racine and Ian Colman},
doi = {10.1177/07067437251315526},
issn = {1497-0015},
year = {2025},
date = {2025-02-01},
journal = {Can J Psychiatry},
pages = {7067437251315526},
abstract = {BACKGROUND: Few studies have explored the potential for family dynamics to hinder or promote help-seeking and disclosure behaviours among adolescents who self-harm or experience suicidality. We sought to examine whether family dynamics may influence self-harm-related disclosure to parents or other family members and online help-seeking.nnMETHODS: We identified youths, 14-17 years, in the 2014 Ontario Child Health Study (OCHS) who self-reported past-year suicidal ideation (with or without a suicide plan or past suicide attempt[s]) and/or non-suicidal self-harm. The OCHS is a provincially representative, cross-sectional survey. The person most knowledgeable about the adolescent, usually the mother, reported family dynamics: family dysfunction and positive and negative parenting practices. We used logistic regression to generate adjusted odds ratios.nnRESULTS: A total of 359 adolescents positively endorsed past-year suicidal ideation and/or non-suicidal self-harm. Disclosure and help-seeking were common (≥67.3% and ≥25.6%, respectively). Adolescents experiencing suicidal ideation and greater family dysfunction were more likely to share their suicidal thoughts with non-family compared to not telling anyone (OR = 1.09, 95% CI: 1.01 to 1.18) and were less likely to tell their parents or other family members about their suicidal thoughts when compared to non-family such as teachers, partners, or friends (OR = 0.82, 95% CI: 0.71 to 0.94). Positive parenting was not associated with any form of disclosure or online help-seeking for non-suicidal self-harm or suicidal ideation. As adolescent exposure to negative parenting increased, so did the likelihood that they would seek help online for their suicidal thoughts (OR = 1.22, 95% CI: 1.08 to 1.37). Sensitivity analyses replicated or were very similar to findings from the main models.nnCONCLUSION: We found that negative family dynamics were related to reduced sharing of suicidal thoughts with parents or other family members and greater online help-seeking. Our findings suggest that the importance of negative family dynamics to disclosure and support-seeking for adolescent suicidality may be under-recognized.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
McGorry, Patrick D; Hickie, Ian B; Kotov, Roman; Schmaal, Lianne; Wood, Stephen J; Allan, Sophie M; Altınbaş, Kürşat; Boyce, Niall; Bringmann, Laura F; Caspi, Avshalom; Cuthbert, Bruce; Gawęda, Łukasz; Groen, Robin N; Guloksuz, Sinan; Hartmann, Jessica A; Krueger, Robert F; Mei, Cristina; Nieman, Dorien; Öngür, Dost; Raballo, Andrea; Scheffer, Marten; Schreuder, Marieke J; Shah, Jai L; Wigman, Johanna T W; Yuen, Hok Pan; Nelson, Barnaby
New diagnosis in psychiatry: beyond heuristics Journal Article
In: Psychol Med, vol. 55, pp. e26, 2025, ISSN: 1469-8978.
@article{pmid39911018,
title = {New diagnosis in psychiatry: beyond heuristics},
author = {Patrick D McGorry and Ian B Hickie and Roman Kotov and Lianne Schmaal and Stephen J Wood and Sophie M Allan and Kürşat Altınbaş and Niall Boyce and Laura F Bringmann and Avshalom Caspi and Bruce Cuthbert and Łukasz Gawęda and Robin N Groen and Sinan Guloksuz and Jessica A Hartmann and Robert F Krueger and Cristina Mei and Dorien Nieman and Dost Öngür and Andrea Raballo and Marten Scheffer and Marieke J Schreuder and Jai L Shah and Johanna T W Wigman and Hok Pan Yuen and Barnaby Nelson},
doi = {10.1017/S003329172400223X},
issn = {1469-8978},
year = {2025},
date = {2025-02-01},
journal = {Psychol Med},
volume = {55},
pages = {e26},
abstract = {BACKGROUND: Diagnosis in psychiatry faces familiar challenges. Validity and utility remain elusive, and confusion regarding the fluid and arbitrary border between mental health and illness is increasing. The mainstream strategy has been conservative and iterative, retaining current nosology until something better emerges. However, this has led to stagnation. New conceptual frameworks are urgently required to catalyze a genuine paradigm shift.nnMETHODS: We outline candidate strategies that could pave the way for such a paradigm shift. These include the Research Domain Criteria (RDoC), the Hierarchical Taxonomy of Psychopathology (HiTOP), and Clinical Staging, which all promote a blend of dimensional and categorical approaches.nnRESULTS: These alternative still heuristic transdiagnostic models provide varying levels of clinical and research utility. RDoC was intended to provide a framework to reorient research beyond the constraints of DSM. HiTOP began as a nosology derived from statistical methods and is now pursuing clinical utility. Clinical Staging aims to both expand the scope and refine the utility of diagnosis by the inclusion of the dimension of timing. None is yet fit for purpose. Yet they are relatively complementary, and it may be possible for them to operate as an ecosystem. Time will tell whether they have the capacity singly or jointly to deliver a paradigm shift.nnCONCLUSIONS: Several heuristic models have been developed that separately or synergistically build infrastructure to enable new transdiagnostic research to define the structure, development, and mechanisms of mental disorders, to guide treatment and better meet the needs of patients, policymakers, and society.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Fischer, Larissa; Molloy, Eóin N; Binette, Alexa Pichet; Vockert, Niklas; Marquardt, Jonas; Pilar, Andrea Pacha; Kreissl, Michael C; Remz, Jordana; Tremblay-Mercier, Jennifer; Poirier, Judes; Rajah, Maria Natasha; Villeneuve, Sylvia; ; Maass, Anne
Precuneus Activity during Retrieval Is Positively Associated with Amyloid Burden in Cognitively Normal Older 4 Carriers Journal Article
In: J Neurosci, vol. 45, no. 6, 2025, ISSN: 1529-2401.
@article{pmid39788739,
title = {Precuneus Activity during Retrieval Is Positively Associated with Amyloid Burden in Cognitively Normal Older 4 Carriers},
author = {Larissa Fischer and Eóin N Molloy and Alexa Pichet Binette and Niklas Vockert and Jonas Marquardt and Andrea Pacha Pilar and Michael C Kreissl and Jordana Remz and Jennifer Tremblay-Mercier and Judes Poirier and Maria Natasha Rajah and Sylvia Villeneuve and and Anne Maass},
doi = {10.1523/JNEUROSCI.1408-24.2024},
issn = {1529-2401},
year = {2025},
date = {2025-02-01},
journal = {J Neurosci},
volume = {45},
number = {6},
abstract = {The precuneus is a site of early amyloid-beta (Aβ) accumulation. Previous cross-sectional studies reported increased precuneus fMRI activity in older adults with mild cognitive deficits or elevated Aβ. However, longitudinal studies in early Alzheimer's disease (AD) are lacking and the relationship to the Apolipoprotein-E () genotype is unclear. Investigating the PREVENT-AD dataset, we assessed how baseline and longitudinal precuneus activity during successful memory retrieval relates to future Aβ and tau burden and change in memory performance. We further studied the moderation by 4 genotype. We included 165 older adults (age, 62.8 ± 4.4 years; 113 female; 66 4 carriers) who were cognitively normal at baseline with a family history of AD. All participants performed task-fMRI at baseline and underwent F-flortaucipir-PET and F-NAV4694-Aβ-PET on average 5 years later. We found that higher baseline activity and greater longitudinal increase in precuneus activity were associated with higher Aβ burden in 4 carriers but not noncarriers. We observed no effects of precuneus activity on tau burden. Finally, 4 noncarriers with low baseline precuneus activity exhibited better longitudinal performance in an independent memory test compared with (1) noncarriers with higher baseline activity and (2) 4 carriers. Our findings suggest that higher task-related precuneus activity during memory retrieval at baseline and over time are associated with greater Aβ burden in cognitively normal 4 carriers. Our results further indicate that the absence of "hyperactivation" and the absence of the 4 allele is related with better future cognitive outcomes in cognitively normal older adults at risk for AD.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Berisha, Fjolla; Paquin, Vincent; Gold, Ian; Misic, Bratislav; Palaniyappan, Lena; Malla, Ashok; Iyer, Srividya; Joober, Ridha; Lepage, Martin; Shah, Jai
Exploring delusional themes and other symptoms in first episode psychosis: A network analysis over two timepoints Journal Article
In: Psychiatry Res, vol. 344, pp. 116349, 2025, ISSN: 1872-7123.
@article{pmid39787740,
title = {Exploring delusional themes and other symptoms in first episode psychosis: A network analysis over two timepoints},
author = {Fjolla Berisha and Vincent Paquin and Ian Gold and Bratislav Misic and Lena Palaniyappan and Ashok Malla and Srividya Iyer and Ridha Joober and Martin Lepage and Jai Shah},
doi = {10.1016/j.psychres.2024.116349},
issn = {1872-7123},
year = {2025},
date = {2025-02-01},
journal = {Psychiatry Res},
volume = {344},
pages = {116349},
abstract = {Delusions are a defining feature of psychosis and play an important role in the conceptualization and diagnosis of psychotic disorders; however, the particular role that different delusions play in the prognosis of these disorders is not well understood. This study explored relationships between delusions and other symptoms in 674 first episode psychosis (FEP) individuals by comparing symptom networks between baseline and 12 months after intake to an early intervention service. Specifically, we (1) estimated regularized partial correlation networks at baseline and month 12, (2) identified the most central symptoms in each network, (3) identified clusters of highly connected symptoms, and (4) compared networks to examine changes in structure and connectivity. At baseline, the most central symptoms were depression, delusions of mind reading, and delusions of thought insertion. At month 12, they were hallucinations, persecutory delusions, and delusions of thought insertion. A symptom cluster was identified at both timepoints comprising of five delusions corresponding to passivity experiences. While network structures did not differ significantly, the month 12 network was significantly more highly connected. Our study captures a shift in illness trajectory over time, wherein transdiagnostic symptomatology at baseline becomes more consolidated around psychotic symptoms by month 12.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Aumont, Etienne; Bedard, Marc-André; Bussy, Aurélie; Arias, Jaime Fernandez; Tissot, Cecile; Hall, Brandon J; Therriault, Joseph; Rahmouni, Nesrine; Stevenson, Jenna; Servaes, Stijn; Macedo, Arthur C; Vitali, Paolo; Poltronetti, Nina Margherita; Fliaguine, Olga; Trudel, Lydia; Gauthier, Serge; Chakravarty, Mallar M; Rosa-Neto, Pedro
Hippocampal atrophy over two years in relation to tau, amyloid-β and memory in older adults Journal Article
In: Neurobiol Aging, vol. 146, pp. 48–57, 2025, ISSN: 1558-1497.
@article{pmid39631245,
title = {Hippocampal atrophy over two years in relation to tau, amyloid-β and memory in older adults},
author = {Etienne Aumont and Marc-André Bedard and Aurélie Bussy and Jaime Fernandez Arias and Cecile Tissot and Brandon J Hall and Joseph Therriault and Nesrine Rahmouni and Jenna Stevenson and Stijn Servaes and Arthur C Macedo and Paolo Vitali and Nina Margherita Poltronetti and Olga Fliaguine and Lydia Trudel and Serge Gauthier and Mallar M Chakravarty and Pedro Rosa-Neto},
doi = {10.1016/j.neurobiolaging.2024.11.007},
issn = {1558-1497},
year = {2025},
date = {2025-02-01},
journal = {Neurobiol Aging},
volume = {146},
pages = {48--57},
abstract = {In this longitudinal brain imaging study, we aimed to characterize hippocampal tau accumulation and subfield atrophy relative to cortical amyloid-β and memory performance. We measured tau-PET in regions associated with Braak stages I to VI, global amyloid-PET burden, hippocampal subfield volumes and memory assessments from 173 participants aged 55-85. Eighty-six of these participants were tested again two years later. Tau-PET change in the Braak II region, corresponding to the hippocampus and the entorhinal cortex, was significantly associated with the cornu ammonis 1 (CA1) atrophy and memory score. This CA1 atrophy did not significantly mediate the association between tau and memory, nor did global amyloid-PET burden correlate with tau-PET changes in the Braak II region. Longitudinal hippocampal tau accumulation is amyloid-β-independent and co-localized with subfield atrophy. As tau-associated memory decline seems to be independent from hippocampal atrophy, other mechanisms could contribute to the deficit.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Gao, Tingting; Chen, Yan; Gai, Qian; Su, Yingying; Meng, Xiangfei
Longitudinal Relationships of Phubbing, Depression, and Anxiety in the Middle and High School Students: A Cross-Lagged Panel Network Analysis Journal Article
In: J Adolesc, 2025, ISSN: 1095-9254.
@article{pmid39916486,
title = {Longitudinal Relationships of Phubbing, Depression, and Anxiety in the Middle and High School Students: A Cross-Lagged Panel Network Analysis},
author = {Tingting Gao and Yan Chen and Qian Gai and Yingying Su and Xiangfei Meng},
doi = {10.1002/jad.12481},
issn = {1095-9254},
year = {2025},
date = {2025-02-01},
journal = {J Adolesc},
abstract = {INTRODUCTION: Prior research has documented the associations among phubbing, depression, and anxiety, while the cross-sectional design failed to clarify the temporal directionality of the relationships between these mental disorders and behavioral issues. To bridge this gap, the present study utilizing longitudinal data aimed to articulate the temporal relationships between these mental disorders and behavioral issues.nnMETHODS: A total of 3296 adolescents from China (54.5% girls; M = 15.17) participated in the study. Symptoms of phubbing, depression, and anxiety were assessed 18 months later (May 2023) after the baseline (November, 2021). The cross-sectional network and cross-lagged panel network models were conducted to explore the associations between the network structures of phubbing, depression, and anxiety. The network comparison test (NCT) was then performed to unveil whether the network structures vary based on school grade.nnRESULTS: In the cross-sectional network, significant differences in the overall structures between middle and high school students were observed. For the longitudinal network, the core symptoms responsible for temporal relationships were mostly between depressive and anxiety symptoms. Phubbing-related symptoms and restlessness (anxiety symptom) were the bridge symptoms of phubbing, depression, and anxiety. Besides, the central bridges associated with phubbing-related symptoms differed significantly across different school stages.nnCONCLUSIONS: Successfully regulating negative emotions can play a pivotal role in tackling the root causes linked to phubbing. Apart from addressing restlessness, future interventions focusing on nomophobia and interpersonal conflict in middle school students, as well as self-isolation in high school students, contributed to mitigating phubbing, depression, and anxiety.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Belliveau, Claudia; Rahimian, Reza; Fakhfouri, Gohar; Hosdey, Clémentine; Simard, Sophie; Davoli, Maria Antonietta; Mirault, Dominique; Giros, Bruno; Turecki, Gustavo; Mechawar, Naguib
Evidence of microglial involvement in the childhood abuse-associated increase in perineuronal nets in the ventromedial prefrontal cortex Journal Article
In: Brain Behav Immun, vol. 124, pp. 321–334, 2025, ISSN: 1090-2139.
@article{pmid39672240,
title = {Evidence of microglial involvement in the childhood abuse-associated increase in perineuronal nets in the ventromedial prefrontal cortex},
author = {Claudia Belliveau and Reza Rahimian and Gohar Fakhfouri and Clémentine Hosdey and Sophie Simard and Maria Antonietta Davoli and Dominique Mirault and Bruno Giros and Gustavo Turecki and Naguib Mechawar},
doi = {10.1016/j.bbi.2024.12.013},
issn = {1090-2139},
year = {2025},
date = {2025-02-01},
journal = {Brain Behav Immun},
volume = {124},
pages = {321--334},
abstract = {Microglia, known for their diverse roles in the central nervous system, have recently been recognized for their involvement in degrading the extracellular matrix. Perineuronal nets (PNNs), a specialized form of this matrix, are crucial for stabilizing neuronal connections and constraining plasticity. Our group recently reported increased PNN densities in the ventromedial prefrontal cortex (vmPFC) of depressed individuals that died by suicide in adulthood after experiencing childhood abuse (DS-CA) compared to matched controls. To explore potential underlying mechanisms, we employed a comprehensive approach in similar postmortem vmPFC samples, combining a human matrix metalloproteinase and chemokine array, isolation of CD11b-positive microglia and enzyme-linked immunosorbent assays (ELISA). Our findings indicate a significant downregulation of matrix metalloproteinase (MMP)-9 and tissue inhibitors of metalloproteinases (TIMP)-2 in both whole vmPFC grey matter and isolated microglial cells from DS-CA samples. Furthermore, our experiments reveal that a history of child abuse is associated with diminished levels of microglial CX3CR1 and IL33R in both vmPFC whole lysate and CD11b isolated cells. However, levels of the CX3CR1 ligand, CX3CL1 (Fractalkine), did not differ between groups. While these data suggest potential long-lasting alterations in microglial markers in the vmPFC of individuals exposed to severe childhood adversity, direct functional assessments were not conducted. Nonetheless, these findings offer insight into how childhood abuse may contribute to PNN alterations via microglial-related mechanisms.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Dhamala, Elvisha; Ricard, Jocelyn A; Uddin, Lucina Q; Galea, Liisa A M; Jacobs, Emily G; Yip, Sarah W; Yeo, B T Thomas; Chakravarty, M Mallar; Holmes, Avram J
Considering the interconnected nature of social identities in neuroimaging research Journal Article
In: Nat Neurosci, vol. 28, no. 2, pp. 222–233, 2025, ISSN: 1546-1726.
@article{pmid39730766,
title = {Considering the interconnected nature of social identities in neuroimaging research},
author = {Elvisha Dhamala and Jocelyn A Ricard and Lucina Q Uddin and Liisa A M Galea and Emily G Jacobs and Sarah W Yip and B T Thomas Yeo and M Mallar Chakravarty and Avram J Holmes},
doi = {10.1038/s41593-024-01832-y},
issn = {1546-1726},
year = {2025},
date = {2025-02-01},
journal = {Nat Neurosci},
volume = {28},
number = {2},
pages = {222--233},
abstract = {Considerable heterogeneity exists in the expression of complex human behaviors across the cognitive, personality and mental health domains. It is increasingly evident that individual variability in behavioral expression is substantially affected by sociodemographic factors that often interact with life experiences. Here, we formally address the urgent need to incorporate intersectional identities in neuroimaging studies of behavior, with a focus on research in mental health. We highlight how diverse sociodemographic factors influence the study of psychiatric conditions, focusing on how interactions between those factors might contribute to brain biology and illness expression, including prevalence, symptom burden, help seeking, treatment response and tolerance, and relapse and remission. We conclude with a discussion of the considerations and actionable items related to participant recruitment, data acquisition and data analysis to facilitate the inclusion and incorporation of diverse intersectional identities in neuroimaging.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Jeffrey, Clayton; Penney, Danielle; Sauvé, Geneviève; Mendelson, Daniel; Thibaudeau, Élisabeth; Moritz, Steffen; Hotte-Meunier, Adèle; Lepage, Martin
Does metacognitive training for psychosis (MCT) improve neurocognitive performance? A systematic review and meta-analysis Journal Article
In: Schizophr Res, vol. 275, pp. 79–86, 2025, ISSN: 1573-2509.
@article{pmid39675227,
title = {Does metacognitive training for psychosis (MCT) improve neurocognitive performance? A systematic review and meta-analysis},
author = {Clayton Jeffrey and Danielle Penney and Geneviève Sauvé and Daniel Mendelson and Élisabeth Thibaudeau and Steffen Moritz and Adèle Hotte-Meunier and Martin Lepage},
doi = {10.1016/j.schres.2024.12.004},
issn = {1573-2509},
year = {2025},
date = {2025-01-01},
journal = {Schizophr Res},
volume = {275},
pages = {79--86},
abstract = {BACKGROUND: Metacognitive training for psychosis (MCT) offers benefits for addressing hallmark deficits/symptoms in schizophrenia spectrum disorders including reductions in cognitive biases and positive/negative symptoms as well as improvements in social cognition and functioning. However, differing results exist regarding the relationship between MCT and neurocognition. A comprehensive understanding of the nature of this relationship would significantly contribute to the existing literature and our understanding of the potential added value of MCT as a cognitive intervention for psychosis.nnMETHODS: Across eleven electronic databases, 1312 sources were identified, and 14 studies examining MCT and neurocognition in psychosis were included in this review. Measures of estimated effect sizes were calculated with Hedge's g, moderator analyses used Cochrane's Q statistic and significance tests to measure group differences according to control conditions.nnRESULTS: Twelve studies, 11 randomized controlled trials (RCTs) and 1 non-RCT, were included in the main meta-analyses, consisting of 673 participants (n = 345, n = 328). When comparing MCT against control interventions, non-significant differences in estimated effect sizes were observed across all neurocognitive domains when evaluating pre-post changes (g ≤ 0.1, p > .05). Two additional studies corroborated these results in a narrative review.nnCONCLUSION: These findings suggest that when compared against control conditions, MCT does not pose a statistically meaningful benefit to neurocognitive performance. General practice/learning effects are likely the main contributor that explains improvement in neurocognitive performance, and not a difference of intervention allocation when considering MCT against the included control comparators. These findings help establish the specificity of the effects of MCT.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Cantave, Christina Y; Ruttle, Paula L; Coté, Sylvana M; Lupien, Sonia J; Geoffroy, Marie-Claude; Vitaro, Frank; Brendgen, Mara; Tremblay, Richard; Boivin, Michel; Ouellet-Morin, Isabelle
Body mass index across development and adolescent hair cortisol: the role of persistence, variability, and timing of exposure Journal Article
In: Int J Obes (Lond), vol. 49, no. 1, pp. 125–132, 2025, ISSN: 1476-5497.
@article{pmid39367209,
title = {Body mass index across development and adolescent hair cortisol: the role of persistence, variability, and timing of exposure},
author = {Christina Y Cantave and Paula L Ruttle and Sylvana M Coté and Sonia J Lupien and Marie-Claude Geoffroy and Frank Vitaro and Mara Brendgen and Richard Tremblay and Michel Boivin and Isabelle Ouellet-Morin},
doi = {10.1038/s41366-024-01640-1},
issn = {1476-5497},
year = {2025},
date = {2025-01-01},
journal = {Int J Obes (Lond)},
volume = {49},
number = {1},
pages = {125--132},
abstract = {BACKGROUND: Research suggests a putative role of the glucocorticoid stress hormone cortisol in the accumulation of adiposity. However, obesity and weight fluctuations may also wear and tear physiological systems promoting adaptation, affecting cortisol secretion. This possibility remains scarcely investigated in longitudinal research. This study tests whether trajectories of body mass index (BMI) across the first 15 years of life are associated with hair cortisol concentration (HCC) measured two years later and whether variability in BMI and timing matter.nnMETHODS: BMI (kg/m) was prospectively measured at twelve occasions between age 5 months and 15 years. Hair was sampled at age 17 in 565 participants. Sex, family socioeconomic status, and BMI measured concurrently to HCC were considered as control variables.nnRESULTS: Latent class analyses identified three BMI trajectories: "low-stable" (59.2%, n = 946), "moderate" (32.6%, n = 507), and "high-rising" (8.2%, n = 128). BMI variability was computed by dividing the standard deviation of an individual's BMI measurements by the mean of these measurements. Findings revealed linear effects, such that higher HCC was noted for participants with moderate BMI trajectories in comparison to low-stable youth (β = 0.10, p = 0.03, 95% confidence interval (CI) = [0.02-0.40]); however, this association was not detected in the high-rising BMI youth (β = -0.02, p = 0.71, 95% CI = [-0.47-0.32]). Higher BMI variability across development predicted higher cortisol (β = 0.17, p = 0.003, 95% CI = [0.10-4.91]), additively to the contribution of BMI trajectories. BMI variability in childhood was responsible for that finding, possibly suggesting a timing effect.nnCONCLUSIONS: This study strengthens empirical support for BMI-HCC association and suggests that more attention should be devoted to BMI fluctuations in addition to persistent trajectories of BMI.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Smith, Eric E; Phillips, Natalie A; Feldman, Howard H; Borrie, Michael; Ganesh, Aravind; Henri-Bhargava, Alexandre; Desmarais, Philippe; Frank, Andrew; Badhwar, AmanPreet; Barlow, Laura; Bartha, Robert; Best, Sarah; Bethell, Jennifer; Bhangu, Jaspreet; Black, Sandra E; Bocti, Christian; Bronskill, Susan E; Burhan, Amer M; Calon, Frederic; Camicioli, Richard; Campbell, Barry; Collins, D Louis; Dadar, Mahsa; DeMarco, Mari L; Ducharme, Simon; Duchesne, Simon; Einstein, Gillian; Fisk, John D; Gawryluk, Jodie R; Grossman, Linda; Ismail, Zahinoor; Itzhak, Inbal; Joshi, Manish; Harrison, Arthur; Kroger, Edeltraut; Kumar, Sanjeev; Laforce, Robert; Lanctot, Krista L; Lau, Meghan; Lee, Linda; Masellis, Mario; Massoud, Fadi; Mitchell, Sara B; Montero-Odasso, Manuel; Barnett, Karen Myers; Nygaard, Haakon B; Pasternak, Stephen H; Peters, Jody; Rajah, M Natasha; Robillard, Julie M; Rockwood, Ken; Rosa-Neto, Pedro; Seitz, Dallas P; Soucy, Jean-Paul; Trenaman, Shanna C; Wellington, Cheryl L; Zadem, Aicha; and, Howard Chertkow
Use of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research Journal Article
In: J Prev Alzheimers Dis, pp. 100068, 2025, ISSN: 2426-0266.
@article{pmid39893139,
title = {Use of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research},
author = {Eric E Smith and Natalie A Phillips and Howard H Feldman and Michael Borrie and Aravind Ganesh and Alexandre Henri-Bhargava and Philippe Desmarais and Andrew Frank and AmanPreet Badhwar and Laura Barlow and Robert Bartha and Sarah Best and Jennifer Bethell and Jaspreet Bhangu and Sandra E Black and Christian Bocti and Susan E Bronskill and Amer M Burhan and Frederic Calon and Richard Camicioli and Barry Campbell and D Louis Collins and Mahsa Dadar and Mari L DeMarco and Simon Ducharme and Simon Duchesne and Gillian Einstein and John D Fisk and Jodie R Gawryluk and Linda Grossman and Zahinoor Ismail and Inbal Itzhak and Manish Joshi and Arthur Harrison and Edeltraut Kroger and Sanjeev Kumar and Robert Laforce and Krista L Lanctot and Meghan Lau and Linda Lee and Mario Masellis and Fadi Massoud and Sara B Mitchell and Manuel Montero-Odasso and Karen Myers Barnett and Haakon B Nygaard and Stephen H Pasternak and Jody Peters and M Natasha Rajah and Julie M Robillard and Ken Rockwood and Pedro Rosa-Neto and Dallas P Seitz and Jean-Paul Soucy and Shanna C Trenaman and Cheryl L Wellington and Aicha Zadem and Howard Chertkow and },
doi = {10.1016/j.tjpad.2025.100068},
issn = {2426-0266},
year = {2025},
date = {2025-01-01},
journal = {J Prev Alzheimers Dis},
pages = {100068},
abstract = {Lecanemab and donanemab are monoclonal antibody therapies that remove amyloid-beta from the brain. They are the first therapies that alter a fundamental mechanism, amyloid-beta deposition, in Alzheimer disease (AD). To inform Canadian decisions on approval and use of these drugs, the Canadian Consortium on Neurodegeneration in Aging commissioned Work Groups to review evidence on the efficacy and safety of these new therapies, as well as their projected impacts on Canadian dementia systems of care. We included persons with lived experience with Alzheimer disease in the discussion about the benefits and harms. Our review of the trial publications found high quality evidence of statistically significant group differences, but also recognized that there are mixed views on the clinical relevance of the observed differences and the value of therapy for individual patients. The drugs are intended for persons with early AD, at a stage of mild cognitive impairment or mild dementia. If patients are treated, then confirmation of AD by positron emission tomography or cerebrospinal fluid analysis and monitoring for risk of amyloid-related imaging abnormalities was recommended, as done in the clinical trials, although it would strain Canadian resource capacity. More data are needed to determine the size of the potentially eligible treatment population in Canada.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Aliaga, Antonio; Therriault, Joseph; Quispialaya, Kely Monica; Aliaga, Arturo; Hopewell, Robert; Rahmouni, Nesrine; Macedo, Arthur C; Kunach, Peter; Soucy, Jean-Paul; Massarweh, Gassan; Diaz, Aida Abreu; Pascoal, Tharick A; Rocha, Andreia; Guiot, Marie-Christine; Machado, Luiza S; Bastiani, Marco Antônio De; de Souza, Débora Guerini; Souza, Diogo O; Gauthier, Serge; Zimmer, Eduardo R; Rosa-Neto, Pedro
Comparison Between Brain and Cerebellar Autoradiography Using [F]Flortaucipir, [F]MK6240, and [F]PI2620 in Postmortem Human Brain Tissue Journal Article
In: J Nucl Med, vol. 66, no. 1, pp. 123–129, 2025, ISSN: 1535-5667.
@article{pmid39477493,
title = {Comparison Between Brain and Cerebellar Autoradiography Using [F]Flortaucipir, [F]MK6240, and [F]PI2620 in Postmortem Human Brain Tissue},
author = {Antonio Aliaga and Joseph Therriault and Kely Monica Quispialaya and Arturo Aliaga and Robert Hopewell and Nesrine Rahmouni and Arthur C Macedo and Peter Kunach and Jean-Paul Soucy and Gassan Massarweh and Aida Abreu Diaz and Tharick A Pascoal and Andreia Rocha and Marie-Christine Guiot and Luiza S Machado and Marco Antônio De Bastiani and Débora Guerini de Souza and Diogo O Souza and Serge Gauthier and Eduardo R Zimmer and Pedro Rosa-Neto},
doi = {10.2967/jnumed.124.267539},
issn = {1535-5667},
year = {2025},
date = {2025-01-01},
journal = {J Nucl Med},
volume = {66},
number = {1},
pages = {123--129},
abstract = {Our objective was to evaluate the in vitro binding properties of [F]flortaucipir, 6-(fluoro-F)-3-(1-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([F]MK6240), and 2-(2-([F]fluoro)pyridin-4-yl)-9-pyrrolo[2,3-b:4,5c']dipyridine ([F]PI2620) head-to-head in postmortem human brain tissue. Autoradiography was used to assess uptake of [F]flortaucipir, [F]MK6240, and [F]PI2620 in control and Alzheimer disease (AD) autopsy-confirmed brain tissues. The study focused on the analysis of the prefrontal cortex, hippocampus, and cerebellum sections in 12 controls and 12 AD cases, as well as whole-brain hemisphere in 1 control and 1 AD sample, for each radiotracer. The binding values of [F]flortaucipir, [F]MK6240, and [F]PI2620 were calculated from regions of interest manually drawn in the prefrontal, hippocampal, and cerebellar cortices. For all 3 radioligands investigated, we observed significant tracer binding differences between control and AD tissues in the whole-brain hemisphere, prefrontal cortex, and hippocampus but not in the cerebellar cortex. [F]MK6240 and [F]PI2620 had higher effect sizes to differentiate control and AD cases than did [F]flortaucipir. Bland-Altman analyses revealed strong correlations between [F]MK6240, [F]PI2620, and [F]flortaucipir, with the highest agreement found for [F]MK6240 versus [F]PI2620. The 3 radioligands showed comparable diagnostic properties to assess tau aggregates in vitro. Binding to AD brain tissues was higher for [F]MK6240 and [F]PI2620 than for [F]flortaucipir. Additionally, [F]MK6240 and [F]PI2620 had greater selectivity, displaying decreased uptake in control brain tissue compared with [F]flortaucipir. These results might provide insights on ongoing initiatives to create a universal scale for tau imaging studies.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Su, Yingying; Chen, Yan; Gai, Qian; Meng, Xiangfei; Gao, Tingting
The prospective associations between problematic gaming and phubbing among Chinese adolescents: Insights from a cross-lagged panel network model Journal Article
In: Compr Psychiatry, vol. 136, pp. 152542, 2025, ISSN: 1532-8384.
@article{pmid39488991,
title = {The prospective associations between problematic gaming and phubbing among Chinese adolescents: Insights from a cross-lagged panel network model},
author = {Yingying Su and Yan Chen and Qian Gai and Xiangfei Meng and Tingting Gao},
doi = {10.1016/j.comppsych.2024.152542},
issn = {1532-8384},
year = {2025},
date = {2025-01-01},
journal = {Compr Psychiatry},
volume = {136},
pages = {152542},
abstract = {BACKGROUND AND AIMS: Previous studies are limited in addressing the directionality of temporal relationships between problematic gaming and phubbing symptoms by exploring cross-sectional studies. Therefore, we estimated the longitudinal relationships between individual behavioral addictive symptoms including problematic gaming and phubbing in adolescence, and explored potential sex differences in these relationships.nnMETHODS: This study included 3296 participants in Shandong Province, China. Data were collected from November 2021 (mean [SD] age: 15.17 [1.44] years) to May 2023 (mean [SD] age: 17.50 [1.18] years), with females comprising 54.5 % of the sample. Problematic gaming and phubbing were assessed using validated scales at each wave. We construct cross-sectional networks and cross-lagged panel networks (CLPN) to explore the contemptuous and temporal relationships between problematic gaming and phubbing.nnRESULTS: Contemporaneous networks revealed significant differences in problematic gaming and phubbing networks between males and females. Additionally, temporal network analyses indicated that among male adolescents, feeling anxious when unable to play games was the most influential predictor of subsequent behavioral addictive symptoms. For female adolescents, fantasizing about gaming had the most significant associations with future addictive behaviors. The strongest bridge symptom linking problematic gaming and phubbing for both sexes was focusing on phones rather than engaging in conversation.nnDISCUSSION AND CONCLUSIONS: The study applied network modeling to panel data from a large, population-based cohort of adolescents, identifying unique longitudinal relationships between problematic gaming and phubbing across symptom domains. It provides valuable insights into the characterization of behavioral addictive symptoms among adolescents and the potential predictive relationships among these symptoms among different sexes, guiding sex-specific targeted interventions for adolescents.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Jaramillo-Ospina, Angela Marcela; Molle, Roberta Dalle; Patel, Sachin; Kelly, Shona; Pokhvisneva, Irina; de Weerth, Carolina; Silveira, Patrícia Pelufo
In: Appetite, vol. 204, pp. 107762, 2025, ISSN: 1095-8304.
@article{pmid39521350,
title = {A mesocorticolimbic insulin receptor gene co-expression network moderates the association between early life adversity and food approach eating behaviour style in childhood},
author = {Angela Marcela Jaramillo-Ospina and Roberta Dalle Molle and Sachin Patel and Shona Kelly and Irina Pokhvisneva and Carolina de Weerth and Patrícia Pelufo Silveira},
doi = {10.1016/j.appet.2024.107762},
issn = {1095-8304},
year = {2025},
date = {2025-01-01},
journal = {Appetite},
volume = {204},
pages = {107762},
abstract = {Insulin receptors, located in brain regions associated with reward sensitivity and decision-making, facilitate insulin action in the brain, modulating intracellular signaling cascades, gene expression, and neural activity. Here, we tested if variations in the expression of the insulin receptor gene network in the prefrontal cortex (PFC) and striatum (STR) moderate the association between early life adversity and eating behaviour in childhood and if this moderation is sex-specific. Participants from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) and Basal Influences on the Baby's Development (BIBO) were included as two independent cohorts. A biologically-informed polygenic score reflecting functional variation of the mesocorticolimbic insulin receptor gene network was created by using insulin receptor co-expression data from the PFC and STR in mice, and validated in humans through filtering by homologous expression in PFC using well-known databases. Early life adversity exposure was measured as a composite score. Eating behaviour was characterized using the Child Eating Behaviour Questionnaire administered to mothers of children aged 4 and 6 years in MAVAN, and 6 years in BIBO. We found that only in those with high expression of the mesocorticolimbic insulin receptor gene network a higher early adversity score associated with a higher desire to drink in 4-year boys and 6-year girls, as well as a higher food approach score and food approach/food avoidance ratio in 4-year girls. Also, a higher early life adversity was associated with higher food responsiveness, food approach score and food approach/food avoidance ratio at 6 years in the MAVAN full sample. The moderation observed on desire to drink was partially replicated in BIBO children aged 6 years. Identifying individual differences in response to early adversity may help to prioritize individuals at high risk for long-term disease and design suitable interventions.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Collet, Ophélie A; Domond, Pascale M; Galéra, Cédric; Luu, Thuy Mai; Loose, Tianna; Vásquez-Echeverría, Alejandro; Orri, Massimiliano; Côté, Sylvana M
School Readiness and Early Childhood Education and Care Services Among Dual Language Learners Journal Article
In: JAMA Pediatr, vol. 179, no. 1, pp. 73–82, 2025, ISSN: 2168-6211.
@article{pmid39527069,
title = {School Readiness and Early Childhood Education and Care Services Among Dual Language Learners},
author = {Ophélie A Collet and Pascale M Domond and Cédric Galéra and Thuy Mai Luu and Tianna Loose and Alejandro Vásquez-Echeverría and Massimiliano Orri and Sylvana M Côté},
doi = {10.1001/jamapediatrics.2024.4489},
issn = {2168-6211},
year = {2025},
date = {2025-01-01},
journal = {JAMA Pediatr},
volume = {179},
number = {1},
pages = {73--82},
abstract = {IMPORTANCE: Dual language learners (DLL) (ie, children learning 2 or more languages) present lower school readiness than non-DLL children, putting DLL children at risk of later school difficulties and adverse outcomes. However, it is unclear whether participation in early childhood education and care (ECEC) services may reduce this gap.nnOBJECTIVE: To assess whether ECEC exposure may reduce the school readiness gap between DLL and non-DLL children in a population-based sample.nnDESIGN, SETTING, AND PARTICIPANTS: This census survey study was performed from February to May 2022 in the Canadian province of Quebec using data from the Quebec Survey of Child Development in Kindergarten, which includes all children who attended kindergarten in the 2021 to 2022 school year in public and private schools in Quebec (n = 80 587), except for Cree and Inuit territories.nnEXPOSURE: Children's ECEC arrangement before kindergarten was retrieved from register-based data and teachers and arrangements were categorized as exclusive parental care, childcare, pre-kindergarten only, or childcare and pre-kindergarten. Based on their mother tongue and language of instruction, children were classified as French speaking, English speaking, bilingual French-English speaking, or neither French nor English speaking (allophone) children, the last 2 groups of which represented the DLL category.nnMAIN OUTCOMES AND MEASURES: Vulnerability in school readiness was defined as a score below the 10th percentile in any of the 5 domains of the validated Early Development Instrument (EDI): (1) physical health and well-being; (2) social competence; (3) emotional maturity; (4) language and cognitive development; and (5) communication skills and general knowledge.nnRESULTS: In total, 80 587 children were surveyed, and 71 585 children were included in analyses. Mean (SD) child age was 6.0 (0.3) years, 34 911 children (48.8%) were female, and 18 341 children (25.6%) were DLL. English-speaking, bilingual French-English-speaking, and allophone children were more likely to be vulnerable in the EDI (769 of 2355 children [32.7%], 4814 of 13 981 children [34.4%], and 1622 of 4360 children [37.2%], respectively) than French-speaking children (13 664 of 50 890 children [26.9%]). In logistic regression analyses adjusted for social selection bias in ECEC arrangement, attending ECEC services was associated with a lower risk of being vulnerable among all language groups compared to parental care, with odds ratios ranging from 0.26 (95% CI, 0.25-0.27) to 0.96 (95% CI, 0.80-1.14), except in the emotional maturity domain. ECEC exposure was associated with reduction in vulnerabilities disparities between DLL and non-DLL children after adjusting for confounding factors, including socioeconomic status.nnCONCLUSIONS AND RELEVANCE: ECEC services may foster school readiness for all children, especially DLL, and should be considered to reduce school inequalities.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Lee, J Quinn; Keinath, Alexandra T; Cianfarano, Erica; Brandon, Mark P
Identifying representational structure in CA1 to benchmark theoretical models of cognitive mapping Journal Article
In: Neuron, vol. 113, no. 2, pp. 307–320.e5, 2025, ISSN: 1097-4199.
@article{pmid39579760,
title = {Identifying representational structure in CA1 to benchmark theoretical models of cognitive mapping},
author = {J Quinn Lee and Alexandra T Keinath and Erica Cianfarano and Mark P Brandon},
doi = {10.1016/j.neuron.2024.10.027},
issn = {1097-4199},
year = {2025},
date = {2025-01-01},
journal = {Neuron},
volume = {113},
number = {2},
pages = {307--320.e5},
abstract = {Decades of theoretical and empirical work have suggested the hippocampus instantiates some form of a cognitive map. Yet, tests of competing theories have been limited in scope and largely qualitative in nature. Here, we develop a novel framework to benchmark model predictions against observed neuronal population dynamics as animals navigate a series of geometrically distinct environments. In this task space, we show a representational structure in the dynamics of hippocampal remapping that generalizes across brains, discriminates between competing theoretical models, and effectively constrains biologically viable model parameters. With this approach, we find that accurate models capture the correspondence in spatial coding of a changing environment. The present dataset and framework thus serve to empirically evaluate and advance theories of cognitive mapping in the brain.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Sasabayashi, Daiki; Tsugawa, Sakiko; Nakajima, Shinichiro; Takahashi, Tsutomu; Takayanagi, Yoichiro; Koike, Shinsuke; Katagiri, Naoyuki; Katsura, Masahiro; Furuichi, Atsushi; Mizukami, Yuko; Nishiyama, Shimako; Kobayashi, Haruko; Yuasa, Yusuke; Tsujino, Naohisa; Sakuma, Atsushi; Ohmuro, Noriyuki; Sato, Yutaro; Tomimoto, Kazuho; Okada, Naohiro; Tada, Mariko; Suga, Motomu; Maikusa, Norihide; Plitman, Eric; Wannan, Cassandra M J; Zalesky, Andrew; Chakravarty, Mallar; Noguchi, Kyo; Yamasue, Hidenori; Matsumoto, Kazunori; Nemoto, Takahiro; Tomita, Hiroaki; Mizuno, Masafumi; Kasai, Kiyoto; Suzuki, Michio
Increased structural covariance of cortical measures in individuals with an at-risk mental state Journal Article
In: Prog Neuropsychopharmacol Biol Psychiatry, vol. 136, pp. 111197, 2025, ISSN: 1878-4216.
@article{pmid39579961,
title = {Increased structural covariance of cortical measures in individuals with an at-risk mental state},
author = {Daiki Sasabayashi and Sakiko Tsugawa and Shinichiro Nakajima and Tsutomu Takahashi and Yoichiro Takayanagi and Shinsuke Koike and Naoyuki Katagiri and Masahiro Katsura and Atsushi Furuichi and Yuko Mizukami and Shimako Nishiyama and Haruko Kobayashi and Yusuke Yuasa and Naohisa Tsujino and Atsushi Sakuma and Noriyuki Ohmuro and Yutaro Sato and Kazuho Tomimoto and Naohiro Okada and Mariko Tada and Motomu Suga and Norihide Maikusa and Eric Plitman and Cassandra M J Wannan and Andrew Zalesky and Mallar Chakravarty and Kyo Noguchi and Hidenori Yamasue and Kazunori Matsumoto and Takahiro Nemoto and Hiroaki Tomita and Masafumi Mizuno and Kiyoto Kasai and Michio Suzuki},
doi = {10.1016/j.pnpbp.2024.111197},
issn = {1878-4216},
year = {2025},
date = {2025-01-01},
journal = {Prog Neuropsychopharmacol Biol Psychiatry},
volume = {136},
pages = {111197},
abstract = {An anomalous pattern of structural covariance has been reported in schizophrenia, which has been suggested to represent connectome changes during brain maturation and neuroprogressive processes. It remains unclear whether similar differences exist in a clinical high-risk state for psychosis, and if they are associated with a prodromal phenotype and/or later psychosis onset. This multicenter magnetic resonance imaging study cross-sectionally examined structural covariance in a large at-risk mental state (ARMS) sample with different outcomes. The whole-brain structural covariance of four cortical measures (thickness, area, volume, and gyrification) was assessed in 155 individuals with ARMS, who were subclassified into 26 (16.8 %) with a later psychosis onset (ARMS-P), 44 with persistent subthreshold psychotic symptoms, and 53 with the remission of psychotic symptoms (ARMS-R) during the clinical follow-up, and 191 healthy controls. The relationships of changes in structural covariance with clinical symptoms and cognitive impairments were also investigated in the ARMS subsample. Structural covariance was significantly higher in widespread cortical regions in the ARMS group than in the controls, with each cortical measure having a different pattern in affected cortical regions. The higher structural covariance of the cortical area was partly related to severe suspiciousness-persecutory ideation. Structural covariance was significantly higher, mainly in fronto-parietal gyrification, in the ARMS-P group than in the ARMS-R group. The present results suggest that changes in structural covariance result in psychosis vulnerability and the excessive structural covariance of brain gyrification in ARMS subjects may contribute to their later clinical course.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
van Paassen, Dirk; Hartog, Luc; de Boer, Sterre; Vijverberg, Everard; Ducharme, Simon; Pijnenburg, Yolande; Santillo, Alexander
In: Eur J Neurol, vol. 32, no. 1, pp. e16537, 2025, ISSN: 1468-1331.
@article{pmid39607834,
title = {Expert opinions on pharmacological symptomatic treatment of behavioral symptoms in frontotemporal dementia: A survey of the Neuropsychiatric International Consortium on Frontotemporal Dementia (NIC-FTD)},
author = {Dirk van Paassen and Luc Hartog and Sterre de Boer and Everard Vijverberg and Simon Ducharme and Yolande Pijnenburg and Alexander Santillo},
doi = {10.1111/ene.16537},
issn = {1468-1331},
year = {2025},
date = {2025-01-01},
journal = {Eur J Neurol},
volume = {32},
number = {1},
pages = {e16537},
abstract = {BACKGROUND AND PURPOSE: Behavioral variant frontotemporal dementia (bvFTD) is essentially characterized by progressive changes in personality and cognition. Clinically, bvFTD presents with often profound behavioral symptomatology. Despite the high burden of these symptoms for both patients and caregivers, there is no general consensus on an effective pharmacological symptomatic treatment. Interestingly, for multiple similar symptoms in primary psychiatric disorders, there is consensus on an effective pharmacological treatment. The aim of this study is to explore currently preferred clinical practices in the pharmacological treatment of specific core behavioral symptoms in bvFTD by world-leading clinical experts.nnMETHODS: A digital survey was conducted among members of the Neuropsychiatric International Consortium on Frontotemporal Dementia, comprising neurologists, psychiatrists, and neuropsychiatrists. Respondents recommended pharmacological treatments targeting symptoms including disinhibition, apathy, loss of empathy, hyperorality, perseverative/compulsive behaviors, and positive psychotic symptoms.nnRESULTS: Of 48 respondents with a median experience of 11.5 years in treating bvFTD, disinhibition was most frequently targeted (58.4%), followed by perseverative/compulsive behaviors (46.5%). Recommended drug classes included atypical antipsychotics (35.1%), selective serotonin reuptake inhibitors (31.2%), antiepileptics (10.0%), serotonin antagonist and reuptake inhibitors (8.4%), benzodiazepines (4.0%), and others (11.4%).nnCONCLUSIONS: Our survey revealed diverse pharmacological treatment practices for behavioral symptoms in bvFTD, reflecting the expected radical heterogeneity in pharmacological treatment strategies. Notwithstanding this, results from this explorative survey could further inform future research directions, and thus in turn potentially aid in establishing more consensus on effective pharmacological management of bvFTD, while the field awaits the development of highly anticipated disease-modifying treatment(s).},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Nadler, Emma; Jacobus, Joanna; Rabin, Rachel A
In: Can J Psychiatry, vol. 70, no. 1, pp. 41–53, 2025, ISSN: 1497-0015.
@article{pmid39140868,
title = {Prenatal Cannabis and Tobacco Co-Exposure and Its Association with Behavioural Outcomes in Middle Childhood: Co-exposition prénatale au cannabis et au tabac et son association avec les résultats comportementaux au cours de l'enfance intermédiaire},
author = {Emma Nadler and Joanna Jacobus and Rachel A Rabin},
doi = {10.1177/07067437241271696},
issn = {1497-0015},
year = {2025},
date = {2025-01-01},
journal = {Can J Psychiatry},
volume = {70},
number = {1},
pages = {41--53},
abstract = {OBJECTIVES: Cannabis legalization has triggered an increase in prenatal cannabis use. Given that tobacco is commonly co-used with cannabis, determining outcomes associated with prenatal cannabis and tobacco co-exposure is crucial. While literature exists regarding the individual effects of prenatal cannabis and tobacco exposure on childhood behaviour, there is a gap regarding their combined use, which may have interactive effects. Therefore, we investigated whether prenatal cannabis and tobacco co-exposure was associated with greater externalizing and internalizing problems in middle childhood compared to prenatal exposure to either substance alone or no exposure.nnMETHODS: Baseline data from the Adolescent Brain Cognitive Development (ABCD) Study (collected in children ages 9-11) were used to explore differences in externalizing and internalizing scores derived from the Childhood Behavior Checklist across four groups: children with prenatal cannabis and tobacco co-exposure (CT, = 290), children with prenatal cannabis-only exposure (CAN, = 225), children with prenatal tobacco-only exposure (TOB, = 966), and unexposed children (CTL, = 8,311). We also examined if the daily quantity of tobacco exposure modulated the effect of cannabis exposure on outcomes.nnRESULTS: Adjusting for covariates, a 2 × 2 ANCOVA revealed significant main effects for prenatal cannabis ( = 0.03) and tobacco exposure ( < 0.001), and a significant interaction effect on externalizing scores ( = 0.032); no significant main effects or interactions were found for internalizing scores. However, interactions between daily quantity of cannabis and tobacco exposure significantly predicted both externalizing and internalizing scores ( < 0.01).nnCONCLUSIONS: These findings indicate that co-exposure is associated with greater externalizing problems than exposure to either substance alone, which did not differ from each other. Further, greater tobacco exposure may amplify the negative effect of cannabis exposure on both externalizing and internalizing behaviours in children. These findings underscore the need for interventions that target cannabis and tobacco co-use in pregnant women to circumvent their adverse impact on middle childhood behaviour.nnPLAIN LANGUAGE SUMMARY TITLE: Prenatal Cannabis and Tobacco Co-exposure and its Association with Middle Childhood Behaviours.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Markam, Pratap S; Bourguignon, Clément; Zhu, Lei; Ward, Bridget; Darvas, Martin; Sabatini, Paul V; Kokoeva, Maia V; Giros, Bruno; Storch, Kai-Florian
Mesolimbic dopamine neurons drive infradian rhythms in sleep-wake and heightened activity state Journal Article
In: Sci Adv, vol. 11, no. 1, pp. eado9965, 2025, ISSN: 2375-2548.
@article{pmid39742489,
title = {Mesolimbic dopamine neurons drive infradian rhythms in sleep-wake and heightened activity state},
author = {Pratap S Markam and Clément Bourguignon and Lei Zhu and Bridget Ward and Martin Darvas and Paul V Sabatini and Maia V Kokoeva and Bruno Giros and Kai-Florian Storch},
doi = {10.1126/sciadv.ado9965},
issn = {2375-2548},
year = {2025},
date = {2025-01-01},
journal = {Sci Adv},
volume = {11},
number = {1},
pages = {eado9965},
abstract = {Infradian mood and sleep-wake rhythms with periods of 48 hours and beyond have been observed in patients with bipolar disorder (BD), which even persist in the absence of exogenous timing cues, indicating an endogenous origin. Here, we show that mice exposed to methamphetamine in drinking water develop infradian locomotor rhythms with periods of 48 hours and beyond which extend to sleep length and manic state-associated behaviors in support of a model for cycling in BD. The cycling capacity is abrogated upon genetic disruption of dopamine (DA) production in DA neurons of the ventral tegmental area (VTA) or ablation of nucleus accumbens projecting DA neurons. Furthermore, chemogenetic activation of DA neurons including those that project to the nucleus accumbens led to locomotor period lengthening in circadian clock-deficient mice, which was counteracted by antipsychotic treatment. Together, our findings argue that BD cycling relies on infradian rhythm generation that depends on mesolimbic DA neurons.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Andrews, Daniel; Ducharme, Simon; Chertkow, Howard; Sormani, Maria Pia; and, D Louis Collins
The higher benefit of lecanemab in males compared to females in CLARITY AD is probably due to a real sex effect Journal Article
In: Alzheimers Dement, vol. 21, no. 1, pp. e14467, 2025, ISSN: 1552-5279.
@article{pmid39887549,
title = {The higher benefit of lecanemab in males compared to females in CLARITY AD is probably due to a real sex effect},
author = {Daniel Andrews and Simon Ducharme and Howard Chertkow and Maria Pia Sormani and D Louis Collins and },
doi = {10.1002/alz.14467},
issn = {1552-5279},
year = {2025},
date = {2025-01-01},
journal = {Alzheimers Dement},
volume = {21},
number = {1},
pages = {e14467},
abstract = {INTRODUCTION: The phase 3 trial CLARITY AD found lecanemab slowed cognitive decline by 27%. However, subgroup analyses indicated a significant 31% sex difference in the effect and suggested no or limited effectiveness in females. We used simulations constrained by the trial design to determine whether that difference reflects a pre-existing sex difference in Alzheimer's disease progression or was a random event.nnMETHODS: Simulations were generated using linear mixed models of cognitive decline fit to data from Alzheimer's Disease Neuroimaging Initiative participants satisfying CLARITY AD inclusion criteria.nnRESULTS: The statistically non-significant 7.9% smaller cognitive decline rate in our cohort's males versus females does not explain CLARITY AD's 31% sex difference in lecanemab's effect. A ≥ 31% difference occurred randomly in only 12 of our 10,000 simulations (0.0012 probability).nnDISCUSSION: CLARITY AD's sex difference was probably not random. Lecanemab is likely less effective in females than males, but we cannot conclude the drug is ineffective in females.nnHIGHLIGHTS: Lecanemab is more clinically effective in males than in females. Forest plots should only report subgroup-specific effects in well-powered subgroups. Trial simulations based on real data enable investigation of subgroup drug effects. We cannot conclude that lecanemab is clinically ineffective in females. A sex difference in lecanemab's efficacy could be linked to its action mechanism.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Guma, Elisa; Chakravarty, M Mallar
Immune Alterations in the Intrauterine Environment Shape Offspring Brain Development in a Sex-Specific Manner Journal Article
In: Biol Psychiatry, vol. 97, no. 1, pp. 12–27, 2025, ISSN: 1873-2402.
@article{pmid38679357,
title = {Immune Alterations in the Intrauterine Environment Shape Offspring Brain Development in a Sex-Specific Manner},
author = {Elisa Guma and M Mallar Chakravarty},
doi = {10.1016/j.biopsych.2024.04.012},
issn = {1873-2402},
year = {2025},
date = {2025-01-01},
journal = {Biol Psychiatry},
volume = {97},
number = {1},
pages = {12--27},
abstract = {Exposure to immune dysregulation in utero or in early life has been shown to increase risk for neuropsychiatric illness. The sources of inflammation can be varied, including acute exposures due to maternal infection or acute stress, or persistent exposures due to chronic stress, obesity, malnutrition, or autoimmune diseases. These exposures may cause subtle alteration in brain development, structure, and function that can become progressively magnified across the lifespan, potentially increasing the likelihood of developing a neuropsychiatric conditions. There is some evidence that males are more susceptible to early-life inflammatory challenges than females. In this review, we discuss the various sources of in utero or early-life immune alteration and the known effects on fetal development with a sex-specific lens. To do so, we leveraged neuroimaging, behavioral, cellular, and neurochemical findings. Gaining clarity about how the intrauterine environment affects offspring development is critically important for informing preventive and early intervention measures that may buffer against the effects of these early-life risk factors.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Arias, Jaime Fernández; Brum, Wagner S; Salvadó, Gemma; Therriault, Joseph; Servaes, Stijn; Wang, Yi-Ting; Aumont, Etienne; Rahmouni, Nesrine; Macedo, Arthur; Quispialaya, Kely; Hosseini, Seyyed Ali; Kunach, Peter; Jia, Wan Lu; Chan, Tevy; Trudel, Lydia; Hall, Brandon; Zheng, Yanseng; Mohapatra, Sejal; Mathotaarachchi, Sulantha S; Vitali, Paolo; Tissot, Cécile; Bezgin, Gleb; Iturria-Medina, Yasser; Ashton, Nicholas J; Benedet, Andréa Lessa; Karikari, Thomas K; Triana-Baltzer, Gallen; Klostranec, Jesse; Kolb, Hartmuth C; Zimmer, Eduardo R; Janelidze, Shorena; Mattson-Carlgren, Niklas; Stomrud, Erik; Palmqvist, Sebastian; Zetterberg, Henrik; Blennow, Kaj; Pascoal, Tharick; Montembeault, Maxime; Hansson, Oskar; Rosa-Neto, Pedro
Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer's disease spectrum Journal Article
In: Brain, 2025, ISSN: 1460-2156.
@article{pmid39879633,
title = {Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer's disease spectrum},
author = {Jaime Fernández Arias and Wagner S Brum and Gemma Salvadó and Joseph Therriault and Stijn Servaes and Yi-Ting Wang and Etienne Aumont and Nesrine Rahmouni and Arthur Macedo and Kely Quispialaya and Seyyed Ali Hosseini and Peter Kunach and Wan Lu Jia and Tevy Chan and Lydia Trudel and Brandon Hall and Yanseng Zheng and Sejal Mohapatra and Sulantha S Mathotaarachchi and Paolo Vitali and Cécile Tissot and Gleb Bezgin and Yasser Iturria-Medina and Nicholas J Ashton and Andréa Lessa Benedet and Thomas K Karikari and Gallen Triana-Baltzer and Jesse Klostranec and Hartmuth C Kolb and Eduardo R Zimmer and Shorena Janelidze and Niklas Mattson-Carlgren and Erik Stomrud and Sebastian Palmqvist and Henrik Zetterberg and Kaj Blennow and Tharick Pascoal and Maxime Montembeault and Oskar Hansson and Pedro Rosa-Neto},
doi = {10.1093/brain/awaf033},
issn = {1460-2156},
year = {2025},
date = {2025-01-01},
journal = {Brain},
abstract = {Plasma phosphorylated tau biomarkers open unprecedented opportunities for identifying carriers of Alzheimer's disease pathophysiology in early disease stages using minimally invasive techniques. Plasma p-tau biomarkers are believed to reflect tau phosphorylation and secretion. However, it remains unclear to what extent the magnitude of plasma p-tau abnormalities reflects neuronal network disturbance in the form of cognitive impairment. To address this question, we included 103 cognitively unimpaired elderly and 40 cognitively impaired, amyloid-β positive individuals from the TRIAD cohort, as well as 336 cognitively unimpaired and 216 cognitively impaired, amyloid-β positive older adults from the BioFINDER-2 cohort. Participants had tau PET scans, amyloid PET scans or amyloid CSF, p-tau217, p-tau181 and p-tau231 blood measures, structural T1-MRI and cognitive assessments. In this cross-sectional study, we used regression models and correlation analyses to assess the relationship between plasma biomarkers and cognitive scores. Furthermore, we applied receiver operating characteristic curves to assess cognitive impairment across plasma biomarkers. Finally, we categorized participants into amyloid (A), p-tau (T1), and tau PET (T2) positive (+) or negative (-) profiles and ran nonparametric comparisons to assess differences across cognitive domains. We found that plasma p-tau217 was more associated with cognitive performance than p-tau181 and p-tau231, and that this relationship was particularly strong for memory scores (TRIAD: βp-tau217=-0.53; βp-tau181=-0.35; βp-tau231=-0.24; BioFINDER-2: βp-tau217=-0.52; βp-tau181=-0.24; βp-tau231=-0.29). Associations in amyloid-β positive participants resembled these results, but other cognitive scores also showed strong associations in cognitively impaired individuals. Moreover, plasma p-tau217 outperformed plasma p-tau181 and plasma p-tau231 in identifying memory impairment (Area Under the Curve values for TRIAD: p-tau217=0.86, p-tau181=0.77, p-tau231=0.75; Area Under the Curve values for BioFINDER-2: p-tau217=0.86, p-tau181=0.76, p-tau231=0.81), and in identifying executive function impairment only in the BioFINDER-2 cohort (p-tau217=0.82, p-tau181=0.76, p-tau231=0.76). Lastly, we showed that subtle memory deficits were present in A+T1+T2- participants for plasma p-tau217 (p=0.007) and plasma p-tau181 (p=0.01) in the TRIAD cohort, and for all biomarkers across cognitive domains in A+T1-T2- and A+T1+T2- individuals (p<0.001 in all) in the BioFINDER-2 cohort. A+T1+T2+ individuals showed cognitive deficits in both cohorts (p<0.001 in all). Together, our results suggest that plasma p-tau217 stands out as a biomarker capable of identifying memory deficits due to Alzheimer's disease and that memory impairment certainly occurs in amyloid and plasma p-tau positive individuals that have no significant amounts of tau in the neocortex.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Vrooman, Roël M; van den Berg, Monica; Desrosiers-Gregoire, Gabriel; van Engelenburg, Wessel A; Galteau, Marie E; Lee, Sung-Ho; Veltien, Andor; Barrière, David A; Cash, Diana; Chakravarty, M Mallar; Devenyi, Gabriel A; Gozzi, Alessandro; Gröhn, Olli; Hess, Andreas; Homberg, Judith R; Jelescu, Ileana O; Keliris, Georgios A; Scheenen, Tom; Shih, Yen-Yu Ian; Verhoye, Marleen; Wary, Claire; Zwiers, Marcel; Grandjean, Joanes
fMRI data acquisition and analysis for task-free, anesthetized rats Journal Article
In: Nat Protoc, 2025, ISSN: 1750-2799.
@article{pmid39875591,
title = {fMRI data acquisition and analysis for task-free, anesthetized rats},
author = {Roël M Vrooman and Monica van den Berg and Gabriel Desrosiers-Gregoire and Wessel A van Engelenburg and Marie E Galteau and Sung-Ho Lee and Andor Veltien and David A Barrière and Diana Cash and M Mallar Chakravarty and Gabriel A Devenyi and Alessandro Gozzi and Olli Gröhn and Andreas Hess and Judith R Homberg and Ileana O Jelescu and Georgios A Keliris and Tom Scheenen and Yen-Yu Ian Shih and Marleen Verhoye and Claire Wary and Marcel Zwiers and Joanes Grandjean},
doi = {10.1038/s41596-024-01110-y},
issn = {1750-2799},
year = {2025},
date = {2025-01-01},
journal = {Nat Protoc},
abstract = {Templates for the acquisition of large datasets such as the Human Connectome Project guide the neuroimaging community to reproducible data acquisition and scientific rigor. By contrast, small animal neuroimaging often relies on laboratory-specific protocols, which limit cross-study comparisons. The establishment of broadly validated protocols may facilitate the acquisition of large datasets, which are essential for uncovering potentially small effects often seen in functional MRI (fMRI) studies. Here, we outline a procedure for the acquisition of fMRI datasets in rats and describe animal handling, MRI sequence parameters, data conversion, preprocessing, quality control and data analysis. The procedure is designed to be generalizable across laboratories, has been validated by using datasets across 20 research centers with different scanners and field strengths ranging from 4.7 to 17.2 T and can be used in studies in which it is useful to compare functional connectivity measures across an extensive range of datasets. The MRI procedure requires 1 h per rat to complete and can be carried out by users with limited expertise in rat handling, MRI and data processing.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Lion, Montaine; Ibrahim, El Chérif; Caccomo-Garcia, Elodie; Bourret, Julie; Cinquanta, Guillaume; Khalfallah, Olfa; Glaichenhaus, Nicolas; Davidovic, Laetitia; Courtet, Philippe; Turecki, Gustavo; Tzavara, Eleni; Belzeaux, Raoul
A specific GPR56/ADGRG1 splicing isoform is associated with antidepressant response in major depressive disorder Journal Article
In: Eur Neuropsychopharmacol, vol. 93, pp. 5–14, 2025, ISSN: 1873-7862.
@article{pmid39874727,
title = {A specific GPR56/ADGRG1 splicing isoform is associated with antidepressant response in major depressive disorder},
author = {Montaine Lion and El Chérif Ibrahim and Elodie Caccomo-Garcia and Julie Bourret and Guillaume Cinquanta and Olfa Khalfallah and Nicolas Glaichenhaus and Laetitia Davidovic and Philippe Courtet and Gustavo Turecki and Eleni Tzavara and Raoul Belzeaux},
doi = {10.1016/j.euroneuro.2025.01.001},
issn = {1873-7862},
year = {2025},
date = {2025-01-01},
journal = {Eur Neuropsychopharmacol},
volume = {93},
pages = {5--14},
abstract = {Major Depressive Episode (MDE) is one of the most common psychiatric disorders. Often difficult to treat, this disease is one of the leading causes of suicide. A recent study showed an association between GPR56/ADGRG1 mRNA, MDE and response to antidepressant treatment in blood and in brain. Among GPR56 splicing variant, the S4 isoform has recently been associated with microglial synaptic pruning, while microglia are already known as a central player in MDE. Therefore, we hypothesized that S4 is the specific isoform associated to MDE and antidepressant response. To test our hypothesis, an in silico analysis was first performed to identify the different proteins and transcript isoforms of GPR56. This analysis allowed to design PCR and qPCR primers. GPR56 total, S4 and S3 were assessed by RT-qPCR in leukocytes from a cohort of 46 MDE patients including non-responders (NR, n = 31) and responders-remitters (R, n = 17) to antidepressant treatment. We replicated the result of one of our previous studies, which described an increase in total GPR56 mRNA in Rs. Additionally, we observed that this variation differs among mRNA splicing variants, with S4 exhibiting a similar pattern of variation while S3 shows no significant change. The differences observed withstood statistical correction for covariates of interest such as smoking, gender and suicidal ideation, demonstrating the robustness of the model. These findings confirm our hypothesis that certain mRNA splicing variants of GPR56 may play a more significant role in depression. This study highlighted a link between the GPR56-S4 and response to antidepressant treatment.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Ma, Xiaoqian; Feng, Nana; Palaniyappan, Lena; Cao, Luolong; Gu, Zixin; Kang, Jujiao; Yuan, Liu; Ouyang, Lijun; Wang, Yujue; Li, Chunwang; Jin, Ke; Chen, Xiaogang; Feng, Jianfeng; He, Ying; Luo, Qiang
Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia Journal Article
In: Transl Psychiatry, vol. 15, no. 1, pp. 18, 2025, ISSN: 2158-3188.
@article{pmid39843416,
title = {Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia},
author = {Xiaoqian Ma and Nana Feng and Lena Palaniyappan and Luolong Cao and Zixin Gu and Jujiao Kang and Liu Yuan and Lijun Ouyang and Yujue Wang and Chunwang Li and Ke Jin and Xiaogang Chen and Jianfeng Feng and Ying He and Qiang Luo},
doi = {10.1038/s41398-025-03237-2},
issn = {2158-3188},
year = {2025},
date = {2025-01-01},
journal = {Transl Psychiatry},
volume = {15},
number = {1},
pages = {18},
abstract = {The striatum, a core brain structure relevant for schizophrenia, exhibits heterogeneous volumetric changes in this illness. Due to this heterogeneity, its role in the risk of developing schizophrenia following exposure to environmental stress remains poorly understood. Using the putamen (a subnucleus of the striatum) as an indicator for convergent genetic risk of schizophrenia, 63 unaffected first-degree relatives of patients (22.08 ± 4.80 years) with schizophrenia (UFR-SZ) were stratified into two groups. Compared with healthy controls (HC; n = 59), voxel-based and brain-wide volumetric changes and their associations with stressful life events (SLE) were tested. These stratified associations were validated using two large population-based cohorts (the ABCD study; n = 1680, 11.92 ± 0.62 years; and UK Biobank, n = 20547, 55.38 ± 7.43 years). Transcriptomic analysis of brain tissues was used to identify the biological processes associated with the brain mediation effects on the SLE-psychosis relationship. The stratified UFR-SZ subgroup with smaller right putamen had a smaller volume in the left caudate when compared to HC; this caudate volume was associated with both a higher level of SLE and more psychotic symptoms. This caudate-SLE association was replicated in two independent large-scale cohorts, when individuals were stratified by both a higher polygenic burden for schizophrenia and smaller right putamen. In UFR-SZ, the caudate cluster mediated the relationship between SLE and more psychotic symptoms. This mediation was associated with the genes enriched in both glutamatergic synapses and response to oxidative stress. The stratified association between the striatum and stress highlights the differential vulnerability to stress, contributing to the complexity of the gene-by-environment etiology of schizophrenia.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Wiels, Wietse A; Oomens, Julie E; Engelborghs, Sebastiaan; Baeken, Chris; von Arnim, Christine A F; Boada, Mercè; Didic, Mira; Dubois, Bruno; Fladby, Tormod; van der Flier, Wiesje M; Frisoni, Giovanni B; Fröhlich, Lutz; Gill, Kiran Dip; Grimmer, Timo; Hildebrandt, Helmut; Hort, Jakub; Itoh, Yoshiaki; Iwatsubo, Takeshi; Klimkowicz-Mrowiec, Aleksandra; Lee, Dong Young; Lleó, Alberto; Martinez-Lage, Pablo; de Mendonça, Alexandre; Meyer, Philipp T; Kapaki, Elisabeth N; Parchi, Piero; Pardini, Matteo; Parnetti, Lucilla; Popp, Julius; Rami, Lorena; Reiman, Eric M; Rinne, Juha O; Rodrigue, Karen M; Sánchez-Juan, Pascual; Santana, Isabel; Sarazin, Marie; Scarmeas, Nikolaos; Skoog, Ingmar; Snyder, Peter J; Sperling, Reisa A; Villeneuve, Sylvia; Wallin, Anders; Wiltfang, Jens; Zetterberg, Henrik; Ossenkoppele, Rik; Verhey, Frans R J; Vos, Stephanie J B; Visser, Pieter Jelle; Jansen, Willemijn J; ; ; Alcolea, Daniel; Altomare, Daniele; Baiardi, Simone; Baldeiras, Ines; Bateman, Randall J; Blennow, Kaj; Bottlaender, Michel; den Braber, Anouk; van Buchem, Mark A; Byun, Min Soo; Cerman, Jirí; Chen, Kewei; Chipi, Elena; Day, Gregory S; Drzezga, Alexander; Eckerström, Marie; Ekblad, Laura L; Epelbaum, Stéphane; Förster, Stefan; Fortea, Juan; Freund-Levi, Yvonne; Frings, Lars; Guedj, Eric; Hausner, Lucrezia; Hellwig, Sabine; Huey, Edward D; Jiménez-Bonilla, Julio F; Johnson, Keith A; Juaristi, Ane Iriondo; Kandimalla, Ramesh; Paraskevas, George; Kern, Silke; Kirsebom, Bjørn-Eivind S; Kornhuber, Johannes; Lagarde, Julien; Landau, Susan M; Legdeur, Nienke; Guerra, Jorge J Llibre; Maserejian, Nancy N; Marquié, Marta; Minatani, Shinobu; Morbelli, Silvia Daniela; Mroczko, Barbara; Ntanasi, Eva; de Oliveira, Catarina Resende; Olivieri, Pauline; Orellana, Adelina; Perrin, Richard J; Peters, Oliver; Prabhakar, Sudesh; Ramakers, Inez H; Rodríguez-Rodriguez, Eloy; Ruiz, Agustín; Rüther, Eckart; Selnes, Per; Silva, Dina; Soininen, Hilkka; Spiru, Luiza; Takeda, Akitoshi; Teichmann, Marc; Tijms, Betty M; Teunissen, Charlotte E; Thompson, Loisa I; Vogelgsangs, Jonathan; Vöglein, Jonathan; Waldemar, Gunhild; Wallin, Åsa K; Yannakoulia, Mary; Yi, Dahyun; Zettergren, Anna
Depressive Symptoms and Amyloid Pathology Journal Article
In: JAMA Psychiatry, 2025, ISSN: 2168-6238.
@article{pmid39841452,
title = {Depressive Symptoms and Amyloid Pathology},
author = {Wietse A Wiels and Julie E Oomens and Sebastiaan Engelborghs and Chris Baeken and Christine A F von Arnim and Mercè Boada and Mira Didic and Bruno Dubois and Tormod Fladby and Wiesje M van der Flier and Giovanni B Frisoni and Lutz Fröhlich and Kiran Dip Gill and Timo Grimmer and Helmut Hildebrandt and Jakub Hort and Yoshiaki Itoh and Takeshi Iwatsubo and Aleksandra Klimkowicz-Mrowiec and Dong Young Lee and Alberto Lleó and Pablo Martinez-Lage and Alexandre de Mendonça and Philipp T Meyer and Elisabeth N Kapaki and Piero Parchi and Matteo Pardini and Lucilla Parnetti and Julius Popp and Lorena Rami and Eric M Reiman and Juha O Rinne and Karen M Rodrigue and Pascual Sánchez-Juan and Isabel Santana and Marie Sarazin and Nikolaos Scarmeas and Ingmar Skoog and Peter J Snyder and Reisa A Sperling and Sylvia Villeneuve and Anders Wallin and Jens Wiltfang and Henrik Zetterberg and Rik Ossenkoppele and Frans R J Verhey and Stephanie J B Vos and Pieter Jelle Visser and Willemijn J Jansen and and and Daniel Alcolea and Daniele Altomare and Simone Baiardi and Ines Baldeiras and Randall J Bateman and Kaj Blennow and Michel Bottlaender and Anouk den Braber and Mark A van Buchem and Min Soo Byun and Jirí Cerman and Kewei Chen and Elena Chipi and Gregory S Day and Alexander Drzezga and Marie Eckerström and Laura L Ekblad and Stéphane Epelbaum and Stefan Förster and Juan Fortea and Yvonne Freund-Levi and Lars Frings and Eric Guedj and Lucrezia Hausner and Sabine Hellwig and Edward D Huey and Julio F Jiménez-Bonilla and Keith A Johnson and Ane Iriondo Juaristi and Ramesh Kandimalla and George Paraskevas and Silke Kern and Bjørn-Eivind S Kirsebom and Johannes Kornhuber and Julien Lagarde and Susan M Landau and Nienke Legdeur and Jorge J Llibre Guerra and Nancy N Maserejian and Marta Marquié and Shinobu Minatani and Silvia Daniela Morbelli and Barbara Mroczko and Eva Ntanasi and Catarina Resende de Oliveira and Pauline Olivieri and Adelina Orellana and Richard J Perrin and Oliver Peters and Sudesh Prabhakar and Inez H Ramakers and Eloy Rodríguez-Rodriguez and Agustín Ruiz and Eckart Rüther and Per Selnes and Dina Silva and Hilkka Soininen and Luiza Spiru and Akitoshi Takeda and Marc Teichmann and Betty M Tijms and Charlotte E Teunissen and Loisa I Thompson and Jonathan Vogelgsangs and Jonathan Vöglein and Gunhild Waldemar and Åsa K Wallin and Mary Yannakoulia and Dahyun Yi and Anna Zettergren},
doi = {10.1001/jamapsychiatry.2024.4305},
issn = {2168-6238},
year = {2025},
date = {2025-01-01},
journal = {JAMA Psychiatry},
abstract = {IMPORTANCE: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology.nnOBJECTIVE: To examine the association between depressive symptoms and amyloid pathology and its dependency on age, sex, education, and APOE genotype in older individuals without dementia.nnDESIGN, SETTING, AND PARTICIPANTS: Cross-sectional analyses were performed using data from the Amyloid Biomarker Study data pooling initiative. Data from 49 research, population-based, and memory clinic studies were pooled and harmonized. The Amyloid Biomarker Study has been collecting data since 2012 and data collection is ongoing. At the time of analysis, 95 centers were included in the Amyloid Biomarker Study. The study included 9746 individuals with normal cognition (NC) and 3023 participants with mild cognitive impairment (MCI) aged between 34 and 100 years for whom data on amyloid biomarkers, presence of depressive symptoms, and age were available. Data were analyzed from December 2022 to February 2024.nnMAIN OUTCOMES AND MEASURES: Amyloid-β1-42 levels in cerebrospinal fluid or amyloid positron emission tomography scans were used to determine presence or absence of amyloid pathology. Presence of depressive symptoms was determined on the basis of validated depression rating scale scores, evidence of a current clinical diagnosis of depression, or self-reported depressive symptoms.nnRESULTS: In individuals with NC (mean [SD] age, 68.6 [8.9] years; 5664 [58.2%] female; 3002 [34.0%] APOE ε4 carriers; 937 [9.6%] had depressive symptoms; 2648 [27.2%] had amyloid pathology), the presence of depressive symptoms was not associated with amyloid pathology (odds ratio [OR], 1.13; 95% CI, 0.90-1.40; P = .29). In individuals with MCI (mean [SD] age, 70.2 [8.7] years; 1481 [49.0%] female; 1046 [44.8%] APOE ε4 carriers; 824 [27.3%] had depressive symptoms; 1668 [55.8%] had amyloid pathology), the presence of depressive symptoms was associated with a lower likelihood of amyloid pathology (OR, 0.73; 95% CI 0.61-0.89; P = .001). When considering subgroup effects, in individuals with NC, the presence of depressive symptoms was associated with a higher frequency of amyloid pathology in APOE ε4 noncarriers (mean difference, 5.0%; 95% CI 1.0-9.0; P = .02) but not in APOE ε4 carriers. This was not the case in individuals with MCI.nnCONCLUSIONS AND RELEVANCE: Depressive symptoms were not consistently associated with a higher frequency of amyloid pathology in participants with NC and were associated with a lower likelihood of amyloid pathology in participants with MCI. These findings were not influenced by age, sex, or education level. Mechanisms other than amyloid accumulation may commonly underlie depressive symptoms in late life.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Ao, Jiarui; Picard, Cynthia; Auld, Daniel; Zetterberg, Henrik; Brinkmalm, Ann; Blennow, Kaj; Villeneuve, Sylvia; Breitner, John C S; and, Judes Poirier
Novel synaptic markers predict early tau pathology and cognitive deficit in an asymptomatic population at risk of Alzheimer's disease Journal Article
In: Mol Psychiatry, 2025, ISSN: 1476-5578.
@article{pmid39827219,
title = {Novel synaptic markers predict early tau pathology and cognitive deficit in an asymptomatic population at risk of Alzheimer's disease},
author = {Jiarui Ao and Cynthia Picard and Daniel Auld and Henrik Zetterberg and Ann Brinkmalm and Kaj Blennow and Sylvia Villeneuve and John C S Breitner and Judes Poirier and },
doi = {10.1038/s41380-024-02884-z},
issn = {1476-5578},
year = {2025},
date = {2025-01-01},
journal = {Mol Psychiatry},
abstract = {Cognitive dysfunction in Alzheimer's disease (AD) correlates closely with pathology in the neuronal microtubule-associated protein tau. Tau pathology may spread via neural synapses. In a population of cognitively unimpaired elderly at elevated risk of AD, we investigated four cerebrospinal (CSF) markers of synaptic dysfunction and degeneration. Three of these (SYT1, SNAP25, and ADAM23) are derived from pre-synaptic structures, while ADAM22 reflects post-synaptic changes. All four markers correlated strongly with tau protein measures. In statistical models, SYT1 accounted for more than half the total variance in both total- and P(181)-tau levels. Observed correlations with CSF levels of Alzheimer amyloid-β (Aβ42) were somewhat weaker. In longitudinal data, baseline levels of ADAM22 and ADAM23 robustly predicted increase over time in both total- and P-tau. CSF SYT1 levels also correlated with PET image uptake of tau and (at a trend level) Aβ in areas of interest for early AD pathology. CSF SYT1 and SNAP25 levels correlated inversely with a global psychometric score and several of its domain subscales. In quantitative trait loci analyses, all four synaptic markers were associated with at least one AD genetic risk locus. Upon "staging" participants by their evidence of amyloid and tau pathology (A/T/N framework), the CSF synaptic markers were unexpectedly reduced in participants with CSF evidence of amyloid but not tau pathology. They were clearly elevated, however, in the CSF of persons with indications of both tau and amyloid pathology. These observations provide evidence for clear pre-synaptic degeneration in cognitively unimpaired persons with biomarker evidence of early AD pathology.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Paquin, Vincent; Guay, Emilie; Moderie, Christophe; Paradis, Camille; Nahiddi, Nima; Philippe, Frederick L; Geoffroy, Marie-Claude
Psychotic-like experiences and associated factors in resident physicians: A Canadian cross-sectional study Journal Article
In: Early Interv Psychiatry, vol. 19, no. 1, pp. e13564, 2025, ISSN: 1751-7893.
@article{pmid38767000,
title = {Psychotic-like experiences and associated factors in resident physicians: A Canadian cross-sectional study},
author = {Vincent Paquin and Emilie Guay and Christophe Moderie and Camille Paradis and Nima Nahiddi and Frederick L Philippe and Marie-Claude Geoffroy},
doi = {10.1111/eip.13564},
issn = {1751-7893},
year = {2025},
date = {2025-01-01},
journal = {Early Interv Psychiatry},
volume = {19},
number = {1},
pages = {e13564},
abstract = {AIM: Medical residency training is associated with a range of sociodemographic, lifestyle and mental health factors that may confer higher risk for psychotic-like experiences (PLEs) in residents, yet little research has examined this question. Thus, we aimed to document the prevalence and associated factors of PLEs among resident physicians.nnMETHODS: Physicians enrolled in residency programmes in the Province of Québec, Canada (four universities) were recruited in Fall 2022 via their programme coordinators and social media. They completed an online questionnaire assessing PLEs in the past 3 months (the 15-item Community Assessment of Psychic Experiences), as well as sociodemographic characteristics, lifestyle and mental health. Analyses included survey weights and gamma regressions.nnRESULTS: The sample included 502 residents (mean age, 27.6 years; 65.9% women). Only 1.3% (95% CI: 0.5%, 4.0%) of residents met the screening cut-off for psychotic disorder. Factors associated with higher scores for PLEs included racialised minority status (relative difference: +7.5%; 95% CI: +2.2%, +13.2%) and English versus French as preferred language (relative difference: +7.9% 95% CI: +3.1%, +12.9%), as well as each additional point on scales of depression (relative difference: +0.8%; 95% CI: +0.3%, +1.3%) and anxiety (relative difference: +1.3%; 95% CI: +0.8%, +1.7%). In secondary analyses, racialised minority status was associated with persecutory items, but not with other PLEs. Gender, residency programmes and lifestyle variables were not associated with PLEs.nnCONCLUSIONS: This study found low reports of PLEs in a sample of resident physicians. Associations of PLEs with minoritised status may reflect experiences of discrimination.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Ruge, Olivia; Hoppe, João Paulo Maires; Molle, Roberta Dalle; Silveira, Patricia Pelufo
Early environmental influences on the orbito-frontal cortex function and its effects on behavior Journal Article
In: Neurosci Biobehav Rev, vol. 169, pp. 106013, 2025, ISSN: 1873-7528.
@article{pmid39814119,
title = {Early environmental influences on the orbito-frontal cortex function and its effects on behavior},
author = {Olivia Ruge and João Paulo Maires Hoppe and Roberta Dalle Molle and Patricia Pelufo Silveira},
doi = {10.1016/j.neubiorev.2025.106013},
issn = {1873-7528},
year = {2025},
date = {2025-01-01},
journal = {Neurosci Biobehav Rev},
volume = {169},
pages = {106013},
abstract = {Early-life adversity during pre- and early post-natal phases can impact brain development and lead to maladaptive changes in executive function related behaviors. This increases the risk for a range of psychopathologies and physical diseases. Importantly, exposure to adversities during these periods is also linked to alterations in the orbito-frontal cortex (OFC) which is a key player in these executive functions. The OFC thus appears to be a central node in this association between early life stress and disease risk. Gaining a clear, and detailed understanding of the association between early life stress, OFC function, and executive function, as well as the underlying mechanisms mediating this association is relevant to inform potential therapeutic interventions. In this paper, we begin by reviewing evidence linking early life adversities to 1) alterations in behaviors regulated by the OFC and 2) changes in OFC anatomy and function. We then present insights into the underlying mechanisms for these changes, stemming from early life adversity models, and highlight important future directions for this line of research.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Somogyi, Peter; Horie, Sawa; Lukacs, Istvan; Hunter, Emily; Sarkany, Barbara; Viney, Tim James; Livermore, James; Plaha, Puneet; Stacey, Richard; Ansorge, Olaf; Mestikawy, Salah El; Zhao, Qianru
In: Eur J Neurosci, vol. 61, no. 1, pp. e16652, 2025, ISSN: 1460-9568.
@article{pmid39810425,
title = {Synaptic Targets and Cellular Sources of CB1 Cannabinoid Receptor and Vesicular Glutamate Transporter-3 Expressing Nerve Terminals in Relation to GABAergic Neurons in the Human Cerebral Cortex},
author = {Peter Somogyi and Sawa Horie and Istvan Lukacs and Emily Hunter and Barbara Sarkany and Tim James Viney and James Livermore and Puneet Plaha and Richard Stacey and Olaf Ansorge and Salah El Mestikawy and Qianru Zhao},
doi = {10.1111/ejn.16652},
issn = {1460-9568},
year = {2025},
date = {2025-01-01},
journal = {Eur J Neurosci},
volume = {61},
number = {1},
pages = {e16652},
abstract = {Cannabinoid receptor 1 (CB1) regulates synaptic transmission through presynaptic receptors in nerve terminals, and its physiological roles are of clinical relevance. The cellular sources and synaptic targets of CB1-expressing terminals in the human cerebral cortex are undefined. We demonstrate a variable laminar pattern of CB1-immunoreactive axons and electron microscopically show that CB1-positive GABAergic terminals make type-2 synapses innervating dendritic shafts (69%), dendritic spines (20%) and somata (11%) in neocortical layers 2-3. Of the CB1-immunopositive GABAergic terminals, 25% were vesicular-glutamate-transporter-3 (VGLUT3)-immunoreactive, suggesting GABAergic/glutamatergic co-transmission on dendritic shafts. In vitro recorded and labelled VGLUT3 or CB1-positive GABAergic interneurons expressed cholecystokinin, vasoactive-intestinal-polypeptide and calretinin, had diverse firing, axons and dendrites, and included rosehip, neurogliaform and basket cells, but not double bouquet or axo-axonic cells. CB1-positive interneurons innervated pyramidal cells and GABAergic interneurons. Glutamatergic synaptic terminals formed type-1 synapses and some were positive for CB1 receptor with a distribution that appeared different from that in GABAergic terminals. From the sampled VGLUT3-positive terminals, 60% formed type-1 synapses with dendritic spines (80%) or shafts (20%) and 52% were also positive for VGLUT1, suggesting intracortical origin. Some VGLUT3-positive terminals were immunopositive for vesicular-monoamine-transporter-2, suggesting 5-HT/glutamate co-transmission. Overall, the results show that CB1 regulates GABA release mainly to dendritic shafts of both pyramidal cells and interneurons and predict CB1-regulated co-release of GABA and glutamate from single cortical interneurons. We also demonstrate the co-existence of multiple vesicular glutamate transporters in a select population of terminals probably originating from cortical neurons and innervating dendritic spines in the human cerebral cortex.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Merrill, Sarah M; Konwar, Chaini; Fatima, Fizza; Dever, Kristy; MacIsaac, Julia L; Letourneau, Nicole; Giesbrecht, Gerald F; Dewey, Deborah; England-Mason, Gillian; Lewis, Candace R; Wang, Dennis; Teh, Ai Ling; Meaney, Michael J; Gonzalez, Andrea; Noll, Jennie G; Weerth, Carolina De; Bush, Nicole R; O'Donnell, Kieran J; Stewart, S Evelyn; Kobor, Michael S
Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research Journal Article
In: Nat Commun, vol. 16, no. 1, pp. 609, 2025, ISSN: 2041-1723.
@article{pmid39800776,
title = {Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research},
author = {Sarah M Merrill and Chaini Konwar and Fizza Fatima and Kristy Dever and Julia L MacIsaac and Nicole Letourneau and Gerald F Giesbrecht and Deborah Dewey and Gillian England-Mason and Candace R Lewis and Dennis Wang and Ai Ling Teh and Michael J Meaney and Andrea Gonzalez and Jennie G Noll and Carolina De Weerth and Nicole R Bush and Kieran J O'Donnell and S Evelyn Stewart and Michael S Kobor},
doi = {10.1038/s41467-025-55909-8},
issn = {2041-1723},
year = {2025},
date = {2025-01-01},
journal = {Nat Commun},
volume = {16},
number = {1},
pages = {609},
abstract = {Cheek swabs, heterogeneous samples consisting primarily of buccal epithelial cells, are widely used in pediatric DNA methylation studies and biomarker creation. However, the decrease in buccal proportion with age in adults remains unexamined in childhood. We analyzed cheek swabs from 4626 typically developing children 2-months to 20-years-old. Estimated buccal proportion declined throughout childhood with both increasing chronological and predicted epigenetic age. However, buccal proportion did not associate with age throughout adolescence. Variability in buccal proportion increased with age through the entire developmental range. These trends held inversely true for neutrophil proportions. Correcting for buccal proportion attenuated the weak association with PedBE age acceleration to non-significance during initial estimation. Notably, correcting for buccal proportion attenuated the association of PedBE age acceleration with obsessive-compulsive disorder and strengthened the association with diurnal cortisol slope. Thus, the age-related change in children's oral cells is a crucial consideration for cell type-sensitive research.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Fleury, Marie-Josée; Rochette, Louis; Cao, Zhirong; Grenier, Guy; Massamba, Victoria; Lesage, Alain
Profiles of physician follow-up care, correlates and outcomes among patients affected by an incident mental disorder Journal Article
In: BMC Prim Care, vol. 26, no. 1, pp. 7, 2025, ISSN: 2731-4553.
@article{pmid39799284,
title = {Profiles of physician follow-up care, correlates and outcomes among patients affected by an incident mental disorder},
author = {Marie-Josée Fleury and Louis Rochette and Zhirong Cao and Guy Grenier and Victoria Massamba and Alain Lesage},
doi = {10.1186/s12875-024-02674-0},
issn = {2731-4553},
year = {2025},
date = {2025-01-01},
journal = {BMC Prim Care},
volume = {26},
number = {1},
pages = {7},
abstract = {OBJECTIVES: This study identified profiles of outpatient physician follow-up care and other practice features, mostly after detection of incident mental disorders (MD), and associated these profiles with patient characteristics and subsequent adverse outcomes.nnMETHODS: A cohort of 170,957 patients age 12 + with a new or recurrent MD detected in 2019-20 was investigated based on data from the Quebec Integrated Chronic Disease Surveillance System. Latent class analysis was performed to identify follow-up care profiles, mostly within one year of MD detection. Bivariate analyses tested associations between profiles and patient characteristics; logistic regressions examined relationships between profiles and adverse outcomes after one year.nnRESULTS: Five profiles were identified: Profiles 2 and 5 (64%) offered low mental health (MH) outpatient follow-up care, while the others dispensed higher MH follow-up care. Profiles differed in patient characteristics and related outcomes. Labelled "Follow-up care by usual psychiatrist", Profile 1 (1% of sample) included younger patients with the most health and social issues. Profile 2 (50%), "Low MH follow-up care but high prior consultations for physical reasons", mostly integrated older patients with chronic physical illnesses. Profile 3 (11%), "Follow-up care by general practitioners (GP) and psychiatrists", referred to physicians other than the usual ones (e.g., walk-in practice) and encompassed patients with severe MD conditions. Profile 4 (23%), "High follow-up care by usual GP and prior consultations for physical reasons", showed the typical characteristics of patients treated in primary care (more common MD, women, less materially and socially deprived). Profile 5 (15%), "Low MH follow-up care and prior consultations for physical reasons", integrated more younger men, materially deprived patients, and with substance-related disorders (SRD) or co-occurring MD-SRD. More Profile 1 and 3 patients lived in university regions - those of Profile 4 were the least numerous in such regions. More Profile 5 patients lived in metropolitan and rural areas. Risk of death was higher in Profiles 5, 2, 3, and risk of frequent ED use and hospitalization higher in Profiles 1, 3, and 5 - patients with severe health and social issues.nnCONCLUSION: The study confirmed the need to improve prompt, adequate and continuous follow-up care for patients with incident MD.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Alasmar, Zaki; Chakravarty, M Mallar; Penhune, Virginia B; Steele, Christopher J
Patterns of Cerebellar-Cortical Structural Covariance Mirror Anatomical Connectivity of Sensorimotor and Cognitive Networks Journal Article
In: Hum Brain Mapp, vol. 46, no. 1, pp. e70079, 2025, ISSN: 1097-0193.
@article{pmid39791308,
title = {Patterns of Cerebellar-Cortical Structural Covariance Mirror Anatomical Connectivity of Sensorimotor and Cognitive Networks},
author = {Zaki Alasmar and M Mallar Chakravarty and Virginia B Penhune and Christopher J Steele},
doi = {10.1002/hbm.70079},
issn = {1097-0193},
year = {2025},
date = {2025-01-01},
journal = {Hum Brain Mapp},
volume = {46},
number = {1},
pages = {e70079},
abstract = {The cortex and cerebellum are densely connected through reciprocal input/output projections that form segregated circuits. These circuits are shown to differentially connect anterior lobules of the cerebellum to sensorimotor regions, and lobules Crus I and II to prefrontal regions. This differential connectivity pattern leads to the hypothesis that individual differences in structure should be related, especially for connected regions. To test this hypothesis, we examined covariation between the volumes of anterior sensorimotor and lateral cognitive lobules of the cerebellum and measures of cortical thickness (CT) and surface area (SA) across the whole brain in a sample of 270 young adults drawn from the HCP dataset. We observed that patterns of cerebellar-cortical covariance differed between sensorimotor and cognitive networks. Anterior motor lobules of the cerebellum showed greater covariance with sensorimotor regions of the cortex, while lobules Crus I and Crus II showed greater covariance with frontal and temporal regions. Interestingly, cerebellar volume showed predominantly negative relationships with CT and predominantly positive relationships with SA. Individual differences in SA are thought to be largely under genetic control while CT is thought to be more malleable by experience. This suggests that cerebellar-cortical covariation for SA may be a more stable feature, whereas covariation for CT may be more affected by development. Additionally, similarity metrics revealed that the pattern of covariance showed a gradual transition between sensorimotor and cognitive lobules, consistent with evidence of functional gradients within the cerebellum. Taken together, these findings are consistent with known patterns of structural and functional connectivity between the cerebellum and cortex. They also shed new light on possibly differing relationships between cerebellar volume and cortical thickness and surface area. Finally, our findings are consistent with the interactive specialization framework which proposes that structurally and functionally connected brain regions develop in concert.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
van der Ven, Els; Yang, Xinyu; Mascayano, Franco; Weinreich, Karl J; Chen, Eric Yh; Tang, Charmaine Yz; Kim, Sung-Wan; Burns, Jonathan K; Chiliza, Bonginkosi; Mohan, Greeshma; Iyer, Srividya N; Rangawsamy, Thara; de Vries, Ralph; Susser, Ezra S
Early intervention in psychosis programs in Africa, Asia and Latin America; challenges and recommendations Journal Article
In: Glob Ment Health (Camb), vol. 12, pp. e3, 2025, ISSN: 2054-4251.
@article{pmid39781337,
title = {Early intervention in psychosis programs in Africa, Asia and Latin America; challenges and recommendations},
author = {Els van der Ven and Xinyu Yang and Franco Mascayano and Karl J Weinreich and Eric Yh Chen and Charmaine Yz Tang and Sung-Wan Kim and Jonathan K Burns and Bonginkosi Chiliza and Greeshma Mohan and Srividya N Iyer and Thara Rangawsamy and Ralph de Vries and Ezra S Susser},
doi = {10.1017/gmh.2024.78},
issn = {2054-4251},
year = {2025},
date = {2025-01-01},
journal = {Glob Ment Health (Camb)},
volume = {12},
pages = {e3},
abstract = {BACKGROUND: While early intervention in psychosis (EIP) programs have been increasingly implemented across the globe, many initiatives from Africa, Asia and Latin America are not widely known. The aims of the current review are (a) to describe population-based and small-scale, single-site EIP programs in Africa, Asia and Latin America, (b) to examine the variability between programs located in low-and-middle income (LMIC) and high-income countries in similar regions and (c) to outline some of the challenges and provide recommendations to overcome existing obstacles.nnMETHODS: EIP programs in Africa, Asia and Latin America were identified through experts from the different target regions. We performed a systematic search in Medline, Embase, APA PsycInfo, Web of Science and Scopus up to February 6, 2024.nnRESULTS: Most EIP programs in these continents are small-scale, single-site programs that serve a limited section of the population. Population-based programs with widespread coverage and programs integrated into primary health care are rare. In Africa, EIP programs are virtually absent. Mainland China is one of the only LMICs that has begun to take steps toward developing a population-based EIP program. High-income Asian countries (e.g. Hong Kong and Singapore) have well-developed, comprehensive programs for individuals with early psychosis, while others with similar economies (e.g. South Korea and Japan) do not. In Latin America, Chile is the only country in the process of providing population-based EIP care.nnCONCLUSIONS: Financial resources and integration in mental health care, as well as the availability of epidemiological data on psychosis, impact the implementation of EIP programs. Given the major treatment gap of early psychosis in Africa, Latin America and large parts of Asia, publicly funded, locally-led and accessible community-based EIP care provision is urgently needed.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Powell, Daniel; Asad, Laiba; Zavaglia, Elissa; Ferrari, Manuela
Promoting Digital Health Data Literacy: The Datum Project Journal Article
In: JMIR Form Res, vol. 9, pp. e60832, 2025, ISSN: 2561-326X.
@article{pmid39773678,
title = {Promoting Digital Health Data Literacy: The Datum Project},
author = {Daniel Powell and Laiba Asad and Elissa Zavaglia and Manuela Ferrari},
doi = {10.2196/60832},
issn = {2561-326X},
year = {2025},
date = {2025-01-01},
journal = {JMIR Form Res},
volume = {9},
pages = {e60832},
abstract = {With the increased use of digital health innovations in Canadian health care, educating health care users, professionals, and researchers on the ethical challenges and privacy implications of these tools is essential. The Datum project, funded by the Fondation Barreau du Quebec, was created to help these actors better understand legal and ethical issues regarding the collection, use, and disclosure of digital health data for the purposes of scientific research, thereby enhancing literacy around data privacy. The project consists of a multimedia website divided into legislation and policy documents and narrative-based video content. Users can access the core legislation and policies governing the collection and use of health care data geared toward researchers and health practitioners. Users can also view the narrative-based video content explaining key concepts related to digital health data. The Datum project makes an original contribution to the field of law and ethics in health science research by using novel approaches, such as learning health systems and data banks, to improve equity in health care delivery and by generating multimedia content aimed at encouraging health care users to become better consumers and supporting the collective use of their data. The Datum project also promotes digital literacy as a digital communication tool, which has the significant potential to improve health outcomes, bridge the digital divide, and reduce health inequities.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Brzezinski-Rittner, Aliza; Moqadam, Roqaie; Iturria-Medina, Yasser; Chakravarty, M Mallar; Dadar, Mahsa; Zeighami, Yashar
Disentangling the effect of sex from brain size on brain organization and cognitive functioning Journal Article
In: Geroscience, 2025, ISSN: 2509-2723.
@article{pmid39757311,
title = {Disentangling the effect of sex from brain size on brain organization and cognitive functioning},
author = {Aliza Brzezinski-Rittner and Roqaie Moqadam and Yasser Iturria-Medina and M Mallar Chakravarty and Mahsa Dadar and Yashar Zeighami},
doi = {10.1007/s11357-024-01486-5},
issn = {2509-2723},
year = {2025},
date = {2025-01-01},
journal = {Geroscience},
abstract = {Neuroanatomical sex differences estimated in neuroimaging studies are confounded by total intracranial volume (TIV) as a major biological factor. Employing a matching approach widely used for causal modeling, we disentangled the effect of TIV from sex to study sex-differentiated brain aging trajectories, their relation to functional networks and cytoarchitectonic classes, brain allometry, and cognition. Using data from the UK Biobank, we created subsamples that removed, maintained, or exaggerated the TIV differences in the original sample. We compared regional and vertex-level sex estimates across subsamples. The overall sex-related differences diminished in head size-matched subsamples, suggesting that most of the observed variability results from TIV differences. Furthermore, bidirectional sex differences in brain neuroanatomy emerged that were previously masked by the effect of TIV. Allometry remained fairly consistent across lifespan and was not sex-differentiated. Finally, the matching process changed the direction of the estimated sex differences in "verbal and numerical reasoning" and "working memory", suggesting that behavioral sex difference investigations can benefit from additional biological analysis to uncover the underlying factors contributing to cognition. Taken together, we provide new evidence disentangling sex differences from TIV as a relevant biological confound.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Stein, Gregor; Aly, Janine S; Manzolillo, Annamaria; Lange, Lisa; Riege, Konstantin; Hussain, Iqra; Heller, Elisabeth A; Cubillos, Susana; Ernst, Thomas; Hübner, Christian A; Turecki, Gustavo; Hoffmann, Steve; Engmann, Olivia
Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience Journal Article
In: Biol Psychiatry, vol. 97, no. 1, pp. 54–63, 2025, ISSN: 1873-2402.
@article{pmid39029777,
title = {Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience},
author = {Gregor Stein and Janine S Aly and Annamaria Manzolillo and Lisa Lange and Konstantin Riege and Iqra Hussain and Elisabeth A Heller and Susana Cubillos and Thomas Ernst and Christian A Hübner and Gustavo Turecki and Steve Hoffmann and Olivia Engmann},
doi = {10.1016/j.biopsych.2024.07.009},
issn = {1873-2402},
year = {2025},
date = {2025-01-01},
journal = {Biol Psychiatry},
volume = {97},
number = {1},
pages = {54--63},
abstract = {BACKGROUND: Chronic stress significantly contributes to mood and anxiety disorders. Previous data suggest a correlative connection between vitamin B12 supplementation, depression, and stress resilience. However, the underlying mechanisms are still poorly understood.nnMETHODS: Using the chronic variable stress mouse model coupled with RNA sequencing, we identified vitamin B12-induced transcriptional changes related to stress resilience. Using viral-mediated gene transfer and in vivo epigenome editing, we revealed a functional pathway linking vitamin B12, DNA methylation (DNAme), and depression-like symptoms.nnRESULTS: We identified Ttr (transthyretin) as a key sex-specific target of vitamin B12 in chronic stress. Accordingly, TTR expression was increased postmortem in the prefrontal cortex of male but not female patients with depression. Virally altered Ttr in the prefrontal cortex functionally contributed to stress- and depression-related behaviors, changes in dendritic spine morphology, and gene expression. In stressed mice, vitamin B12 reduced DNAme in the Ttr promoter region. Importantly, using in vivo epigenome editing to alter DNAme in the brains of living mice for the first time, we established a direct causal link between DNAme and Ttr and stress-associated behaviors.nnCONCLUSIONS: Using state-of-the-art techniques, this study uncovered a mechanistic link between vitamin B12 supplementation, Ttr, and markers of chronic stress and depression, encouraging further studies into dietary interventions for mood disorders.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Fleury, Marie-Josée; Cao, Zhirong; Grenier, Guy; Huỳnh, Christophe; Meng, Xianghei
Classes of outpatient quality of care among individuals with substance-related disorders, based on a survey and health insurance registry Journal Article
In: J Subst Use Addict Treat, vol. 170, pp. 209619, 2025, ISSN: 2949-8759.
@article{pmid39755156,
title = {Classes of outpatient quality of care among individuals with substance-related disorders, based on a survey and health insurance registry},
author = {Marie-Josée Fleury and Zhirong Cao and Guy Grenier and Christophe Huỳnh and Xianghei Meng},
doi = {10.1016/j.josat.2024.209619},
issn = {2949-8759},
year = {2025},
date = {2025-01-01},
journal = {J Subst Use Addict Treat},
volume = {170},
pages = {209619},
abstract = {OBJECTIVES: Improving quality of care for individuals with substance-related disorders (SRD) should be a priority considering SRD are associated with high morbidity. This study aimed to identify classes of individuals with SRD based on their clinical characteristics and the quality of outpatient care they received, and to verify whether better quality of care was associated with other respondent characteristics and more favorable subsequent outcomes.nnMETHODS: Data came from the 2013-14 and 2015-16 Canadian Community Health Survey (N = 42,099), merged with administrative data from Quebec's health insurance registry. Investigating a cohort of 1473 individuals with SRD, we conducted Latent class analysis based on the respondents' diagnoses and outpatient quality of care indicators such as access, diversity, continuity and regularity of care received in the 12 months preceding interview. Chi-Square, Fisher's exact tests or t-tests, and logistic regression associate classes with sociodemographic and health behavior (e.g., suicidal behaviors) correlates, and outcomes (repeated emergency department use, hospitalization, quality of life) over the three months following interview, respectively.nnRESULTS: The study identified four classes: (1) Individuals with polysubstance-related disorders and other health disorders, receiving high diversity and moderate regularity of care (6 % of sample); (2) Individuals with alcohol-related disorders, receiving low quality of care (41 %); (3) Individuals with drug-related disorders, receiving high overall quality of care (9 %); and (4) Individuals with alcohol-related disorders, receiving high continuity of family doctor care (44 %). Classes 2 and 4 showed better social conditions (e.g., higher education), health behaviors, and subsequent outcomes than Classes 1 and 3, despite receiving lower quality of care - especially mental healthcare.nnCONCLUSION: Study outcomes related more to health and social conditions than to the quality of outpatient care received, especially as outpatient care alone might not meet needs of Classes 1 and 3 individuals having important health and social issues, unmet care needs and worse outcomes. Results suggest that interventions like assertive community treatment or intensive case management with integrated SRD-mental health disorders treatment could better respond to the needs of Classes 1 and 3. Overall, enhanced care, including peer support, might benefit all individuals with SRD.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Careau, Juliette; Larmuseau, Maarten H D; Drumsta, Rebekah; Whitley, Rob
In: BMC Psychiatry, vol. 25, no. 1, pp. 9, 2025, ISSN: 1471-244X.
@article{pmid39757164,
title = {"I'm trying to figure out who the hell I am": Examining the psychosocial and mental health experience of individuals learning "Not Parent Expected" news from a direct-to-consumer DNA ancestry test},
author = {Juliette Careau and Maarten H D Larmuseau and Rebekah Drumsta and Rob Whitley},
doi = {10.1186/s12888-024-06380-0},
issn = {1471-244X},
year = {2025},
date = {2025-01-01},
journal = {BMC Psychiatry},
volume = {25},
number = {1},
pages = {9},
abstract = {BACKGROUND: According to recent estimates, around 30 million people have taken Direct-to-Consumer DNA ancestry tests, typically marketed as a fun, harmless and exciting process of discovery. These tests estimate a user's ethnic ancestry, also matching users with biological relations on their database. This matching can produce a surprising 'not parent expected' discovery, where a user learns that an assumed parent (typically the father) is not a biological parent. Such news may negatively affect mental health, self-identity and familial relationships, while prompting the utilization of putatively helpful resources by affected individuals. However, there is a lack of research on this topic. Thus, this study aimed to document the psychosocial experience of adults who have learnt that an assumed parent is not a biological parent via a Direct-to-Consumer DNA ancestry test. Specific objectives include investigating and understanding impact on mental health, familial relationships and subsequent resources mobilized.nnMETHODS: To meet these objectives, we conducted an inductive qualitative study, allowing for the documentation of common experiences and perspectives. This involved 52 semi-structured interviews with affected individuals, analyzed using thematic analysis.nnRESULTS: This resulted in five overlapping themes, namely (i) participants typically described their experience as an extraordinary shock that had a negative impact on their mental health, with some exceptions; (ii) the experience typically led to a severe and troubling disruption of their self-identity, with some exceptions; (iii) the news often ruptured extant familial relationships, especially with the mother, and any experiences with the new biological family were mixed; (iv) participants sought support from a variety of resources including spouses, siblings, and online peer support groups, which were generally considered helpful, with some exceptions; and (v) many participants consulted mental health professionals, who were sometimes considered supportive, but some participants noted that they were ill-equipped to help. Common across these themes were issues of grief, loss and trauma.nnCONCLUSIONS: This study reveals an expanding, vulnerable, and under-researched population facing unique stressors, that may be at high risk of developing a psychiatric disorder. There is a need for new services and supports for this population including tailored clinical interventions and specific self-care resources.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
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