Publications

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Journal Article
Tanti A, Lutz P-E, Kim J, O'Leary L, Théroux J-F, Turecki G, Mechawar N.  2019.  Evidence of decreased gap junction coupling between astrocytes and oligodendrocytes in the anterior cingulate cortex of depressed suicides.. Neuropsychopharmacology. 44(12):2099-2111.
Huh CYL, Amilhon B, Ferguson KA, Manseau F, Torres-Platas SG, Peach JP, Scodras S, Mechawar N, Skinner FK, Williams S.  2016.  Excitatory Inputs Determine Phase-Locking Strength and Spike-Timing of CA1 Stratum Oriens/Alveus Parvalbumin and Somatostatin Interneurons during Intrinsically Generated Hippocampal Theta Rhythm.. J Neurosci. 36(25):6605-22.
Maitra M, Nagy C, Chawla A, Wang YChang, Nascimento C, Suderman M, Théroux J-F, Mechawar N, Ragoussis J, Turecki G.  2021.  Extraction of nuclei from archived postmortem tissues for single-nucleus sequencing applications.. Nat Protoc. 16(6):2788-2801.
Perlman K, Chouinard-Watkins R, Tanti A, Cisbani G, Orri M, Turecki G, Bazinet RP, Mechawar N.  2021.  Fatty acid dysregulation in the anterior cingulate cortex of depressed suicides with a history of child abuse.. Transl Psychiatry. 11(1):535.
Rocco BR, Oh H, Shukla R, Mechawar N, Sibille E.  2017.  Fluorescence-based cell-specific detection for laser-capture microdissection in human brain.. Sci Rep. 7(1):14213.
Maussion G, Yang J, Suderman M, Diallo A, Nagy C, Arnovitz M, Mechawar N, Turecki G.  2014.  Functional DNA methylation in a transcript specific 3'UTR region of TrkB associates with suicide.. Epigenetics. 9(8):1061-70.
Torres-Platas SG, Nagy C, Wakid M, Turecki G, Mechawar N.  2016.  Glial fibrillary acidic protein is differentially expressed across cortical and subcortical regions in healthy brains and downregulated in the thalamus and caudate nucleus of depressed suicides.. Mol Psychiatry. 21(4):509-15.
Gross JA, Nagy C, Lin L, Bonneil É, Maheu M, Thibault P, Mechawar N, Jin P, Turecki G.  2016.  Global and Site-Specific Changes in 5-Methylcytosine and 5-Hydroxymethylcytosine after Extended Post-mortem Interval.. Front Genet. 7:120.
Belzeaux R, Gorgievski V, Fiori LM, Lopez JPablo, Grenier J, Lin R, Nagy C, Ibrahim EChérif, Gascon E, Courtet P et al..  2020.  GPR56/ADGRG1 is associated with response to antidepressant treatment.. Nat Commun. 11(1):1635.
Bouvier DS, Jones EV, Quesseveur G, Davoli MAntonietta, Ferreira TA, Quirion R, Mechawar N, Murai KK.  2016.  High Resolution Dissection of Reactive Glial Nets in Alzheimer's Disease.. Sci Rep. 6:24544.
Kaul D, Schwab SG, Mechawar N, Matosin N.  2021.  How stress physically re-shapes the brain: Impact on brain cell shapes, numbers and connections in psychiatric disorders.. Neurosci Biobehav Rev. 124:193-215.
O'Leary LAnuj, Mechawar N.  2021.  Implication of cerebral astrocytes in major depression: A review of fine neuroanatomical evidence in humans.. Glia. 69(9):2077-2099.
Maheu ME, Devorak J, Freibauer A, Davoli MAntonietta, Turecki G, Mechawar N.  2015.  Increased doublecortin (DCX) expression and incidence of DCX-immunoreactive multipolar cells in the subventricular zone-olfactory bulb system of suicides.. Front Neuroanat. 9:74.
Bell S, McCarty V, Peng H, Jefri M, Hettige N, Antonyan L, Crapper L, O'Leary LA, Zhang X, Zhang Y et al..  2021.  Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells.. Stem Cell Reports. 16(7):1749-1762.
Chen GG, Gross JA, Lutz P-E, Vaillancourt K, Maussion G, Bramoulle A, Théroux J-F, Gardini ES, Ehlert U, Bourret G et al..  2017.  Medium throughput bisulfite sequencing for accurate detection of 5-methylcytosine and 5-hydroxymethylcytosine.. BMC Genomics. 18(1):96.
Vaillancourt K, Chen GG, Fiori L, Maussion G, Yerko V, Théroux J-F, Ernst C, Labonte B, Calipari E, Nestler EJ et al..  2021.  Methylation of the tyrosine hydroxylase gene is dysregulated by cocaine dependence in the human striatum.. iScience. 24(10):103169.
Pidsley R, Viana J, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk LC, Bray NJ et al..  2014.  Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.. Genome Biol. 15(10):483.
Salamanca L, Mechawar N, Murai KK, Balling R, Bouvier DS, Skupin A.  2019.  MIC-MAC: An automated pipeline for high-throughput characterization and classification of three-dimensional microglia morphologies in mouse and human postmortem brain samples.. Glia. 67(8):1496-1509.
Maheu M, Lopez JP, Crapper L, Davoli MA, Turecki G, Mechawar N.  2015.  MicroRNA regulation of central glial cell line-derived neurotrophic factor (GDNF) signalling in depression.. Transl Psychiatry. 5:e511.
Lopez JPablo, Fiori LM, Cruceanu C, Lin R, Labonte B, Cates HM, Heller EA, Vialou V, Ku SM, Gerald C et al..  2017.  MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes.. Nat Commun. 8:15497.
Lopez JPablo, Lim R, Cruceanu C, Crapper L, Fasano C, Labonte B, Maussion G, Yang JP, Yerko V, Vigneault E et al..  2014.  miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment.. Nat Med. 20(7):764-8.
Fiori LM, Kos A, Lin R, Théroux J-F, Lopez JPablo, Kühne C, Eggert C, Holzapfel M, Huettl R-E, Mechawar N et al..  2020.  miR-323a regulates ERBB4 and is involved in depression.. Mol Psychiatry.
Poirel O, Mella S, Videau C, Ramet L, Davoli MAntonietta, Herzog E, Katsel P, Mechawar N, Haroutunian V, Epelbaum J et al..  2018.  Moderate decline in select synaptic markers in the prefrontal cortex (BA9) of patients with Alzheimer's disease at various cognitive stages.. Sci Rep. 8(1):938.
Torres-Platas SG, Comeau S, Rachalski A, Dal Bo G, Cruceanu C, Turecki G, Giros B, Mechawar N.  2014.  Morphometric characterization of microglial phenotypes in human cerebral cortex.. J Neuroinflammation. 11:12.
Bell S, Rousseau J, Peng H, Aouabed Z, Priam P, Théroux J-F, Jefri M, Tanti A, Wu H, Kolobova I et al..  2019.  Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons.. Am J Hum Genet. 104(5):815-834.

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