Publications

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2021
Bell S, McCarty V, Peng H, Jefri M, Hettige N, Antonyan L, Crapper L, O'Leary LA, Zhang X, Zhang Y et al..  2021.  Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells.. Stem Cell Reports. 16(7):1749-1762.
Vaillancourt K, Chen GG, Fiori L, Maussion G, Yerko V, Théroux J-F, Ernst C, Labonte B, Calipari E, Nestler EJ et al..  2021.  Methylation of the tyrosine hydroxylase gene is dysregulated by cocaine dependence in the human striatum.. iScience. 24(10):103169.
Lutz P-E, Chay M-A, Pacis A, Chen GG, Aouabed Z, Maffioletti E, Théroux J-F, Grenier J-C, Yang J, Aguirre M et al..  2021.  Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation.. Nat Commun. 12(1):1132.
2020
Vaillancourt K, Yang J, Chen GG, Yerko V, Théroux J-F, Aouabed Z, Lopez A, Thibeault KC, Calipari ES, Labonte B et al..  2020.  Cocaine-related DNA methylation in caudate neurons alters 3D chromatin structure of the IRXA gene cluster.. Mol Psychiatry.
Ernst C.  2020.  A roadmap for neurodevelopmental disease modeling for non-stem cell biologists.. Stem Cells Transl Med. 9(5):567-574.
Jefri M, Bell S, Peng H, Hettige N, Maussion G, Soubannier V, Wu H, Silveira H, Théroux J-F, Moquin L et al..  2020.  Stimulation of L-type calcium channels increases tyrosine hydroxylase and dopamine in ventral midbrain cells induced from somatic cells.. Stem Cells Transl Med. 9(6):697-712.
2019
Hettige NC, Ernst C.  2019.   Dose in Brain Development.. Front Pediatr. 7:482.
Bell S, Rousseau J, Peng H, Aouabed Z, Priam P, Théroux J-F, Jefri M, Tanti A, Wu H, Kolobova I et al..  2019.  Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons. The American Journal of Human Genetics.
Bell S, Rousseau J, Peng H, Aouabed Z, Priam P, Théroux J-F, Jefri M, Tanti A, Wu H, Kolobova I et al..  2019.  Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons.. Am J Hum Genet. 104(5):815-834.
2018
Bell S, Maussion G, Jefri M, Peng H, Théroux J-F, Silveira H, Soubannier V, Wu H, Hu P, Galat E et al..  2018.  Disruption of GRIN2B Impairs Differentiation in Human Neurons.. Stem Cell Reports. 11(1):183-196.
2017
Lutz P-E, Tanti A, Gasecka A, Barnett-Burns S, Kim JJ, Zhou Y, Chen GG, Wakid M, Shaw M, Almeida D et al..  2017.  Association of a History of Child Abuse With Impaired Myelination in the Anterior Cingulate Cortex: Convergent Epigenetic, Transcriptional, and Morphological Evidence.. Am J Psychiatry. :appiajp201716111286.
Maussion G, Cruceanu C, Rosenfeld JA, Bell SC, Jollant F, Szatkiewicz J, Collins RL, Hanscom C, Kolobova I, de Champfleur NMenjot et al..  2017.  Cover Image, Volume 173A, Number 2, February 2017.. Am J Med Genet A. 173(2):i.
Vaillancourt K, Ernst C, Mash D, Turecki G.  2017.  DNA Methylation Dynamics and Cocaine in the Brain: Progress and Prospects.. Genes (Basel). 8(5)
Maussion G, Cruceanu C, Rosenfeld JA, Bell SC, Jollant F, Szatkiewicz J, Collins RL, Hanscom C, Kolobova I, de Champfleur NMenjot et al..  2017.  Implication of LRRC4C and DPP6 in neurodevelopmental disorders.. Am J Med Genet A. 173(2):395-406.
Chen GG, Gross JA, Lutz P-E, Vaillancourt K, Maussion G, Bramoulle A, Théroux J-F, Gardini ES, Ehlert U, Bourret G et al..  2017.  Medium throughput bisulfite sequencing for accurate detection of 5-methylcytosine and 5-hydroxymethylcytosine.. BMC Genomics. 18(1):96.
Jacobsen JC, Erdin S, Chiang C, Hanscom C, Handley RR, Barker DD, Stortchevoi A, Blumenthal I, Reid SJ, Snell RG et al..  2017.  Potential molecular consequences of transgene integration: The R6/2 mouse example.. Sci Rep. 7:41120.
Bell S, Peng H, Crapper L, Kolobova I, Maussion G, Vasuta C, Yerko V, Wong TPan, Ernst C.  2017.  A Rapid Pipeline to Model Rare Neurodevelopmental Disorders with Simultaneous CRISPR/Cas9 Gene Editing.. Stem Cells Transl Med. 6(3):886-896.
Hettige NC, Manzano-Vargas K, Jefri M, Ernst C.  2017.  Strategies to advance drug discovery in rare monogenic intellectual disability syndromes.. Int J Neuropsychopharmacol.
2016
Merner N, d'Arc BForgeot, Bell SC, Maussion G, Peng H, Gauthier J, Crapper L, Hamdan FF, Michaud JL, Mottron L et al..  2016.  A de novo frameshift mutation in chromodomain helicase DNA-binding domain 8 (CHD8): A case report and literature review.. Am J Med Genet A. 170A(5):1225-35.
Bell S, Kolobova I, Crapper L, Ernst C.  2016.  Lesch-Nyhan Syndrome: Models, Theories, and Therapies.. Mol Syndromol. 7(6):302-311.
W Farmer T, Abrahamsson T, Chierzi S, Lui C, Zaelzer C, Jones EV, Bally BPonroy, Chen GG, Théroux J-F, Peng J et al..  2016.  Neurons diversify astrocytes in the adult brain through sonic hedgehog signaling.. Science. 351(6275):849-54.
Ernst C.  2016.  Proliferation and Differentiation Deficits are a Major Convergence Point for Neurodevelopmental Disorders.. Trends Neurosci. 39(5):290-9.
2015
Nagy C, Suderman M, Yang J, Szyf M, Mechawar N, Ernst C, Turecki G.  2015.  Astrocytic abnormalities and global DNA methylation patterns in depression and suicide.. Mol Psychiatry. 20(3):320-8.
Lopez JPablo, Diallo A, Cruceanu C, Fiori LM, Laboissiere S, Guillet I, Fontaine J, Ragoussis J, Benes V, Turecki G et al..  2015.  Biomarker discovery: quantification of microRNAs and other small non-coding RNAs using next generation sequencing.. BMC Med Genomics. 8:35.
Gross JA, Pacis A, Chen GG, Barreiro LB, Ernst C, Turecki G.  2015.  Characterizing 5-hydroxymethylcytosine in human prefrontal cortex at single base resolution.. BMC Genomics. 16:672.

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