Publications
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18F-MK-6240 PET for early and late detection of neurofibrillary tangles.. Brain. 143(9):2818-2830.
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2021. Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease.. Eur J Nucl Med Mol Imaging. 45(6):1021-1030.
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2018. Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer's disease.. Mol Psychiatry.
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2020. Brain perfusion during rapid-eye-movement sleep successfully identifies amnestic mild cognitive impairment.. Sleep Med. 34:134-140.
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2017. Canadian Consensus Guidelines on Use of Amyloid Imaging in Canada: Update and Future Directions from the Specialized Task Force on Amyloid imaging in Canada.. Can J Neurol Sci. 43(4):503-12.
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2016. Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [(11)C]ABP688 PET.. Eur J Nucl Med Mol Imaging. 43(1):152-62.
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2016. Co-registration of Imaging Modalities (MRI, CT and PET) to Perform Frameless Stereotaxic Robotic Injections in the Common Marmoset.. Neuroscience. 480:143-154.
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2022. Deficit in sustained attention following selective cholinergic lesion of the pedunculopontine tegmental nucleus in rat, as measured with both post-mortem immunocytochemistry and in vivo PET imaging with [¹⁸F]fluoroethoxybenzovesamicol.. Behav Brain Res. 278:107-14.
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2015. FEOBV-PET to quantify cortical cholinergic denervation in AD: Relationship to basal forebrain volumetry.. J Neuroimaging. 31(6):1077-1081.
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2021. First-in-Human Brain Imaging of [F]TRACK, a PET tracer for Tropomyosin Receptor Kinases.. ACS Chem Neurosci. 10(6):2697-2702.
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2019. Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, ε4, and Cognitive Impairment.. Neurology. 96(7):e975-e985.
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2021. Imaging in vivo glutamate fluctuations with [(11)C]ABP688: a GLT-1 challenge with ceftriaxone.. J Cereb Blood Flow Metab. 35(7):1169-74.
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2015. In vivo characterization of metabotropic glutamate receptor type 5 abnormalities in behavioral variant FTD.. Brain Struct Funct.
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2015. In vivo quantification of neurofibrillary tangles with [F]MK-6240.. Alzheimers Res Ther. 10(1):74.
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2018. A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation, and First-in-Human.. J Med Chem. 60(16):6897-6910.
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2017. Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia.. Neuroimage Clin. 29:102552.
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2021. Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages.. Brain. 144(11):3517-3528.
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2016. Microglial activation and tau propagate jointly across Braak stages.. Nat Med. 27(9):1592-1599.
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2021. Molecular Imaging of the Cholinergic System in Alzheimer and Lewy Body Dementias: Expanding Views.. Curr Neurol Neurosci Rep. 21(10):52.
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2021. Monoamine oxidase B inhibitor, selegiline, reduces (18)F-THK5351 uptake in the human brain.. Alzheimers Res Ther. 9(1):25.
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2017. Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities.. J Neurosci. 37(50):12263-12271.
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