Publications

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Journal Article
Charbogne P, Kieffer BL, Befort K.  2014.  15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse.. Neuropharmacology. 76 Pt B:204-17.
Mann A, Moulédous L, Froment C, O'Neill PR, Dasgupta P, Günther T, Brunori G, Kieffer BL, Toll L, Bruchas MR et al..  2019.  Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists.. Sci Signal. 12(574)
Pradhan AA, Perroy J, Walwyn WM, Smith ML, Vicente-Sanchez A, Segura L, Bana A, Kieffer BL, Evans CJ.  2016.  Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function.. J Neurosci. 36(12):3541-51.
Becker JAJ, Clesse D, Spiegelhalter C, Schwab Y, Le Merrer J, Kieffer BL.  2014.  Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity.. Neuropsychopharmacology. 39(9):2049-60.
Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M et al..  2019.  Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons.. iScience. 14:47-57.
Moore K, Madularu D, Iriah S, Yee JR, Kulkarni P, Darcq E, Kieffer BL, Ferris CF.  2016.  BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone.. Front Neurosci. 10:471.
Yoo JHoon, Borsodi A, Tóth G, Benyhe S, Gaspar R, Matifas A, Kieffer BL, Metaxas A, Kitchen I, Bailey A.  2017.  Characterization of [(3)H] oxymorphone binding sites in mouse brain: Quantitative autoradiography in opioid receptor knockout mice.. Neurosci Lett. 643:16-21.
Darcq E, Kieffer BL.  2018.  The Control of Reward Seeking.. Biol Psychiatry. 83(12):981-983.
Nasseef MTaufiq, Devenyi GA, Mechling AE, Harsan L-A, M Chakravarty M, Kieffer BL, Darcq E.  2018.  Deformation-based Morphometry MRI Reveals Brain Structural Modifications in Living Mu Opioid Receptor Knockout Mice.. Front Psychiatry. 9:643.
Mechling AE, Arefin T, Lee H-L, Bienert T, Reisert M, Ben Hamida S, Darcq E, Ehrlich A, Gaveriaux-Ruff C, Parent MJ et al..  2016.  Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome.. Proc Natl Acad Sci U S A. 113(41):11603-11608.
Chung PChu Sin, Boehrer A, Stephan A, Matifas A, Scherrer G, Darcq E, Befort K, Kieffer BL.  2015.  Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures.. Behav Brain Res. 278:429-34.
Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith K et al..  2014.  Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn.. Neuron. 81(6):1312-27.
Massart R, Mignon V, Stanic J, Munoz-Tello P, Becker JAJ, Kieffer BL, Darmon M, Sokoloff P, Diaz J.  2016.  Developmental and adult expression patterns of the G-protein-coupled receptor GPR88 in the rat: Establishment of a dual nuclear-cytoplasmic localization.. J Comp Neurol. 524(14):2776-802.
Becker JAJ, Kieffer BL, Le Merrer J.  2016.  Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol.. Addict Biol.
Varga AG, Reid BT, Kieffer BL, Levitt ES.  2019.  Differential impact of two critical respiratory centers in opioid-induced respiratory depression in awake mice.. J Physiol.
Jin C, Decker AM, Makhijani VH, Besheer J, Darcq E, Kieffer BL, Maitra R.  2018.  Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake.. J Med Chem. 61(15):6748-6758.
Ozawa A, Brunori G, Cippitelli A, Toll N, Schoch J, Kieffer BL, Toll L.  2018.  Dissecting the spinal NOP receptor distribution under a chronic pain model using NOP-eGFP knock-in mice.. Br J Pharmacol.
Ayranci G, Befort K, Lalanne L, Kieffer BL, Lutz P-E.  2015.  Dissociation of heroin-induced emotional dysfunction from psychomotor activation and physical dependence among inbred mouse strains.. Psychopharmacology (Berl). 232(11):1957-71.
Lutz P-E, Ayranci G, Chu-Sin-Chung P, Matifas A, Koebel P, Filliol D, Befort K, Ouagazzal A-M, Kieffer BL.  2014.  Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence.. Neuropsychopharmacology. 39(11):2694-705.
Kieffer BL.  2016.  Drug discovery: Designing the ideal opioid.. Nature. 537(7619):170-171.
Zanos P, Georgiou P, Gonzalez LRojo, Hourani S, Chen Y, Kitchen I, Kieffer BL, Winsky-Sommerer R, Bailey A.  2016.  Emotional Impairment and Persistent Upregulation of mGlu5 Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction.. Int J Neuropsychopharmacol. 19(7)
Gardon O, Faget L, P Chung CSin, Matifas A, Massotte D, Kieffer BL.  2014.  Expression of mu opioid receptor in dorsal diencephalic conduction system: new insights for the medial habenula.. Neuroscience. 277:595-609.
Belzeaux R, Lalanne L, Kieffer BL, Lutz P-E.  2018.  Focusing on the Opioid System for Addiction Biomarker Discovery.. Trends Mol Med. 24(2):206-220.
Mambretti EM, Kistner K, Mayer S, Massotte D, Kieffer BL, Hoffmann C, Reeh PW, Brack A, Asan E, Rittner HL.  2016.  Functional and structural characterization of axonal opioid receptors as targets for analgesia.. Mol Pain. 12
Meirsman ACarole, Robé A, d'Exaerde Ade Kerchov, Kieffer BL.  2016.  GPR88 in A2AR Neurons Enhances Anxiety-Like Behaviors.. eNeuro. 3(4)

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