Publications

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2021
Ehrlich AT, Semache M, Couvineau P, Wojcik S, Kobayashi H, Thelen M, Gross F, Hogue M, Le Gouill C, Darcq E et al..  2021.  Ackr3-Venus knock-in mouse lights up brain vasculature.. Mol Brain. 14(1):151.
Nasseef MTaufiq, Ma W, Singh JPuneet, Dozono N, Lançon K, Séguéla P, Darcq E, Ueda H, Kieffer BL.  2021.  Chronic generalized pain disrupts whole brain functional connectivity in mice.. Brain Imaging Behav. 15(5):2406-2416.
Rahman MToufiqur, Decker AM, Laudermilk L, Maitra R, Ma W, Ben Hamida S, Darcq E, Kieffer BL, Jin C.  2021.  Evaluation of Amide Bioisosteres Leading to 1,2,3-Triazole Containing Compounds as GPR88 Agonists: Design, Synthesis, and Structure-Activity Relationship Studies.. J Med Chem. 64(16):12397-12413.
Lutz P-E, Almeida D, Filliol D, Jollant F, Kieffer BL, Turecki G.  2021.  Increased functional coupling of the mu opioid receptor in the anterior insula of depressed individuals.. Neuropsychopharmacology. 46(5):920-927.
Karatas M, Noblet V, Nasseef MTaufiq, Bienert T, Reisert M, Hennig J, Yalcin I, Kieffer BL, von Elverfeldt D, Harsan L-A.  2021.  Mapping the living mouse brain neural architecture: strain-specific patterns of brain structural and functional connectivity.. Brain Struct Funct. 226(3):647-669.
Han J, Andreu V, Langreck C, Pekarskaya EA, Grinnell SG, Allain F, Magalong V, Pintar J, Kieffer BL, Harris AZ et al..  2021.  Mu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine.. Neuropsychopharmacology.
Rebeillard F, De Gois S, Pietrancosta N, Mai THue, Lai-Kuen R, Kieffer BL, Giros B, Massart R, Darmon M, Diaz J.  2021.  The Orphan GPCR Receptor, GPR88, Interacts with Nuclear Protein Partners in the Cerebral Cortex.. Cereb Cortex.
2020
Chen C, Willhouse AH, Huang P, Ko N, Wang Y, Xu B, Huang LHsuan Melo, Kieffer BL, Barbe MF, Liu-Chen L-Y.  2020.  Characterization of a Knock-In Mouse Line Expressing a Fusion Protein of κ Opioid Receptor Conjugated with tdTomato: 3-Dimensional Brain Imaging via CLARITY.. eNeuro. 7(4)
Rahman MToufiqur, Decker AM, Langston TL, Mathews KM, Laudermilk L, Maitra R, Ma W, Darcq E, Kieffer BL, Jin C.  2020.  Design, Synthesis, and Structure-Activity Relationship Studies of (4-Alkoxyphenyl)glycinamides and Bioisosteric 1,3,4-Oxadiazoles as GPR88 Agonists.. J Med Chem. 63(23):14989-15012.
Dripps IJ, Bertels Z, Moye LS, Tipton AF, Siegersma K, Baca SM, Kieffer BL, Pradhan AA.  2020.  Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia.. Sci Rep. 10(1):17629.
Targowska-Duda KM, Ozawa A, Bertels Z, Cippitelli A, Marcus JL, Mielke-Maday HK, Zribi G, Rainey AN, Kieffer BL, Pradhan AA et al..  2020.  NOP receptor agonist attenuates nitroglycerin-induced migraine-like symptoms in mice.. Neuropharmacology. 170:108029.
Bailly J, Del Rossi N, Runtz L, Li J-J, Park DW, Scherrer G, Tanti A, Birling M-C, Darcq E, Kieffer BL.  2020.  Targeting Morphine-Responsive Neurons: Generation of a Knock-In Mouse Line Expressing Cre Recombinase from the Mu-Opioid Receptor Gene Locus.. eNeuro. 7(3)
Severino AL, Mittal N, Hakimian JK, Velarde N, Minasyan A, Albert R, Torres C, Romaneschi N, Johnston C, Tiwari S et al..  2020.  μ-Opioid Receptors on Distinct Neuronal Populations Mediate Different Aspects of Opioid Reward-Related Behaviors.. eNeuro. 7(5)
2019
Mann A, Moulédous L, Froment C, O'Neill PR, Dasgupta P, Günther T, Brunori G, Kieffer BL, Toll L, Bruchas MR et al..  2019.  Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists.. Sci Signal. 12(574)
Kieffer BL.  2019.  An Anti-Opioid System, Courtesy of a Worm Model.. N Engl J Med. 381(21):2067-2069.
Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M et al..  2019.  Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons.. iScience. 14:47-57.
Varga AG, Reid BT, Kieffer BL, Levitt ES.  2019.  Differential impact of two critical respiratory centres in opioid-induced respiratory depression in awake mice.. J Physiol.
Martínez-Navarro M, Cabañero D, Wawrzczak-Bargiela A, Robé A, Gaveriaux-Ruff C, Kieffer BL, Przewlocki R, Baños JE, Maldonado R.  2019.  Mu and delta opioid receptors play opposite nociceptive and behavioural roles on nerve-injured mice.. Br J Pharmacol.
Welsch L, Bailly J, Darcq E, Kieffer BL.  2019.  The Negative Affect of Protracted Opioid Abstinence: Progress and Perspectives From Rodent Models.. Biol Psychiatry.
Nasseef MTaufiq, Singh JPuneet, Ehrlich AT, McNicholas M, Park DWoon, Ma W, Kulkarni P, Kieffer BL, Darcq E.  2019.  Oxycodone-Mediated Activation of the Mu Opioid Receptor Reduces Whole Brain Functional Connectivity in Mice.. ACS Pharmacol Transl Sci. 2(4):264-274.
Sikora J, Kieffer BL, Paoletti P, Ouagazzal A-M.  2019.  Synaptic zinc contributes to motor and cognitive deficits in 6-hydroxydopamine mouse models of Parkinson's disease.. Neurobiol Dis. 134:104681.
2018
Darcq E, Kieffer BL.  2018.  The Control of Reward Seeking.. Biol Psychiatry. 83(12):981-983.
Nasseef MTaufiq, Devenyi GA, Mechling AE, Harsan L-A, Chakravarty MM, Kieffer BL, Darcq E.  2018.  Deformation-based Morphometry MRI Reveals Brain Structural Modifications in Living Mu Opioid Receptor Knockout Mice.. Front Psychiatry. 9:643.
Jin C, Decker AM, Makhijani VH, Besheer J, Darcq E, Kieffer BL, Maitra R.  2018.  Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake.. J Med Chem. 61(15):6748-6758.
Ozawa A, Brunori G, Cippitelli A, Toll N, Schoch J, Kieffer BL, Toll L.  2018.  Dissecting the spinal NOP receptor distribution under a chronic pain model using NOP-eGFP knock-in mice.. Br J Pharmacol.

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