Publications

@article{pmid39706485,

title = {Longitudinal analysis of lifetime stressors and depression: Exploring intersectionality and tailoring social support for better mental health in a community population cohort},

author = {Xiangfei Meng and Muzi Li and Yingying Su and Jean Caron and Yu-Tao Xiang},

doi = {10.1016/j.jad.2024.12.066},

issn = {1573-2517},

year  = {2025},

date = {2025-03-01},

journal = {J Affect Disord},

volume = {372},

pages = {643--652},

abstract = {AIMS: Health inequalities studies need to understand how individuals simultaneously defined by several socioeconomic factors differ from others when facing a series of stressors across the lifespan in the risk of major depression (MD). Theoretical efforts, as well as empirical studies, have suggested a pertinent role of social support in mental health outcomes. However, little is known about which forms of social support would alleviate the negative impact of MD vulnerability in self-rated mental health (SRMH) across different socioeconomic groups. We investigated 1) differential associations between lifetime stressors and MD across social groups and 2) explored diverse social support forms mediating the associations between MD vulnerability and SRMH.nnMETHODS: Data analyzed were from a large longitudinal population-based cohort. Multilevel analysis of individual heterogeneity and discriminatory accuracy was used to articulate MD vulnerability in different social groups defined by ethnicity, gender, and socioeconomic status (SES). Genetic predispositions were also included in the modeling process. These social groups were then regrouped based on their vulnerability level of MD. Mediation analyses were then applied to identify which social support forms mediate the effect of MD vulnerability on SRMH.nnRESULTS: Higher levels of stressors were associated with higher risks of MD, and their associations varied by different social groups. The social groups (White men with medium SES or White women with high SES) had the lowest predicted incidence of MD, whereas White women with low SES reported the highest predicted incidence of MD. Two social support forms (guidance and opportunity for nurturance) significantly mediated the indirect paths between MD vulnerability and SRMH.nnCONCLUSIONS: By applying an intersectional lens, the present study provides a novel quantitative instrument for documenting the associations of stress and depression in various social identities. The findings of the study suggest more focused intervention programs and strategies for risk reduction should focus on identified characteristics and pay particular attention to the combined effect of lifetime stressors and discovered social identities.},

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@article{pmid39935825,

title = {Pathophysiological Models of Hypersomnolence Associated With Depression},

author = {Christophe Moderie and Diane B Boivin},

doi = {10.1016/j.bpsgos.2024.100445},

issn = {2667-1743},

year  = {2025},

date = {2025-03-01},

journal = {Biol Psychiatry Glob Open Sci},

volume = {5},

number = {2},

pages = {100445},

abstract = {Up to 25% of patients with depression experience hypersomnolence (e.g., excessive daytime sleepiness, hypersomnia, and/or sleep inertia), which is associated with treatment resistance, overall poorer outcomes, and safety concerns while driving. Hypersomnolence can result from various sleep/neurological disorders or side effects from medication but is often medically unexplained in depression. In this review, we aimed to summarize the different pathophysiological models of hypersomnolence in depression to discuss their impact on nosology and to foster the development of better tailored diagnostics and treatments. We identified several potential mechanisms underlying hypersomnolence including a daytime hypoactivity of dopaminergic and noradrenergic systems, nighttime GABA (gamma-aminobutyric acid) hypoactivation, hypoperfusion, and hypoconnectivity in the medial prefrontal cortex, as well as a longer circadian period and light hyposensitivity. In some patients with depression, nighttime hyperarousal can fragment sleep and result in a complaint of excessive daytime sleepiness, thus mimicking hypersomnolence. Others might adopt maladaptive behaviors such as spending excessive time in bed, a term coined clinophilia. Objective markers of hypersomnolence, such as ambulatory ad libitum polysomnography may facilitate distinguishing between conditions that mimic hypersomnolence. Our review identified several clinical targets for hypersomnolence in depression. Low-sodium oxybate, which is approved for idiopathic hypersomnia, needs additional study in patients with depression. Neuromodulation that targets prefrontal cortex anomalies should be systematically explored, while tailored light therapy protocols may mitigate light hyposensitivity. Additionally, cognitive behavioral therapy for hypersomnolence is being developed as a nonpharmacological adjunct to these treatments.},

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@article{pmid39644928,

title = {Cognitive control impairment in suicide behaviors: what do we know? A systematic review and meta-analysis of Stroop in suicide behaviors},

author = {Stéphane Richard-Devantoy and Ayla Inja and Marina Dicker and Josie-Anne Bertrand and Gustavo Turecki and M Orri and John G Keilp},

doi = {10.1016/j.jad.2024.12.009},

issn = {1573-2517},

year  = {2025},

date = {2025-03-01},

journal = {J Affect Disord},

volume = {372},

pages = {358--369},

abstract = {BACKGROUND: Suicidal behavior results from a complex interplay between stressful events and vulnerability factors, including cognitive deficits. Poorer performance on the Stroop task, a measure of cognitive control, has been associated with suicidal behavior in numerous studies. The objective was to conduct an updated systematic review of the literature on the Stroop task as a neuropsychological test of vulnerability to suicidal acts in patients with mood and other psychiatric disorders, while also looking at how the type (classic versus emotional) or the version (paper or computerized) of the Stroop task, as well as the characteristics of the patient (clinical population, age, sex) moderated the Stroop effect.nnMETHODS: A search on Medline, Embase, PsycInfo databases, and article references was performed. 53 studies (6781 participants) met the selection criteria. Interference time and errors of the Stroop Test were assessed in at least 3 studies to be analyzed. Moderators, such as the type (classic versus emotional) of the Stroop task and the characteristics of the patient (clinical population, age, sex) were also assessed.nnRESULTS: Interference time on Stroop performance was lower in suicide attempters than in patient controls (g = 0.20; 95%CI [0.10-0.30]) and healthy controls (g = 0.79; 95 % CI [0.29-1.29]), with patient controls scoring lower than healthy controls (g = -0.63; 95%CI [-1.01-0.25]). This was moderated by age and having a mood disorder. In terms of interference errors, suicide attempters performed worse than healthy controls (g = 0.57; 95%CI [0.01-1.15]) but did not perform differently from patient controls (g = 0.20; 95 % CI [-0.06-0.45]). Patient controls also did not score differently than healthy controls (g = -0.18; 95 % CI [-0.54-0.18]). There was a significant moderation effect for the type (i.e., original Stroop task) and version (i.e., paper format) of the Stroop task, and for some characteristics of the patient (i.e., older patients and having a mood disorder).nnCONCLUSIONS: Cognitive control impairment was associated with a history of suicidal behavior in patients, especially in older populations and those with mood disorders, however this result was moderated by outcome measure (interference time vs. errors), the type (i.e., original Stroop task) and the version (i.e., paper format) of the Stroop task. Cognitive control processes may be an important factor of suicidal vulnerability. Choosing the right neurocognitive test in the right population to detect suicide vulnerability is important direction for future research.},

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@article{pmid39632555,

title = {Impact of Stress on the Endocannabinoid System: A [C]-CURB Positron Emission Tomography Study in Early Psychosis: Les effets du stress sur le système endocannabinoïde : étude par tomographie par émission de positons avec l'indicateur radioactif [11C-CURB] dans la psychose précoce},

author = {Ana Weidenauer and Ranjini Garani and Paula Campos Oller and Maira Belén Blasco and Pablo M Rusjan and Romina Mizrahi},

doi = {10.1177/07067437241300958},

issn = {1497-0015},

year  = {2025},

date = {2025-03-01},

journal = {Can J Psychiatry},

volume = {70},

number = {3},

pages = {251--259},

abstract = {BACKGROUND: Stress and traumatic experiences are well-established risk factors for psychiatric disorders. Stressful events can induce symptoms of anxiety and depression and may lead to overt psychosis, especially when there is an innate biological vulnerability. This study explores the role of the stress-regulating endocannabinoid system, specifically the activity of the enzyme fatty acid amid hydrolase (FAAH), a key regulatory enzyme for endocannabinoids, in association with stress by analysing data from healthy individuals and patients with psychosis.nnMETHODS: We performed a post-hoc exploratory analysis on 65 positron emission tomography scans using the selective FAAH radioligand [C]CURB, encompassing 30 patients with psychosis (6 female) and 35 healthy controls (19 female). The study aimed to examine the association between FAAH activity and stressful life events, assessed through the Recent Life Events, Survey of Life Experiences, and Hassles and Uplifts Scale.nnRESULTS: There was a significant difference regarding the number of recent stressors with higher levels in patients compared to healthy subjects (Survey of Life Experiences: = 4.88,  < 0.001, hassles: = 3.14,  = 0.003), however there was no significant relationship of brain FAAH activity and stressful life events in any of the applied scales across groups (Recent Life Events: = 0.07,  = 0.80; Survey of Life Experiences: = 1.75,  = 0.19; hassles: = 1.06,  = 0.31). Linear mixed models performed separately for each group revealed that there was a positive association between FAAH activity and Recent Life Events in patients with psychosis only (= 8.07,  = 0.009).nnCONCLUSIONS: Our data reveal a significant disparity in recent stressors between the two groups, and a correlation between brain FAAH activity and stressful life events in patients with psychosis only. This suggests a complex interplay between stress and the endocannabinoid system.nnPLAIN LANGUAGE SUMMARY TITLE: How Stress Affects the Brain’s Endocannabinoid System in Early Psychosis: A PET Study.},

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@article{pmid39867567,

title = {Small Nucleolar RNAs and the Brain: Growing Evidence Supporting Their Role in Psychiatric Disorders},

author = {Juliette Salles and Rixing Lin and Gustavo Turecki},

doi = {10.1016/j.bpsgos.2024.100415},

issn = {2667-1743},

year  = {2025},

date = {2025-03-01},

journal = {Biol Psychiatry Glob Open Sci},

volume = {5},

number = {2},

pages = {100415},

abstract = {Noncoding RNAs comprise most of the transcriptome and represent an emerging area of research. Among them, small nucleolar RNAs (snoRNAs) have emerged as a promising target because they have been associated with the development and evolution of several diseases, including psychiatric disorders. snoRNAs are expressed in the brain, with some showing brain-specific expression that indicates specific roles in brain development, function, and dysfunction. However, the role of snoRNAs in conditions that affect the brain needs further investigation to be better understood. This scoping review summarizes existing literature on studies that have investigated snoRNAs in psychiatry and offers insight into potential pathophysiological mechanisms to be further investigated in future research.},

keywords = {},

pubstate = {published},

tppubtype = {article}

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@article{pmid38600593,

title = {Speech based natural language profile before, during and after the onset of psychosis: A cluster analysis},

author = {Tyler C Dalal and Liangbing Liang and Angelica M Silva and Michael Mackinley and Alban Voppel and Lena Palaniyappan},

doi = {10.1111/acps.13685},

issn = {1600-0447},

year  = {2025},

date = {2025-03-01},

journal = {Acta Psychiatr Scand},

volume = {151},

number = {3},

pages = {332--347},

abstract = {BACKGROUND AND HYPOTHESIS: Speech markers are digitally acquired, computationally derived, quantifiable set of measures that reflect the state of neurocognitive processes relevant for social functioning. "Oddities" in language and communication have historically been seen as a core feature of schizophrenia. The application of natural language processing (NLP) to speech samples can elucidate even the most subtle deviations in language. We aim to determine if NLP based profiles that are distinctive of schizophrenia can be observed across the various clinical phases of psychosis.nnDESIGN: Our sample consisted of 147 participants and included 39 healthy controls (HC), 72 with first-episode psychosis (FEP), 18 in a clinical high-risk state (CHR), 18 with schizophrenia (SZ). A structured task elicited 3 minutes of speech, which was then transformed into quantitative measures on 12 linguistic variables (lexical, syntactic, and semantic). Cluster analysis that leveraged healthy variations was then applied to determine language-based subgroups.nnRESULTS: We observed a three-cluster solution. The largest cluster included most HC and the majority of patients, indicating a 'typical linguistic profile (TLP)'. One of the atypical clusters had notably high semantic similarity in word choices with less perceptual words, lower cohesion and analytical structure; this cluster was almost entirely composed of patients in early stages of psychosis (EPP - early phase profile). The second atypical cluster had more patients with established schizophrenia (SPP - stable phase profile), with more perceptual but less cognitive/emotional word classes, simpler syntactic structure, and a lack of sufficient reference to prior information (reduced givenness).nnCONCLUSION: The patterns of speech deviations in early and established stages of schizophrenia are distinguishable from each other and detectable when lexical, semantic and syntactic aspects are assessed in the pursuit of 'formal thought disorder'.},

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@article{pmid39893139,

title = {Use of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research},

author = {Eric E Smith and Natalie A Phillips and Howard H Feldman and Michael Borrie and Aravind Ganesh and Alexandre Henri-Bhargava and Philippe Desmarais and Andrew Frank and AmanPreet Badhwar and Laura Barlow and Robert Bartha and Sarah Best and Jennifer Bethell and Jaspreet Bhangu and Sandra E Black and Christian Bocti and Susan E Bronskill and Amer M Burhan and Frederic Calon and Richard Camicioli and Barry Campbell and D Louis Collins and Mahsa Dadar and Mari L DeMarco and Simon Ducharme and Simon Duchesne and Gillian Einstein and John D Fisk and Jodie R Gawryluk and Linda Grossman and Zahinoor Ismail and Inbal Itzhak and Manish Joshi and Arthur Harrison and Edeltraut Kröger and Sanjeev Kumar and Robert Laforce and Krista L Lanctot and Meghan Lau and Linda Lee and Mario Masellis and Fadi Massoud and Sara B Mitchell and Manuel Montero-Odasso and Karen Myers Barnett and Haakon B Nygaard and Stephen H Pasternak and Jody Peters and M Natasha Rajah and Julie M Robillard and Ken Rockwood and Pedro Rosa-Neto and Dallas P Seitz and Jean-Paul Soucy and Shanna C Trenaman and Cheryl L Wellington and Aicha Zadem and Howard Chertkow and },

doi = {10.1016/j.tjpad.2025.100068},

issn = {2426-0266},

year  = {2025},

date = {2025-03-01},

journal = {J Prev Alzheimers Dis},

volume = {12},

number = {3},

pages = {100068},

abstract = {Lecanemab and donanemab are monoclonal antibody therapies that remove amyloid-beta from the brain. They are the first therapies that alter a fundamental mechanism, amyloid-beta deposition, in Alzheimer disease (AD). To inform Canadian decisions on approval and use of these drugs, the Canadian Consortium on Neurodegeneration in Aging commissioned Work Groups to review evidence on the efficacy and safety of these new therapies, as well as their projected impacts on Canadian dementia systems of care. We included persons with lived experience with Alzheimer disease in the discussion about the benefits and harms. Our review of the trial publications found high quality evidence of statistically significant group differences, but also recognized that there are mixed views on the clinical relevance of the observed differences and the value of therapy for individual patients. The drugs are intended for persons with early AD, at a stage of mild cognitive impairment or mild dementia. If patients are treated, then confirmation of AD by positron emission tomography or cerebrospinal fluid analysis and monitoring for risk of amyloid-related imaging abnormalities was recommended, as done in the clinical trials, although it would strain Canadian resource capacity. More data are needed to determine the size of the potentially eligible treatment population in Canada.},

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tppubtype = {article}

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@article{pmid39893761,

title = {Construct validity of probable child maltreatment indicators using prospectively recorded information in a longitudinal cohort of Canadian children},

author = {Rachel Langevin and Isabelle Ouellet-Morin and Sebastian Kay and Elise Chartrand and Natalie Castellanos-Ryan and Delphine Collin-Vezina and Marie-Claude Geoffroy},

doi = {10.1016/j.chiabu.2025.107300},

issn = {1873-7757},

year  = {2025},

date = {2025-03-01},

journal = {Child Abuse Negl},

volume = {161},

pages = {107300},

abstract = {BACKGROUND: Officially reported and self-reported measures of child maltreatment show poor agreement and may differentially predict psychosocial problems in adulthood. However, research remains primarily based on retrospective self-reports, warranting examination of the validity of prospective assessments of maltreatment.nnOBJECTIVE: To assess the construct validity of prospective indicators of child maltreatment using a longitudinal cohort of Canadian children.nnPARTICIPANTS AND SETTING: The population-based cohort comprises 2120 participants born between 1997 and 1998 in Quebec, Canada.nnMETHODS: Maternal and familial risk factors (maternal age, depressive symptoms, and antisocial behaviors, socioeconomic status, and single-parent home) and early adulthood functioning difficulties (depression, anxiety, suicidality, alcohol misuse, and unemployment status) were assessed across various time points (0-23 years). Associations between factors and prospective and retrospective maltreatment indicators were appraised.nnRESULTS: Most maternal and familial risk factors (80 %) showed associations with indicators of prospective maltreatment (ΔM = +/-0.04 to 0.72; p < 0.05). Several early adulthood functioning difficulties (30 %) showed associations with physical (ΔM = 0.05 to 0.22; p < 0.05) and sexual abuse (ΔM = 0.33 to 0.34; p < 0.05), while emotional, supervisory, and physical neglect were only associated with educational/employment status (ΔM = 0.04 to 0.10; p < 0.05). Cumulatively assessed maltreatment also showed a dose-response relationship with maternal and familial risk factors/functioning difficulties.nnCONCLUSIONS: The strong construct validity exhibited by our prospective indicators highlights the need to assess child maltreatment multi-modally. Our findings further contribute to the wider discussion surrounding the measurement of child maltreatment.},

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tppubtype = {article}

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@article{pmid40015754,

title = {Protocol for an intergenerational randomized controlled trial to enhance physical activity in older adults at risk for Alzheimer's disease},

author = {Caitlin S Walker and Adrián E Noriega de la Colina and Linda Li and Carolynn Boulanger and Nagashree Thovinakere and Alix Noly-Gandon and Garance Barnoin and Mitchell Bennett and Jillian Caplan and Laurence Côté and Sarah Elbaz and Shania Fock Ka Bao and Ryan Kara and Nicolas Lavoie and Maggie Nguyen and Franciska Otaner and Helen Pallett-Wiesel and Johanie Victoria Piché and Andreanne Powers and Sofia Ricciardelli and Kayla Williams and Christine Déry and Jennifer Tremblay-Mercier and Judes Poirier and Sylvia Villeneuve and Arthur F Kramer and Maiya R Geddes and },

doi = {10.1016/j.tjpad.2024.100039},

issn = {2426-0266},

year  = {2025},

date = {2025-03-01},

journal = {J Prev Alzheimers Dis},

volume = {12},

number = {3},

pages = {100039},

abstract = {BACKGROUND: Physical inactivity is one of the most important modifiable risk factors for Alzheimer's disease in North America. Despite this, most older adults are physically inactive. It is currently unknown how to successfully motivate physical activity behavior in older adults at risk for Alzheimer's disease, and this knowledge is crucial for early and effective disease prevention. Prior research has shown that intergenerational social engagement and prosocial behaviours can enhance the health and well-being of older adults.nnOBJECTIVES: This manuscript describes the design of a randomized controlled trial that will test the efficacy of a behavioral intervention to enhance physical activity in older adults at risk for Alzheimer's disease.nnDESIGN/SETTING: This is a single-blinded, two-arm stratified randomized controlled trial that incorporates a hybrid efficacy and implementation design. Participants are randomized to an intervention or control condition in a 1:1 ratio and are stratified by a multimodal Alzheimer's disease risk score. All study visits are conducted remotely through videoconferencing.nnPARTICIPANTS: The study aims to recruit 60 older adults with a first-degree family history of Alzheimer's disease from the PREVENT-AD cohort and 30 younger adults who are paired with older adults in the intervention condition.nnINTERVENTION: Older participants in the intervention group will be paired with younger study partners and receive positive, daily messages over four weeks using a novel technology platform. The daily messages combine intergenerational social engagement (growing a virtual garden with a younger study partner) and prosocial goals (donations to charity after reaching step count goals).nnMEASUREMENTS: The primary outcome is change in step count compared to baseline measured using a wrist-worn triaxial accelerometer. Secondary outcomes include time spent physically active, mood, generativity, loneliness, and cognition. Target mechanisms (social support and generativity) of physical activity engagement will be examined. Ease of use, acceptability, and feasibility of the technology as well as barriers and facilitators of participation will be assessed.nnCONCLUSIONS: This research will advance our understanding of mechanisms and individual differences underlying successful physical activity engagement in older adults who are at risk for Alzheimer's disease. This knowledge will contribute to strategies for promoting health behaviours that can prevent the risk of Alzheimer's disease.},

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@article{pmid39730766,

title = {Considering the interconnected nature of social identities in neuroimaging research},

author = {Elvisha Dhamala and Jocelyn A Ricard and Lucina Q Uddin and Liisa A M Galea and Emily G Jacobs and Sarah W Yip and B T Thomas Yeo and M Mallar Chakravarty and Avram J Holmes},

doi = {10.1038/s41593-024-01832-y},

issn = {1546-1726},

year  = {2025},

date = {2025-02-01},

journal = {Nat Neurosci},

volume = {28},

number = {2},

pages = {222--233},

abstract = {Considerable heterogeneity exists in the expression of complex human behaviors across the cognitive, personality and mental health domains. It is increasingly evident that individual variability in behavioral expression is substantially affected by sociodemographic factors that often interact with life experiences. Here, we formally address the urgent need to incorporate intersectional identities in neuroimaging studies of behavior, with a focus on research in mental health. We highlight how diverse sociodemographic factors influence the study of psychiatric conditions, focusing on how interactions between those factors might contribute to brain biology and illness expression, including prevalence, symptom burden, help seeking, treatment response and tolerance, and relapse and remission. We conclude with a discussion of the considerations and actionable items related to participant recruitment, data acquisition and data analysis to facilitate the inclusion and incorporation of diverse intersectional identities in neuroimaging.},

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tppubtype = {article}

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@article{pmid39672240,

title = {Evidence of microglial involvement in the childhood abuse-associated increase in perineuronal nets in the ventromedial prefrontal cortex},

author = {Claudia Belliveau and Reza Rahimian and Gohar Fakhfouri and Clémentine Hosdey and Sophie Simard and Maria Antonietta Davoli and Dominique Mirault and Bruno Giros and Gustavo Turecki and Naguib Mechawar},

doi = {10.1016/j.bbi.2024.12.013},

issn = {1090-2139},

year  = {2025},

date = {2025-02-01},

journal = {Brain Behav Immun},

volume = {124},

pages = {321--334},

abstract = {Microglia, known for their diverse roles in the central nervous system, have recently been recognized for their involvement in degrading the extracellular matrix. Perineuronal nets (PNNs), a specialized form of this matrix, are crucial for stabilizing neuronal connections and constraining plasticity. Our group recently reported increased PNN densities in the ventromedial prefrontal cortex (vmPFC) of depressed individuals that died by suicide in adulthood after experiencing childhood abuse (DS-CA) compared to matched controls. To explore potential underlying mechanisms, we employed a comprehensive approach in similar postmortem vmPFC samples, combining a human matrix metalloproteinase and chemokine array, isolation of CD11b-positive microglia and enzyme-linked immunosorbent assays (ELISA). Our findings indicate a significant downregulation of matrix metalloproteinase (MMP)-9 and tissue inhibitors of metalloproteinases (TIMP)-2 in both whole vmPFC grey matter and isolated microglial cells from DS-CA samples. Furthermore, our experiments reveal that a history of child abuse is associated with diminished levels of microglial CX3CR1 and IL33R in both vmPFC whole lysate and CD11b isolated cells. However, levels of the CX3CR1 ligand, CX3CL1 (Fractalkine), did not differ between groups. While these data suggest potential long-lasting alterations in microglial markers in the vmPFC of individuals exposed to severe childhood adversity, direct functional assessments were not conducted. Nonetheless, these findings offer insight into how childhood abuse may contribute to PNN alterations via microglial-related mechanisms.},

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@article{pmid39757311,

title = {Disentangling the effect of sex from brain size on brain organization and cognitive functioning},

author = {Aliza Brzezinski-Rittner and Roqaie Moqadam and Yasser Iturria-Medina and M Mallar Chakravarty and Mahsa Dadar and Yashar Zeighami},

doi = {10.1007/s11357-024-01486-5},

issn = {2509-2723},

year  = {2025},

date = {2025-02-01},

journal = {Geroscience},

volume = {47},

number = {1},

pages = {247--262},

abstract = {Neuroanatomical sex differences estimated in neuroimaging studies are confounded by total intracranial volume (TIV) as a major biological factor. Employing a matching approach widely used for causal modeling, we disentangled the effect of TIV from sex to study sex-differentiated brain aging trajectories, their relation to functional networks and cytoarchitectonic classes, brain allometry, and cognition. Using data from the UK Biobank, we created subsamples that removed, maintained, or exaggerated the TIV differences in the original sample. We compared regional and vertex-level sex estimates across subsamples. The overall sex-related differences diminished in head size-matched subsamples, suggesting that most of the observed variability results from TIV differences. Furthermore, bidirectional sex differences in brain neuroanatomy emerged that were previously masked by the effect of TIV. Allometry remained fairly consistent across lifespan and was not sex-differentiated. Finally, the matching process changed the direction of the estimated sex differences in "verbal and numerical reasoning" and "working memory", suggesting that behavioral sex difference investigations can benefit from additional biological analysis to uncover the underlying factors contributing to cognition. Taken together, we provide new evidence disentangling sex differences from TIV as a relevant biological confound.},

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tppubtype = {article}

}

@article{pmid39763223,

title = {A Time-Series Analysis of News Media Coverage of Suicide in Canada from 2019 to 2023: Une analyse de séries chronologiques de la couverture responsable du suicide par les médias au Canada de 2019 à 2023},

author = {Juliette Careau and Justin Bélair and Rob Whitley},

doi = {10.1177/07067437241309677},

issn = {1497-0015},

year  = {2025},

date = {2025-02-01},

journal = {Can J Psychiatry},

volume = {70},

number = {2},

pages = {98--108},

abstract = {OBJECTIVE: Evidence suggests that the media can play a role in preventing suicide, as well as contributing to suicide contagion. As such, the primary objective is to assess adherence to responsible reporting of suicide recommendations in news articles about suicide over time. A secondary objective is to assess whether reporting changed significantly during the COVID-19 pandemic. The tertiary objective is to assess overall patterns regarding types of suicide reported.nnMETHODS: We collected news articles with the keyword "suicide" from 47 Canadian news sources between April 1, 2019, and March 31, 2023. Articles were coded for adherence to key responsible reporting of suicide guidelines. Frequency counts and percentages of adherence were calculated for all key variables. Time series analyses using a Generalized Linear Autoregressive Moving Average model assessed for adherence trends over time, including measuring for any changes during the COVID-19 years.nnRESULTS: Study procedures resulted in 3,232 coded news articles. Overall, the results indicate that adherence to the guidelines has moderately improved over the course of the 4-year period. This is especially true for recommendations regarding avoiding putatively harmful content, such as detailed descriptions of the suicide method. Similar improvements were seen in adherence to guidelines related to the inclusion of putatively helpful content, with significantly more articles providing help-seeking information. However, in the final year of the study, less than a third of articles included educational content about suicide, help-seeking information, or quotes from suicide experts. Reporting of suicide during the COVID-19 period showed some positive improvements; however, these were not sustained after the pandemic ended.nnCONCLUSIONS: On the plus side, adherence to responsible suicide reporting guidelines improved over the 4-year period, especially for recommendations concerning putatively helpful content. However, there remains room for improvement regarding the inclusion of putatively protective content such as including help-seeking information, educating about suicide, and quoting experts.},

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@article{pmid39631245,

title = {Hippocampal atrophy over two years in relation to tau, amyloid-β and memory in older adults},

author = {Etienne Aumont and Marc-André Bedard and Aurélie Bussy and Jaime Fernandez Arias and Cecile Tissot and Brandon J Hall and Joseph Therriault and Nesrine Rahmouni and Jenna Stevenson and Stijn Servaes and Arthur C Macedo and Paolo Vitali and Nina Margherita Poltronetti and Olga Fliaguine and Lydia Trudel and Serge Gauthier and Mallar M Chakravarty and Pedro Rosa-Neto},

doi = {10.1016/j.neurobiolaging.2024.11.007},

issn = {1558-1497},

year  = {2025},

date = {2025-02-01},

journal = {Neurobiol Aging},

volume = {146},

pages = {48--57},

abstract = {In this longitudinal brain imaging study, we aimed to characterize hippocampal tau accumulation and subfield atrophy relative to cortical amyloid-β and memory performance. We measured tau-PET in regions associated with Braak stages I to VI, global amyloid-PET burden, hippocampal subfield volumes and memory assessments from 173 participants aged 55-85. Eighty-six of these participants were tested again two years later. Tau-PET change in the Braak II region, corresponding to the hippocampus and the entorhinal cortex, was significantly associated with the cornu ammonis 1 (CA1) atrophy and memory score. This CA1 atrophy did not significantly mediate the association between tau and memory, nor did global amyloid-PET burden correlate with tau-PET changes in the Braak II region. Longitudinal hippocampal tau accumulation is amyloid-β-independent and co-localized with subfield atrophy. As tau-associated memory decline seems to be independent from hippocampal atrophy, other mechanisms could contribute to the deficit.},

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pubstate = {published},

tppubtype = {article}

}

@article{pmid39787740,

title = {Exploring delusional themes and other symptoms in first episode psychosis: A network analysis over two timepoints},

author = {Fjolla Berisha and Vincent Paquin and Ian Gold and Bratislav Misic and Lena Palaniyappan and Ashok Malla and Srividya Iyer and Ridha Joober and Martin Lepage and Jai Shah},

doi = {10.1016/j.psychres.2024.116349},

issn = {1872-7123},

year  = {2025},

date = {2025-02-01},

journal = {Psychiatry Res},

volume = {344},

pages = {116349},

abstract = {Delusions are a defining feature of psychosis and play an important role in the conceptualization and diagnosis of psychotic disorders; however, the particular role that different delusions play in the prognosis of these disorders is not well understood. This study explored relationships between delusions and other symptoms in 674 first episode psychosis (FEP) individuals by comparing symptom networks between baseline and 12 months after intake to an early intervention service. Specifically, we (1) estimated regularized partial correlation networks at baseline and month 12, (2) identified the most central symptoms in each network, (3) identified clusters of highly connected symptoms, and (4) compared networks to examine changes in structure and connectivity. At baseline, the most central symptoms were depression, delusions of mind reading, and delusions of thought insertion. At month 12, they were hallucinations, persecutory delusions, and delusions of thought insertion. A symptom cluster was identified at both timepoints comprising of five delusions corresponding to passivity experiences. While network structures did not differ significantly, the month 12 network was significantly more highly connected. Our study captures a shift in illness trajectory over time, wherein transdiagnostic symptomatology at baseline becomes more consolidated around psychotic symptoms by month 12.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39788739,

title = {Precuneus Activity during Retrieval Is Positively Associated with Amyloid Burden in Cognitively Normal Older 4 Carriers},

author = {Larissa Fischer and Eóin N Molloy and Alexa Pichet Binette and Niklas Vockert and Jonas Marquardt and Andrea Pacha Pilar and Michael C Kreissl and Jordana Remz and Jennifer Tremblay-Mercier and Judes Poirier and Maria Natasha Rajah and Sylvia Villeneuve and  and Anne Maass},

doi = {10.1523/JNEUROSCI.1408-24.2024},

issn = {1529-2401},

year  = {2025},

date = {2025-02-01},

journal = {J Neurosci},

volume = {45},

number = {6},

abstract = {The precuneus is a site of early amyloid-beta (Aβ) accumulation. Previous cross-sectional studies reported increased precuneus fMRI activity in older adults with mild cognitive deficits or elevated Aβ. However, longitudinal studies in early Alzheimer's disease (AD) are lacking and the relationship to the Apolipoprotein-E () genotype is unclear. Investigating the PREVENT-AD dataset, we assessed how baseline and longitudinal precuneus activity during successful memory retrieval relates to future Aβ and tau burden and change in memory performance. We further studied the moderation by 4 genotype. We included 165 older adults (age, 62.8 ± 4.4 years; 113 female; 66 4 carriers) who were cognitively normal at baseline with a family history of AD. All participants performed task-fMRI at baseline and underwent F-flortaucipir-PET and F-NAV4694-Aβ-PET on average 5 years later. We found that higher baseline activity and greater longitudinal increase in precuneus activity were associated with higher Aβ burden in 4 carriers but not noncarriers. We observed no effects of precuneus activity on tau burden. Finally, 4 noncarriers with low baseline precuneus activity exhibited better longitudinal performance in an independent memory test compared with (1) noncarriers with higher baseline activity and (2) 4 carriers. Our findings suggest that higher task-related precuneus activity during memory retrieval at baseline and over time are associated with greater Aβ burden in cognitively normal 4 carriers. Our results further indicate that the absence of "hyperactivation" and the absence of the 4 allele is related with better future cognitive outcomes in cognitively normal older adults at risk for AD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39535765,

title = {Synaptic Density in Early Stages of Psychosis and Clinical High Risk},

author = {M Belen Blasco and Kankana Nisha Aji and Christian Ramos-Jiménez and Ilana Ruth Leppert and Christine Lucas Tardif and Johan Cohen and Pablo M Rusjan and Romina Mizrahi},

doi = {10.1001/jamapsychiatry.2024.3608},

issn = {2168-6238},

year  = {2025},

date = {2025-02-01},

journal = {JAMA Psychiatry},

volume = {82},

number = {2},

pages = {171--180},

abstract = {IMPORTANCE: Synaptic dysfunction is involved in schizophrenia pathophysiology. However, whether in vivo synaptic density is reduced in early stages of psychosis, including its high-risk states, remains unclear.nnOBJECTIVE: To investigate whether synaptic density (synaptic vesicle glycoprotein 2A [SV2A] binding potential) is reduced in first-episode psychosis (FEP) and in clinical high risk (CHR) and investigate the effect of cannabis use on synaptic density and examine its relationship with psychotic symptoms and gray matter microstructure across groups.nnDESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study was performed in a tertiary care psychiatric hospital from July 2021 to October 2023. Participants were patients with antipsychotic-free or minimally exposed FEP or CHR and healthy controls with a clean urine drug screen (except cannabis).nnMAIN OUTCOMES AND MEASURES: Synaptic density was quantified with dynamic 90-minute [18F]SynVesT-1 positron emission tomography (PET) scans across prioritized brain regions of interest (ROIs) delineated in individual magnetic resonance images (MRIs). Cannabis use was confirmed with urine drug screens. Gray matter microstructure was assessed using diffusion-weighted MRI to estimate neurite density.nnRESULTS: A total of 49 participants were included, including 16 patients with FEP (mean [SD] age, 26.1 [4.6] years; 9 males and 7 females), 17 patients at CHR (mean [SD] age, 21.2 [3.5] years; 8 males and 9 females), and 16 healthy controls (mean [SD] age, 23.4 [3.6] years; 7 males and 9 females). Synaptic density was significantly different between groups (F2,273 = 4.02, P = .02, Cohen F = 0.17; ROI: F5,273 = 360.18, P < .01, Cohen F = 2.55) with a group × ROI interaction (F10,273 = 2.67, P < .01, Cohen F = 0.32). Synaptic density was lower in cannabis users (F1,272 = 5.31, P = .02, Cohen F = 0.14). Lower synaptic density across groups was associated with more negative symptoms (Positive and Negative Syndrome Scale negative scores: F1,81 = 4.31, P = .04, Cohen F = 0.23; Scale of Psychosis-Risk Symptoms negative scores: F1,90 = 4.12, P = .04, Cohen F = 0.21). SV2A binding potential was significantly associated with neurite density index (F1,138 = 6.76, P = .01, Cohen F = 0.22).nnCONCLUSIONS AND RELEVANCE: This study found that synaptic density reductions were present during the early stages of psychosis and its risk states and associated with negative symptoms. The implications of SV2A for negative symptoms in psychosis and CHR warrant further investigation. Future studies should investigate the impact of cannabis use on synaptic density in CHR longitudinally.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39814119,

title = {Early environmental influences on the orbito-frontal cortex function and its effects on behavior},

author = {Olivia Ruge and João Paulo Maires Hoppe and Roberta Dalle Molle and Patricia Pelufo Silveira},

doi = {10.1016/j.neubiorev.2025.106013},

issn = {1873-7528},

year  = {2025},

date = {2025-02-01},

journal = {Neurosci Biobehav Rev},

volume = {169},

pages = {106013},

abstract = {Early-life adversity during pre- and early post-natal phases can impact brain development and lead to maladaptive changes in executive function related behaviors. This increases the risk for a range of psychopathologies and physical diseases. Importantly, exposure to adversities during these periods is also linked to alterations in the orbito-frontal cortex (OFC) which is a key player in these executive functions. The OFC thus appears to be a central node in this association between early life stress and disease risk. Gaining a clear, and detailed understanding of the association between early life stress, OFC function, and executive function, as well as the underlying mechanisms mediating this association is relevant to inform potential therapeutic interventions. In this paper, we begin by reviewing evidence linking early life adversities to 1) alterations in behaviors regulated by the OFC and 2) changes in OFC anatomy and function. We then present insights into the underlying mechanisms for these changes, stemming from early life adversity models, and highlight important future directions for this line of research.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39428944,

title = {A longitudinal study of adolescent pathways differentiating suicide ideation and attempt in early adulthood},

author = {Geneviève Morneau-Vaillancourt and Massimiliano Orri and Isabelle Ouellet-Morin and Marie-Claude Geoffroy and Michel Boivin},

doi = {10.1002/jad.12427},

issn = {1095-9254},

year  = {2025},

date = {2025-02-01},

journal = {J Adolesc},

volume = {97},

number = {2},

pages = {395--408},

abstract = {OBJECTIVE: Suicide ideation and attempt are leading risk factors for mortality in young adults. However, the adolescent risk factors distinguishing suicide ideation from attempt in young adults remain unclear. The present study aimed to examine the extent to which within-person stability and change in depressive symptoms, school difficulties, and peer victimization from ages 12 to 17 were differentially associated with later suicide ideation and attempt from ages 20 to 23.nnMETHOD: The study included 1647 participants from the Quebec Longitudinal Study of Child Development (QLSCD; 52% female). Participants reported on their depressive symptoms, school difficulties, and peer victimization at ages 12, 13, 15, and 17, and on suicide ideation and attempt at ages 20 and 23. Data were collected in the Province of Quebec, Canada, between 2010 and 2021.nnRESULTS: Results indicated that 11% (N = 121) and 8% (N = 86) reported suicide ideation and attempt, respectively, between ages 20 and 23. A random-intercept cross-lagged panel model showed that within-person increases in depressive symptoms during adolescence were related to both suicide ideation and attempt, whereas within-person increases in school difficulties and peer victimization were for the most part related to suicide attempt only. Within-person stability in depressive symptoms from ages 12 to 17 years were also related to suicide attempt, and not ideation. However, this association was only marginally significant.nnCONCLUSION: Findings suggest that experiencing unusual rises in school difficulties and peer victimization during adolescence, as well as depressive symptoms persisting over time, may distinguish young adults who think about suicide from those who attempt suicide.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39334334,

title = {Reasons Explaining High Emergency Department Use in Patients With Mental Illnesses: Different Staff Perspectives},

author = {Marie-Josée Fleury and Francine Ferland and Lambert Farand and Guy Grenier and Armelle Imboua and Firas Gaida},

doi = {10.1111/inm.13442},

issn = {1447-0349},

year  = {2025},

date = {2025-02-01},

journal = {Int J Ment Health Nurs},

volume = {34},

number = {1},

pages = {e13442},

abstract = {For patients with mental illnesses (MIs), emergency departments (EDs) are often the entry point into the healthcare system, or their only resort for quickly accessing mental health treatment. A better understanding of the various barriers justifying high ED use among patients with MIs may help recommend targeted interventions that better meet their needs. This explorative qualitative study aimed to identify such barriers and the solutions brought forth to reduce ED use based on the perspectives of clinicians and managers working in EDs, other hospital departments or the community sector. Interviews were conducted between April 2021 and February 2022; 86 mental health professionals (22% were nurses) from four large urban ED sites in Quebec (Canada) were interviewed. Barriers were identified in relation to patient profiles, healthcare system and organisational features and professional characteristics. The key barriers that were found to explain high ED use were patients having serious MIs (e.g., psychotic disorders) or social issues (e.g., poverty), lack of coordination and patient referrals between EDs and other health services, insufficient access to mental health and addiction services and inadequacy of care. Very few solutions were implemented to improve care for high ED users. Better deployment of ED interventions in collaboration with outpatient care may be prioritised to reduce high ED use for patients with MIs. Improvements to the referral and transfer processes to outpatient care, particularly through care plans and case management programs, may be implemented to reduce high ED use and improve outpatient care among patients with multiple health and social needs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39255831,

title = {The interplay of maternal and paternal postpartum depressive symptoms with children's internalizing and externalizing symptoms from childhood to adolescence: does socioeconomic status matter? A longitudinal cohort study},

author = {Myriam Clément and Marilyn N Ahun and Massimiliano Orri and Tina C Montreuil and Martin St-André and Catherine M Herba and Gregory Moullec and Sylvana M Côté},

doi = {10.1111/jcpp.14051},

issn = {1469-7610},

year  = {2025},

date = {2025-02-01},

journal = {J Child Psychol Psychiatry},

volume = {66},

number = {2},

pages = {225--240},

abstract = {BACKGROUND: Maternal postpartum depression is an important risk factor for internalizing and externalizing problems in children. The role of concurrent paternal depression remains unclear, especially by socioeconomic status. This study examined independent and interactive associations of postpartum maternal and paternal depression with children's internalizing/externalizing symptoms throughout childhood and adolescence (ages 3.5-17 years).nnMETHODS: We used data from the Québec Longitudinal Study of Child Development, a representative birth cohort (1997-1998) in Canada. Data included self-reported maternal and paternal depressive symptoms at 5 months' postpartum using the Center for Epidemiologic Studies Depression Scale. Internalizing and externalizing symptoms in children were reported by parents, teachers and children/adolescents using the Social Behaviour Questionnaire (ages 3.5-13 years) and the Mental Health and Social Inadaptation Assessment for Adolescents (ages 15-17 years). We used three-level mixed effects modelling to test associations after adjusting for confounding factors.nnRESULTS: With 168 single-parent families excluded, our sample consisted of 1,700 families with useable data. Of these, 275 (16.2%) families reported maternal depression (clinically elevated symptoms), 135 (7.9%) paternal depression and 39 (2.3%) both. In families with high socioeconomic status, maternal depression was associated with greater child internalizing (β = .34; p < .001) and externalizing symptoms (β = .22; p = .002), regardless of the presence/absence of paternal depression. In families with low socioeconomic status, associations with symptoms were stronger with concurrent paternal depression (internalizing, β = .84, p < .001; externalizing, β = .71, p = .003) than without (internalizing, β = .30, p < .001; externalizing, β = .24, p = .002).nnCONCLUSIONS: Maternal depression increases the risk for children's internalizing/externalizing problems in all socioeconomic contexts. In families with low socioeconomic status, risks were exacerbated by concurrent paternal depression. Postpartum depression, especially in low socioeconomic environments, should be a primary focus to optimize mental health across generations.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39890228,

title = {Social and health disparities associated with healthy brain ageing in Brazil and in other Latin American countries},

author = {Lucas U Da Ros and Wyllians Vendramini Borelli and Cristiano Schaffer Aguzzoli and Marco Antônio De Bastiani and Lucas Porcello Schilling and Hernando Santamaria-Garcia and Tharick A Pascoal and Pedro Rosa-Neto and Diogo O Souza and Jaderson Costa da Costa and Agustin Ibañez and Claudia Kimie Suemoto and Eduardo R Zimmer},

doi = {10.1016/S2214-109X(24)00451-0},

issn = {2214-109X},

year  = {2025},

date = {2025-02-01},

journal = {Lancet Glob Health},

volume = {13},

number = {2},

pages = {e277--e284},

abstract = {BACKGROUND: Latin American countries present major health-related inequities due to historical, cultural, and social aspects. Recent evidence highlights that factors related to social and health disparities outweigh classic demographic factors in determining healthy brain aging in these populations. However, these analyses have not been conducted with the Brazilian population, the largest and most ethnically diverse population in Latin America.nnMETHODS: Here, we evaluated demographic, social, and health factors for healthy brain ageing using a machine learning model in a Brazilian population-based cohort (n=9412) and in additional cohorts from other Latin American countries, including Colombia (n=23 694), Chile (n=1301), Ecuador (n=5235), and Uruguay (n=1450).nnFINDINGS: In the Brazilian population and other Latin American countries, social and health disparities were more influential than demographic factors for cognition and functional ability. Uniquely in Brazil, education emerged as the primary risk factor impacting cognitive outcomes, diverging from other Latin American countries where mental health symptoms played more prominent roles. In terms of functional ability, Brazil displayed a distinct pattern, with mental health symptoms identified as the primary contributing factor.nnINTERPRETATION: Our findings indicate that Brazil converges with other Latin American countries to show that heterogeneous factors impacted more than demographic factors, but also showed a unique set of health factors when compared with other Latin American countries. Therefore, our study emphasises that social and health disparity factors are relevant predictors of healthy brain ageing in Latin America, but population-specific analyses are necessary to identify the specific risk profiles of each country.nnFUNDING: None.nnTRANSLATIONS: For the Portuguese and Spanish translations of the abstract see Supplementary Materials section.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40016352,

title = {Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood-brain barrier alterations},

author = {Katarzyna A Dudek and Sam E J Paton and Luisa Bandeira Binder and Adeline Collignon and Laurence Dion-Albert and Alice Cadoret and Manon Lebel and Olivier Lavoie and Jonathan Bouchard and Fernanda Neutzling Kaufmann and Valerie Clavet-Fournier and Claudia Manca and Manuel Guzmán and Matthew Campbell and Gustavo Turecki and Naguib Mechawar and Nicolas Flamand and Flavie Lavoie-Cardinal and Cristoforo Silvestri and Vincenzo Di Marzo and Caroline Menard},

doi = {10.1038/s41593-025-01891-9},

issn = {1546-1726},

year  = {2025},

date = {2025-02-01},

journal = {Nat Neurosci},

abstract = {Blood-brain barrier (BBB) alterations contribute to stress vulnerability and the development of depressive behaviors. In contrast, neurovascular adaptations underlying stress resilience remain unclear. Here we report that high expression of astrocytic cannabinoid receptor 1 (CB1) in the nucleus accumbens (NAc) shell, particularly in the end-feet ensheathing blood vessels, is associated with resilience during chronic social stress in adult male mice. Viral-mediated overexpression of Cnr1 in astrocytes of the NAc shell results in baseline anxiolytic effects and dampens stress-induced anxiety- and depression-like behaviors in male mice. It promotes the expression of vascular-related genes and reduces astrocyte inflammatory response and morphological changes following an immune challenge with the cytokine interleukin-6, linked to stress susceptibility and mood disorders. Physical exercise and antidepressant treatment increase the expression of astrocytic Cnr1 in the perivascular region in male mice. In human tissue from male donors with major depressive disorder, we observe loss of CNR1 in the NAc astrocytes. Our findings suggest a role for the astrocytic endocannabinoid system in stress responses via modulation of the BBB.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40015233,

title = {Association of anticholinergic burden with hippocampal subfields volume in first-episode psychosis},

author = {Agnès Belkacem and Katie M Lavigne and Delphine Raucher-Chéné and Carolina Makowski and Mallar Chakravarty and Ridha Joober and Ashok Malla and Jai Shah and Martin Lepage},

doi = {10.1016/j.pscychresns.2025.111968},

issn = {1872-7506},

year  = {2025},

date = {2025-02-01},

journal = {Psychiatry Res Neuroimaging},

volume = {348},

pages = {111968},

abstract = {Polypharmacy is relatively common in early psychosis, but little attention has been paid to the anticholinergic burden of medication use (the cumulative effect of medications that block the cholinergic system). Evidence suggests that anticholinergic burden is associated with cognitive deficits and that hippocampal dysfunction may be involved in those impairments. We aimed to examine this association in a cohort of patients with first-episode psychosis. We hypothesized that patients with the highest burden would experience a more significant reduction in hippocampal volume compared to those with low burden and healthy controls, both at baseline (3 months) and at month 12. Patients (n = 82; low burden [n = 64] and high burden [n = 18], defined by a Drug Burden Index cut-off of 1) followed at the PEPP-Montreal clinic, and controls (n = 55) completed a 3T MRI at both timepoints. After controlling for antipsychotic dosage at both timepoints, results at baseline and over time revealed a greater reduction in left fimbria volumes in high-burden patients compared to low-burden patients and controls. Overall, the associations observed between high anticholinergic burden and hippocampal volume provide further evidence for considering this dimension when prescribing medication in early psychosis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40015076,

title = {Commentary: Examining language and selfhood in hallucinations},

author = {Lena Palaniyappan and Oliver Delgaram-Nejad},

doi = {10.1016/j.schres.2025.02.014},

issn = {1573-2509},

year  = {2025},

date = {2025-02-01},

journal = {Schizophr Res},

volume = {277},

pages = {42--43},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40013320,

title = {The association between temperament and polygenic score for psychopathology from infancy to middle childhood},

author = {Eloise Freitag and Caroline Kelsey and Euclides José de Mendonça Filho and Irina Pokhvisneva and Sachin Patel and Patricia Pelufo Silveira and Michelle Bosquet Enlow and Charles A Nelson},

doi = {10.1111/jcpp.14140},

issn = {1469-7610},

year  = {2025},

date = {2025-02-01},

journal = {J Child Psychol Psychiatry},

abstract = {BACKGROUND: Certain temperament characteristics, such as low effortful control and high negative affectivity, are linked to an elevated likelihood for later psychopathology. Although genetic vulnerability has been associated with a number of psychiatric conditions, little work has examined the genetic architecture underlying temperament or the genetic overlap between early temperament profiles and later mental health outcomes. The present study examined associations of polygenic scores for anxiety (PGS-Anxiety) and ADHD (PGS-ADHD) with temperament characteristics in a longitudinal sample of children assessed from infancy through age 7 years.nnMETHODS: Analyses were conducted in a sample of children (European Ancestry n = 476; Full Sample [European and other ancestries] N = 606).nnRESULTS: We observed an age-by-PGS interaction on effortful control. As children aged, there appeared to be stronger negative associations between PGS-ADHD and effortful control. No associations were observed between PGS-Anxiety and negative affectivity.nnCONCLUSIONS: Overall, the findings suggest some support for associations between genetic underpinnings for externalizing psychopathology and temperament that increase over time.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40009399,

title = {An Approach to Providing Timely Mental Health Services to Diverse Youth Populations},

author = {Srividya N Iyer and Patricia Boksa and Ridha Joober and Jai Shah and Rebecca Fuhrer and Neil Andersson and Shalini Lal and Giuseppe D'Andrea and Nora Morrison and Valerie Noel and Daniel Rabouin and Tovah Cowan and Kathleen MacDonald and Mary Anne Levasseur and Feodor Poukhovski-Sheremetyev and Amal Abdel-Baki and Lacey Augustine and Kevin Friese and Isabelle Godin and Katherine Hay and Daphne Hutt-MacLeod and Vickie Plourde and Norma Rabbitskin and Paula Reaume-Zimmer and Cécile Rousseau and Heather Rudderham and Adam Abba-Aji and Diane Aubin and Liana Urichuk and Helen Vallianatos and Shirin Golchi and Ina Winkelmann and Jessica Chisholm-Nelson and Ashok Malla},

doi = {10.1001/jamapsychiatry.2024.4880},

issn = {2168-6238},

year  = {2025},

date = {2025-02-01},

journal = {JAMA Psychiatry},

abstract = {IMPORTANCE: Accessing mental health care is challenging for youths, especially those facing intersectional disadvantages, but whether enhancing youth services increases reach and timeliness has rarely been investigated. ACCESS Open Minds (ACCESS-OM) transformed services at urban, rural, and Indigenous sites in Canada using 5 principles (early identification, rapid access, appropriate care, no age-based transitions from 11-25 years, and youth and family engagement).nnOBJECTIVE: To evaluate whether the number of youths referred (hypothesis 1), offered evaluation appointments within 72 hours of referral (hypothesis 2), and receiving services within 30 days of the first appointment (hypothesis 3) increased over the course of ACCESS-OM's implementation.nnDESIGN, SETTING, AND PARTICIPANTS: This cohort study included youths (aged 11-25 years) at 11 sites referred between March 2016 and December 2020. Data were analyzed from April 2022 to April 2024.nnEXPOSURE: Existing primary and/or community services implemented ACCESS-OM's core components: broad-spectrum mental health services, outreach, youth-friendly walk-in spaces, open systems accepting referrals from multiple sources, and response-time benchmarks (72 hours to evaluation and 30 days to start treatment).nnMAIN OUTCOMES AND MEASURES: Outcomes were the referral rate and the probability of being offered a first evaluation within 72 hours and receiving services within 30 days. Dates of referral and/or help-seeking, first offered appointment, first evaluation, and first services received were recorded. Multilevel negative binomial regression was used for hypothesis 1, and time-to-event analyses followed by multilevel accelerated failure time (AFT) models were used for hypotheses 2 and 3.nnRESULTS: A total of 7889 youths were referred; 4519 (mean [SD] age, 19.3 [3.4] years; 2440 [54%] cisgender women; 1049 [23.21%] Indigenous; 991 [21.93%] Visible Minority [Arab, Black, Chinese, Filipino, Japanese, Korean, Latin American, South Asian, Southeast Asian, West Asian, other ethnicity, and multiple ethnicities]; and 1525 [49.10%] White) were evaluated before March 2020. Each 6-month progression after implementation was associated with a 10% increase in referral rates (IRR, 1.10; 95% CI, 1.07-1.13). The probability of being offered an initial appointment (χ22 = 20.30; P < .001) and receiving services (χ22 = 4.48; P = .01) after any given delay differed significantly over the 3 years. In adjusted AFT models, each 6-month progression was associated with a 3% decrease in time to offered evaluation (time ratio [TR], 0.97; 95% CI, 0.95-0.99) and first services (TR, 0.97; 95% CI, 0.94-1.00). Moderate to severe mental health problems were associated with longer delays to offered first appointments (TR, 1.14; 95% CI, 1.06-1.24) and services (TR, 1.11; 95% CI, 1.01-1.22).nnCONCLUSIONS AND RELEVANCE: As hypothesized, after ACCESS-OM implementation, more youths sought help, and the timeliness of initial response and services improved over time. These findings suggest that core principles, benchmarks, and implementation supports are valuable in organizing youth mental health care. Future efforts should make benefits equitable for those with severe problems.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39916486,

title = {Longitudinal Relationships of Phubbing, Depression, and Anxiety in the Middle and High School Students: A Cross-Lagged Panel Network Analysis},

author = {Tingting Gao and Yan Chen and Qian Gai and Yingying Su and Xiangfei Meng},

doi = {10.1002/jad.12481},

issn = {1095-9254},

year  = {2025},

date = {2025-02-01},

journal = {J Adolesc},

abstract = {INTRODUCTION: Prior research has documented the associations among phubbing, depression, and anxiety, while the cross-sectional design failed to clarify the temporal directionality of the relationships between these mental disorders and behavioral issues. To bridge this gap, the present study utilizing longitudinal data aimed to articulate the temporal relationships between these mental disorders and behavioral issues.nnMETHODS: A total of 3296 adolescents from China (54.5% girls; M = 15.17) participated in the study. Symptoms of phubbing, depression, and anxiety were assessed 18 months later (May 2023) after the baseline (November, 2021). The cross-sectional network and cross-lagged panel network models were conducted to explore the associations between the network structures of phubbing, depression, and anxiety. The network comparison test (NCT) was then performed to unveil whether the network structures vary based on school grade.nnRESULTS: In the cross-sectional network, significant differences in the overall structures between middle and high school students were observed. For the longitudinal network, the core symptoms responsible for temporal relationships were mostly between depressive and anxiety symptoms. Phubbing-related symptoms and restlessness (anxiety symptom) were the bridge symptoms of phubbing, depression, and anxiety. Besides, the central bridges associated with phubbing-related symptoms differed significantly across different school stages.nnCONCLUSIONS: Successfully regulating negative emotions can play a pivotal role in tackling the root causes linked to phubbing. Apart from addressing restlessness, future interventions focusing on nomophobia and interpersonal conflict in middle school students, as well as self-isolation in high school students, contributed to mitigating phubbing, depression, and anxiety.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39956789,

title = {Quantitative natural language processing markers of psychoactive drug effects: A pre-registered systematic review},

author = {Sachin Ahuja and Farida Zaher and Lena Palaniyappan},

doi = {10.1177/02698811251319455},

issn = {1461-7285},

year  = {2025},

date = {2025-02-01},

journal = {J Psychopharmacol},

pages = {2698811251319455},

abstract = {Psychoactive substances used for recreational purposes have mind-altering effects, but systematic evaluation of these effects is largely limited to self-reports. Automated analysis of expressed language (speech and written text) using natural language processing (NLP) tools can provide objective readouts of mental states. In this pre-registered systematic review, we investigate findings from applying the emerging field of computational linguistics to substance use with specific focus on identifying short-term effects of psychoactive drugs. From the literature identified to date, we note that all the studied drugs - stimulants, 3,4-methylenedioxymethamphetamine (MDMA), cannabis, ketamine and psychedelics - affect language production. Based on two or more studies per substance, we note some emerging patterns: stimulants increase verbosity; lysergic acid diethylamide reduces the lexicon; MDMA increases semantic proximity to emotional words; psilocybin increases positive sentiment and cannabis affects speech stream acoustics. Ketamine and other drugs are understudied regarding NLP features (one or no studies). One study provided externally validated support for NLP and machine learning-based identification of MDMA intoxication. We could not undertake a meta-analysis due to the high degree of heterogeneity among outcome measures and the lack of sufficient number of studies. We identify a need for harmonised speech tasks to improve replicability and comparability, standardisation of methods for curating and analysing speech and text data, theory-driven inquiries and the need for developing a shared 'substance use language corpus' for data mining. The growing field of computational linguistics can be utilized to advance human behavioral pharmacology of psychoactive substances. Achieving this will require concerted efforts towards consistency in research methods.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39960728,

title = {Temporal Dynamics and Biological Variability of Alzheimer Biomarkers},

author = {Jihwan Yun and Daeun Shin and Eun Hye Lee and Jun Pyo Kim and Hongki Ham and Yuna Gu and Min Young Chun and Sung Hoon Kang and Hee Jin Kim and Duk L Na and Chi-Hun Kim and Ko Woon Kim and Si Eun Kim and Yeshin Kim and Jaeho Kim and Na-Yeon Jung and Yeo Jin Kim and Soo Hyun Cho and Henrik Zetterberg and Kaj Blennow and Fernando Gonzalez-Ortiz and Nicholas J Ashton and Joseph Therriault and Nesrine Rahmouni and Pedro Rosa-Neto and Michael W Weiner and Sang Won Seo and Hyemin Jang and },

doi = {10.1001/jamaneurol.2024.5263},

issn = {2168-6157},

year  = {2025},

date = {2025-02-01},

journal = {JAMA Neurol},

abstract = {IMPORTANCE: Understanding the characteristics of discordance between plasma biomarkers and positron emission tomography (PET) results in Alzheimer disease (AD) is crucial for accurate interpretation of the findings.nnOBJECTIVE: To compare (1) medical comorbidities affecting plasma biomarker concentrations, (2) imaging and clinical features, and (3) cognitive changes between plasma biomarker and PET discordant and concordant cases.nnDESIGN, SETTING, AND PARTICIPANTS: This multicenter cohort study, conducted between 2016 and 2023, included individuals with unimpaired cognition, mild cognitive impairment, or Alzheimer-type dementia, who had both amyloid β (Aβ) PET imaging and plasma biomarkers. A subset of participants also underwent tau PET imaging.nnEXPOSURES: Participants were categorized into 4 groups based on their plasma and PET biomarker results: plasma-/PET-, plasma+/PET-, plasma-/PET+, and plasma+/PET+.nnMAIN OUTCOMES AND MEASURES: Clinical characteristics were compared between the 4 groups, focusing on the discordant groups.nnRESULTS: A total of 2611 participants (mean [SD] age was 71.2 [8.7] years; 1656 female [63.4%]), of whom 124 additionally underwent tau PET, were included. Among the plasma biomarkers, phosphorylated tau (p-tau) 217 exhibited the highest concordance rate with Aβ (2326 of 2571 [90.5%]) and tau (100 of 120 [83.3%]) PET. The p-tau217+/Aβ PET- group was older (mean [SD] age, 75.8 [7.2] years vs 70.0 [8.8] years; P < .001) with a higher prevalence of hypertension (56 of 152 [36.8%] vs 266 of 1073 [25.0%]), diabetes (40 of 152 [26.3%] vs 156 of 1059 [14.7%]), and chronic kidney disease (17 of 152 [11.2%] vs 21 of 1073 [2.0%]) compared with the p-tau217-/Aβ PET- group (P < .001 for all). Body mass index was higher in p-tau217-/Aβ PET+ than in p-tau217+/Aβ PET+ (mean [SD], 24.1 [2.8] vs 23.1 [3.1], respectively; P = .001; calculated as weight in kilograms divided by height in meters squared). The p-tau217+/Aβ PET- group had lower hippocampal volume (mean [SD], 2555.4 [576.9] vs 2979.1 [545.8]; P < .001) and worse clinical trajectory compared with p-tau217-/Aβ PET- (β = -0.53; P < .001). In contrast, tau PET discordant cases did not show significant differences in medical comorbidities or clinical outcomes compared with the p-tau217-/tau PET- group. Only the p-tau 217+/tau PET+ group demonstrated faster cognitive deterioration compared with the p-tau 217-/tau PET- group (β = -1.66; P < .001).nnCONCLUSIONS AND RELEVANCE: Results of this cohort study suggest that the mechanisms underlying the discordance between plasma biomarkers and PET findings may be multifaceted, underscoring the need to consider the temporal dynamics and biological variability of plasma biomarkers.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39954253,

title = {A multi-omics and cell type-specific characterization of the ventral striatum in human cocaine use disorder},

author = {Eric Zillich and Annasara Artioli and Andrea C Rossetti and Diana Avetyan and Hanna Belschner and Josef Frank and Frank Stein and Jennifer J Schwarz and Naguib Mechawar and Gustavo Turecki and Markus M Nöthen and Anita C Hansson and Christian C Witt and Marcella Rietschel and Philipp Koch and Rainer Spanagel and Lea Zillich and Stephanie H Witt},

doi = {10.1016/j.celrep.2025.115332},

issn = {2211-1247},

year  = {2025},

date = {2025-02-01},

journal = {Cell Rep},

volume = {44},

number = {2},

pages = {115332},

abstract = {Epigenome, transcriptome, and proteome analyses of postmortem brains have revealed initial molecular insights into cocaine use disorder (CUD). However, the inter-relationship between these omics and the contribution of individual cell types remains largely unknown. We present an in-depth analysis of molecular changes in the ventral striatum in CUD at multi-omics and single-cell resolution. Integrative multi-omics analyses of microRNA sequencing (microRNA-seq), RNA sequencing (RNA-seq), and proteomics datasets in 41 individuals and single-nuclei RNA-seq in a subset of 16 individuals revealed conserved deregulation of metabolic pathways, oxidative phosphorylation, and glutamatergic signaling. Cell type-specific analyses identified inverse metabolic pathway deregulation patterns in glial and neuronal cells, notably in astrocytes and medium-spiny neurons (MSNs). Characterizing astrocyte-neuron crosstalk revealed altered glutamatergic and cell-cell adhesion signaling in CUD. By applying a comprehensive multi-omics analytical framework, our study provides novel insights into CUD-associated molecular changes in the ventral striatum highlighting the perturbation of astrocytes, MSNs, and their crosstalk in CUD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39954093,

title = {Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus},

author = {Sonja Fixemer and Mónica Miranda de la Maza and Gaël Paul Hammer and Félicia Jeannelle and Sophie Schreiner and Jean-Jacques Gérardy and Susana Boluda and Dominique Mirault and Naguib Mechawar and Michel Mittelbronn and David S Bouvier},

doi = {10.1007/s00401-025-02857-8},

issn = {1432-0533},

year  = {2025},

date = {2025-02-01},

journal = {Acta Neuropathol},

volume = {149},

number = {1},

pages = {19},

abstract = {In Alzheimer's disease (AD), microglia form distinct cellular aggregates that play critical roles in disease progression, including Aβ plaque-associated microglia (PaM) and the newly identified coffin-like microglia (CoM). PaM are closely associated with amyloid-β (Aβ) plaques, while CoM are enriched in the pyramidal layer of the CA2/CA1 hippocampal subfields, where they frequently engulf neurons and associate with tau-positive tangles and phosphorylated α-synuclein. To elucidate the role of these microglial subtypes, we employed high-content neuropathology, integrating Deep Spatial Profiling (DSP), multiplex chromogenic immunohistochemistry and confocal microscopy, to comprehensively map and characterise their morphological and molecular signatures, as well as their neuropathological and astrocytic microenvironments, in AD and control post-mortem samples. PaM and PaM-associated astrocytes exhibited signatures related to complement system pathways, ErbB signalling, and metabolic and neurodegenerative processes. In contrast, CoM displayed markers associated with protein degradation and immune signalling pathways, including STING, TGF-β, and NF-κB. While no direct association between CD8 + T cells and either microglial type was observed, CD163 + perivascular macrophages were frequently incorporated into PaM. These findings provide novel insights into the heterogeneity of microglial responses, in particular their distinct interactions with astrocytes and infiltrating immune cells, and shed light on specific neurodegenerative hotspots and their implications for hippocampal deterioration in AD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39952947,

title = {Patient-centered brain transcriptomic and multimodal imaging determinants of clinical progression, physical activity, and treatment needs in Parkinson's disease},

author = {Quadri Adewale and Ahmed Faraz Khan and Sue-Jin Lin and Tobias R Baumeister and Yashar Zeighami and Felix Carbonell and Daniel Ferreira and Yasser Iturria-Medina},

doi = {10.1038/s41531-025-00878-4},

issn = {2373-8057},

year  = {2025},

date = {2025-02-01},

journal = {NPJ Parkinsons Dis},

volume = {11},

number = {1},

pages = {29},

abstract = {We continue to lack a clear understanding on how the biological and clinical complexity of Parkinson's disease emerges from molecular to macroscopic brain interactions. Here, we use personalized multiscale spatiotemporal computational brain models to characterize for the first time the synergistic links between genes, several multimodal neuroimaging-derived biological factors, clinical profiles, and therapeutic needs in PD. We identified genes modulating PD-caused brain reorganization in dopamine transporter level, neuronal activity integrity, microstructure, dendrite density and tissue atrophy. Inter-individual heterogeneity in the identified gene-mediated biological mechanisms was associated with five distinct configurations of PD motor and non-motor symptoms. Notably, the protein-protein interaction networks underlying both brain phenotypic and symptom configurations in PD revealed distinct hub genes including MYC, CCNA2, CCDK1, SRC, STAT3 and PSMD4. We also studied the biological mechanisms associated with physical activities performance, observing that leisure and work activities are strongly related to neurotypical cholesterol homeostasis and inflammatory response processes, respectively. Finally, patient-tailored in silico gene perturbations revealed a set of putative disease-modifying drugs with potential to effectively treat PD across different biological levels, most of which are associated with dopamine reuptake and anti-inflammation. Our study constitutes the first self-contained multiscale spatiotemporal computational approach providing comprehensive insights into the complex multifactorial pathogenesis of PD, unraveling key biological modulators of physical and clinical deterioration, and serving as a blueprint for optimum drug selection at personalized level.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39961166,

title = {Exploring morphological and microstructural signatures across the Alzheimer's spectrum and risk factors},

author = {Aurélie Bussy and Raihaan Patel and Olivier Parent and Alyssa Salaciak and Saashi A Bedford and Sarah Farzin and Stephanie Tullo and Cynthia Picard and Sylvia Villeneuve and Judes Poirier and John Cs Breitner and Gabriel A Devenyi and  and Christine L Tardif and M Mallar Chakravarty},

doi = {10.1016/j.neurobiolaging.2025.01.011},

issn = {1558-1497},

year  = {2025},

date = {2025-02-01},

journal = {Neurobiol Aging},

volume = {149},

pages = {1--18},

abstract = {Neural alterations, including myelin degeneration and inflammation-related iron burden, may accompany early Alzheimer's disease (AD) pathophysiology. This study aims to identify multi-modal signatures associated with MRI-derived atrophy and quantitative MRI (qMRI) measures of myelin and iron in a unique dataset of 158 participants across the AD spectrum, including those without cognitive impairment, at familial risk for AD, with mild cognitive impairment, and with AD dementia. Our results revealed a brain pattern with decreased cortical thickness, indicating increased neuronal death, and compromised hippocampal integrity due to reduced myelin content. This pattern was associated with lifestyle factors such as smoking, high blood pressure, high cholesterol, and anxiety, as well as older age, AD progression, and APOE-ɛ4 carrier status. These findings underscore the value of qMRI metrics as a non-invasive tool, offering sensitivity to lifestyle-related modifiable risk factors and medical history, even in preclinical stages of AD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39966047,

title = {Impact of Respiratory Discomfort on Vocal Quality and Perceived Effort: The Moderating Role of Fear},

author = {Maude Desjardins and Valérie Jomphe and Alexane Gilbert and Vincent Martel-Sauvageau and Alexandre David-Uraz and Shaheen N Awan and Jorge L Armony},

doi = {10.1016/j.jvoice.2025.01.034},

issn = {1873-4588},

year  = {2025},

date = {2025-02-01},

journal = {J Voice},

abstract = {OBJECTIVES/HYPOTHESIS: The goal of this study was to investigate the relationship between respiratory discomfort and voice measures, including perceived vocal effort and selected acoustic parameters. A secondary aim was to examine whether threat appraisal-measured as susceptibility to experience fear of suffocation-modulated these relationships. We hypothesized that greater dyspnea would predict worse voice outcomes, especially in speakers with greater fear susceptibility.nnSTUDY DESIGN: Repeated measures study.nnMETHODS: Fifty-eight healthy females were submitted to various levels of respiratory discomfort through rounds of breath-holding while they rated their perceived dyspnea. Participants performed a phonation task-in a comfortable and a loud voice-immediately after each breath hold and rated their perceived vocal effort and fear of suffocation. Smoothed cepstral peak prominence (CPPS), harmonics-to-noise ratio (HNR), mean fundamental frequency (mean F), relative level of high-frequency noise (Hfno), and amplitude difference between the first two harmonics (H-H) were extracted. Linear mixed models and repeated measures correlations were generated to assess the relationships between dyspnea, fear susceptibility, and voice measures.nnRESULTS: In the vocal effort models for comfortable and loud phonation, dyspnea was a significant predictor (P < 0.0001) and interacted significantly with fear susceptibility (P < 0.0001). In the comfortable condition, dyspnea was also found to be a significant predictor for CPPS (P = 0.0014) and mean F (P = 0.0003) and interacted significantly with fear susceptibility in the CPPS model (P = 0.0051). Post hoc analyses showed that perceived vocal effort increased as dyspnea intensified, especially in participants with greater fear susceptibility. The direction of CPPS fluctuations with increasing dyspnea varied based on level of fear susceptibility, although correlations were weak.nnCONCLUSIONS: The relationships between respiratory discomfort and voice were influenced by fear, suggesting that sensory and affective mechanisms interact when impacting voice production and vocal effort perception. Future studies could investigate whether similar interactions may impact laryngeal function in voice and upper airway disorders.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39911018,

title = {New diagnosis in psychiatry: beyond heuristics},

author = {Patrick D McGorry and Ian B Hickie and Roman Kotov and Lianne Schmaal and Stephen J Wood and Sophie M Allan and Kürşat Altınbaş and Niall Boyce and Laura F Bringmann and Avshalom Caspi and Bruce Cuthbert and Łukasz Gawęda and Robin N Groen and Sinan Guloksuz and Jessica A Hartmann and Robert F Krueger and Cristina Mei and Dorien Nieman and Dost Öngür and Andrea Raballo and Marten Scheffer and Marieke J Schreuder and Jai L Shah and Johanna T W Wigman and Hok Pan Yuen and Barnaby Nelson},

doi = {10.1017/S003329172400223X},

issn = {1469-8978},

year  = {2025},

date = {2025-02-01},

journal = {Psychol Med},

volume = {55},

pages = {e26},

abstract = {BACKGROUND: Diagnosis in psychiatry faces familiar challenges. Validity and utility remain elusive, and confusion regarding the fluid and arbitrary border between mental health and illness is increasing. The mainstream strategy has been conservative and iterative, retaining current nosology until something better emerges. However, this has led to stagnation. New conceptual frameworks are urgently required to catalyze a genuine paradigm shift.nnMETHODS: We outline candidate strategies that could pave the way for such a paradigm shift. These include the Research Domain Criteria (RDoC), the Hierarchical Taxonomy of Psychopathology (HiTOP), and Clinical Staging, which all promote a blend of dimensional and categorical approaches.nnRESULTS: These alternative still heuristic transdiagnostic models provide varying levels of clinical and research utility. RDoC was intended to provide a framework to reorient research beyond the constraints of DSM. HiTOP began as a nosology derived from statistical methods and is now pursuing clinical utility. Clinical Staging aims to both expand the scope and refine the utility of diagnosis by the inclusion of the dimension of timing. None is yet fit for purpose. Yet they are relatively complementary, and it may be possible for them to operate as an ecosystem. Time will tell whether they have the capacity singly or jointly to deliver a paradigm shift.nnCONCLUSIONS: Several heuristic models have been developed that separately or synergistically build infrastructure to enable new transdiagnostic research to define the structure, development, and mechanisms of mental disorders, to guide treatment and better meet the needs of patients, policymakers, and society.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39938231,

title = {Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelination},

author = {Jian Huang and Jinyi Che and Michelle Z L Kee and Ai Peng Tan and Evelyn C Law and Patricia Pelufo Silveira and Irina Pokhvisneva and Sachin Patel and Keith M Godfrey and Lourdes Mary Daniel and Kok Hian Tan and Yap Seng Chong and Shiao-Yng Chan and Johan G Eriksson and Dennis Wang and Jonathan Yinhao Huang},

doi = {10.1016/j.ebiom.2025.105579},

issn = {2352-3964},

year  = {2025},

date = {2025-02-01},

journal = {EBioMedicine},

volume = {113},

pages = {105579},

abstract = {BACKGROUND: The association between childhood obesity and language development may be confounded by socio-environmental factors and attributed to comorbid pathways.nnMETHODS: In a longitudinal Singaporean mother-offspring cohort, we leveraged trans-ancestry polygenic predictions of body mass index (BMI) to interrogate the causal effects of early-life BMI on child language development and its effects on molecular and neuroimaging measures. Leveraging large genome-wide association studies, we examined whether the link between obesity and language development is causal or due to a shared genetic basis.nnFINDINGS: We found an inverse association between polygenic risk for obesity, which is less susceptible to confounding, and language ability assessed at age 9. Our findings suggested a shared genetic basis between obesity and language development rather than a causal effect of obesity on language development. Interrogating early-life mechanisms including neurology-related proteomics and language-related white matter microstructure, we found that EFNA4 and VWC2 expressions were associated with language ability as well as fractional anisotropy of language-related white matter tracts, suggesting a role in brain myelination. Additionally, the expression of the EPH-Ephrin signalling pathway in the hippocampus might contribute to language development. Polygenic risk for obesity was nominally associated with EFNA4 and VWC2 expression. However, we did not find support for mediating mechanisms via these proteins.nnINTERPRETATION: This study demonstrates the potential of examining early-life proteomics in conjunction with deep genotyping and phenotyping and provides biological insights into the shared genomic links between obesity and language development.nnFUNDING: Singapore National Research Foundation and Agency for Science, Technology and Research.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39923816,

title = {Transcriptional and neurochemical signatures of cerebral blood flow alterations in schizophrenia and individuals at clinical high-risk for psychosis},

author = {Samuel R Knight and Leyla Abbasova and Yashar Zeighami and Justine Y Hansen and Daniel Martins and Fernando Zelaya and Ottavia Dipasquale and Thomas Liu and David Shin and Matthijs Bossong and Matilda Azis and Mathilde Antoniades and Oliver D Howes and Ilaria Bonoldi and Alice Egerton and Paul Allen and Owen O'Daly and Philip McGuire and Gemma Modinos},

doi = {10.1016/j.biopsych.2025.01.028},

issn = {1873-2402},

year  = {2025},

date = {2025-02-01},

journal = {Biol Psychiatry},

abstract = {BACKGROUND: The brain integrates multiple scales of description, from the level of cells and molecules to large-scale networks and behaviour. Understanding relationships across these scales may be fundamental to advancing understanding of brain function in health and disease. Recent neuroimaging research has shown that functional brain alterations that are associated with schizophrenia spectrum disorders (SSD) are already present in young adults at clinical high-risk for psychosis (CHR-P), yet the cellular and molecular determinants of these alterations remain unclear.nnMETHODS: Here, we used regional cerebral blood flow (rCBF) data from 425 individuals (122 SSD compared to 116 HCs, and 129 CHR-P compared to 58 HCs) and applied a novel pipeline to integrate brain-wide rCBF case-control maps with publicly available transcriptomic data (17,205 gene maps) and neurotransmitter atlases (19 maps) from 1074 healthy volunteers.nnRESULTS: We identified significant correlations between astrocyte, oligodendrocyte precursor cell, and vascular leptomeningeal cell gene modules for both SSD and CHR-P rCBF phenotypes, and additionally microglia and oligodendrocytes in CHR-P. Receptor distribution significantly predicted case-control rCBF differences, with dominance analysis highlighting dopamine (D, D, DAT), acetylcholine (VAChT, M), GABA, and NMDA receptors as key predictors for SSD (R=.58, P<.05) and CHR-P (R=.6, P<.05) rCBF phenotypes. These associations were primarily localised in subcortical regions and implicate cell-types involved in stress response and inflammation, alongside specific neuroreceptor systems, in shared and distinct rCBF phenotypes in psychosis.nnCONCLUSIONS: Our findings underscore the value of integrating multi-scale data as a promising hypothesis-generating approach towards decoding biological pathways involved in neuroimaging-based psychosis phenotypes, potentially guiding novel interventions.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39967311,

title = {The Deubiquitinase USP2 Modulates Photic Entrainment of the Circadian Clock at the Level of the Suprachiasmatic Nucleus},

author = {Shashank B Srikanta and Thomas W Brown and Antoine Malescot and Marie-Ève Cloutier and Lei Zhu and Christine Coutanson and Maryam Malki and Kai-Florian Storch and Ravi Rungta and Michel Cayouette and Ouria Dkhissi-Benyahya and Nicolas Cermakian},

doi = {10.1111/jnc.70018},

issn = {1471-4159},

year  = {2025},

date = {2025-02-01},

journal = {J Neurochem},

volume = {169},

number = {2},

pages = {e70018},

abstract = {Ubiquitin-specific peptidase 2 (USP2) is a deubiquitinase (DUB) with a diversity of functions in physiology. One of these functions is the regulation of circadian rhythms, which are physiological rhythms with a period of ~24 h. Previous studies have indicated a role for USP2 in photic entrainment, the process by which circadian clocks synchronize to environmental light cues. Here, we investigated the implication of USP2 in this process, using Usp2 knockout (KO) mice. Using different light treatments and running wheel recordings, we established that USP2 controls entrainment of the clock to light cues at dusk. Further, we showed that Usp2 is expressed throughout the suprachiasmatic nucleus (SCN), the site of the central clock, and in the retina. This raised the question of where USP2 acts on circadian photoreception. We found that it is not within the retina, as retinas of Usp2 KO mice have an intact structure and unaltered photoreception through intrinsically photosensitive retinal ganglion cells. Moreover, KO of Usp2 within the retina does not alter clock entrainment to light. In contract, KO of Usp2 in the SCN causes a light entrainment phenotype similar to full-body KO mice, showing that the action of USP2 in modulating photic entrainment predominantly takes place in the SCN. Finally, within the SCN, we found that induction of clock gene Per1 and activation of MAPK/ERK pathway in response to light were blunted in Usp2 KO mice. Altogether, we established a key role for USP2 in regulating photic entrainment by modulating light-responsive pathways within the SCN.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39972340,

title = {The impact of kidney function on Alzheimer's disease blood biomarkers: implications for predicting amyloid-β positivity},

author = {Burak Arslan and Wagner S Brum and Ilaria Pola and Joseph Therriault and Nesrine Rahmouni and Jenna Stevenson and Stijn Servaes and Kübra Tan and Paolo Vitali and Maxime Montembeault and Jesse Klostranec and Arthur C Macedo and Cecile Tissot and Serge Gauthier and Juan Lantero-Rodriguez and Eduardo R Zimmer and Kaj Blennow and Henrik Zetterberg and Pedro Rosa-Neto and Andrea L Benedet and Nicholas J Ashton},

doi = {10.1186/s13195-025-01692-z},

issn = {1758-9193},

year  = {2025},

date = {2025-02-01},

journal = {Alzheimers Res Ther},

volume = {17},

number = {1},

pages = {48},

abstract = {BACKGROUND: Impaired kidney function has a potential confounding effect on blood biomarker levels, including biomarkers for Alzheimer's disease (AD). Given the imminent use of certain blood biomarkers in the routine diagnostic work-up of patients with suspected AD, knowledge on the potential impact of comorbidities on the utility of blood biomarkers is important. We aimed to evaluate the association between kidney function, assessed through estimated glomerular filtration rate (eGFR) calculated from plasma creatinine and AD blood biomarkers, as well as their influence over predicting Aβ-positivity.nnMETHODS: We included 242 participants from the Translational Biomarkers in Aging and Dementia (TRIAD) cohort, comprising cognitively unimpaired individuals (CU; n = 124), mild cognitive impairment (MCI; n = 58), AD dementia (n = 34), and non-AD dementia (n = 26) patients all characterized by [F] AZD-4694. Plasma samples were analyzed for Aβ42, Aβ40, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), tau phosphorylated at threonine 181 (p-tau181), 217 (p-tau217), 231 (p-tau231) and N-terminal containing tau fragments (NTA-tau) using Simoa technology. Kidney function was assessed by eGFR in mL/min/1.73 m, based on plasma creatinine levels, age, and sex. Participants were also stratified according to their eGFR-indexed stages of chronic kidney disease (CKD). We evaluated the association between eGFR and blood biomarker levels with linear models and assessed whether eGFR provided added predictive value to determine Aβ-positivity with logistic regression models.nnRESULTS: Biomarker concentrations were highest in individuals with CKD stage 3, followed by stages 2 and 1, but differences were only significant for NfL, Aβ42, and Aβ40 (not Aβ42/Aβ40). All investigated biomarkers showed significant associations with eGFR except plasma NTA-tau, with stronger relationships observed for Aβ40 and NfL. However, after adjusting for either age, sex or Aβ-PET SUVr, the association with eGFR was no longer significant for all biomarkers except Aβ40, Aβ42, NfL, and GFAP. When evaluating whether accounting for kidney function could lead to improved prediction of Aβ-positivity, we observed no improvements in model fit (Akaike Information Criterion, AIC) or in discriminative performance (AUC) by adding eGFR to a base model including each plasma biomarker, age, and sex. While covariates like age and sex improved model fit, eGFR contributed minimally, and there were no significant differences in clinical discrimination based on AUC values.nnCONCLUSIONS: We found that kidney function seems to be associated with AD blood biomarker concentrations. However, these associations did not remain significant after adjusting for age and sex, except for Aβ40, Aβ42, NfL, and GFAP. While covariates such as age and sex improved prediction of Aβ-positivity, including eGFR in the models did not lead to improved prediction for any biomarker. Our findings indicate that renal function, within the normal to mild impairment range, does not seem to have a clinically relevant impact when using highly accurate blood biomarkers, such as p-tau217, in a biomarker-supported diagnosis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39986368,

title = {White matter integrity and verbal memory following a first episode of psychosis: A longitudinal study},

author = {Joseph Ghanem and Jana F Totzek and Charlie Henri-Bellemare and Delphine Raucher-Chéné and Gregory Kiar and Raihaan Patel and M Mallar Chakravarty and Jai L Shah and Ridha Joober and Ashok Malla and Martin Lepage and Katie M Lavigne},

doi = {10.1016/j.pnpbp.2025.111294},

issn = {1878-4216},

year  = {2025},

date = {2025-02-01},

journal = {Prog Neuropsychopharmacol Biol Psychiatry},

volume = {137},

pages = {111294},

abstract = {Psychotic disorders are heterogeneous disorders for which there is evidence of structural and functional brain abnormalities. The role of white matter integrity, often measured via Fractional Anisotropy (FA), has played a controversial role in individuals with a first episode of psychosis (FEP). Similarly, some FEP studies have observed that higher FA is associated with better verbal memory, but others failed to find such an association. Studying the early stages of psychosis represents a promising avenue to overcome previous confounding factors and characterize the disease in its early clinical stages. Eighty individuals with a FEP were recruited from a specialized early intervention program for psychosis alongside 55 non-clinical controls from the community matched for age and sex. Both groups were followed and scanned 4 times: at baseline (within 3 months after program entry), 6 months, 12 months, and 18 months. Tract-Based Spatial Statistics (TBSS) were used on 3.0 Tesla diffusion-weighted images to extract fractional anisotropy values for white matter regions of interest in accordance with the John Hopkins University white-matter tractography atlas. The analysis revealed no significant main effect of group or time, and no significant associations between FA and verbal memory. Overall, differences in FA are small early in the course of illness and longer follow-up periods may be required to identify possible changes during a critical intervention window.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40000900,

title = {Neurite development varies across the hippocampus and covaries with the cellular composition of hippocampal tissue},

author = {Jonah Kember and Zeus Gracia-Tabuenca and Raihann Patel and Mallar Chakravarty and Xiaoqian J Chai},

doi = {10.1038/s42003-025-07725-5},

issn = {2399-3642},

year  = {2025},

date = {2025-02-01},

journal = {Commun Biol},

volume = {8},

number = {1},

pages = {302},

abstract = {The hippocampus is a critical brain structure supporting memory encoding and retrieval, yet the development of its microstructure in humans remains unknown. Understanding this development may provide insight into the mechanisms underlying memory and their disruption in disease. To address this, we non-invasively estimated the density and branching complexity of neurite (dendrites, axons, glial processes) using diffusion-weighted MRI in 364 participants aged 8-21. With development, large increases in neurite density and branching complexity persisted until ~15 years of age before stabilizing at adult-like values. Neurite density increases were relatively homogenous across hippocampal axes, whereas branching-complexity increases were heterogeneous: increasing primarily in CA1, SRLM, subiculum, and anterior hippocampus. To assess whether this development may be attributable to specific cell-types, we tested for spatial overlap between age-related change in neurite and cell-type composition of the adult hippocampus via cross-reference with an out-of-sample gene-expression atlas. We found age-related changes in neurite density occur in hippocampal locations which, in adults, consist of granule cells, whereas age-related changes in neurite branching complexity occur in locations consisting of pyramidal neurons. These results provide the first glimpse at the nonlinear maturation of hippocampal microstructure and the cell-type composition of hippocampal tissue underlying these changes.},

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}

@article{pmid39995200,

title = {Behavioral Tasks for Examining Identity Recognition In Mice},

author = {Amanda Larosa and Qi Wei Xu and Nastasia Maria Mitrikeski and Tak Pan Wong},

doi = {10.3791/67547},

issn = {1940-087X},

year  = {2025},

date = {2025-02-01},

journal = {J Vis Exp},

number = {216},

abstract = {Social animals, like rodents, are able to recognize and differentiate between the identity of familiar individuals. Recognizing the identity of familiar individuals is important for developing social structures such as hierarchy, kinship, and family. However, mechanisms underlying the recognition of social identity remain unclear. Most rodent studies of social recognition are based on the propensity of rodents to interact with a novel social target, a phenomenon known as social novelty. However, behavioral tasks for examining social novelty cannot reveal the recognition of familiar conspecifics based on their identities. Presented here are behavioral tasks allowing for the examination of identity recognition in C57BL/6 mice by associating two familiar mice with or without a valenced experience. Subjects had interactions with two mice either without (neutral) or with a valenced experience (negative or positive) and became familiar with these mice. The negatively valenced mouse was associated with shocks, while the positively valenced mouse was associated with a food reward. Following training, the recognition of the identity of these familiar mice can be revealed in a social discrimination test, which is represented as the preference for the positively valenced mouse and avoidance of the negatively valenced mouse compared to the neutral mouse. Behavioral tasks for identity recognition could be useful in probing social memory mechanisms and the pathophysiology of disorders with impaired social cognition, such as autism spectrum disorder or schizophrenia.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39992362,

title = {Perinatal risk factors for young adults to be not engaged in employment, education or training (NEET) and its mediators: longitudinal analysis of the QLSCD cohort study},

author = {Rebecca Falutz and Massimiliano Orri and Michel Boivin and Richard E Tremblay and Sylvana M Côté and Marilyn N Ahun},

doi = {10.1007/s00127-025-02841-3},

issn = {1433-9285},

year  = {2025},

date = {2025-02-01},

journal = {Soc Psychiatry Psychiatr Epidemiol},

abstract = {PURPOSE: In 2019, 31% and 14% of young women and men worldwide - respectively - reported being not engaged in employment, education, or training (NEET), an important indicator of long-term socioeconomic vulnerability. This study examined the developmental pathways leading to NEET status in young adulthood by investigating the association between perinatal adversities and NEET status and the mediating role of adolescent externalizing behaviours.nnMETHODS: Data were from the Québec Longitudinal Study of Child Development (QLSCD, n = 974). Latent class analysis identified four profiles of exposures to 30 perinatal adversities: Low adversity, the reference group; Fetal growth adversity, which includes participants experiencing adversity related to growth problems in utero and after birth; Delivery complications, which includes participants - or their mothers - who experience complications during birth; and Familial adversity, which includes participants who experienced adversity related to their family life. The associations between the perinatal profiles, NEET status - which was self-reported at age 21 years - and the putative mediating role of externalizing behavioural problems (self-reported at ages 15 and 17) were investigated using structural equation modeling.nnRESULTS: The risk of becoming NEET at age 21 was higher for children who experienced familial (OR = 3.19 [95% CI: 2.31-4.40], p < 0.001) and fetal growth (2.03 [1.11-3.71], p = 0.022) adversity. Externalizing behaviour problems mediated the association between familial adversity and NEET status (1.17 [1.05-1.30], p = 0.004).nnCONCLUSION: Interventions targeting perinatal risk factors and adolescent mental health can contribute to efforts to prevent NEET status in young adulthood.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39901502,

title = {The Relationship Between Family Dynamics and Help-Seeking and Disclosure of Adolescent Self-Harm and Suicidality: A Population-Representative Study: Relation entre dynamique familiale et recherche d'aide, et dévoilement des actes d'automutilation et de la suicidalité chez les adolescents : étude représentative de la population},

author = {Nicole G Hammond and Christopher Gravel and Mark A Ferro and Hannah Landry and Marie-Claude Geoffroy and Nicole Racine and Ian Colman},

doi = {10.1177/07067437251315526},

issn = {1497-0015},

year  = {2025},

date = {2025-02-01},

journal = {Can J Psychiatry},

pages = {7067437251315526},

abstract = {BACKGROUND: Few studies have explored the potential for family dynamics to hinder or promote help-seeking and disclosure behaviours among adolescents who self-harm or experience suicidality. We sought to examine whether family dynamics may influence self-harm-related disclosure to parents or other family members and online help-seeking.nnMETHODS: We identified youths, 14-17 years, in the 2014 Ontario Child Health Study (OCHS) who self-reported past-year suicidal ideation (with or without a suicide plan or past suicide attempt[s]) and/or non-suicidal self-harm. The OCHS is a provincially representative, cross-sectional survey. The person most knowledgeable about the adolescent, usually the mother, reported family dynamics: family dysfunction and positive and negative parenting practices. We used logistic regression to generate adjusted odds ratios.nnRESULTS: A total of 359 adolescents positively endorsed past-year suicidal ideation and/or non-suicidal self-harm. Disclosure and help-seeking were common (≥67.3% and ≥25.6%, respectively). Adolescents experiencing suicidal ideation and greater family dysfunction were more likely to share their suicidal thoughts with non-family compared to not telling anyone (OR = 1.09, 95% CI: 1.01 to 1.18) and were less likely to tell their parents or other family members about their suicidal thoughts when compared to non-family such as teachers, partners, or friends (OR = 0.82, 95% CI: 0.71 to 0.94). Positive parenting was not associated with any form of disclosure or online help-seeking for non-suicidal self-harm or suicidal ideation. As adolescent exposure to negative parenting increased, so did the likelihood that they would seek help online for their suicidal thoughts (OR = 1.22, 95% CI: 1.08 to 1.37). Sensitivity analyses replicated or were very similar to findings from the main models.nnCONCLUSION: We found that negative family dynamics were related to reduced sharing of suicidal thoughts with parents or other family members and greater online help-seeking. Our findings suggest that the importance of negative family dynamics to disclosure and support-seeking for adolescent suicidality may be under-recognized.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39989284,

title = {Altered Proteomics in Brain Extracellular Vesicles from Depressed Individuals Who Died by Suicide Implicates Synaptic Processes},

author = {Pascal Ibrahim and Haruka Mitsuhashi and Lorne Taylor and Jenna Cleyle and Naguib Mechawar and Corina Nagy and Gustavo Turecki},

doi = {10.1093/ijnp/pyaf012},

issn = {1469-5111},

year  = {2025},

date = {2025-02-01},

journal = {Int J Neuropsychopharmacol},

abstract = {BACKGROUND: Major Depressive Disorder (MDD) is a common and debilitating disorder whose molecular neurobiology remains unclear. Extracellular vesicles (EVs) are small vesicles that are released by cells and are involved in intercellular communication. They carry bioactive molecules, such as proteins, that reflect the state of their cell of origin. In this study, we sought to investigate the proteomic cargo of brain EVs from depressed individuals as compared to EVs from matched neurotypical individuals. In addition, we investigated how the EV proteomic cargo compares to the proteomic profile of bulk tissue.nnMETHODS: Using mass spectrometry and label-free quantification (LFQ), we investigated the EV and bulk tissue protein profile from anterior cingulate cortex (ACC) samples from 86 individuals. We performed differential expression analysis to compare cases and controls, followed by in silico analysis to determine potential implicated functions of dysregulated proteins.nnRESULTS: EVs display distinct proteomic profiles compared to bulk tissue. Differential expression analysis showed that 70 proteins were differentially packaged in EVs in MDD, while there was no significant difference in protein levels between groups in bulk tissue. In silico analysis points to a strong role of these differential EV proteins in synaptic functions.nnCONCLUSION: To our knowledge, this is the first study to profile EV proteins in depression, providing novel information to better understand the pathophysiology of MDD. This work paves the way for discovering new therapeutic targets for MDD and prompts more investigations into EVs in MDD and other psychiatric disorders.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39988244,

title = {Cerebellum as a neural substrate for impoverishment in early psychosis},

author = {Eric Toyota and Michael Mackinley and Angelica M Silva and Yuchao Jiang and Tyler C Dalal and Caroline Nettekoven and Lena Palaniyappan},

doi = {10.1016/j.neuropsychologia.2025.109094},

issn = {1873-3514},

year  = {2025},

date = {2025-02-01},

journal = {Neuropsychologia},

volume = {210},

pages = {109094},

abstract = {BACKGROUND: Formal Thought Disorder and includes both positive (i.e., disorganized speech) and negative (i.e., impoverished speech) symptoms. Emerging evidence suggests that the cerebellum plays a critical role in cognitive functions, including language processing. This study leverages Natural Language Processing to objectively measure language disturbances in patients with first-episode psychosis and investigates the relationship between these disturbances and cerebellar structure.nnMETHODS: Fifty-four patients with schizophrenia, either drug-naïve or minimally medicated, were recruited from an early psychosis program. Impoverished thought was assessed using the Thought Language Index while lexico-semantic features (affect, cognitive, linguistic, perception, time) were identified from speech samples analyzed using the Linguistic Inquiry Word Count-22 software. Structural cerebellar analysis was completed on 7.0 Tesla MRI scans using voxel-based morphometry (VBM) to measure global and regional grey matter volume changes.nnRESULTS: Linear regression analysis revealed that reduced perceptual word usage was the strongest predictor of impoverished thinking. Correlational analysis identified reduced cerebellar volumes in patients with lower LIWC-based perception scores. VBM localized this relationship to a cluster in the right posterolateral cerebellar hemisphere, an area related to executive demand and verb generation function.nnCONCLUSION: The cerebellum contributes to impoverished thinking in early psychosis, likely by influencing the lexical expression of perceptual experiences. This underscores the cerebellum's role in higher-order cognitive processes relevant to psychotic disorders and its potential as a therapeutic target for language and cognitive deficits in schizophrenia.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39987244,

title = {Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils},

author = {Stephanie Tullo and Janice Park and Daniel Gallino and Megan Park and Kristie Mar and Vladislav Novikov and Rodrigo Sandoval Contreras and Raihaan Patel and Esther Del Cid-Pellitero and Edward A Fon and Wen Luo and Irina Shlaifer and Thomas M Durcan and Marco A M Prado and Vania F Prado and Gabriel A Devenyi and M Mallar Chakravarty},

doi = {10.1038/s42003-025-07680-1},

issn = {2399-3642},

year  = {2025},

date = {2025-02-01},

journal = {Commun Biol},

volume = {8},

number = {1},

pages = {288},

abstract = {Despite known sex differences in human synucleinopathies such as Parkinson's disease, the impact of sex on alpha-synuclein pathology in mouse models has been largely overlooked. To address this need, we examine sex differences in whole brain signatures of neurodegeneration due to aSyn toxicity in the M83 mouse model using longitudinal magnetic resonance imaging (MRI; T1-weighted; 100 μm isotropic voxel; -7, 30, 90 and 120 days post-injection [dpi]; n ≥ 8 mice/group/sex/time point). To initiate aSyn spreading, M83 mice are inoculated with recombinant human aSyn preformed fibrils (Hu-PFF) or phosphate buffered saline in the right striatum. We observe more aggressive neurodegenerative profiles over time for male Hu-PFF-injected mice when examining voxel-wise trajectories. However, at 90 dpi, we observe widespread patterns of neurodegeneration in the female Hu-PFF-injected mice. These differences are not accompanied by any differences in motor symptom onset between the sexes. However, male Hu-PFF-injected mice reached their humane endpoint sooner. These findings suggest that post-motor symptom onset, despite accelerated disease trajectories for male Hu-PFF-injected mice, neurodegeneration may appear sooner in the female Hu-PFF-injected mice (prior to motor symptomatology). These findings suggest that sex-specific synucleinopathy phenotypes urgently need to be considered to improve our understanding of neuroprotective and neurodegenerative mechanisms.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39985309,

title = {Regional Cerebral Atrophy Contributes to Personalized Survival Prediction in Amyotrophic Lateral Sclerosis: A Multicentre, Machine Learning, Deformation-Based Morphometry Study},

author = {Isabelle Lajoie and  and Sanjay Kalra and Mahsa Dadar},

doi = {10.1002/ana.27196},

issn = {1531-8249},

year  = {2025},

date = {2025-02-01},

journal = {Ann Neurol},

abstract = {OBJECTIVE: Accurate personalized survival prediction in amyotrophic lateral sclerosis is essential for effective patient care planning. This study investigates whether grey and white matter changes measured by magnetic resonance imaging can improve individual survival predictions.nnMETHODS: We analyzed data from 178 patients with amyotrophic lateral sclerosis and 166 healthy controls in the Canadian Amyotrophic Lateral Sclerosis Neuroimaging Consortium study. A voxel-wise linear mixed-effects model assessed disease-related and survival-related atrophy detected through deformation-based morphometry, controlling for age, sex, and scanner variations. Additional linear mixed-effects models explored associations between regional imaging and clinical measurements, and their associations with time to the composite outcome of death, tracheostomy, or permanent assisted ventilation. We evaluated whether incorporating imaging features alongside clinical data could improve the performance of an individual survival distribution model.nnRESULTS: Deformation-based morphometry uncovered distinct voxel-wise atrophy patterns linked to disease progression and survival, with many of these regional atrophies significantly associated with clinical manifestations of the disease. By integrating regional imaging features with clinical data, we observed a substantial enhancement in the performance of survival models across key metrics. Our analysis identified specific brain regions, such as the corpus callosum, rostral middle frontal gyrus, and thalamus, where atrophy predicted an increased risk of mortality.nnINTERPRETATION: This study suggests that brain atrophy patterns measured by deformation-based morphometry provide valuable insights beyond clinical assessments for prognosis. It offers a more comprehensive approach to prognosis and highlights brain regions involved in disease progression and survival, potentially leading to a better understanding of amyotrophic lateral sclerosis. ANN NEUROL 2025.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39983366,

title = {SARPEP, a rapid-learning healthcare system of early intervention services for psychosis in Quebec, Canada: Feasibility, acceptability and early impacts},

author = {Amal Abdel-Baki and Manuela Ferrari and Annie Leblanc and Camille Arbaud and Daniel Rabouin and Marc-André Roy and Srividya N Iyer},

doi = {10.1016/j.schres.2025.02.001},

issn = {1573-2509},

year  = {2025},

date = {2025-02-01},

journal = {Schizophr Res},

volume = {277},

pages = {20--30},

abstract = {INTRODUCTION: Despite growing interest in learning health systems, their application and evaluation in mental health have been scarce. This study aimed to evaluate the feasibility, acceptability and early impacts of SARPEP, a rapid learning healthcare system (RLHS) for early intervention services for psychosis in Quebec, Canada.nnMETHODS: SARPEP comprised technology-supported monitoring of program and patient outcomes, feedback and capacity-building. It involved 11 services (128 professionals, 1700+ patients). We descriptively analyzed quantitative data on the RE-AIM framework (Reach, Effectiveness, Adoption, Implementation, Maintenance) collected in the first two years.nnRESULTS: Reach: Patient and family partners, all programs (clinicians, managers), government representatives and the provincial early psychosis association agreed to co-design and implement all SARPEP components.nnEFFECTIVENESS: Data informed program- and provincial-level decision-making. Some quality indicators (e.g., timely access) improved over time. 80 % of youth were satisfied with services. Adoption: All programs collected data on satisfaction and quality, with data collection improving over time. Eight programs and all stakeholder groups participated in most community-of-practice sessions.nnIMPLEMENTATION: The time required for data collection and providing feedback decreased over time. SARPEP offered rapid, flexible support; tools; and a community of practice that facilitated collecting data, and monitoring and improving practices. Maintenance: All programs remained in SARPEP post study.nnCONCLUSION: Involving all stakeholders, RLHSs can be deployed, adopted, and maintained in mental healthcare and increase the measurement of practices and quality improvement efforts. Strategies are needed to increase the completion of patient-reported measures and to rigorously evaluate the RLHS' effectiveness in improving service quality and outcomes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}