Publications

@article{pmid39306959,

title = {Sleep problems in preschool mediate the association between chronotype and socioemotional problems at school-age},

author = {Derric Z H Eng and Elaine K H Tham and Nur K Jafar and Jael S Y Tan and Daniel Y T Goh and Yung Seng Lee and Lynette P Shek and Oon-Hoe Teoh and Fabian Yap and Kok Hian Tan and Johan G Eriksson and Yap Seng Chong and Michael J Meaney and Shirong Cai and Birit F P Broekman},

doi = {10.1016/j.sleep.2024.09.003},

issn = {1878-5506},

year  = {2024},

date = {2024-12-01},

journal = {Sleep Med},

volume = {124},

pages = {174--186},

abstract = {OBJECTIVES: Evening-chronotype is associated with increased socioemotional problems among school-aged children. Inadequate sleep and increased sleep problems are also prevalent among evening-chronotype children and may underlie the relationship between chronotype and socioemotional problems. However, it is unclear whether the association between chronotype and socioemotional problems at school-age may be mediated by poorer sleep during late preschool.nnMETHODS: Our study utilized cross-sectional data to examine the relations between chronotype, sleep duration, sleep problems and socioemotional problems in preschoolers. We subsequently performed longitudinal mediation analyses to examine how the association between chronotype at preschool-age and later socioemotional problems at school-age may be mediated by sleep problems and sleep duration during late preschool. 399 children from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study were included for analyses. Children's chronotype were identified with the Children's Chronotype Questionnaire at 4.5 years old. Sleep duration and problems were measured with the Children's Sleep Habits Questionnaire at 4.5 and 6 years old. Socioemotional problems were evaluated using the Child Behavioral Checklist at 4 and 7 years of age. All questionnaires were caregiver-reported.nnRESULTS: Linear regressions demonstrated that eveningness was associated with concurrent sleep problems and internalizing, externalizing and total behavioral problems at 4-4.5 years old, but not sleep duration. Mediation analyses supported that sleep problems (and not sleep duration) at 6 years old mediated the relationship between chronotype and socioemotional problems at 7 years old.nnCONCLUSIONS: Our findings suggest addressing sleep problems during early development may reduce socioemotional problems at school-age, especially among evening-chronotype children.},

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@article{pmid39326302,

title = {Modeling the progression of neuropsychiatric symptoms in Alzheimer's disease with PET-based Braak staging},

author = {Arthur C Macedo and Joseph Therriault and Cécile Tissot and Étienne Aumont and Stijn Servaes and Nesrine Rahmouni and Jaime Fernandez-Arias and Firoza Z Lussier and Yi-Ting Wang and Kok Pin Ng and Marie Vermeiren and Gleb Bezgin and Kely Quispialaya Socualaya and Jenna Stevenson and Seyyed Ali Hosseini and Mira Chamoun and João Pedro Ferrari-Souza and Pâmela C L Ferreira and Bruna Bellaver and Douglas Teixeira Leffa and Paolo Vitali and Eduardo R Zimmer and Zahinoor Ismail and Tharick A Pascoal and Serge Gauthier and Pedro Rosa-Neto},

doi = {10.1016/j.neurobiolaging.2024.09.009},

issn = {1558-1497},

year  = {2024},

date = {2024-12-01},

journal = {Neurobiol Aging},

volume = {144},

pages = {127--137},

abstract = {In Alzheimer's disease (AD), neuropsychiatric symptoms (NPS) correlate with tau deposition in the brain. Here, we investigated the association of PET-based Braak stages with NPS and assessed whether they predict annual changes in NPS. We evaluated 231 individuals in the aging and AD continuum. Participants were assigned a Braak stage at baseline and followed for 1.97 (s.d. 0.62) years. NPS were investigated using the Mild Behavioral Impairment Checklist (MBI-C) and the Neuropsychiatric Inventory Questionnaire severity (NPI-Q-S) and distress (NPI-Q-D) scales. Multiple linear regressions (MLR) assessed the association of Braak stages with baseline NPS and the annual change in NPS scores. At baseline, stages I-II, III-IV, and V-VI were associated with higher MBI-C, NPI-Q-S, and NPI-Q-D scores. Stages V-VI were associated with a significant annual increase in MBI-C scores. These findings suggest that tau accumulation may manifest clinically with an increase in NPS, which seems to be an early event in AD pathophysiology. Moreover, PET-based Braak staging appears to be a good predictor of NPS severity progression.},

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@article{pmid39591741,

title = {Investigating the contribution of childhood maltreatment to suicide attempt: A multivariable Mendelian randomization study},

author = {Min-Hyuk Kim and Gustavo Turecki and Massimiliano Orri},

doi = {10.1016/j.psychres.2024.116278},

issn = {1872-7123},

year  = {2024},

date = {2024-12-01},

journal = {Psychiatry Res},

volume = {342},

pages = {116278},

abstract = {Childhood maltreatment has been associated with suicidal behavior. However, whether this risk is causal and uniquely due to consequences of childhood maltreatment such as mental disorders, socioeconomic difficulties, and cognitive skills impairments needs clarification. We investigated direct and indirect contributions of childhood maltreatment to suicide attempt using a two-sample multivariable Mendelian randomization design. We used 7 single nucleotide polymorphisms from the childhood maltreatment genome-wide association study as instruments for childhood maltreatment. Multivariable Mendelian randomization was used to investigate the association of childhood maltreatment with suicide attempt accounting for risk of major psychiatric disorders (major depression, schizophrenia, attention-deficit/hyperactivity disorder), cognitive factors, and socioeconomic factors. Evidence supported a possible causal role of childhood maltreatment on suicide attempt (OR 4.36, CI 2.36-7.97). Significant associations with suicide attempt were identified for subtypes of maltreatment (physical abuse, physical neglect, emotional abuse, emotional neglect, sexual abuse), although unclear for sexual abuse. In multivariable analyses, childhood maltreatment was associated with suicidal attempt independently from selected mental disorders, socioeconomic factors, and cognitive factors although these factors accounted for most of the association (OR 1.51, CI 1.10-2.09). To prevent suicide among children exposed to maltreatment, it may be important to combine interventions to reduce mental disorders, psychosocial intervention, and suicide-specific preventive intervention.},

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@article{pmid38821194,

title = {Omics Approaches to Investigate the Pathogenesis of Suicide},

author = {Maura Boldrini and Yang Xiao and Tarjinder Singh and Chenxu Zhu and Mbemba Jabbi and Harry Pantazopoulos and Gamze Gürsoy and Keri Martinowich and Giovanna Punzi and Eric J Vallender and Michael Zody and Sabina Berretta and Thomas M Hyde and Joel E Kleinman and Stefano Marenco and Panagiotis Roussos and David A Lewis and Gustavo Turecki and Thomas Lehner and J John Mann},

doi = {10.1016/j.biopsych.2024.05.017},

issn = {1873-2402},

year  = {2024},

date = {2024-12-01},

journal = {Biol Psychiatry},

volume = {96},

number = {12},

pages = {919--928},

abstract = {Suicide is the second leading cause of death in U.S. adolescents and young adults and is generally associated with a psychiatric disorder. Suicidal behavior has a complex etiology and pathogenesis. Moderate heritability suggests genetic causes. Associations between childhood and recent life adversity indicate contributions from epigenetic factors. Genomic contributions to suicide pathogenesis remain largely unknown. This article is based on a workshop held to design strategies to identify molecular drivers of suicide neurobiology that would be putative new treatment targets. The panel determined that while bulk tissue studies provide comprehensive information, single-nucleus approaches that identify cell type-specific changes are needed. While single-nuclei techniques lack information on cytoplasm, processes, spines, and synapses, spatial multiomic technologies on intact tissue detect cell alterations specific to brain tissue layers and subregions. Because suicide has genetic and environmental drivers, multiomic approaches that combine cell type-specific epigenome, transcriptome, and proteome provide a more complete picture of pathogenesis. To determine the direction of effect of suicide risk gene variants on RNA and protein expression and how these interact with epigenetic marks, single-nuclei and spatial multiomics quantitative trait loci maps should be integrated with whole-genome sequencing and genome-wide association databases. The workshop concluded with a recommendation for the formation of an international suicide biology consortium that will bring together brain banks and investigators with expertise in cutting-edge omics technologies to delineate the biology of suicide and identify novel potential treatment targets to be tested in cellular and animal models for drug and biomarker discovery to guide suicide prevention.},

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pubstate = {published},

tppubtype = {article}

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@article{pmid39069958,

title = {Sleep, chronotype, social jetlag, and mental health in resident physicians: a cross-sectional study},

author = {Christophe Moderie and Camille Paradis and Frederick L Philippe and Marie-Claude Geoffroy and Emilie Guay and Vincent Paquin},

doi = {10.5664/jcsm.11288},

issn = {1550-9397},

year  = {2024},

date = {2024-12-01},

journal = {J Clin Sleep Med},

volume = {20},

number = {12},

pages = {1915--1922},

abstract = {STUDY OBJECTIVES: Social jetlag, the difference between imposed and endogenous sleep schedules, may be detrimental to resident physicians' health. The current profiles of sleep habits, particularly the differences between workdays and free days, are unknown in that population. This cross-sectional study of Quebec resident physicians aimed at assessing sleep habits on workdays and free days and predictors of social jetlag.nnMETHODS: Residents were recruited via their residency programs and social media to complete an online questionnaire. Measures included means of sleep duration and timing, chronotype, sleep debt, sleep disturbances, and social jetlag. A range of sociodemographic variables, lifestyle characteristics, and mental health indicators were examined as predictors of severe social jet lag using logistic regressions.nnRESULTS: A total of 492 residents were included in the study (mean [standard deviation] age, 27.6 [3.6] years; 330 females [67.1%]). The mean sleep duration was 7.15 hours (95% confidence interval [CI], 7.02-7.28 hours) on workdays and 8.36 hours (95% CI, 8.18-8.54 hours) on free days. The mean sleep debt was 1.59 hours (95% CI, 1.37-1.81 hours), and mean social jetlag was 1.37 hours (95% CI, 1.28-1.47 hours), with 31.9% (95% CI, 25.0-39.6%) of residents experiencing ≥2 hours of sleep debt and 21.8% (95% CI, 16.5-28.3%) experiencing severe social jetlag. The prevalence of sleep disturbances was 51.7% (95% CI, 44.4-58.8%). Severe social jetlag was associated with earlier stage of training, later chronotype, decreased physical activity, increased sleep debt, and depressive symptoms.nnCONCLUSIONS: Many residents experience severe social jetlag, chronic sleep deprivation, and sleep disturbances. Importantly, severe social jetlag was associated with depressive symptoms, suggesting a potential intervention target for promoting residents' mental health.nnCITATION: Moderie C, Paradis C, Philippe FL, Geoffroy M-C, Guay E, Paquin V. Sleep, chronotype, social jetlag, and mental health in resident physicians: a cross-sectional study.  2024;20(12):1915-1922.},

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pubstate = {published},

tppubtype = {article}

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@article{pmid39419121,

title = {T1- and T2-weighted MRI signal and histology findings in suboptimally fixed human brains},

author = {Eve-Marie Frigon and Philippe Pharand and Amy Gérin-Lajoie and Liana Guerra Sanches and Denis Boire and Mahsa Dadar and Josefina Maranzano},

doi = {10.1016/j.jneumeth.2024.110301},

issn = {1872-678X},

year  = {2024},

date = {2024-12-01},

journal = {J Neurosci Methods},

volume = {412},

pages = {110301},

abstract = {Neuroscientific research that requires brain tissue depends on brain banks that provide very small tissue samples fixed by immersion in neutral-buffered formalin (NBF), while anatomy laboratories could provide full brain specimens. However, these brains are generally fixed by perfusion of the full body with solutions other than NBF generally used by brain banks, such as an alcohol-formaldehyde solution (AFS) that is typically used for dissection and teaching. Therefore, fixation quality of these brains needs to be assessed to determine their usefulness in post-mortem investigations through magnetic resonance imaging (MRI) and histology, two common neuroimaging modalities. Here, we report the characteristics of five brains fixed by full body perfusion of an AFS from our Anatomy Laboratory suspected of being poorly fixed, given the altered signal seen on T1w MRI scans in situ. We describe 1- the characteristics of the donors; 2- the fixation procedures applied for each case; 3- the tissue contrast characteristics of the T1w and T2w images; 4- the macroscopic tissue quality after extraction of the brains; 5- the macroscopic arterial characteristics and presence or absence of blood clots; and 6- four histological stains of the areas that we suspected were poorly fixed. We conclude that multiple factors can affect the fixation quality of the brain. Nevertheless, cases in which brain fixation is suboptimal, consequently altering the T1w signal, still have T2w of adequate gray-matter to white-matter contrast and may also be used for histology stains with sufficient quality.},

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tppubtype = {article}

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@article{pmid39423674,

title = {Diagnosing and treating hypersomnolence in depression},

author = {Christophe Moderie and Diane B Boivin},

doi = {10.1016/j.sleep.2024.10.008},

issn = {1878-5506},

year  = {2024},

date = {2024-12-01},

journal = {Sleep Med},

volume = {124},

pages = {462--470},

abstract = {Hypersomnolence, a broad presentation encompassing excessive daytime sleepiness, hypersomnia and sleep inertia, affects around 25 % of patients with a major depressive disorder. Yet, hypersomnolence is often overlook in clinical settings - which can prevent remission of the mood disorder in addition to significantly interfering with quality of life. Clinical guidelines are lacking to support clinicians in the diagnosis and treatment of hypersomnolence in depression. Pharmacological treatment with selective serotonin reuptake inhibitors is insufficient and noradrenaline and dopamine reuptake inhibitors or similar molecules are generally indicated. Low-sodium oxybate was recently approved for Idiopathic Hypersomnia, but studies are needed to assess its efficacy in patients with comorbid depression. In parallel, cognitive behavioral therapy for hypersomnia is being developed as adjunct non-pharmacological treatment. Light therapy might also be beneficial in these populations. This narrative review aims at proposing a diagnostic approach reconciliating psychiatry and sleep medicine nosologies, as well as offering a multimodal treatment algorithm for hypersomnolence in depression.},

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pubstate = {published},

tppubtype = {article}

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@article{pmid39426730,

title = {Early Influences on Development of Sensory Perception and Eating Habits},

author = {Kelly Guedes de Oliveira Scudine and Paula Midori Castelo and João Paulo Maires Hoppe and André Krumel Portella and Patricia Pelufo Silveira},

doi = {10.1016/j.advnut.2024.100325},

issn = {2156-5376},

year  = {2024},

date = {2024-12-01},

journal = {Adv Nutr},

volume = {15},

number = {12},

pages = {100325},

abstract = {Infancy and early childhood are important periods for the development of food choices and eating preferences that are tracked into adult life, influencing weight gain, body composition, and metabolism and ultimately affecting the balance between health and disease. In this narrative review, we discuss studies focused on the effects of fetal programming and early food experiences, highlighting recent advances in the discovery of factors that contribute to the development of food preferences and eating behavior. Food preference can be influenced by early direct contact with flavors, textures, and aromas, as well as by environmental adversities during early development. Evidence suggests that exposure to intrauterine growth restriction is associated with increased preferences for highly palatable foods, such as those rich in carbohydrates and fats, over the life course. Early flavor experiences, whether from amniotic fluid or human milk, may also shape the development of food preferences. Finally, children are more likely to accept textures that they are able to manipulate, and early exposure to a range of textures facilitates the acceptance of foods of various textures later on. Improving dietary habits during gestation (fetal) and postnatal periods is of critical importance for the establishment of positive eating habits and healthy growth in infants and should be an important focus of primary prevention efforts.},

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@article{pmid39427811,

title = {Role of the locus coeruleus-noradrenergic system in stress-related psychopathology and resilience: Clinical and pre-clinical evidences},

author = {Déa Slavova and Vanesa Ortiz and Maud Blaise and Marya Bairachnaya and Bruno Giros and Elsa Isingrini},

doi = {10.1016/j.neubiorev.2024.105925},

issn = {1873-7528},

year  = {2024},

date = {2024-12-01},

journal = {Neurosci Biobehav Rev},

volume = {167},

pages = {105925},

abstract = {Stressful events, from daily stressors to traumatic experiences, are common and occur at any age. Despite the high prevalence of trauma, not everyone develops stress-related disorders like major depressive disorder (MDD) and post-traumatic stress disorder (PTSD), a variation attributed to resilience, the ability to adapt and avoid negative consequences of significant stress. This review examines the locus coeruleus-norepinephrine (LC-NE) system, a critical component in the brain's stress response. It discusses the LC-NE system's anatomical and functional complexity and its role in individual variability in stress responses. How different etiological factors and stress modalities affect the LC-NE system, influencing both adaptive stress responses and psychopathologies, are discussed and supported by evidence from human and animal studies. It also explores molecular and cellular adaptations in the LC that contribute to resilience, including roles of neuropeptide, inflammatory cytokines, and genetic modulation, and addresses developmental and sex differences in stress vulnerability. The need for a multifaceted approach to understand stress-induced psychopathologies is emphasized and pave the way for more personalized interventions for stress-related disorders.},

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tppubtype = {article}

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@article{pmid39430603,

title = {Prenatal cannabis exposure in the clinic and laboratory: What do we know and where do we need to go?},

author = {Lani Cupo and Karen A Dominguez-Cancino and José Ignacio Nazif-Munoz and M Mallar Chakravarty},

doi = {10.1016/j.dadr.2024.100282},

issn = {2772-7246},

year  = {2024},

date = {2024-12-01},

journal = {Drug Alcohol Depend Rep},

volume = {13},

pages = {100282},

abstract = {Coincident with the legalisation of cannabis in many nations, rates of cannabis use during pregnancy have increased. Like prior investigations on smoking and alcohol, understanding how prenatal cannabis exposure (PCE) impacts offspring outcomes across the lifespan will be critical for informing choices for pregnant people, clinicians, and policy makers alike. A thorough characterization of the life-long impacts is especially urgent for supporting all of these stakeholders in the decision-making process. While studies in humans bring forth the most direct information, it can be difficult to parse the impact of PCE from confounding variables. Laboratory studies in animal models can provide experimental designs that allow for causal inferences to be drawn, however there can be challenges in designing experiments with external validity in mirroring real-world exposure, as well as challenges translating results from the laboratory back to the clinic. In this literature review, we first highlight what is known about patterns of cannabis use during pregnancy. We then seek to lay out updates to the current understanding of the impact of PCE on offspring development informed by both human and nonhuman animal experiments. Finally we highlight opportunities for information exchange among the laboratory, clinic, and policy, identifying gaps to be filled by future research.},

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@article{pmid39447157,

title = {Plasma phosphorylated tau181 outperforms [F] fluorodeoxyglucose positron emission tomography in the identification of early Alzheimer disease},

author = {Kely Monica Quispialaya and Joseph Therriault and Antonio Aliaga and Cécile Tissot and Stijn Servaes and Nesrine Rahmouni and Thomas K Karikari and Andrea L Benedet and Nicholas J Ashton and Arthur C Macedo and Firoza Z Lussier and Jenna Stevenson and Yi-Ting Wang and Jaime Fernandez Arias and Ali Hosseini and Takashi Matsudaira and Bertrand Jean-Claude and Brian M Gilfix and Eduardo R Zimmer and Jean-Paul Soucy and Tharick A Pascoal and Serge Gauthier and Henrik Zetterberg and Kaj Blennow and Pedro Rosa-Neto and },

doi = {10.1111/ene.16255},

issn = {1468-1331},

year  = {2024},

date = {2024-12-01},

journal = {Eur J Neurol},

volume = {31},

number = {12},

pages = {e16255},

abstract = {BACKGROUND AND PURPOSE: This study was undertaken to compare the performance of plasma p-tau181 with that of [F]fluorodeoxyglucose (FDG) positron emission tomography (PET) in the identification of early biological Alzheimer disease (AD).nnMETHODS: We included 533 cognitively impaired participants from the Alzheimer's Disease Neuroimaging Initiative. Participants underwent PET scans, biofluid collection, and cognitive tests. Receiver operating characteristic analyses were used to determine the diagnostic accuracy of plasma p-tau181 and [F]FDG-PET using clinical diagnosis and core AD biomarkers ([F]florbetapir-PET and cerebrospinal fluid [CSF] p-tau181) as reference standards. Differences in the diagnostic accuracy between plasma p-tau181 and [F]FDG-PET were determined by bootstrap-based tests. Correlations of [F]FDG-PET and plasma p-tau181 with CSF p-tau181, amyloid β (Aβ) PET, and cognitive performance were evaluated to compare associations between measurements.nnRESULTS: We observed that both plasma p-tau181 and [F]FDG-PET identified individuals with positive AD biomarkers in CSF or on Aβ-PET. In the MCI group, plasma p-tau181 outperformed [F]FDG-PET in identifying AD measured by CSF (p = 0.0007) and by Aβ-PET (p = 0.001). We also observed that both plasma p-tau181 and [F]FDG-PET metabolism were associated with core AD biomarkers. However, [F]FDG-PET uptake was more closely associated with cognitive outcomes (Montreal Cognitive Assessment, Mini-Mental State Examination, Clinical Dementia Rating Sum of Boxes, and logical memory delayed recall, p < 0.001) than plasma p-tau181.nnCONCLUSIONS: Overall, although both plasma p-tau181 and [F]FDG-PET were associated with core AD biomarkers, plasma p-tau181 outperformed [F]FDG-PET in identifying individuals with early AD pathophysiology. Taken together, our study suggests that plasma p-tau181 may aid in detecting individuals with underlying early AD.},

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@article{pmid39447739,

title = {Perceptual and semantic deficits in face recognition in semantic dementia},

author = {Golnaz Yadollahikhales and Maria Luisa Mandelli and Zoe Ezzes and Janhavi Pillai and Buddhika Ratnasiri and David Paul Baquirin and Zachary Miller and Jessica de Leon and Boon Lead Tee and William Seeley and Howard Rosen and Bruce Miller and Joel Kramer and Virginia Sturm and Maria Luisa Gorno-Tempini and Maxime Montembeault},

doi = {10.1016/j.neuropsychologia.2024.109020},

issn = {1873-3514},

year  = {2024},

date = {2024-12-01},

journal = {Neuropsychologia},

volume = {205},

pages = {109020},

abstract = {STATE OF THE ART: Semantic dementia (SD) patients including semantic variant primary progressive aphasia (svPPA) and semantic behavioral variant frontotemporal dementia (sbvFTD) patients show semantic difficulties identifying faces and known people related to right anterior temporal lobe (ATL) atrophy. However, it remains unclear whether they also have perceptual deficits in face recognition.nnMETHODOLOGY: We selected 74 SD patients (54 with svPPA and predominant left ATL atrophy and 20 with sbvFTD and predominant right ATL atrophy) and 36 cognitively healthy controls (HC) from UCSF Memory and Aging Center. They underwent a perceptual face processing test (Benton facial recognition test-short version; BFRT-S), and semantic face processing tests (UCSF Famous people battery - Recognition, Naming, Semantic associations - pictures and words subtests), as well as structural magnetic resonance imaging (MRI). Neural correlates with the task's performance were conducted with a Voxel-based morphometry approach using CAT12.nnRESULTS: svPPA and sbvFTD patients were impaired on all semantic face processing tests, with sbvFTD patients performing significantly lower on the famous faces' recognition task in comparison to svPPA, and svPPA performing significantly lower on the naming task in comparison to sbvFTD. These tasks predominantly correlated with grey matter (GM) volumes in the right and left ATL, respectively. Compared to HC, both svPPA and sbvFTD patients showed preserved performance on the perceptual face processing test (BFRT-S), and performance on the BFRT-S negatively correlated with GM volume in the right posterior superior temporal sulcus (pSTS).nnCONCLUSION: Our results suggest that early in the disease, with the atrophy mostly restricted to the anterior temporal regions, SD patients do not present with perceptual deficits. However, more severe SD cases with atrophy in right posterior temporal regions might show lower performance on face perception tests, in addition to the semantic face processing deficits. Early sparing of face perceptual deficits in SD patients, regardless of hemispheric lateralization, furthers our understanding of clinical phenomenology and therapeutical approaches of this complex disease.},

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tppubtype = {article}

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@article{pmid39505286,

title = {Effects of home-based exercise alone or combined with cognitive training on cognition in community-dwelling older adults: A randomized clinical trial},

author = {Emma Gabrielle Dupuy and Florent Besnier and Christine Gagnon and Thomas Vincent and Tudor Vrinceanu and Caroll-Ann Blanchette and Jeremy Gervais and Juliana Breton and Kathia Saillant and Josep Iglesies-Grau and Sylvie Belleville and Martin Juneau and Paolo Vitali and Anil Nigam and Mathieu Gayda and Louis Bherer},

doi = {10.1016/j.exger.2024.112628},

issn = {1873-6815},

year  = {2024},

date = {2024-12-01},

journal = {Exp Gerontol},

volume = {198},

pages = {112628},

abstract = {BACKGROUND: Structured and supervised physical exercise and cognitive training are two efficient ways to enhance cognition in older adults. Performing both within a combined intervention could maximize their effect on cognition due to their potential synergy on brain functions. During the COVID-19 pandemic, these interventions were particularly relevant due to the collateral impact of social restrictions regarding physical activity and the level of cognitive stimulation. However, the benefits of remotely monitored intervention combining physical exercise and cognitive training for older adult cognition remain to be demonstrated.nnMETHODS: 127 older adults (age: 65.20 ± 7.95) were randomized in two arms, encouraging self-engagement in six months of home-based physical exercise alone or combined with cognitive training, monitored by phone once a week. Neuropsychological assessment was performed under videoconference supervision at baseline and after three and six months. Composite Z-scores were calculated for processing speed, executive functioning, working, and episodic memory to assess changes after three and six months of training. The weekly metabolic expenditure of self-reported activities was estimated using the compendium of physical activity to distinguish participants performing higher and lower doses of exercise (median split).nnRESULTS: 106 participants (83.46 %) completed the 6-month training. Results showed a greater Z-score change in executive functioning for participants in the combined arm than those who only exercised (F = 4.127, p = 0.046, η = 0.050). Group x Exercise dose interaction was observed for episodic memory Z-score change (F = 6.736, p = 0.011, η = 0.070), with a greater improvement for participants performing higher doses of exercise compared to those who performed a lower dose, only in exercise alone arm. Performing a higher dose of exercise increased the working memory Z-score change in both intervention arms compared to a lower dose (F = 7.391, p = 0.008, η  = 0.076).nnCONCLUSION: Remote combined training may lead to larger improvement in executive functioning than exercise alone. Physical exercise showed a dose-related improvement in working and episodic memory performances. The combination of cognitive interventions mitigated the effects of exercise on episodic memory. These results suggest that home-based exercise and cognitive training may help improve older adults' cognition.nnTRIAL REGISTRATION: COVEPIC was retrospectively registered on December 03, 2020.nnCLINICAL TRIALS IDENTIFIER: NCT04635462 - https://clinicaltrials.gov/ct2/show/record/NCT04635462?term=NCT04635462&draw=2&rank=1.},

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@article{pmid39467482,

title = {Acceptability, engagement, and efficacy of cognitive remediation for cognitive outcomes in young adults with first-episode psychosis and social anxiety: A randomized-controlled trial},

author = {Elisabeth Thibaudeau and Christopher R Bowie and Tina Montreuil and Larry Baer and Tania Lecomte and Ridha Joober and Amal Abdel-Baki and G Eric Jarvis and Howard C Margolese and Luigi De Benedictis and Norbert Schmitz and Ashok K Malla and Martin Lepage},

doi = {10.1016/j.psychres.2024.116243},

issn = {1872-7123},

year  = {2024},

date = {2024-12-01},

journal = {Psychiatry Res},

volume = {342},

pages = {116243},

abstract = {Social anxiety disorder (SAD) is a frequent comorbidity in first-episode psychosis (FEP) and may increase cognitive impairments. Cognitive remediation (CR) is an effective treatment for cognition, particularly in a group format. This study aims to assess the efficacy, acceptability and engagement of group CR on cognitive outcomes in FEP+SAD compared to group cognitive-behavioral therapy (CBT). Participants with FEP+SAD were randomized to group CR (n = 45) or CBT-SAD (n = 51). They were assessed for cognition at baseline, post-therapy and 3- and 6-month follow-up. The CR group additionally completed scale to assess perceived competency and enjoyment in CR. Linear mixed models for repeated measures were used for cognitive scores. Descriptive statistics and t-tests were used to summarize acceptability, perceived competency, and enjoyment, for CR completers and non-completers. The CR group performed significantly better than CBT on executive functions and visual memory at post-therapy compared to baseline. Twenty participants completed CR (44 %; mean 5.5 sessions). At week 1, CR non-completers presented higher levels of perceived competency. Completers reported higher enjoyment scores at the last session compared to the first session. Group CR is effective for cognitive outcomes in FEP+SAD, but acceptability and engagement present a challenge. Future studies are necessary to explore approaches promoting engagement.},

keywords = {},

pubstate = {published},

tppubtype = {article}

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@article{pmid39128570,

title = {Proteomic evidence of depression-associated astrocytic dysfunction in the human male olfactory bulb},

author = {Reza Rahimian and Kelly Perlman and Gohar Fakhfouri and Refilwe Mpai and Vincent R Richard and Christa Hercher and Lucy Penney and Maria Antonietta Davoli and Corina Nagy and René P Zahedi and Christoph H Borchers and Bruno Giros and Gustavo Turecki and Naguib Mechawar},

doi = {10.1016/j.bbi.2024.08.016},

issn = {1090-2139},

year  = {2024},

date = {2024-11-01},

journal = {Brain Behav Immun},

volume = {122},

pages = {110--121},

abstract = {The olfactory bulb (OB), a major structure of the limbic system, has been understudied in human investigations of psychopathologies such as depression. To explore more directly the molecular features of the OB in depression, a global comparative proteome analysis was carried out with human post-mortem OB samples from 11 males having suffered from depression and 12 healthy controls. We identified 188 differentially abundant proteins (with adjusted p < 0.05) between depressed cases and controls. Gene ontology and gene enrichment analyses suggested that these proteins are involved in biological processes including the complement and coagulation cascades. Cell type enrichment analysis displayed a significant reduction in several canonical astrocytic proteins in OBs from depressed patients. Furthermore, using RNA-fluorescence in-situ hybridization, we observed a decrease in the percentage of ALDH1L1 cells expressing canonical astrocytic markers including ALDOC, NFIA, GJA1 (connexin 43) and SLC1A3 (EAAT1). These results are consistent with previous reports of downregulated astrocytic marker expression in other brain regions in depressed patients. We also conducted a comparative phosphoproteomic analysis of OB samples and found a dysregulation of proteins involved in neuronal and astrocytic functions. To determine whether OB astrocytic abnormalities is specific to humans, we also performed proteomics on the OB of socially defeated male mice, a commonly used model of depression. Cell-type specific analysis revealed that in socially defeated animals, the most striking OB protein alterations were associated with oligodendrocyte-lineage cells rather than with astrocytes, highlighting an important species difference. Overall, this study further highlights cerebral astrocytic abnormalities as a consistent feature of depression in humans.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39153518,

title = {Inflammatory plasma profile in genetic symptomatic and presymptomatic Frontotemporal Dementia - A GENFI study},

author = {Chiara Fenoglio and Maria Serpente and Marina Arcaro and Tiziana Carandini and Luca Sacchi and Manuela Pintus and Emanuela Rotondo and Vittoria Borracci and Laura Ghezzi and Arabella Bouzigues and Lucy L Russell and Phoebe H Foster and Eve Ferry-Bolder and John C van Swieten and Lize C Jiskoot and Harro Seelaar and Raquel Sánchez Valle and Robert Laforce and Caroline Graff and Rik Vandenberghe and Alexandre de Mendonça and Pietro Tiraboschi and Isabel Santana and Alexander Gerhard and Johannes Levin and Sandro Sorbi and Markus Otto and Florence Pasquier and Simon Ducharme and Chris R Butler and Isabelle Le Ber and Elizabeth Finger and Maria Carmela Tartaglia and Mario Masellis and James B Rowe and Matthis Synofzik and Fermin Moreno and Barbara Borroni and Jonathan D Rohrer and Andrea Arighi and Daniela Galimberti and },

doi = {10.1016/j.bbi.2024.08.030},

issn = {1090-2139},

year  = {2024},

date = {2024-11-01},

journal = {Brain Behav Immun},

volume = {122},

pages = {231--240},

abstract = {BACKGROUND: Inflammation has been proposed as a crucial player in neurodegeneration, including Frontotemporal Dementia (FTD). A few studies on sporadic FTD lead to inconclusive results, whereas large studies on genetic FTD are lacking. The aim of this study is to determine cytokine and chemokine plasma circulating levels in a large cohort of genetic FTD, collected within the GENetic Frontotemporal dementia Initiative (GENFI).nnMETHODS: Mesoscale technology was used to analyse levels of 30 inflammatory factors in 434 plasma samples, including 94 Symptomatic Mutation carriers [(SMC); 15 with mutations in Microtubule Associated Protein Tau (MAPT) 34 in Progranulin (GRN) and 45 in Chromosome 9 Open Reading Frame (C9ORF)72], 168 Presymptomatic Mutation Carriers (PMC; 34 MAPT, 70 GRN and 64 C9ORF72) and 173 Non-carrier Controls (NC)].nnRESULTS: The following cytokines were significantly upregulated (P<0.05) in MAPT and GRN SMC versus NC: Tumor Necrosis Factor (TNF)α, Interleukin (IL)-7, IL-15, IL-16, IL-17A. Moreover, only in GRN SMC, additional factors were upregulated, including: IL-1β, IL-6, IL-10, IL-12/IL-23p40, eotaxin, eotaxin-3, Interferon γ-induced Protein (IP-10), Monocyte Chemotactic Protein (MCP)4. On the contrary, IL-1α levels were decreased in SMC compared with NC. Significantly decreased levels of this cytokine were also found in PMC, independent of the type of mutation. In SMC, no correlations between disease duration and cytokine and chemokine levels were found. Considering NfL and GFAP levels, as expected, significant increases were observed in SMC as compared to NC. These differences in mean values remain significant even when stratifying symptomatic patients by the mutated gene (P<0.0001). Considering instead the levels of NfL, GFAP, and the altered inflammatory molecules, no significant correlations emerged.nnCONCLUSION: We showed that inflammatory proteins are upregulated in MAPT and GRN SMC, with some specific factors altered in GRN only, whereas no changes were seen in C9ORF72 carriers. Notably, only IL-1α levels were decreased in both SMC and PMC, independent of the type of causal mutation, suggesting common modifications occurring in the preclinical phase of the disease.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39221760,

title = {The longitudinal patterns of depression subtypes and stressors in depression severity in the Canadian longitudinal study on aging (CLSA)},

author = {Yingying Su and Muzi Li and Norbert Schmitz and Xiangfei Meng},

doi = {10.1111/pcn.13728},

issn = {1440-1819},

year  = {2024},

date = {2024-11-01},

journal = {Psychiatry Clin Neurosci},

volume = {78},

number = {11},

pages = {703--711},

abstract = {AIM: The current study aims to characterize the longitudinal patterns of depression subtypes and investigate the associations among the stability of depression subtypes, COVID-19-related stressors, and depression severity.nnMETHODS: The study utilized data from the Canadian Longitudinal Study on Aging, which is a national, long-term study of Canadian adults aged 45 and older (n = 12,957). Latent profile analysis was used to identify latent depression subtypes. Latent transition analysis was then applied to assess the stability of these subtypes over time. Hierarchical multivariate linear regression was used to explore the relationships among these identified depression subtypes, COVID-19-related stressors, and depression severity among males and females, respectively.nnRESULTS: Distinct depression subtypes were identified. Except for atypical depression, other depression subtypes showed greater stability over time. We also found that melancholic depression (B = 9.432) and typical depression (B = 6.677) were strongly associated with depression severity during the pandemic. Health-related stressors (B = 0.840), conflict (B = 3.639), difficulties accessing resources (B = 0.927), separation from family (B = 0.840), and caregiving experience (B = 0.764), were significantly associated with increased depression severity. Sex-specific analyses also revealed differences in the associations between stressors and depression severity between males and females.nnCONCLUSIONS: This study contributes valuable insights into the latent clustering of depression subtypes and their stability. Stressors were associated with increased depression severity, with distinct associations observed among males and females. These findings have implications for targeted early interventions and integrated clinical management strategies by providing the evidence base for tailored mental health care during and after the pandemic.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39294489,

title = {Synergistic association of Aβ and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults},

author = {Jonathan Gallego-Rudolf and Alex I Wiesman and Alexa Pichet Binette and Sylvia Villeneuve and Sylvain Baillet and },

doi = {10.1038/s41593-024-01763-8},

issn = {1546-1726},

year  = {2024},

date = {2024-11-01},

journal = {Nat Neurosci},

volume = {27},

number = {11},

pages = {2130--2137},

abstract = {Animal and computational models of Alzheimer's disease (AD) indicate that early amyloid-β (Aβ) deposits drive neurons into a hyperactive regime, and that subsequent tau depositions manifest an opposite, suppressive effect as behavioral deficits emerge. Here we report analogous changes in macroscopic oscillatory neurophysiology in the human brain. We used positron emission tomography and task-free magnetoencephalography to test the effects of Aβ and tau deposition on cortical neurophysiology in 104 cognitively unimpaired older adults with a family history of sporadic AD. In these asymptomatic individuals, we found that Aβ depositions colocalize with accelerated neurophysiological activity. In those also presenting medial-temporal tau pathology, linear mixed effects of Aβ and tau depositions indicate a shift toward slower neurophysiological activity, which was also linked to cognitive decline. We conclude that early Aβ and tau depositions relate synergistically to human cortical neurophysiology and subsequent cognitive decline. Our findings provide insight into the multifaceted neurophysiological mechanisms engaged in the preclinical phases of AD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38844534,

title = {Shared and unique transcriptomic signatures of antidepressant and probiotics action in the mammalian brain},

author = {Nirmala Arul Rayan and Jonathan Aow and Michelle Gek Liang Lim and Danusa Mar Arcego and Richard Ryan and Nooshin Nourbakhsh and Randriely Merscher Sobreira de Lima and Kelly Craig and Tie Yuan Zhang and Yeek Teck Goh and Alfred Xuyang Sun and Thomas Tompkins and Stéphane Bronner and Sylvie Binda and Josie Diorio and Carine Parent and Michael J Meaney and Shyam Prabhakar},

doi = {10.1038/s41380-024-02619-0},

issn = {1476-5578},

year  = {2024},

date = {2024-11-01},

journal = {Mol Psychiatry},

volume = {29},

number = {11},

pages = {3653--3668},

abstract = {Understanding the shared and divergent mechanisms across antidepressant (AD) classes and probiotics is critical for improving treatment for mood disorders. Here we examine the transcriptomic effects of bupropion (NDRI), desipramine (SNRI), fluoxetine (SSRI) and a probiotic formulation (Lacidofil®) on 10 regions across the mammalian brain. These treatments massively alter gene expression (on average, 2211 differentially expressed genes (DEGs) per region-treatment combination), highlighting the biological complexity of AD and probiotic action. Intersection of DEG sets against neuropsychiatric GWAS loci, sex-specific transcriptomic portraits of major depressive disorder (MDD), and mouse models of stress and depression reveals significant similarities and differences across treatments. Interestingly, molecular responses in the infralimbic cortex, basolateral amygdala and locus coeruleus are region-specific and highly similar across treatments, whilst responses in the Raphe, medial preoptic area, cingulate cortex, prelimbic cortex and ventral dentate gyrus are predominantly treatment-specific. Mechanistically, ADs concordantly downregulate immune pathways in the amygdala and ventral dentate gyrus. In contrast, protein synthesis, metabolism and synaptic signaling pathways are axes of variability among treatments. We use spatial transcriptomics to further delineate layer-specific molecular pathways and DEGs within the prefrontal cortex. Our study reveals complex AD and probiotics action on the mammalian brain and identifies treatment-specific cellular processes and gene targets associated with mood disorders.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39605735,

title = {A meta-analysis of the effects of early life stress on the prefrontal cortex transcriptome suggests long-term effects on myelin},

author = {Toni Q Duan and Megan H Hagenauer and Elizabeth I Flandreau and Anne Bader and Duy Manh Nguyen and Pamela M Maras and Randriely Merscher S De Lima and Trevonn Gyles and Christabel Mclain and Michael J Meaney and Eric J Nestler and Stanley J Watson and Huda Akil},

doi = {10.1101/2024.11.22.624315},

issn = {2692-8205},

year  = {2024},

date = {2024-11-01},

journal = {bioRxiv},

abstract = {BACKGROUND: Early life stress (ELS) refers to exposure to negative childhood experiences, such as neglect, disaster, and physical, mental, or emotional abuse. ELS can permanently alter the brain, leading to cognitive impairment, increased sensitivity to future stressors, and mental health risks. The prefrontal cortex (PFC) is a key brain region implicated in the effects of ELS.nnMETHODS: To better understand the effects of ELS on the PFC, we ran a meta-analysis of publicly available transcriptional profiling datasets. We identified five datasets (GSE89692, GSE116416, GSE14720, GSE153043, GSE124387) that characterized the long-term effects of multi-day postnatal ELS paradigms (maternal separation, limited nesting/bedding) in male and female laboratory rodents (rats, mice). The outcome variable was gene expression in the PFC later in adulthood as measured by microarray or RNA-Seq. To conduct the meta-analysis, preprocessed gene expression data were extracted from the Gemma database. Following quality control, the final sample size was n=89: n=42 controls & n=47 ELS: GSE116416 n=23 (no outliers); GSE116416 n=44 (2 outliers); GSE14720 n=7 (no outliers); GSE153043 n=9 (1 outlier), and GSE124387 n=6 (no outliers). Differential expression was calculated using the  pipeline followed by an empirical Bayes correction. For each gene, a random effects meta-analysis model was then fit to the ELS vs. Control effect sizes (Log2 Fold Changes) from each study.nnRESULTS: Our meta-analysis yielded stable estimates for 11,885 genes, identifying five genes with differential expression following ELS (false discovery rate< 0.05):  (,  (,  (,  ( and  (, all of which were downregulated. Broadly, gene sets associated with oligodendrocyte differentiation, myelination, and brain development were downregulated following ELS. In contrast, genes previously shown to be upregulated in Major Depressive Disorder patients were upregulated following ELS.nnCONCLUSION: These findings suggest that ELS during critical periods of development may produce long-term effects on the efficiency of transmission in the PFC and drive changes in gene expression similar to those underlying depression.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39580319,

title = {Emotional information processing in depressed elderly with suicidal behavior},

author = {Yoan Barsznica and Pierre Vandel and Bérénice Lambert and Julie Monnin and Magali Nicolier and Claire De Pinho and Julia Hickel and Stephane Richard-Devantoy and Cynthia Morgny and Monika Szymanska and Emmanuel Haffen and Eric Laurent and Gilles Chopard and Nicolas Noiret},

doi = {10.1016/j.encep.2024.09.004},

issn = {0013-7006},

year  = {2024},

date = {2024-11-01},

journal = {Encephale},

abstract = {Elderly suicide is a public health problem, especially in the presence of unipolar depression. Very few tools have been developed to assess suicide risk in the elderly. Suicidal behaviors (SB) are often associated with perturbations of emotional information processing. Recent eye-tracking evidence has indicated specific visual exploration of emotional facial expressions based on age, pathological status, or type of facial emotion expression, which encourage the development of more specific and reliable tools to help in the detection of SB in depressed elderly patients. The aim of this study was to characterize emotional facial information processing in elderly depressed patients with SB vs. patients without SB. We assessed fixation time on their facial expressions (SB n=10 and with noSB n=11). Results showed that depressed SB patients spent more time on emotional regions (i.e. eyes and mouth) of disgust, fear and neutral emotions than did depressed noSB patients. Conversely, fixation time did not differ between the groups for angry, sad and happy emotions. We discuss the difficulties in disengaging attention from emotional information congruent with the patient's emotional state. Specific visual exploration observed in suicidal depressed patients could be used as novel risk factors to more accurately assess and predict suicide risk.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39342899,

title = {Pandemic-related prenatal maternal stress, model of maternity care and postpartum mental health: The Australian BITTOC study},

author = {Belinda Lequertier and Mia A McLean and Sue Kildea and Suzanne King and Hazel Keedle and Jacqueline A Boyle and Hannah G Dahlen},

doi = {10.1016/j.wombi.2024.101827},

issn = {1878-1799},

year  = {2024},

date = {2024-11-01},

journal = {Women Birth},

volume = {37},

number = {6},

pages = {101827},

abstract = {PROBLEM: Women pregnant during the COVID-19 pandemic may be at risk of elevated postpartum mental health problems.nnBACKGROUND: Social support protects maternal mental health during a pandemic. It is possible that formal supports, such as continuity maternity models of care, may also support maternal wellbeing.nnAIM: To investigate whether model of care moderates the association between prenatal maternal stress from the COVID-19 pandemic, and postpartum (a) depression and (b) anxiety.nnMETHODS: Women in Australia, pregnant during the COVID-19 pandemic (n = 3048), completed a survey detailing their COVID-19-related objective hardship and subjective distress during pregnancy and completed depression and anxiety measures at birth to six weeks ("Early"), seven to 21 weeks ("Moderate"), and/or 22-30 weeks ("Late") postpartum.nnFINDINGS: Higher subjective distress was associated with elevated depression and anxiety at all timepoints. Model of care did not moderate the association of objective hardship or subjective distress and depression or anxiety at any timepoint. Compared with Standard Care, women receiving private midwifery care had a 74 % reduction in the odds of elevated anxiety in early postpartum.nnDISCUSSION: Women receiving private midwifery may have experienced lower anxiety due to a greater duration of postpartum in-home care, fewer changes to service delivery, and the option of homebirth. Women pregnant during a pandemic should be screened for higher subjective distress about the event.nnCONCLUSION: These results suggest that continuity of private midwifery care may be beneficial for supporting postpartum mental health during a pandemic, with implications for practice and policy for the current and future pandemics.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39580147,

title = {Understanding mental health in breast cancer from screening to Survivorship: an integrative phasic Model and tool},

author = {Justine Fortin and Émilie Rudd and Claudia Trudel-Fitzgerald and Matthew J Cordova and Marie-France Marin and Alain Brunet},

doi = {10.1080/13548506.2024.2430796},

issn = {1465-3966},

year  = {2024},

date = {2024-11-01},

journal = {Psychol Health Med},

pages = {1--23},

abstract = {Integrative models of mental illness and health in psycho-oncology are aimed at all types of cancer, although the patients' experiences and issues may vary. This review summarizes the different theories and models of mental illness and health pertaining to the breast cancer experience and proposes an integrative phasic model applicable to the breast cancer trajectory. Five databases were searched for studies related to breast cancer mental health and illness theories and models. The PRISMA checklist form was used to extract the essential information from the included studies. Eleven theories and models on the experience of breast cancer were found. The integrative model based on these theories and models illustrates that the breast cancer experience is conceptualized as a trajectory with seven landmark '', each associated with a pathogenic '' leading to six possible '', 1) psychological distress with anxious features, 2) psychological distress with depressive features, 3) non-specific distress 4) psychological distress with trauma-related features 5) low health-related quality of life, and 6) fear of recurrence. The Breast Cancer Psychological Integrative Phasic Model is supported by a simple clinical tool (BreastCancerPsych - Integrative Clinical Tool) that serves as a valuable resource throughout the care trajectory. These integrative phasic model and clinical tool are designed to help mental health clinicians formulate treatments that are tailored to the needs of their patients, especially for trajectories that are not marked by resilience.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39576638,

title = {Medication Exposure and Mortality in Patients With Schizophrenia},

author = {Sébastien Brodeur and Yohann M Chiu and Josiane Courteau and Marc Dorais and Dominic Oliver and Emmanuel Stip and Marie-Josée Fleury and Marc-André Roy and Alain Vanasse and Alain Lesage and Jacinthe Leclerc},

doi = {10.1001/jamanetworkopen.2024.47137},

issn = {2574-3805},

year  = {2024},

date = {2024-11-01},

journal = {JAMA Netw Open},

volume = {7},

number = {11},

pages = {e2447137},

abstract = {IMPORTANCE: The use of antipsychotics, antidepressants, and benzodiazepines may influence the risk of mortality in people with schizophrenia. However, many observational studies have not accounted for immortal time bias (ITB), which occurs when there is a period during which patients in the exposed group are necessarily alive and misclassified as exposed (the period between start of follow-up and initiation of drug). Ignoring ITB may lead to misinterpretation of the association between these drugs and mortality.nnOBJECTIVES: To examine whether the cumulative dose of antipsychotics, antidepressants, and benzodiazepines is associated with mortality risk in patients with schizophrenia and discuss the potential impacts of ignoring ITB.nnDESIGN, SETTING, AND PARTICIPANTS: This cohort study used administrative data from Québec, Canada, including patients aged 17 to 64 years diagnosed with schizophrenia between January 1, 2002, and December 31, 2012. Data analysis was performed from June 22, 2022, to September 30, 2024.nnMAIN OUTCOMES AND MEASURES: The primary outcome was all-cause mortality, with follow-up from January 1, 2013, to December 31, 2017, or until death. Mortality risk was assessed for low, moderate, and high exposure to antipsychotics, antidepressants, and benzodiazepines. Cox proportional hazards regression models with time-fixed exposure (not controlling for ITB) and time-dependent exposure (controlling for ITB) were performed.nnRESULTS: The cohort included 32 240 patients (mean [SD] age, 46.1 [11.6] years; 19 776 [61.3%] men), of whom 1941 (6.0%) died during follow-up. No dose-response association was found for antipsychotics with mortality using the time-fixed method. However, high-dose antipsychotic use was associated with increased mortality after correcting for ITB (adjusted hazard ratio [AHR], 1.28; 95% CI, 1.07-1.55; P = .008). Antidepressants showed a reduced mortality risk using the time-fixed method, but only at high doses when correcting for ITB (AHR, 0.86; 95% CI, 0.74-1.00; P = .047). Benzodiazepines were associated with increased mortality risk regardless of the method.nnCONCLUSIONS AND RELEVANCE: The findings of this study do not dispute the known efficacy of antipsychotics in schizophrenia, but they call into question the magnitude of long-term mortality benefits.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39364682,

title = {Psilocybin reduces functional correlation and the encoding of spatial information by neurons in mouse retrosplenial cortex},

author = {Victorita E Ivan and David P Tomàs-Cuesta and Ingrid M Esteves and Artur Luczak and Majid Mohajerani and Bruce L McNaughton and Aaron J Gruber},

doi = {10.1111/ejn.16558},

issn = {1460-9568},

year  = {2024},

date = {2024-11-01},

journal = {Eur J Neurosci},

volume = {60},

number = {10},

pages = {6395--6407},

abstract = {Psychedelic drugs have profound effects on perception, cognition and mood. How psychedelics affect neural signaling to produce these effects remains poorly understood. We investigated the effect of the classic psychedelic psilocybin on neural activity patterns and spatial encoding in the retrosplenial cortex of head-fixed mice navigating on a treadmill. The place specificity of neurons to distinct locations along the belt was reduced by psilocybin. Moreover, the stability of place-related activity across trials decreased. Psilocybin also reduced the functional correlation among simultaneously recorded neurons. The 5-HTR (serotonin 2A receptor) antagonist ketanserin blocked these effects. These data are consistent with proposals that psychedelics increase the entropy of neural signaling and provide a potential neural mechanism contributing to disorientation frequently reported by humans after taking psychedelics.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39111125,

title = {The role of motivation in clinical presentation, treatment engagement and response in schizophrenia-spectrum disorders: A systematic review},

author = {Helen Thai and Élodie C Audet and Richard Koestner and Martin Lepage and Gillian A O'Driscoll},

doi = {10.1016/j.cpr.2024.102471},

issn = {1873-7811},

year  = {2024},

date = {2024-11-01},

journal = {Clin Psychol Rev},

volume = {113},

pages = {102471},

abstract = {Schizophrenia, a debilitating psychiatric disorder, has a long-term impact on social and occupational functioning. While negative symptoms, notably amotivation, are recognized as poor prognostic factors, the positive force of patient motivation (autonomous motivation) remains underexplored. This systematic review, guided by Self-Determination Theory (SDT), investigated the impact of motivation on clinical presentation, and treatment engagement and response in schizophrenia-spectrum disorders. Fifty-five independent studies (N = 6897), using 23 different motivation scales, met inclusion criteria. Results were categorized into cross-sectional and longitudinal correlates of autonomous motivation, and the effects of motivational interventions. Cross-sectionally, autonomous motivation was positively associated with social/occupational functioning, and negatively associated with negative and positive symptom severity. In longitudinal studies, baseline autonomous motivation predicted engagement in and response to social/occupational treatments, with mixed results in cognitive interventions. In the 16 randomized controlled trials (RCTs), the most common motivational interventions were individualized goal setting and goal attainment support, followed by increasing sense of competence by challenging defeatist beliefs, and enhancing relatedness by increasing contact time. Motivational interventions consistently increased autonomous motivation, treatment engagement and response. More studies are needed, particularly studies that monitor motivation during treatment: proximal assessments could facilitate the identification of treatment elements that impact motivation and engagement and inform treatment modifications to enhance the patient experience and improve treatment efficacy.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39552391,

title = {Regional neural functional efficiency across schizophrenia, bipolar disorder, and major depressive disorder: a transdiagnostic resting-state fMRI study},

author = {Jun Yang and Zhening Liu and Yunzhi Pan and Zebin Fan and Yixin Cheng and Feiwen Wang and Fuping Sun and Guowei Wu and Xuan Ouyang and Haojuan Tao and Jie Yang and Lena Palaniyappan},

doi = {10.1017/S0033291724001685},

issn = {1469-8978},

year  = {2024},

date = {2024-11-01},

journal = {Psychol Med},

volume = {54},

number = {15},

pages = {1--12},

abstract = {BACKGROUND: Major psychiatric disorders (MPDs) are delineated by distinct clinical features. However, overlapping symptoms and transdiagnostic effectiveness of medications have challenged the traditional diagnostic categorisation. We investigate if there are shared and illness-specific disruptions in the regional functional efficiency (RFE) of the brain across these disorders.nnMETHODS: We included 364 participants (118 schizophrenia [SCZ], 80 bipolar disorder [BD], 91 major depressive disorder [MDD], and 75 healthy controls [HCs]). Resting-state fMRI was used to caclulate the RFE based on the static amplitude of low-frequency fluctuation, regional homogeneity, and degree centrality and corresponding dynamic measures indicating variability over time. We used principal component analysis to obtain static and dynamic RFE values. We conducted functional and genetic annotation and enrichment analysis based on abnormal RFE profiles.nnRESULTS: SCZ showed higher static RFE in the cortico-striatal regions and excessive variability in the cortico-limbic regions. SCZ and MDD shared lower static RFE with higher dynamic RFE in sensorimotor regions than BD and HCs. We observed association between static RFE abnormalities with reward and sensorimotor functions and dynamic RFE abnormalities with sensorimotor functions. Differential spatial expression of genes related to glutamatergic synapse and calcium/cAMP signaling was more likely in the regions with aberrant RFE.nnCONCLUSIONS: SCZ shares more regions with disrupted functional integrity, especially in sensorimotor regions, with MDD rather than BD. The neural patterns of these transdiagnostic changes appear to be potentially driven by gene expression variations relating to glutamatergic synapses and calcium/cAMP signaling. The aberrant sensorimotor, cortico-striatal, and cortico-limbic integrity may collectively underlie neurobiological mechanisms of MPDs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39548958,

title = {Examining Dimensionality and Item-Quality of the Eating Disorder Examination Questionnaire in Individuals With Eating Disorders Using Item Response Theory Analysis},

author = {Rachel Dufour and Howard Steiger and Linda Booij},

doi = {10.1002/eat.24330},

issn = {1098-108X},

year  = {2024},

date = {2024-11-01},

journal = {Int J Eat Disord},

abstract = {OBJECTIVE: The Eating Disorder Examination Questionnaire (EDE-Q) is a widely-used measure of eating-disorder symptoms. However, inconsistent replication of the subscale structure raises concern about validity. To provide a rigorous test of the EDE-Q's dimensionality and item-quality, we applied modern and classical test theory approaches to data obtained from a large, transdiagnostic sample of people with clinical eating disorders.nnMETHOD: We analyzed data from 1197 individuals (M = 27.9 years, SD = 10.08, 95% female) with various eating disorders, who had been assessed for treatment at a specialized program. Exploratory analyses (including Parallel Analyses), Confirmatory Factor Analyses (CFA) and graded-response Item Response Theory (IRT) analyses, were conducted with Mplus.nnRESULTS: Factor analyses showed inappropriate fit to the original EDE-Q subscales, as well as for alternative 1,2,3, and 4-factor solutions. Parallel analyses suggested a one-dimensional structure as best fit. IRT analyses showed substantial variability in EDE-Q-item quality and indicated that five items (fear of weight gain, feeling fat, desire to lose weight, importance of weight, importance of shape) were most pertinent to determining severity. The construct validity of the five EDE-Q items was confirmed by a CFA, showing excellent fit.nnDISCUSSION: Our results suggest that EDE-Q scores are best interpreted as spanning a one-factor continuum. IRT results suggest that some items are more pertinent than others for determining eating-disorder severity. Results could be useful for establishing short EDE-Q versions, such as a five-item version, which, in turn, would be helpful for measurement-based clinical practice and for data-collection in epidemiological and experimental studies.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39546315,

title = {A Nature-Based Intervention and Mental Health of Schoolchildren: A Cluster Randomized Clinical Trial},

author = {Tianna Loose and Julia Fuoco and Catherine Malboeuf-Hurtubise and Jean-Philippe Ayotte-Beaudet and Lise Gauvin and Nicholas Chadi and Isabelle Ouellet-Morin and Benoît Mâsse and Sylvana M Côté and Marie-Claude Geoffroy},

doi = {10.1001/jamanetworkopen.2024.44824},

issn = {2574-3805},

year  = {2024},

date = {2024-11-01},

journal = {JAMA Netw Open},

volume = {7},

number = {11},

pages = {e2444824},

abstract = {IMPORTANCE: Nature-based therapeutic or preventive interventions for mental health are increasingly popular, but their effectiveness for improving mental health is not well documented.nnOBJECTIVE: To investigate the effectiveness of the Open Sky School Program (École à Ciel Ouvert), a 12-week nature-based intervention for elementary schoolchildren in grades 5 and 6, for reducing mental health symptoms.nnDESIGN, SETTING, AND PARTICIPANTS: This 2-arm, cluster randomized clinical trial was conducted from February 27 to June 16, 2023, in French-language elementary schools in Quebec, Canada, with green space within 1 km. Participants were teachers and students in grades 5 and 6.nnINTERVENTION: In the intervention group, for 2 hours per week for 12 weeks, classes were taught outdoors in a nearby park or wooded area. Teachers were encouraged to engage students in basic subjects and in 10 or more mental health activities (mindfulness, philosophy, and/or art therapy). Control group schools conducted classes as usual.nnMAIN OUTCOMES AND MEASURES: The primary outcome was change in student mental health (internalizing and externalizing symptoms, social problems) based on teacher- and student-reported 30-item Social Behavior Questionnaire (SBQ) scores (3-point scale) from baseline to the immediate postintervention follow-up, assessed in per-protocol and intent-to-treat mixed-model analyses. Secondary outcomes were student self-reported changes in depressive symptoms, positive or negative affect, pro-environmental efforts and/or attitudes, and nature connectedness.nnRESULTS: A total of 33 schools participated (53 teachers, 1015 students), including 16 schools (25 teachers, 515 students) in the intervention group and 17 schools (28 teachers, 500 students) in the control group. Student mean (SD) age was 10.9 (0.75) years; 507 (50.7%) were girls. Per-protocol and intent-to-treat mixed-model analyses showed no differences in mental health symptom change between groups; for example, the adjusted mean difference in SBQ scores between the intervention and control groups for externalizing symptoms was -0.04 (95% CI, -0.13 to 0.04) in the intent-to-treat analysis and -0.06 (95% CI, -0.16 to 0.04) in the per-protocol analysis. Post hoc analyses revealed low mental health symptoms at baseline, with low variability. Slightly greater reductions in symptoms were observed in the intervention group, but only for children with higher mental health symptoms at baseline (P < .05 for interaction). For example, for children with internalizing symptoms 1 SD above the mean at baseline, internalizing symptoms decreased by 0.38 SD (mean change, -0.15; P < .001) in the intervention group vs the control group.nnCONCLUSIONS AND RELEVANCE: In this large cluster randomized clinical trial in daily-life elementary school settings, 12 weeks of classes in green space for 2 hours per week did not reduce mental health symptoms in students aged 10 to 12 years in either the per-protocol or the intent-to-treat analysis. However, this low-cost, safe outdoor intervention may provide unmeasured or longer-term benefits for children with higher risk of mental health symptoms.nnTRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05662436.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39545969,

title = {Mental health, risk behaviors, and social life factors in relation to adolescents' suicide ideation, plans and attempt},

author = {Stine Danielsen and Katrine Strandberg-Larsen and Massimiliano Orri and Merete Nordentoft and Annette Erlangsen and Trine Madsen},

doi = {10.1007/s00787-024-02616-2},

issn = {1435-165X},

year  = {2024},

date = {2024-11-01},

journal = {Eur Child Adolesc Psychiatry},

abstract = {OBJECTIVE: This study investigated differences in mental health and well-being, risk behaviors, and social life factors among adolescents who experienced different forms of suicidality.nnMETHODS: We examined 18-years-olds in the Danish National Birth Cohort (N = 47,852). Suicidality was defined with mutually exclusive categories ranging from no suicidality, self-reported suicide ideation, plans, and attempt as well as hospital-recorded suicide attempt. The proportion of adolescents with self-reported poor mental health and well-being, risk behaviors, and social life factors were compared across forms of suicidality. Sample weights were applied.nnRESULTS: Depressive symptoms were reported by 14% (95% CI 13%;14%) of girls with no suicidality, 44% (95% CI 43%;45%) of girls with suicide ideation, and 68% (95% CI 65%;72%) 66% (95% CI 60%;72%) of girls with self-reported suicide attempt or hospital-recorded suicide attempt respectively. Among boys, depressive symptoms were reported by 5% (95% CI 4%;5%) of those with no suicidality, 27% (95% CI 26%;28%) of those with suicide ideation, and 51% (95% CI 45%;57%) and 40% (95% CI 22%;58%) of those with self-reported suicide attempt or hospital-recorded suicide attempt respectively. Likewise, other aspects of poor mental health and well-being gradually increased relative with more severe forms of suicidality, while no notable differences were identified between adolescents with self-reported and hospital-recorded suicide attempt. Similar tendencies were observed for risk behaviors and social life factors.nnCONCLUSION: These findings suggest that adolescents with suicidality, including the large proportion with suicide ideation only, faces challenges across several parameters of mental health and well-being, risk behavior, and social life factors. This emphasizes the need for community-based interventions to identify and support the large group of adolescents experiencing both more and less severe forms of suicidality. Clinicians should prioritize comprehensive psychiatric intervention to address the complex needs of suicidal adolescents effectively.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39395793,

title = {Apolipoprotein B gene expression and regulation in relation to Alzheimer's disease pathophysiology},

author = {Gabriel Aumont-Rodrigue and Cynthia Picard and Anne Labonté and Judes Poirier},

doi = {10.1016/j.jlr.2024.100667},

issn = {1539-7262},

year  = {2024},

date = {2024-11-01},

journal = {J Lipid Res},

volume = {65},

number = {11},

pages = {100667},

abstract = {Apolipoprotein B (APOB), a receptor-binding protein present in cholesterol-rich lipoproteins, has been implicated in Alzheimer's disease (AD). High levels of APOB-containing low-density lipoproteins (LDL) are linked to the pathogenesis of both early-onset familial and late-onset sporadic AD. Rare coding mutations in the APOB gene are associated with familial AD, suggesting a role for APOB-bound lipoproteins in the central nervous system. This research explores APOB gene regulation across the AD spectrum using four cohorts: BRAINEAC (elderly control brains), DBCBB (controls, AD brains), ROSMAP (controls, MCI, AD brains), and ADNI (control, MCI, AD clinical subjects). APOB protein levels, measured via mass spectrometry and ELISA, positively correlated with AD pathology indices and cognition, while APOB mRNA levels showed negative correlations. Brain APOB protein levels are also correlated with cortical Aβ levels. A common coding variant in the APOB gene locus affected its expression but didn't impact AD risk or brain cholesterol concentrations, except for 24-S-hydroxycholesterol. Polymorphisms in the CYP27A1 gene, notably rs4674344, were associated with APOB protein levels. A negative correlation was observed between brain APOB gene expression and AD biomarker levels. CSF APOB correlated with Tau pathology in presymptomatic subjects, while cortical APOB was strongly associated with cortical Aβ deposition in late-stage AD. The study discusses the potential link between blood-brain barrier dysfunction and AD symptoms in relation to APOB neurobiology. Overall, APOB's involvement in lipoprotein metabolism appears to influence AD pathology across different stages of the disease.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38819494,

title = {Perceived Higher Unmet Care Needs among Adults in Permanent Supportive Housing},

author = {Bahram Armoon and Guy Grenier and Marie-Josée Fleury},

doi = {10.1007/s10488-024-01390-2},

issn = {1573-3289},

year  = {2024},

date = {2024-11-01},

journal = {Adm Policy Ment Health},

volume = {51},

number = {6},

pages = {843--856},

abstract = {This study is original in that it assesses various types of care needs, barriers to care, and factors associated with higher unmet needs among 308 permanent supportive housing (PSH) residents in Quebec (Canada). Data from structured interviews that featured the Perceived Need for Care Questionnaire were collected from 2020 to 2022, controlling for the COVID-19 pandemic period. Eight types of care (e.g., information, counseling) were accounted for. Based on the Behavioral Model for Vulnerable Populations, predisposing, need, and enabling factors associated with higher unmet care needs were assessed using a negative binomial regression model. The study found that 56% of adult PSH residents, even those who had lived in PSH for 5 + years, had unmet care needs. Twice as many unmet needs were due to structural (e.g., care access) rather than motivational barriers. Living in single-site PSH, in healthier neighborhoods, having better quality of life and self-esteem, and being more satisfied with housing and outpatient care were associated with fewer unmet care needs. PSH residents with co-occurring mental disorders (MD) and substance use disorders (SUD), and with moderate or severe psychological distress were likely to have more unmet needs. Better access to care, counseling and integrated treatment for co-occurring MD-SUD might be improved, as well as access to information on user rights, health and available support. Welfare benefits could be increased, with more peer support and meaningful activities, especially in single-site PSH. The quality of the neighborhoods where PSH are located might also be better monitored.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39535920,

title = {Idiothetic representations are modulated by availability of sensory inputs and task demands in the hippocampal-septal circuit},

author = {Guillaume Etter and Suzanne van der Veldt and Coralie-Anne Mosser and Michael E Hasselmo and Sylvain Williams},

doi = {10.1016/j.celrep.2024.114980},

issn = {2211-1247},

year  = {2024},

date = {2024-11-01},

journal = {Cell Rep},

volume = {43},

number = {11},

pages = {114980},

abstract = {The hippocampus is a higher-order brain structure responsible for encoding new episodic memories and predicting future outcomes. In the absence of external stimuli, neurons in the hippocampus track elapsed time, distance traveled, and other idiothetic variables. To this day, the exact determinants of idiothetic representations during free navigation remain unclear. Here, we developed unsupervised approaches to extract population and single-cell properties of more than 30,000 CA1 pyramidal neurons in freely moving mice. We find that spatiotemporal representations are composed of a mixture of idiothetic and allocentric information, the balance of which is dictated by task demand and environmental conditions. Additionally, a subset of CA1 pyramidal neurons encodes the spatiotemporal distance to rewards. Finally, distance and time information is integrated postsynaptically in the lateral septum, indicating that these high-level representations are effectively integrated in downstream neurons.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39533113,

title = {Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical probability},

author = {Joseph Therriault and Shorena Janelidze and Andréa Lessa Benedet and Nicholas J Ashton and Javier Arranz Martínez and Armand Gonzalez-Escalante and Bruna Bellaver and Daniel Alcolea and Agathe Vrillon and Helmet Karim and Michelle M Mielke and Chang Hyung Hong and Hyun Woong Roh and José Contador and Albert Puig Pijoan and Alicia Algeciras-Schimnich and Prashanthi Vemuri and Jonathan Graff-Radford and Val J Lowe and Thomas K Karikari and Erin Jonaitis and Wagner Brum and Cécile Tissot and Stijn Servaes and Nesrine Rahmouni and Arthur C Macedo and Jenna Stevenson and Jaime Fernandez-Arias and Yi-Ting Wang and Marcel S Woo and Manuel A Friese and Wan Lu Jia and Julien Dumurgier and Claire Hourregue and Emmanuel Cognat and Pamela Lukasewicz Ferreira and Paolo Vitali and Sterling Johnson and Tharick A Pascoal and Serge Gauthier and Alberto Lleó and Claire Paquet and Ronald C Petersen and David Salmon and Niklas Mattsson-Carlgren and Sebastian Palmqvist and Erik Stomrud and Douglas Galasko and Sang Joon Son and Henrik Zetterberg and Juan Fortea and Marc Suárez-Calvet and Clifford R Jack and Kaj Blennow and Oskar Hansson and Pedro Rosa-Neto},

doi = {10.1038/s43587-024-00731-y},

issn = {2662-8465},

year  = {2024},

date = {2024-11-01},

journal = {Nat Aging},

volume = {4},

number = {11},

pages = {1529--1537},

abstract = {Recently approved anti-amyloid immunotherapies for Alzheimer's disease (AD) require evidence of amyloid-β pathology from positron emission tomography (PET) or cerebrospinal fluid (CSF) before initiating treatment. Blood-based biomarkers promise to reduce the need for PET or CSF testing; however, their interpretation at the individual level and the circumstances requiring confirmatory testing are poorly understood. Individual-level interpretation of diagnostic test results requires knowledge of disease prevalence in relation to clinical presentation (clinical pretest probability). Here, in a study of 6,896 individuals evaluated from 11 cohort studies from six countries, we determined the positive and negative predictive value of five plasma biomarkers for amyloid-β pathology in cognitively impaired individuals in relation to clinical pretest probability. We observed that p-tau217 could rule in amyloid-β pathology in individuals with probable AD dementia (positive predictive value above 95%). In mild cognitive impairment, p-tau217 interpretation depended on patient age. Negative p-tau217 results could rule out amyloid-β pathology in individuals with non-AD dementia syndromes (negative predictive value between 90% and 99%). Our findings provide a framework for the individual-level interpretation of plasma biomarkers, suggesting that p-tau217 combined with clinical phenotyping can identify patients where amyloid-β pathology can be ruled in or out without the need for PET or CSF confirmatory testing.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39526850,

title = {Putative risk and resiliency factors after an augmented training program for preventing posttraumatic stress injuries among public safety personnel from diverse sectors},

author = {Juliana M B Khoury and Taylor A Teckchandani and Jolan Nisbet and Sherry H Stewart and Gordon J G Asmundson and Tracie O Afifi and Michelle C E McCarron and Gregory P Kratzig and Shannon Sauer-Zavala and J Patrick Neary and Renée S MacPhee and Alain Brunet and Terence M Keane and R Nicholas Carleton},

doi = {10.1080/16506073.2024.2420636},

issn = {1651-2316},

year  = {2024},

date = {2024-11-01},

journal = {Cogn Behav Ther},

pages = {1--20},

abstract = {Mental health disorders are particularly prevalent among public safety personnel (PSP). Emotional Resilience Skills Training (ERST) is a cognitive behavioural training program for PSP based on the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (i.e. Unified Protocol). The current study was designed to assess whether ERST is associated with reduced putative risk factors for mental disorders and increased individual resilience. The PSP-PTSI Study used a longitudinal prospective sequential experimental cohort design that engaged each participant for approximately 16 months. PSP from diverse sectors (i.e. firefighters, municipal police, paramedics, public safety communicators) completed self-report measures of several putative risk variables (i.e. anxiety sensitivity, fear of negative evaluation, pain anxiety, illness and injury sensitivity, intolerance of uncertainty, state anger) and resilience at three time points: pre-training ( = 191), post-training ( = 103), and 1-year follow-up ( = 41). Participant scores were statistically compared across time points. Participants reported statistically significantly lower scores on all putative risk variables except pain anxiety, and statistically significantly higher resilience from pre- to post-training. Changes were sustained at 1-year follow-up. The results indicate that ERST is associated with reductions in several putative risk variables and improvement in resilience among PSP.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39523517,

title = {Brain Age Gap as a Predictor of Early Treatment Response and Functional Outcomes in First-Episode Schizophrenia: A Longitudinal Study: L'écart d'âge cérébral comme prédicteur de la réponse en début de traitement et des résultats fonctionnels dans un premier épisode de schizophrénie : une étude longitudinale},

author = {Lejia Fan and Zhenmei Zhang and Xiaoqian Ma and Liangbing Liang and Liu Yuan and Lijun Ouyang and Yujue Wang and Zongchang Li and Xiaogang Chen and Ying He and Lena Palaniyappan},

doi = {10.1177/07067437241293981},

issn = {1497-0015},

year  = {2024},

date = {2024-11-01},

journal = {Can J Psychiatry},

pages = {7067437241293981},

abstract = {OBJECTIVES: Accelerated brain aging, i.e., the age-related structural changes in the brain appearing earlier than expected from one's chronological age, is a feature that is now well established in schizophrenia. Often interpreted as a feature of a progressive pathophysiological process that typifies schizophrenia, its prognostic relevance is still unclear. We investigate its role in response to antipsychotic treatment in first-episode schizophrenia.nnMETHODS: We recruited 49 drug-naive patients with schizophrenia who were then treated with risperidone at a standard dose range of 2-6 mg/day. We followed them up for 3 months to categorize their response status. We acquired T1-weighted anatomical images and used the XGboost method to evaluate individual brain age. The brain age gap (BAG) is the difference between the predicted brain age and chronological age.nnRESULTS: Patients with FES had more pronounced BAG compared to healthy subjects, and this difference was primarily driven by those who did not respond adequately after 12 weeks of treatment. BAG did not worsen significantly over the 12-week period, indicating a lack of prominent brain-ageing effect induced by the early antipsychotic exposure per se. However, highly symptomatic patients had a more prominent increase in BAG, while patients with higher BAG when initiating treatment later showed lower gains in global functioning upon treatment, highlighting the prognostic value of BAG measures in FES.nnCONCLUSIONS: Accelerated brain aging is a feature of first-episode schizophrenia that is more likely to be seen among those who will not respond adequately to first-line antipsychotic use. Given that early poor response indicates later treatment resistance, measuring BAG using structural MRI in the first 12 weeks of treatment initiation may provide useful prognostic information when considering second-line treatments in schizophrenia.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39521843,

title = {Striatal dopamine gene network moderates the effect of early adversity on the risk for adult psychiatric and cardiometabolic comorbidity},

author = {Barbara Barth and Danusa Mar Arcego and Euclides José de Mendonça Filho and Randriely Merscher Sobreira de Lima and Carine Parent and Carla Dalmaz and André Krumel Portella and Irina Pokhvisneva and Michael J Meaney and Patricia Pelufo Silveira},

doi = {10.1038/s41598-024-78465-5},

issn = {2045-2322},

year  = {2024},

date = {2024-11-01},

journal = {Sci Rep},

volume = {14},

number = {1},

pages = {27349},

abstract = {Cardiometabolic and psychiatric disorders often co-exist and share common early life risk factors, such as low birth weight. However, the biological pathways linking early adversity to adult cardiometabolic/psychiatric comorbidity remain unknown. Dopamine (DA) neurotransmission in the striatum is sensitive to early adversity and influences the development of both cardiometabolic and psychiatric diseases. Here we show that a co-expression based polygenic score (ePGS) reflecting individual variations in the expression of the striatal dopamine transporter gene (SLC6A3) network significantly interacts with birth weight to predict psychiatric and cardiometabolic comorbidities in both adults (UK Biobank, N = 225,972) and adolescents (ALSPAC, N = 1188). Decreased birth weight is associated with an increased risk for psychiatric and cardiometabolic comorbidities, but the effect is dependent on a striatal SLC6A3 ePGS, that reflects individual variation in gene expression of genes coexpressed with the SLC6A3 gene in the striatum. Neuroanatomical analyses revealed that SNPs from the striatum SLC6A3 ePGS were significantly associated with prefrontal cortex gray matter density, suggesting a neuroanatomical basis for the link between early adversity and psychiatric and cardiometabolic comorbidity. Our study reveals that psychiatric and cardiometabolic diseases share common developmental pathways and underlying neurobiological mechanisms that includes dopamine signaling in the striatum.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39432105,

title = {Exploring the efficacy of cholinergic agents for the treatment of psychostimulant use disorder: a systematic review},

author = {Nicolas Salloum and Margot Chouchana and Romain Icick and Vanessa Bloch and Stéphanie Daumas and Salah El Mestikawy and Florence Vorspan and Virgile Clergue-Duval},

doi = {10.1007/s00213-024-06696-5},

issn = {1432-2072},

year  = {2024},

date = {2024-11-01},

journal = {Psychopharmacology (Berl)},

volume = {241},

number = {11},

pages = {2205--2222},

abstract = {RATIONALE: No drugs are currently validated to treat psychostimulant use disorder (PUD). Pathophysiological studies consistently highlight the contribution of cholinergic mechanisms in psychostimulant use, including the vulnerability to PUD, paving the way for potential therapeutic strategies.nnOBJECTIVES: The aim of this systematic review is to describe and discuss the efficacy of cholinergic agents in drug trials for patients with PUD.nnMETHODS: A systematic review was conducted on April 4, 2024 in MedLine, Embase and Cochrane Library databases on controlled clinical drug trial of cholinergic agents in humans with PUD, psychostimulant abuse or dependence and psychostimulant use in recent year.nnRESULTS: Twenty-eight articles were included, twenty-one on cocaine and seven on amphetamines. Cholinergic agents used in these studies were biperiden (a muscarinic antagonist), mecamylamine (a nicotinic antagonist), nicotinic agonists, acetylcholinesterase inhibitors (AChEI), or citicoline. Two types of trials were identified. There were seventeen randomized controlled clinical trials evaluating cholinergic agents on psychostimulant use reduction in outpatients seeking treatment. Additionally, we retrieved eleven short-term «proof-of-concept» laboratory trials mainly with supervised psychostimulant administration and/or triggered craving challenges. Outpatient trials were heterogeneous and for most, inconclusive. Only two studies on galantamine (AChEI) and citicoline, reported a significant reduction of cocaine consumption. «Proof-of-concept» laboratory trials showed no evidence of efficacy on the selected outcomes, notably on craving.nnCONCLUSIONS: This review does not support the current prescription of cholinergic agents to treat PUD. Replication clinical trials notably on galantamine or other AChEI, and proof-of-concept trials on comedown symptoms will be necessary to identify a potential therapeutic indication for cholinergic agents in PUD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39516835,

title = {Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study},

author = {Li Chen and Karen Mei-Ling Tan and Jia Xu and Priti Mishra and Sartaj Ahmad Mir and Min Gong and Kothandaraman Narasimhan and Bryan Ng and Jun Shi Lai and Mya Thway Tint and Shirong Cai and Suresh Anand Sadananthan and Navin Michael and Jadegoud Yaligar and Sambasivam Sendhil Velan and Melvin Khee Shing Leow and Kok Hian Tan and Jerry Chan and Michael J Meaney and Shiao-Yng Chan and Yap Seng Chong and Johan G Eriksson},

doi = {10.1186/s13073-024-01403-7},

issn = {1756-994X},

year  = {2024},

date = {2024-11-01},

journal = {Genome Med},

volume = {16},

number = {1},

pages = {128},

abstract = {BACKGROUND: Phenotypic age (PhenoAge), a widely used marker of biological aging, has been shown to be a robust predictor of all-cause mortality and morbidity in different populations. Existing studies on biological aging have primarily focused on individual domains, resulting in a lack of a comprehensive understanding of the multi-systemic dysregulation that occurs in aging.nnMETHODS: PhenoAge was evaluated based on a linear combination of chronological age (CA) and 9 clinical biomarkers in 952 multi-ethnic Asian women of reproductive age. Phenotypic age acceleration (PhenoAgeAccel), an aging biomarker, represents PhenoAge after adjusting for CA. This study conducts an in-depth association analysis of PhenoAgeAccel with clinical, nutritional, lipidomic, gut microbiome, and genetic factors.nnRESULTS: Higher adiposity, glycaemia, plasma saturated fatty acids, kynurenine pathway metabolites, GlycA, riboflavin, nicotinamide, and insulin-like growth factor binding proteins were positively associated with PhenoAgeAccel. Conversely, a healthier diet and higher levels of pyridoxal phosphate, all-trans retinol, betaine, tryptophan, glutamine, histidine, apolipoprotein B, and insulin-like growth factors were inversely associated with PhenoAgeAccel. Lipidomic analysis found 132 lipid species linked to PhenoAgeAccel, with PC(O-36:0) showing the strongest positive association and CE(24:5) demonstrating the strongest inverse association. A genome-wide association study identified rs9864994 as the top genetic variant (P = 5.69E-07) from the ZDHHC19 gene. Gut microbiome analysis revealed that Erysipelotrichaceae UCG-003 and Bacteroides vulgatus were inversely associated with PhenoAgeAccel. Integrative network analysis of aging-related factors underscored the intricate links among clinical, nutritional and lipidomic variables, such as positive associations between kynurenine pathway metabolites, amino acids, adiposity, and insulin resistance. Furthermore, potential mediation effects of blood biomarkers related to inflammation, immune response, and nutritional and energy metabolism were observed in the associations of diet, adiposity, genetic variants, and gut microbial species with PhenoAgeAccel.nnCONCLUSIONS: Our findings provide a comprehensive analysis of aging-related factors across multiple platforms, delineating their complex interconnections. This study is the first to report novel signatures in lipidomics, gut microbiome and blood biomarkers specifically associated with PhenoAgeAccel. These insights are invaluable in understanding the molecular and metabolic mechanisms underlying biological aging and shed light on potential interventions to mitigate accelerated biological aging by targeting modifiable factors.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39511452,

title = {Evidence of altered monoamine oxidase B, an astroglia marker, in early psychosis and high-risk state},

author = {Kankana Nisha Aji and Nittha Lalang and Christian Ramos-Jiménez and Reza Rahimian and Naguib Mechawar and Gustavo Turecki and Daniel Chartrand and Isabelle Boileau and Jeffrey H Meyer and Pablo M Rusjan and Romina Mizrahi},

doi = {10.1038/s41380-024-02816-x},

issn = {1476-5578},

year  = {2024},

date = {2024-11-01},

journal = {Mol Psychiatry},

abstract = {A novel radiotracer, [C]SL25.1188, targets monoamine oxidase-B (MAO-B) enzyme, found primarily in astrocytes, which metabolizes monoamines (including dopamine), particularly in subcortical regions. Altered astrocyte function in schizophrenia is supported by convergent evidence from post-mortem, genetic, transcriptomic, peripheral and preclinical findings. We aimed to test whether levels of MAO-B, an index of astrocyte function are low in the living brains of early psychosis and their high-risk states. Thirty-eight participants including antipsychotic-free/minimally exposed clinical participants with first-episode psychosis (FEP), clinical high-risk (CHR) individuals and healthy volunteers (HVs) underwent a 90-min positron emission tomography (PET) scan with [C]SL25.1188, to measure MAO-B V, an index of MAO-B concentration. Participants were excluded if tested positive on urine drug screen (except for cannabis). This study of 14 FEP (mean[SD] age, 25.7[5.7] years; 6 F), 7 CHR (mean[SD] age, 20.9[3.7] years; 4 F) and 17 HV (mean[SD] age, 31.2[13.9] years; 9 F) demonstrated significant group differences in regional MAO-B V (F = 4.56, p = 0.02, Cohen's f = 0.49), controlling for tobacco (F  = 5.37, p = 0.03) and cannabis use (F = 5.11, p = 0.03) with significantly lower MAO-B V in CHR compared to HV (Cohen's d = 0.99). We report a significant cannabis effect on MAO-B V (F = 12.57, p = 0.001, Cohen's f = 0.57), with a significant group-by-cannabis interaction (F = 3.82, p = 0.03, Cohen's f = 0.45), indicating lower MAO-B V in cannabis-using clinical groups. Lower MAO-B V levels were more robust in striatal than cortical regions, in both clinical groups (F = 2.08, p = 0.04, Cohen's f = 0.73) and in cannabis users (F = 6.42, p < 0.001, Cohen's f = 0.91). Lower MAO-B concentration supports astrocyte dysfunction in cannabis-using CHR and FEP clinical populations. Lower MAO-B is consistent with replicated striatal dopamine elevation in psychosis, as well as astrocyte dysfunction in schizophrenia.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39494933,

title = {Recommendations on Imaging in the Context of Alzheimer's Disease-Modifying Therapies from the CCNA Imaging Workgroup},

author = {Simon Duchesne and D Louis Collins and Laura Barlow and Robert Bartha and Sandra Black and Howard Chertkow and Mahsa Dadar and Manish Joshi and Pedro Rosa-Neto and Jean-Paul Soucy and Eric E Smith},

doi = {10.1017/cjn.2024.338},

issn = {0317-1671},

year  = {2024},

date = {2024-11-01},

journal = {Can J Neurol Sci},

pages = {1--9},

abstract = {BACKGROUND: Disease-modifying therapies (DMTs) for Alzheimer's disease (AD) are emerging following successful clinical trials of therapies targeting amyloid beta (Aβ) protofibrils or plaques. Determining patient eligibility and monitoring treatment efficacy and adverse events, such as Aβ-related imaging abnormalities, necessitates imaging with MRI and PET. The Canadian Consortium on Neurodegeneration in Aging (CCNA) Imaging Workgroup aimed to synthesize evidence and provide recommendations on implementing imaging protocols for AD DMTs in Canada.nnMETHODS: The workgroup employed a Delphi process to develop these recommendations. Experts from radiology, neurology, biomedical engineering, nuclear medicine, MRI and medical physics were recruited. Surveys and meetings were conducted to achieve consensus on key issues, including protocol standardization, scanner strength, monitoring protocols based on risk profiles and optimal protocol lengths. Draft recommendations were refined through multiple iterations and expert discussions.nnRESULTS: The recommendations emphasize standardized acquisition imaging protocols across manufacturers and scanner strengths to ensure consistency and reliability of clinical treatment decisions, tailored monitoring protocols based on DMTs' safety and efficacy profiles, consistent monitoring regardless of perceived treatment efficacy and MRI screening on 1.5T or 3T scanners with adapted protocols. An optimal protocol length of 20-30 minutes was deemed feasible; specific sequences are suggested.nnCONCLUSION: The guidelines aim to enhance imaging data quality and consistency, facilitating better clinical decision-making and improving patient outcomes. Further research is needed to refine these protocols and address evolving challenges with new DMTs. It is recognized that administrative, financial and logistical capacity to deliver additional MRI and positron emission tomography scans require careful planning.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39465601,

title = {Prediction of depressive symptoms in young adults by polygenic score and childhood maltreatment: Results from a population-based birth cohort},

author = {Sara Scardera and Marie-Claude Geoffroy and Rachel Langevin and Lea C Perret and Delphine Collin-Vézina and Ivan Voronin and Jean-Philippe Gouin and Xiangfei Meng and Michel Boivin and Isabelle Ouellet-Morin},

doi = {10.1017/S0954579424001688},

issn = {1469-2198},

year  = {2024},

date = {2024-10-01},

journal = {Dev Psychopathol},

pages = {1--12},

abstract = {Childhood maltreatment is linked with later depressive symptoms, but not every maltreated child will experience symptoms later in life. Therefore, we investigate whether genetic predisposition for depression (i.e., polygenic score for depression, PGS) modifies the association between maltreatment and depressive symptoms, while accounting for different types of maltreatment and whether it was evaluated through prospective and retrospective reports. The sample included 541-617 participants from the Quebec Longitudinal Study of Child Development with information on maltreatment, including threat, deprivation, assessed prospectively (5 months-17 years) and retrospectively (reported at 23 years), PGS and self-reported depressive symptoms (20-23 years). Using hierarchical linear regressions, we found that retrospective, but not prospective indicators of maltreatment (threat/deprivation/cumulative) were associated with later depressive symptoms, above and beyond the PGS. Our findings also show the presence of gene-environment interactions, whereby the association between maltreatment (retrospective cumulative maltreatment/threat, prospective deprivation) and depression was strengthened among youth with higher PGS scores. Consistent with the Diathesis-Stress hypothesis, our findings suggest that a genetic predisposition for depression may exacerbate the putative impact of maltreatment on later depressive symptoms, especially when maltreatment is retrospective. Understanding the gene-environment interplay emerging in the context of maltreatment has the potential to guide prevention efforts.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38991360,

title = {Relationship between maternal biological features, environmental factors, and newborn neuromotor development associated with visual fixation abilities},

author = {Fernanda Rombaldi Bernardi and Marta Knijnik Lucion and Roberta Dalle Mole and Tania Diniz Machado and Bibiana Bolten Lucion Loreto and Bruna Luciano Farias and Tatiane Madeira Reis and Roberta Sena Reis and Solange Mara Bigonha and Maria do Carmo Gouveia Peluzio and Danusa Mar Arcego and Carla Dalmaz and Patrícia Pelufo Silveira},

doi = {10.1016/j.bandc.2024.106202},

issn = {1090-2147},

year  = {2024},

date = {2024-10-01},

journal = {Brain Cogn},

volume = {180},

pages = {106202},

abstract = {Newborn visual fixation abilities predict future cognitive, perceptive, and motor skills. However, little is known about the factors associated with the newborn visual fixation, which is an indicator of neurocognitive abilities. We analyzed maternal biological and environmental characteristics associated with fine motor skills (visual tracking) in 1 month old infants. Fifty-one infants were tested on visual tracking tasks (Infant Visuomotor Behavior Assessment Scale/ Guide for the Assessment of Visual Ability in Infants) and classified according to visual conducts scores. Differences between groups were compared considering motor development (Alberta Infant Motor Scale) maternal mental health (Edinburgh Postnatal Depression Scale and Hamilton Anxiety Scale); home environment (Affordances in the Home Environment for Development Scale); maternal care (Coding Interactive Behavior); breastmilk composition (total fatty acids, proteins, and cortisol); and maternal metabolic profile (serum hormones and interleukins). Mothers of infants with lower visual fixation scores had higher levels of protein in breastmilk at 3 months. Mothers of infants with better visual conduct scores had higher serum levels of T4 (at 1 month) and prolactin (at 3 months). There were no associations between visual ability and motor development, home environment, or maternal care. Early newborn neuromotor development, especially visual and fine motor skills, is associated with maternal biological characteristics (metabolic factors and breastmilk composition), highlighting the importance of early detection of maternal metabolic changes for the healthy neurodevelopment of newborns.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38997243,

title = {Outcomes of a Virtual Day Treatment Program for Adults With Eating Disorders-Comparison With In-Person Day Treatment},

author = {Lea Thaler and Linda Booij and Annie St-Hilaire and Chloé Paquin-Hodge and Nesrine Mesli and Hope Burko and Viveca Lee and Stephanie Oliverio and Mimi Israël and Howard Steiger},

doi = {10.1002/eat.24263},

issn = {1098-108X},

year  = {2024},

date = {2024-10-01},

journal = {Int J Eat Disord},

volume = {57},

number = {10},

pages = {2135--2140},

abstract = {OBJECTIVE: Previous studies have indicated that virtual treatments for eating disorders (EDs) are roughly as effective as are in-person treatments; the present nonrandomized study aimed to expand on the current body of evidence by comparing outcomes from a virtual day treatment program with those of an in-person program in an adult ED sample.nnMETHOD: Participants were 109 patients who completed at least 60% of day treatment sessions (n = 55 in-person and n = 54 virtual). Outcome measures included ED and comorbid symptoms, and motivation.nnRESULTS: Linear mixed models showed that global EDE-Q scores decreased during treatment (AIC = 376.396, F = 10.94, p = 0.002), irrespective of treatment modality (p = 0.186). BMI significantly increased over time (AIC = 389.029, F = 27.97, p < 0.001), with no effect of treatment modality (p = 0.779).nnDISCUSSION: Our findings suggest that the virtual delivery of day treatments produces comparable outcomes to those obtained using in-person formats, and that virtual formats may represent a pragmatic treatment option, especially in situations in which access to in-person care is limited.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39029669,

title = {Differential interactions between gene expressions and stressors across the lifespan in major depressive disorder},

author = {Ruiyang Wang and Yingying Su and Kieran O'Donnell and Jean Caron and Michael Meaney and Xiangfei Meng and Yue Li},

doi = {10.1016/j.jad.2024.07.069},

issn = {1573-2517},

year  = {2024},

date = {2024-10-01},

journal = {J Affect Disord},

volume = {362},

pages = {688--697},

abstract = {BACKGROUND: Both genetic predispositions and exposures to stressors have collectively contributed to the development of major depressive disorder (MDD). To deep dive into their roles in MDD, our study aimed to examine which susceptible gene expression interacts with various dimensions of stressors in the MDD risk among a large population cohort.nnMETHODS: Data analyzed were from a longitudinal community-based cohort from Southwest Montreal, Canada (N = 1083). Latent profile models were used to identify distinct patterns of stressors for the study cohort. A transcriptome-wide association study (TWAS) method was performed to examine the interactive effects of three dimensions of stressors (threat, deprivation, and cumulative lifetime stress) and gene expression on the MDD risk in a total of 48 tissues from GTEx. Additional analyses were also conducted to further explore and specify these associations including colocalization, and fine-mapping analyses, in addition to enrichment analysis investigations based on TWAS.nnRESULTS: We identified 3321 genes linked to MDD at the nominal p-value <0.05 and found that different patterns of stressors can amplify the genetic susceptibility to MDD. We also observed specific genes and pathways that interacted with deprivation and cumulative lifetime stressors, particularly in specific brain tissues including basal ganglia, prefrontal cortex, brain amygdala, brain cerebellum, brain cortex, and the whole blood. Colocalization analysis also identified these genes as having a high probability of sharing MDD causal variants.nnLIMITATIONS: The study cohort was composed exclusively of individuals of Caucasians, which restricts the generalizability of the findings to other ethnic population groups.nnCONCLUSIONS: The findings of the study unveiled significant interactions between potential tissue-specific gene expression × stressors in the MDD risk and shed light on the intricate etiological attributes of gene expression and specific stressors across the lifespan in MDD. These genetic and environmental attributes in MDD corroborate the vulnerability-stress theory and direct future stress research to have a closer examination of genetic predisposition and potential involvements of omics studies to specify the intricate relationships between genes and stressful environments.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39031622,

title = {Profiles of quality of outpatient care among individuals with mental disorders based on survey and administrative data},

author = {Marie-Josée Fleury and Zhirong Cao and Guy Grenier and Elham Rahme},

doi = {10.1111/jep.14052},

issn = {1365-2753},

year  = {2024},

date = {2024-10-01},

journal = {J Eval Clin Pract},

volume = {30},

number = {7},

pages = {1373--1385},

abstract = {RATIONALE: Though it is crucial to contribute to patient recovery through access, diversity, continuity and regularity of outpatient care, still today most of these are deemed nonoptimal. Identifying patient profiles based on outpatient service use and quality of care indicators might help formulate more personalized interventions and reduce adverse outcomes.nnAIMS AND OBJECTIVES: This study aimed to identify profiles of individuals with mental disorders (MDs) patterned after their outpatient care use and quality of care received, and to link those profiles to individual characteristics and subsequent outcomes.nnMETHODS: A cohort of 5669 individuals with MDs was considered based on data from the 2013-2014 and 2015-2016 Canadian Community Health Survey, which were linked to administrative data from the Quebec health insurance registry. Latent class analysis generated profiles based on service use over the 12 months preceding each respondent's interview, and comparative analyses were used to associate profiles with sociodemographic and clinical characteristics, and health outcomes over the three following months.nnRESULTS: Four profiles were identified. Profile 1 (P-1) was labelled 'Low service use'; P-2 'Moderate general practitioner (GP) care and continuity and regularity of care'; P-3 'High GP care, continuity and regularity of care, and low psychiatrist care'; and P-4 'High psychiatrist care and regularity of care, and low GP care'. Profiles 3 and 4 (~50% of the cohort) were provided with better care, but showed worse outcomes, mainly acute care use due to more complex conditions and unmet needs. Profiles 1 and 2 had better outcomes as they showed fewer risk factors such as being younger and having better social conditions.nnCONCLUSION: Intensity, diversity and regularity of care were higher in profiles with more complex MDs, chronic physical illnesses, and worse perceived health conditions. Adapting specific interventions for each profile, such as assertive community treatment or intensive case management for Profile 4, is recommended.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39363747,

title = {Differential effects of lifetime stressors on major depressive disorder severity: a longitudinal community-based cohort study},

author = {Yingying Su and Muzi Li and Jean Caron and Daqi Li and Xiangfei Meng},

doi = {10.1192/j.eurpsy.2024.1783},

issn = {1778-3585},

year  = {2024},

date = {2024-10-01},

journal = {Eur Psychiatry},

volume = {67},

number = {1},

pages = {e66},

abstract = {BACKGROUND: Stressors across the lifespan are associated with the onset of major depressive disorder (MDD) and increased severity of depressive symptoms. However, it is unclear how lifetime stressors are related to specific MDD subtypes. The present study aims to examine the relationships between MDD subtypes and stressors experienced across the lifespan while considering potential confounders.nnMETHODS: Data analyzed were from the Zone d'Épidémiologie Psychiatrique du Sud-Ouest de Montréal ( = 1351). Lifetime stressors included childhood maltreatment, child-parent bonding, and stressful life events. Person-centered analyses were used to identify the clusters/profiles of the studied variables and multinomial logistic regression analyses were performed to examine the relationships between stressors and identified MDD subtypes. Intersectional analysis was applied to further examine how distal stressors interact with proximal stressors to impact the development of MDD subtypes.nnRESULTS: There was a significant association between proximal stressors and melancholic depression, whereas severe atypical depression and moderate depression were only associated with some domains of stressful life events. Additionally, those with severe atypical depression and melancholic depression were more likely to be exposed to distal stressors such as childhood maltreatment. The combinations of distal and proximal stressors predicted a greater risk of all MDD subtypes except for moderate atypical depression.nnCONCLUSIONS: MDD was characterized into four subtypes based on depressive symptoms and severity. Different stressor profiles were linked with various MDD subtypes. More specific interventions and clinical management are called to provide precision treatment for MDD patients with unique stressor profiles and MDD subtypes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}