Publications

@article{pmid42288478,

title = {Regional sex differences in human cortical anatomy vary in their morphometric bases and overlap with sex chromosomal and gonadal influences},

author = {Hyo M Lee and Siyuan Liu and Elisa Guma and Elizabeth Levitis and Rebecca Shafee and Gabrielle Dugan and François M Lalonde and Liv Clasen and Alex DeCasien and M Mallar Chakravarty and Jason P Lerch and Konrad Wagstyl and Angela Delaney and Armin Raznahan},

doi = {10.1038/s41467-026-74274-8},

issn = {2041-1723},

year  = {2026},

date = {2026-06-01},

journal = {Nat Commun},

volume = {17},

number = {1},

abstract = {Humans show reproducible sex differences in regional cortical volume (CV), but it remains unclear how these relate to the two biologically dissociable determinants of CV - surface area (SA) and cortical thickness (CT) - or to potentially causal sex chromosomal and gonadal effects. Here, we analyze neuroimaging data in two independent human cohorts (N = 1754) to identify and interrelate highly reproducible sex differences in regional CV, SA and CT - as well as their alignment with distinct functional networks and histomolecular signatures. Integrating neuroimaging data from clinical cohorts with sex chromosome aneuploidy and isolated gonadotropin-releasing hormone deficiency (N = 313) establishes that regions of sex-biased cortical anatomy are enriched for congruent effects of X-chromosome dosage (e.g., primary sensory and insular cortices) and gonadal hormones (e.g., dorsal parietal regions and angular gyrus). This work refines maps of sex-biased human cortical organization and helps to narrow hypotheses regarding their potential genetic and endocrine causes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42109592,

title = {TOPSY: A picture description dataset to examine speech, language and communication in untreated first episode psychosis},

author = {Sharan Bhullar and Chaimaa El Mouslih and Michael Mackinley and Julie Richard and Lena Palaniyappan},

doi = {10.1016/j.dib.2026.112788},

issn = {2352-3409},

year  = {2026},

date = {2026-06-01},

journal = {Data Brief},

volume = {66},

pages = {112788},

abstract = {Recordings of human behaviour provide a rich source of data to detect features of conditions such as psychosis. Advanced technologies can now detect subtle speech aberrations that often go unnoticed by clinicians and family members. This is particularly important given that behavioral data, especially from untreated samples, are scarce. Speech is a crucial verbal behavioral data point for understanding psychosis, but the lack of comprehensive datasets has been a major limitation in research. Furthermore, long-term antipsychotic treatment can significantly affect speech, impacting both its tone and content. This makes it critical to collect longitudinal data to understand these effects. Tracking Outcomes of Psychosis (TOPSY) study aims to address these gaps by providing a rich dataset that includes not only speech data collected using a semi-structured picture description protocol but also a range of other valuable measures based on a validated Thought and Language Index. The TOPSY dataset offers naturalistic speech samples from individuals in an early-stage psychosis treatment program (<2 median days of antipsychotic treatment) and demographically matched healthy controls. This data is complemented by a comprehensive neurobiological and clinical battery, including: MRS (Magnetic Resonance Spectroscopy), Structural MRI, T1 structural data with myelin mapping, DTI (Diffusion Tensor Imaging), Resting fMRI (functional Magnetic Resonance Imaging). In addition to the neuroimaging data, we have collected detailed clinical and cognitive information, including TLI scores (Thought and Language Index) verbal fluency, modified DSST, and PANSS-8 item scores. The protocol and clinical assessments were repeated after a 12-month interval to assess the longitudinal stability of speech, symptom burden, and functional status. Transcripts were extracted from conversations lasting between 3 and 5 min, allowing for in-depth analysis of acoustic, semantic, syntactic, and pragmatic measures related to psychosis. We expect this dataset to be invaluable for future investigations into the clinical utility of speech measures for assessing thought disorder and other psychosis-related symptoms.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42064576,

title = {Alterations of microRNAs across human and mouse limbic brain areas: molecular mechanisms and biological processes involved in major depressive disorder},

author = {Samantha Saleri and Moira Marizzoni and Patrizia Genini and Chiara Galbiati and Annamaria Cattaneo and Gustavo Turecki and Henning Grosskopf and Petra Steinacker and Markus Otto and Giulia Poggi and Christopher R Pryce and Naguib Mechawar and Nadia Cattane},

doi = {10.1016/j.ynstr.2026.100816},

issn = {2352-2895},

year  = {2026},

date = {2026-06-01},

journal = {Neurobiol Stress},

volume = {42},

pages = {100816},

abstract = {The etiology of major depressive disorder (MDD) is multifactorial with both genetic and environmental factors, such as adverse/stressful life events, contributing to risk. There is some evidence suggesting that microRNAs (miRNAs) mediate environmental-genetic interaction leading to the brain dysfunctions that underlie MDD. However, changes in miRNAs expression in human brain regions due to stress and associated with MDD are unclear. To increase the evidence in this regard, miRNA sequencing was performed on tissue samples of subgenual anterior cingulate cortex (sgACC) obtained from depressed patients and control subjects, as well on tissue samples of medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) from mice exposed to chronic social stress (CSS) and control animals. DESeq2 was applied to identify differentially expressed miRNAs (DEMs) and weighted co-expression network preservation analysis to uncover conserved molecular mechanisms between species. Finally, pathways obtained from DESeq2 and preservation analyses were overlapped to robustly identify MDD-related processes across bioinformatic approaches.Eighteen DEMs were identified in the human sgACC, 11 in the mPFC and 9 in the BLA of mice. The human sgACC DEMs were involved mainly in intracellular signaling and immune system-related pathways. The mouse mPFC and BLA DEMs were mainly involved in, respectively, intracellular signaling and nervous system functions. Preservation patterns between humans and mice indicated an over-representation of processes related to cellular signaling. Transcriptional regulation by MECP2 and Protein Kinase A signaling were the two pathways consistently altered across species, brain regions, and bioinformatic approaches. Although further studies are needed, they could represent a novel target for intervention strategies and confirm the dysregulation of intracellular signaling, immune, neuronal and synaptic functions in MDD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42441714,

title = {Isolation of Small Extracellular Vesicles from Murine Skeletal Muscle and Bone Marrow by Size-Exclusion Chromatography},

author = {Reine Khoury and Laura Montermini and Nadim Tawil and Corina Nagy},

doi = {10.3791/70894},

issn = {1940-087X},

year  = {2026},

date = {2026-06-01},

journal = {J Vis Exp},

number = {232},

abstract = {Small extracellular vesicles (sEVs) are nanosized, lipid-bound particles that mediate intercellular communication through the transfer of proteins, lipids, and ribonucleic acids (RNAs). Isolation of sEVs from solid tissues such as skeletal muscle (SkM) and bone marrow (BM) remains challenging due to low yield and contamination from non-vesicular components. This protocol describes a reproducible workflow for isolating sEVs from mouse SkM and BM. SkM is enzymatically digested, whereas BM is processed directly and subsequently subjected to differential centrifugation and size-exclusion chromatography (SEC). For SkM, the void volume (~2.5 mL) is discarded, and the subsequent ~1.6 mL is collected as EV-enriched fractions, typically subdivided into 400 µL sequential fractions (F1-F4). For BM, a 700 µL void volume is discarded, followed by collection of an ~850 µL EV-enriched fraction, which can be subdivided into ~170 µL sequential fractions (F1-F5) and pooled based on EV marker enrichment. Using this approach, sEVs can be isolated from small tissue volumes (approximately 500 µL from a single quadriceps and 150 µL from pooled femur and tibia BM), yielding ~10 particles·mL·mg tissue with particle diameters predominantly <200 nm. Vesicle integrity and purity are validated using transmission electron microscopy, nanoparticle tracking analysis, and Western blotting for canonical EV markers, with additional characterization by single-particle interferometric detection to quantify tetraspanin-defined vesicle subpopulations. This method enables reproducible isolation of high-purity sEVs from structurally complex tissues using minimal input material, supporting downstream molecular and functional analyses of tissue-derived vesicles.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42442393,

title = {Cohort Profile: The Early Childhood Longitudinal Survey (ELPI), Chile},

author = {Pablo Martínez and Vania Martínez and Gabriel Sotomayor López and Vicky Rojas and Jenny Encina and Matías Cociña and Massimiliano Orri},

doi = {10.1093/ije/dyag105},

issn = {1464-3685},

year  = {2026},

date = {2026-06-01},

journal = {Int J Epidemiol},

volume = {55},

number = {4},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42005377,

title = {Early adversity alters neurodevelopmental milestones in male and female rat pups and motor cortex morphology and gait in juveniles},

author = {Annie Phan and Michael Ru and Brianna Latremouille and Hong Long and Claire-Dominique Walker},

doi = {10.1016/j.ynstr.2026.100814},

issn = {2352-2895},

year  = {2026},

date = {2026-06-01},

journal = {Neurobiol Stress},

volume = {42},

pages = {100814},

abstract = {Early life stress (ELS) and adversity influences neurodevelopmental trajectories and affects maturation of brain circuits, network connectivity and epigenetic regulation, leading to increased vulnerability to adult psychopathology. ELS timing targets sensitive periods for neural plasticity, which are identified by the ability to reach physical and sensorimotor developmental milestones. In particular, motor development, being highly dependent on coordinated activity across several brain regions, is especially susceptible to environmental challenges, although detailed modifications are unclear. Here we used the limited bedding (LB) paradigm in rats to examine the effects of ELS longitudinally on physical and sensorimotor milestones as well as morphological changes in the motor cortex (M1) and motor behavior in male and female juveniles. Neonates from the LB litters displayed delayed eye opening and reduced weight gain compared to NB pups. Reaching sensory milestones such as cliff avoidance, ear twitch and auditory startle responses was delayed by LB exposure, similarly to surface righting reflex, grasping reflex and orienting behavior that were significantly impaired in both male and female LB pups. In juvenile LB rats, locomotion in the openfield was reduced and hind limb gait was impaired. There were no bedding or sex effects on skilled walking. Morphological analysis of Layer V motor cortex neurons (M1) in juveniles revealed that LB reduced dendritic length and increased spine density, but in females only. These data show that LB exposure during the neonatal period delays the reaching of multiple developmental milestones in several domains associated with the maturation of motor function and coordination.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41571895,

title = {Association between maternal infections during pregnancy and offspring suicide risk: A national cohort study},

author = {Massimiliano Orri and Ellen Christine Leth Løkkegaard and Merete Nordentoft and Annette Erlangsen},

doi = {10.1038/s41380-025-03430-1},

issn = {1476-5578},

year  = {2026},

date = {2026-06-01},

journal = {Mol Psychiatry},

volume = {31},

number = {6},

pages = {3010--3021},

abstract = {Maternal infections during pregnancy may impact offspring brain development and increase the risk of mental disorders, but their impact on suicidal behavior remains unclear. In this study, we investigated associations between maternal infections before, during, and after pregnancy and offspring suicide attempt later in life to understand the mechanisms explaining these associations. Furthermore, paternal infections during these same periods were examined to pinpoint the possible specific role of intra-uterine exposure vs. genetic and socioeconomic confounding factors. A cohort design was applied to individual-level register-based data including all persons aged 10+ years and living in Denmark in 1987-2021. Information on maternal infection (bacterial, viral, and other, as well as at different body sites) was obtained from the Medical Birth Register based of diagnoses received during hospital contacts. The main outcome was hospital presentations for suicide attempt in the offspring. Adjusted Incidence Rate Ratios (IRR) were estimated to quantify the association between exposure to maternal infections and offspring suicide attempt. Of 2,157,641 individuals (35,047,803 person-years), 38,840 (1.8%), 26,158 (1.2%), and 34,853 (1.6%), had been exposed to maternal infection during, before, and after pregnancy, respectively, while 32,275 attempted suicide. Rates among those exposed to maternal infection during pregnancy and those non-exposed were 141.2 and 90.0 per 100,000 person-years, respectively. After adjustment, individuals exposed to maternal infections during pregnancy had higher risk of suicide attempt when compared to non-exposed (IRR 1.46 [1.36-1.56]), particularly those exposed in the second and third trimesters. Elevated risks were also observed among individuals whose mothers with infections prior (incidence rate: 144.3 per 100,000; IRR 1.45 [1.33-1.57]) and after pregnancy (incidence rate: 128.3 per 100,000; IRR 1.31 [1.21-1.42]). However, no associations were found for paternal infections during, before, or after pregnancy and offspring suicide attempt. These findings show that maternal, but not paternal, infections were associated with later risk of suicide attempt in the offspring, pointing out to a possible role of the intra-uterine environment. The similar estimates obtained for exposure to maternal infections before and after pregnancy suggests that part of this risk may stem from an underlying susceptibility to infections or socioeconomic confounding factors, as well as to possible measurement errors in the onset of infections.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41632632,

title = {Health-Related Outcome Improvements Via the ACCESS Open Minds Youth Mental Health Service Transformation Project in Edmonton, Canada: Amélioration des résultats en matière de santé grâce au projet de transformation des services de santé mentale jeunes d'ACCESS Open Minds/Esprits ouverts à Edmonton, Canada},

author = {Jai L Shah and Nguyen Xuan Thanh and Shireen Surood and April Gusnowski and Surya Poudel and Liana Urichuk and Giuseppe D'Andrea and Srividya N Iyer and Ashok K Malla and Eric Latimer and Philip Jacobs and },

doi = {10.1177/07067437251412570},

issn = {1497-0015},

year  = {2026},

date = {2026-05-01},

journal = {Can J Psychiatry},

volume = {71},

number = {5},

pages = {359--368},

abstract = {ObjectiveGrowing efforts to transform youth mental health (YMH) services rest on the assumption that they will produce superior outcomes to those of traditional services. We therefore aimed to determine whether implementation of a broad YMH service model in Edmonton, Alberta (the largest site in the pan-Canadian ACCESS Open Minds [AOM] network) resulted in greater improvements in individual-level outcomes compared to a matched control group seen at non-AOM community mental health services.MethodThis retrospective cohort study used data on the Health of Nation Outcomes Scale (HoNOS) collected by trained clinicians, in youth aged 15-25 attending AOM or comparator services for any mental health problem between April 2016 and September 2019. A difference-in-differences approach compared HoNOS outcomes pre- versus post-exposure to the AOM service over a 1-year time horizon, in relation to youth attending a non-transformed service. Propensity score matching and sensitivity analyses were conducted to ensure bias reduction and robustness of observations, respectively.ResultsThe number of referrals to AOM Edmonton increased over time (36.3% [95%CI = 11.0%-68.0%] per month), and the site met benchmarks for rapid assessment (within 72 hours) and time to appropriate care (within 30 days). Of 1,078 youth (344 in the intervention [AOM] group and 734 in the control [non-AOM] group) aged 15-25 visiting community mental health centres, the intervention group had statistically greater improvements (7.4% absolute improvement or 1.2× relative improvement) in total HoNOS scores and its behavioural and symptom subscales.ConclusionsIn addition to improving the reach and timeliness of YMH services, AOM Edmonton produced greater improvements in HoNOS total scores (and two of four subscale scores) compared to a matched control group. Comparative evaluations such as these are essential to demonstrating the value of such services and generating continuous cycles of learning and improvement.Plain Language Summary TitleWhat are the outcomes of transforming youth mental health services in community settings?},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41392092,

title = {In vivo-measured Lewy body pathology is associated with neuropsychiatric symptoms across the Alzheimer's disease continuum},

author = {Douglas Teixeira Leffa and Guilherme Povala and Pamela C L Ferreira and João Pedro Ferrari-Souza and Guilherme Bauer-Negrini and Matheus Scarpatto Rodrigues and Livia Amaral and Firoza Z Lussier and Marina Scop Medeiros and Carolina Soares and Cristiano Schaffer Aguzzoli and Arthur C Macedo and Joseph Therriault and Pedro Rosa-Neto and Dana L Tudorascu and Eduardo R Zimmer and Bruna Bellaver and Tharick A Pascoal},

doi = {10.1038/s41380-025-03400-7},

issn = {1476-5578},

year  = {2026},

date = {2026-05-01},

journal = {Mol Psychiatry},

volume = {31},

number = {5},

pages = {2472--2480},

abstract = {Intracellular alpha-synuclein aggregates, known as Lewy bodies (LB), are commonly observed in Alzheimer's disease (AD) dementia. Post-mortem studies have shown a higher frequency of neuropsychiatric symptoms among individuals with AD and LB co-pathology. However, the effects of in vivo-measured LB pathology on neuropsychiatric symptoms in AD remain underexplored. This study aimed to evaluate cross-sectional and longitudinal effects of in vivo-measured LB pathology on neuropsychiatric symptoms across the AD continuum. We analyzed data from 1169 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Participants had in vivo measures of LB pathology (assessed using an alpha-synuclein seed amplification assay), amyloid-beta (Aβ) and phosphorylated tau (p-tau) levels in cerebrospinal fluid, and neuropsychiatric symptoms evaluated using the Neuropsychiatric Inventory-Questionnaire (NPI-Q). Logistic and Cox proportional hazards regression models were used to assess cross-sectional and longitudinal effects, respectively, adjusting for age, sex, and cognitive status. Participants had a mean baseline age of 73.05 (SD 7.22) years, 47.13% were women, 426 (36.44%) cognitively unimpaired, and 743 (63.56%) cognitively impaired. In cross-sectional analyses, LB pathology was associated with higher rates of anxiety, apathy, motor disturbances, and appetite disturbances. In longitudinal analyses, LB pathology increased the risk of developing psychosis and anxiety. These effects were independent of Aβ and p-tau. Our results suggest that in vivo-measured LB pathology is closely associated with neuropsychiatric symptoms across the AD continuum. These findings underscore the potential of in vivo LB detection as a marker for identifying individuals at increased risk of neuropsychiatric symptoms, both in clinical trials and in clinical practice.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42204548,

title = {Putative glymphatic dysfunction links extracellular fluid dysregulation to white matter degeneration and clinical impairment in amyotrophic lateral sclerosis},

author = {Xin Jin and Yan Fu and Ting Qiu and Jianyu Li and Huixiong Zhang and Yifan Chen and Kewei Chen and Yuanchao Zhang and Junling Wang and Xiaoping Yi and Lena Palaniyappan and B Blair Braden},

doi = {10.1186/s12916-026-04948-z},

issn = {1741-7015},

year  = {2026},

date = {2026-05-01},

journal = {BMC Med},

volume = {24},

number = {1},

abstract = {BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron degeneration and prominent extra-motor involvement. Impaired clearance of neurotoxic proteins has led to increasing interest in the brain glymphatic system; however, its in vivo associations with brain microstructure and clinical heterogeneity remain incompletely understood.nnMETHODS: One hundred forty-six patients with ALS and 149 demographically matched healthy controls (HCs) underwent multimodal MRI and comprehensive clinical assessments. Putative glymphatic function was quantified using diffusion tensor imaging along perivascular space (DTI-ALPS). Extracellular free water fraction (FWF) and free-water-corrected fractional anisotropy (fwcFA) were derived to characterize extracellular fluid and white matter microstructure. Group differences were assessed using vertex-wise and voxel-wise analyses with correction for multiple comparisons. Associations among imaging metrics and clinical measures were evaluated using correlation and serial mediation analyses.nnRESULTS: Compared with HCs, patients with ALS exhibited significantly reduced DTI-ALPS index, widespread increases in cortical FWF, bidirectional alterations in white matter FWF, and extensive reductions in fwcFA across major white matter tracts. Reduced DTI-ALPS was associated with changes in extracellular free water and white matter microstructural integrity, whereas FWF and fwcFA measures were associated with functional, cognitive, and emotional outcomes. Mediation analyses identified significant indirect associations between DTI-ALPS and both functional and cognitive measures through a pathway involving cortical FWF, white matter FWF, and fwcFA, although direct associations were not observed.nnCONCLUSIONS: These findings provide in vivo evidence that putative glymphatic dysfunction co-occurs with extracellular fluid alterations, white matter microstructural changes, and clinical impairment in ALS. Multi-compartment diffusion imaging may offer complementary markers for characterizing brain microstructure and its clinical relevance in ALS.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41608854,

title = {Individualized Atrophy-Based Prediction of Dementia Progression in Familial Frontotemporal Lobar Degeneration With Bayesian Linear Mixed-Effects Modeling},

author = {Shubir Dutt and Dana Leichter and Yann Cobigo and Amy Wolf and John Kornak and Annie Clark and Lucy L Russell and Arabella Bouzigues and David M Cash and Martina Bocchetta and Molly Olzinski and Brian Appleby and Ece Bayram and Barbara Borroni and Andrea Bozoki and Chris R Butler and David Clark and Rhian S Convery and R Ryan Darby and Alexandre de Mendonça and Bradford Dickerson and Kimiko Domoto-Reilly and Simon Ducharme and Eve Ferry-Bolder and Elizabeth Finger and Phoebe H Foster and Douglas R Galasko and Daniela Galimberti and Alexander Gerhard and Nupur Ghoshal and Caroline Graff and Neill Graff-Radford and Ian M Grant and Chadwick M Hales and Lawrence S Honig and Ging-Yuek Hsiung and Edward D Huey and David Irwin and Lize C Jiskoot and Walter Kremers and Justin Y Kwan and Robert Laforce and Isabelle Le Ber and Gabriel C Léger and Johannes Levin and Irene Litvan and Ian R Mackenzie and Mario Masellis and Mario F Mendez and Fermin Moreno and Chiadi Onyike and Markus Otto and Belen Pascual and Peter Pressman and Rosa Rademakers and Eliana Marisa Ramos and Aaron Ritter and Erik D Roberson and James B Rowe and Raquel Sanchez-Valle and Isabel Santana and Harro Seelaar and Allison Snyder and Sandro Sorbi and Matthis Synofzik and Maria Carmela Tartaglia and Pietro Tiraboschi and John C van Swieten and Marijne Vandebergh and Rik Vandenberghe and Hilary W Heuer and Bruce L Miller and William W Seeley and Maria Luisa Gorno-Tempini and Joel H Kramer and Leah Forsberg and Kejal Kantarci and Bradley F Boeve and Adam L Boxer and Jonathan D Rohrer and Howard J Rosen and Adam M Staffaroni and },

doi = {10.1002/ana.78167},

issn = {1531-8249},

year  = {2026},

date = {2026-05-01},

journal = {Ann Neurol},

volume = {99},

number = {5},

pages = {1315--1326},

abstract = {OBJECTIVE: Age of symptom onset is highly variable in familial frontotemporal lobar degeneration (f-FTLD). Accurate prediction of onset would inform clinical management and trial enrollment. Prior studies indicate that individualized maps of brain atrophy can predict conversion to dementia in f-FTLD. We used a Bayesian linear mixed-effect (BLME) prediction method for identifying accelerated brain volume loss to predict conversion to dementia.nnMETHODS: Participants included 234 asymptomatic or prodromal carriers of C9orf72, GRN, or MAPT mutations (including 21 dementia converters) with ≥3 longitudinal magnetic resonance imaging (MRI) T1-weighted scans. The BLME models established individual voxel-wise gray matter trajectories using the first 2 scans. Person-specific clusters of accelerated volume loss were estimated in subsequent scans and tested as predictors of dementia conversion compared with other approaches in time-varying Cox proportional hazard models covarying for age. Receiver-operating characteristic (ROC) curves estimated utility of cluster volume in discriminating which participants converted to dementia within 24 months.nnRESULTS: The BLME cluster volume predicted conversion to dementia in f-FTLD mutation carriers overall and separately in C9orf72, GRN, and MAPT, with comparable hazard ratios observed for atrophy W-maps and regional volumes. Within a 24-month timeframe, BLME cluster volume discriminated dementia converters from non-converters with larger areas under the curve (AUCs) than other approaches.nnINTERPRETATION: Bayesian-modeled individualized atrophy scores predict dementia progression among asymptomatic f-FTLD mutation carriers and may have increased utility compared with other structural imaging methods when studying individuals over shorter timeframes that align with clinical trial design. ANN NEUROL 20269999:n/a-n/a.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42082796,

title = {Characterizing neuronal cell bodies in white matter tracts of the human brain},

author = {Drew VanderBerg and Kelly Perlman and Maria Antonietta Davoli and Gustavo Turecki and Naguib Mechawar},

doi = {10.1007/s00429-026-03112-w},

issn = {1863-2661},

year  = {2026},

date = {2026-05-01},

journal = {Brain Struct Funct},

volume = {231},

number = {5},

abstract = {Until the discovery of white matter neurons (WMN) in the 19th century, white matter (WM) was considered to be completely devoid of neuronal cell bodies. Despite evidence consistently showing neuronal soma within cortical WM and their purported implication in neuropsychiatric disorders, these neurons are understudied and have not been characterized in human long-range WM tracts. Using postmortem human brain tissue, we investigated the presence, densities and proportions of excitatory/inhibitory neurons in the uncinate fasciculus (UF) and corpus callosum (CC). We also investigated the ventromedial prefrontal cortex (vmPFC) to validate our methods by comparing our results with previously reported densities of neurons in cortical WM. To identify WMN, we employed fluorescence in situ hybridization with excitatory (SLC17A7) and inhibitory (GAD1) neuronal markers and subsequently validated these neurons at the protein level with NeuN immunohistochemistry. We found that the density of WMN in the vmPFC corresponded with previous independent estimates. The UF displayed a similar, though slightly lower density of WMN compared to the vmPFC, while the CC had a far lower density of WMN than both of these regions. Due to the higher-than-expected density of WMN in the UF, we validated the findings at a second location along the UF temporal segment and confirmed the presence of substantial numbers of WMN in this tract. This research constitutes the first ever validated observation of WMN in human long-range WM tracts, laying the foundation for future research on the phenotype and function of these neurons, and how they may be affected in brain disorders.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42092769,

title = {Home-based physical exercice with additional cognitive training for improving mobility in older adults: a secondary analysis of the COVEPIC randomized controlled trial},

author = {Emma Gabrielle Dupuy and Caroll-Ann Blanchette and Florent Besnier and Christine Gagnon and Thomas Vincent and Tudor Vrinceanu and Juliana Breton and Kathia Saillant and Josep Iglesies-Grau and Sylvie Belleville and Martin Juneau and Paolo Vitali and Anil Nigam and Mathieu Gayda and Louis Bherer},

doi = {10.1186/s11556-026-00415-z},

issn = {1813-7253},

year  = {2026},

date = {2026-05-01},

journal = {Eur Rev Aging Phys Act},

abstract = {BACKGROUND: Home-based physical exercise is an accessible strategy to help maintain physical functioning in adults over 50, but mobility gains may be limited without direct supervision. By improving cognitive processes involved in motor control, cognitive training may help enhance the effectiveness of home-based physical exercise in preventing age-related decline in mobility. This study compares the effects of a six-month home-based physical exercise, with or without cognitive training, on gait speed and balance.nnMETHODS: 127 community-dwelling adults aged 50-87 years (mean 65.20 ± 7.93; 76% women) were randomly assigned to (1) home-based, remotely monitored physical exercise alone (n = 64; 72% women) or (2) combined with cognitive training (n = 63; 81% women) for six months. The primary outcome was the change from baseline in usual gait speed, measured by the 4-meter walking test. Secondary outcomes included fast gait speed, balance (one-leg stance test), and lower-limb strength (five-time sit-to-stand test), all of which were assessed via videoconference at 3 and 6 months. Changes in outcomes were analyzed using adjusted mixed linear models with intervention group, time (ΔT0-T3, ΔT0-T6), and their interaction as fixed effects.nnRESULTS: Change in usual gait speed did not differ between groups. In contrast, the combined group showing greater improvements than the physical exercise alone group in fast gait speed (+ 0.07 m/s; F(1,199) = 6.24, p = 0.013, ηp ≃0.03) and one-leg balance test (+ 3.83 s; F(1,202) = 6.05, p = 0.015, ηp ≃0.03) in response to intervention. No significant group × time interaction was observed, indicating similar changes at 3 and 6 months.nnCONCLUSION: Adding cognitive training to home-based physical exercise may improve fast gait speed and balance in adults aged 50 and above. These findings support the interplay between sensorimotor and cognitive functions in older adults and suggest that combined physical and cognitive interventions could help prevent age-related mobility decline.nnCLINICAL TRIAL REGISTRATION ID: COVEPIC was retrospectively registered on November 19, 2020.nnCLINICAL TRIAL IDENTIFIER: NCT04635462. https://clinicaltrials.gov/ct2/show/record/NCT04635462?term=NCT04635462&draw=2&rank=1.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41603617,

title = {Clinical and Imaging Characteristics of Parkinson's Disease with Negative Alpha-Synuclein Seed Amplification Assay},

author = {Sarah M Brooker and Jacopo Pasquini and Seung Ho Choi and David-Erick Lafontant and Seyed-Mohammad Fereshtehnejad and Yashar Zeighami and Piergiorgio Grillo and Giulietta M Riboldi and Houman Azizi and Roqaie Moqadam and Un Jung Kang and Kelly N H Nudelman and Andrew Siderowf and Caroline M Tanner and Thomas F Tropea and Tatiana Foroud and Lana M Chahine and Brit Mollenhauer and Kalpana M Merchant and Douglas Galasko and Christopher S Coffey and Roseanne D Dobkin and Ethan G Brown and Roy N Alcalay and Daniel Weintraub and Kenneth Marek and Tanya Simuni and Paulina Gonzalez-Latapi and Nicola Pavese and Kathleen L Poston and },

doi = {10.1002/mds.70197},

issn = {1531-8257},

year  = {2026},

date = {2026-05-01},

journal = {Mov Disord},

volume = {41},

number = {5},

pages = {1114--1127},

abstract = {BACKGROUND: The cerebrospinal fluid alpha-synuclein seed amplification assay (CSFasynSAA) detects alpha-synuclein aggregation in over 90% of individuals with sporadic PD (sPD). However, the clinical characteristics of sPD with negative CSFasynSAA remain undefined.nnOBJECTIVES: Describe clinical and neuroimaging characteristics of CSFasynSAA-negative sPD individuals in the Parkinson's Progression Markers Initiative (PPMI).nnMETHODS: We identified sPD PPMI participants with a negative CSFasynSAA (SAA-, n = 80) or positive CSFasynSAA (SAA+, n = 856) result at baseline. For comparative analysis between groups, we used a reduced dataset (n = 79 SAA- and n = 237 SAA+) propensity-score matched on age, sex, and time since clinical diagnosis. Clinical parameters, dopamine transporter-single photon emission computed tomography (DAT-SPECT), and magnetic resonance imaging (MRI) brain volumetrics were analyzed.nnRESULTS: The SAA- and matched SAA+ groups had similar motor performance on the Movement Disorder Society Unified Parkinson's Disease Rating Scale-Part III (MDS-UPDRS-III) and similar cognitive performance on the Montreal Cognitive Assessment (MoCA) at baseline. The proportion with severe hyposmia was 12% for SAA- versus 73% for SAA+ (P < 0.001). Per PPMI enrollment criteria all participants were classified as having an abnormal DAT-SPECT. There were no significant differences in median quantitative DAT-SPECT measures between groups. The SAA- group showed a higher degree of atrophy in subcortical brain regions including substantia nigra. Longitudinally, 14.3% of SAA- participants had a change in diagnosis versus 0.9% of SAA+ participants.nnCONCLUSIONS: At baseline, SAA- sPD PPMI participants have a substantially lower rate of hyposmia, but otherwise cannot be readily distinguished from SAA+ participants based on clinical characteristics. However, SAA- participants have a greater degree of subcortical brain atrophy, and approximately one out of seven SAA- participants received a change in diagnosis. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42106478,

title = {PET imaging of FAAH in chronic Cannabis users: longitudinal assessment during short-term abstinence},

author = {Claudia Poluga and Shahtaj S Dheda and Nadia Boachie and Tina McCluskey and Lucas Narciso and Maia Zilberman and Cassie Côté and Marilyn A Huestis and Rachel F Tyndale and Stefan Kloiber and Nathan J Kolla and Pablo M Rusjan and Bernard Le Foll and Jerry J Warsh and Tony P George and Isabelle Boileau},

doi = {10.1038/s41386-026-02438-7},

issn = {1740-634X},

year  = {2026},

date = {2026-05-01},

journal = {Neuropsychopharmacology},

abstract = {Cannabis withdrawal in cannabis use disorder (CUD) increase the risk of relapse and lacks effective treatments. The endocannabinoid enzyme fatty acid amide hydrolase (FAAH) may influence cannabis use and withdrawal, but the relationship between FAAH levels and withdrawal symptoms remains unclear. This study aims to investigate changes in FAAH levels during short-term abstinence from cannabis and their relationship with withdrawal symptoms. FAAH levels were measured in whole-brain regions of interest using positron emission tomography (PET) with the FAAH-specific probe [C]CURB. An irreversible two-tissue compartment model determined [C]CURB binding. Participants with CUD were scanned once after overnight abstinence (T1) and ~3-7 days after monitored last use (T2). FAAH polymorphism (rs324420) was determined from blood samples, and mood, cognition, withdrawal symptoms, and craving were assessed. In a sample of 14 participants (N = 17 prior to attrition) who completed both scans, FAAH binding in whole-brain increased between T1 and T2 (n = 14; %ΔFAAH = 10%; p = 0.003), with the largest change in the ventral striatum (11%, p = 0.026). Increases in FAAH (%ΔFAAH whole-brain) were significantly associated with longer cannabis abstinence, greater baseline depression severity, and tendency to act without thinking (p < 0.001). Short-term cannabis abstinence is associated with increases in brain FAAH levels. These changes are linked to traits and symptoms associated with relapse vulnerability, including negative mood and impulsivity. These preliminary findings suggest that FAAH may play a key role in the neurobiological response to short-term abstinence and could represent a potential target for interventions.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42126077,

title = {Fostering Accessibility to Mental Health Services for Youth Experiencing Homelessness in Montreal, Canada: A Historical Cohort Comparison Study},

author = {Amal Abdel-Baki and Giuseppe D'Andrea and Charles Tessier and Diane Aubin and Nora Morrison and Marie-Eve Dupont and Camille Arbaud and Pasquale Bauco and Jai L Shah and Ashok Malla and Srividya N Iyer},

doi = {10.1177/00207640261446109},

issn = {1741-2854},

year  = {2026},

date = {2026-05-01},

journal = {Int J Soc Psychiatry},

pages = {207640261446109},

abstract = {BACKGROUND: Youth experiencing homelessness face significant barriers to mental healthcare. To address this gap, the  (RIPAJ) was established in Montréal in 2003 through collaboration between community and governmental health organizations. In 2016, RIPAJ joined the national Adolescent/Young Adult Connections to Community-driven Early Strengths-based Stigma-free services-Open Minds (ACCESS-OM) initiative, aiming to enhance mental healthcare accessibility for youth experiencing homelessness.nnAIMS: This study evaluates the impact of this integrated approach on referral trends and wait times before and during ACCESS-OM RIPAJ implementation.nnMETHOD: Monthly referrals and wait times for first appointment were recorded for a historical cohort (2014-2015) and the ACCESS-OM RIPAJ period (2016-2020). We used Poisson and Cox regression models to analyze trends in referral rates and wait times, with 2014 as reference period. Seasonality was controlled by incorporating calendar month in the models. Additional Cox regressions examined individual-level sociodemographic and clinical factors associated with post-implementation wait times.nnRESULTS: We analyzed 158 referrals for 2014 to 2015 and 681 for 2016 to 2020. Monthly referrals increased significantly, peaking at 2.5 times the 2014 level. Wait times remained stable, with 73.5% evaluated within 72 hr. The hazard ratio for wait times during the peak period was 0.87 (95% CI [0.63, 1.20]) indicating no significant change despite the surge in referrals. Older age and self-referral were associated with reduced wait times.nnCONCLUSIONS: This collaborative model successfully increased mental healthcare utilization among youth experiencing homelessness, providing valuable insights for addressing the unmet needs of this vulnerable population and potentially reducing homelessness perpetuation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42127906,

title = {Traumatic life experiences during critical periods lead to diverse developmental trajectories},

author = {Giovanni Morelli and Greta Visintin and Elisa Gelli and Angelo Serani and Martina Bartolucci and Sara Uccella and Maria D'Apruzzo and Deborah Preiti and Mariam Marie Chellali and Alessandra Cucinelli and Mohit Rastogi and Matteo Falappa and Andrea Scalabrini and Gustavo Turecki and Andrea Petretto and Valter Tucci and Laura Cancedda},

doi = {10.1016/j.xcrm.2026.102798},

issn = {2666-3791},

year  = {2026},

date = {2026-05-01},

journal = {Cell Rep Med},

pages = {102798},

abstract = {Traumatic events can disrupt neurodevelopment, increasing the risk for neuropsychiatric disorders. However, the relationships between specific types of traumas and the emergence of particular neuropsychiatric traits remain elusive. Here, we examine the long-term consequences of different life-threatening events experienced during four distinct developmental periods in mice. Our findings at the behavioral and molecular/cellular levels in adulthood suggest a crucial role for timing (rather than type) of stress during development in shaping long-term outcomes. Our parallel analysis of individuals exposed to trauma at diverse life stages reveals similar results. Finally, our proteomic data suggest the brain-derived neurotrophic factor (BDNF)-pathway as a promising therapeutic target for ameliorating psychopathology related to trauma experienced specifically in early adulthood in mice and potentially in individuals. Our results point to the existence of critical periods for trauma exposure that uniquely influence adult behavioral outcomes and induce time-specific molecular/cellular patterns in the brain, which may have therapeutic implications.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42135321,

title = {Case report of Parkinson's disease in isolated congenital anosmia with absent olfactory bulbs},

author = {Sarah Brosse and Ronald B Postuma and Yosef Shechter and Cécilia Tremblay and Walter Adame Gonzalez and Mahsa Dadar and Johannes Frasnelli},

doi = {10.1038/s41531-026-01386-9},

issn = {2373-8057},

year  = {2026},

date = {2026-05-01},

journal = {NPJ Parkinsons Dis},

abstract = {Olfactory dysfunction is an early, prodromal feature of Parkinson's disease (PD), often preceding motor symptoms by years. This has fueled the hypothesis that PD pathology may originate in the olfactory bulb (OB), where early Lewy-type α-synucleinopathy is frequently observed and from which pathology could propagate to neural systems. In this context, Arshamian et al. (2022) hypothesized that isolated congenital anosmia (ICA), a rare lifelong absence of smell typically associated with bilateral OB aplasia, might confer immunity to PD. They argued that identifying a single individual with both ICA and PD would constitute a "black swan", falsifying the claim that an intact OB is necessary for PD initiation. We describe such a case: an individual with lifelong anosmia, MRI-based evidence of bilateral OB aplasia, and a clinically established diagnosis of PD. This counterexample challenges strict OB-necessity models and suggests PD can arise despite apparent congenital absence of an intact OB.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42142164,

title = {Age of onset: static and dynamic brain regional activity in first-episode drug-naïve schizophrenia},

author = {Maoxing Zhong and Jie Yang and Miao Zhang and Feiwen Wang and Yiju Wang and Lifu Tan and Zhening Liu and Lena Palaniyappan},

doi = {10.1007/s00787-026-03056-w},

issn = {1435-165X},

year  = {2026},

date = {2026-05-01},

journal = {Eur Child Adolesc Psychiatry},

abstract = {The age at which schizophrenia manifests is a critical factor influencing long-term outcomes. It is essential to distinguish the effects of the illness phase from those of the age of onset. We assessed static/dynamic brain regional activity from 428 participants, split into four groups based on onset-age (early-onset schizophrenia [EOS] and adult-onset schizophrenia [AOS]) and treatment status: (1) drug-naïve first-episode patients (48 EOS and 62 AOS); (2) patients treated for ≤ 12 months (60 EOS and 53 AOS); (3) patients treated for > 12 months (56 EOS and 56 AOS); and (4) 93 healthy controls (32 age-matched with EOS, 61 age-matched with AOS). We conducted a principal component analysis and subsequent 2 × 2 factorial analysis on the extracted first component representing static/dynamic regional activity, followed by an out-of-sample imaging transcriptomics analysis. The stability of results from the drug-naïve groups were tested on the treated groups to account for antipsychotic effects. Onset-age had a notable interaction with diagnosis on the static activity of the thalamus, mid-cingulate cortex (MCC), cerebellum posterior lobe (CPL), precuneus, and putamen, and on the dynamic stability of the CPL, thalamus, and superior parietal lobule (SPL). Phase of illness and medication exposure did not affect the onset-age effect seen at the MCC, thalamus, and SPL. Transcriptomics analysis pointed to the possibility of a shared disruption in neuronal differentiation across the MCC, thalamus and SPL. Onset-age affects thalamo-fronto-parietal regional hemodynamic activity, possibly through disrupted neuronal differentiation, in schizophrenia. Exposure to antipsychotics do not reverse this functional imprint of the earlier illness onset, raising the question of alternate therapeutic approaches to close the observed "neurophysiological gap".},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42142295,

title = {Development and in vivo proof-of-concept of delayed alternating nutation tailored excitation point resolved spectroscopy (dante-press): a frequency-selective single voxel spectroscopy sequence applied to in vivo measurements of naa and glu at 7.0 T},

author = {Kesavi Kanagasabai and Omer Oran and Lena Palaniyappan and Jean Théberge},

doi = {10.1007/s10334-026-01365-4},

issn = {1352-8661},

year  = {2026},

date = {2026-05-01},

journal = {MAGMA},

abstract = {OBJECTIVE: Single-voxel proton magnetic resonance spectroscopy (1H-MRS) is a non-invasive in vivo imaging technique used to quantify the concentration of human brain metabolites. Frequency-selective 1H-MRS techniques reduce spectral complexity and simplify spectral modeling. We introduce a single-shot frequency-selective sequence known as Delays-Alternating-Nutation-Tailored-Excitation-Point-RESolved-Spectroscopy (DANTE-PRESS) and test its precision when measuring glutamate and NAA at 7 Tesla in phantoms and human brain in vivo.nnMATERIAL AND METHODS: DANTE-PRESS was programmed within the software environment of the Siemens Magnetom 7 Tesla MR scanner at the Centre for Functional Metabolic Mapping in London, Ontario. Two scans were obtained on phantoms and in 4 healthy volunteers (20 × 20x20mm voxel at the dorsal anterior cingulate cortex) as an in vivo proof-of-concept to refocus glutamate or NAA.nnRESULTS: DANTE-PRESS preserves the signal of the metabolite of interest while suppressing unwanted signals via a narrow-band frequency-selective refocusing pulse. DANTE-PRESS produces metabolite spectral signatures with J-evolution equivalent to that seen in a PRESS sequence with less than half the echo time. The inter-individual coefficients of variance were low and Cramer-Rao Lower Bounds were less than 5.1% for glutamate and NAA.nnDISCUSSION: Future work involving test-retest in vivo study in healthy volunteers to get measurements of glutamate along with other metabolites such as glutathione and GABA.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42162419,

title = {Dopamine drives persistent remodelling of the maternal brain},

author = {Jennifer C O'Chan and Giuseppina Di Salvo and Ashley M Cunningham and Sohini Dutta and Elizabeth Brindley and Benjamin H Weekley and Winnie Chen and Rasika R Iyer and Ethan Wan and Cindy Zhang and Naguib Mechawar and Gustavo Turecki and Ian Maze},

doi = {10.1038/s41586-026-10509-4},

issn = {1476-4687},

year  = {2026},

date = {2026-05-01},

journal = {Nature},

abstract = {Pregnancy and postpartum experiences represent transformative physiological states that impose lasting demands on the maternal body and brain, resulting in lifelong neural adaptations. However, the precise molecular mechanisms that drive these persistent alterations remain poorly understood. Here we used brain-wide transcriptomic profiling to define the molecular landscape of neuroplasticity induced by reproductive experience, identifying the dorsal hippocampal formation (dHF) as a key site of transcriptional remodelling. Combining single-cell RNA sequencing with a maternal-pup separation paradigm, we additionally found that chronic postpartum stress significantly disrupts dHF adaptations by altering dopamine dynamics, leading to changes in the dopamine-dependent histone post-translational modification, H3 dopaminylation, which causally mediates downstream alterations in gene expression and behaviour. In human dorsal subiculum, a brain structure within the dHF, we uncovered conserved patterns of parity-dependent alterations in H3 dopaminylation and transcription. We further established the sufficiency of dopamine modulation in regulating these adaptations via chemogenetic suppression of dopamine release into the dHF, which recapitulated key epigenomic and behavioural features of reproductive experience in virgin female mice. In sum, our findings establish dopamine as a central regulator of parity-induced neuroadaptations in humans and mice, revealing a fundamental transcriptional mechanism by which female reproductive experience remodels the brain to sustain long-term behavioural adaptations.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42169034,

title = {A longitudinal study of the trajectory of life satisfaction before, during and after the outbreak of the COVID-19 pandemic, and its associations with sociodemographic characteristics, psychological distress, and stressors during the pandemic},

author = {Saleh Molla and Xiang Wang and Yingying Su and Marie-Josée Fleury and Carl D'Arcy and Muzi Li and Chris Barrington-Leigh and Danielle Maltais and Jean Caron and Sajedeh Nejatian and Xiangfei Meng},

doi = {10.1186/s12889-026-27735-0},

issn = {1471-2458},

year  = {2026},

date = {2026-05-01},

journal = {BMC Public Health},

abstract = {BACKGROUND: There has been a paucity of literature on the long-term changes in well-being since the outbreak of COVID-19 pandemic. We explored a 12-year change in life satisfaction (LS) in Canada before and after COVID-19 and identified sociodemographic, psychological, and stressors during the pandemic associated with LS in 2024.nnMETHODS: Data were drawn from a community-based longitudinal population cohort established in 2007. Multivariate logistic regression was used to examine LS trajectories across four data collections: T3 (2012-2013), T4 (2014-2015), T7 (2022-2023), and T8 (2024), and LS in 2024 and their related correlates.nnRESULTS: Compared to pre-pandemic, participants at T7 (Adjusted Odds Ratio (AOR) = 0.71; 95% CI: 0.55-0.91) and T8 (AOR = 0.66; 95% CI: 0.51-0.85) reported having lower odds of high LS. Singles, middle-aged adults, and those with higher psychological distress were less likely to report high LS. Income-related stressors at T8 and financial hardship at T7 were also associated with lower odds of high LS at T8.nnCONCLUSION: Compared to pre-pandemic, LS declined during the pandemic (T7) and remained lower in 2024 (T8), with no evidence of recovery. Certain population subgroups were at even elevated risk of experiencing a decline in LS and of reporting low LS in 2024, which underscores the importance of financial support for individuals experiencing income instability and psychological distress.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42178538,

title = {Exploring experts' views on "Not Parent Expected" discoveries via direct-to-consumer DNA ancestry testing},

author = {Juliette Careau and Roel Feys and Maarten H D Larmuseau and Rebekah Drumsta and Rob Whitley},

doi = {10.1186/s12910-026-01494-4},

issn = {1472-6939},

year  = {2026},

date = {2026-05-01},

journal = {BMC Med Ethics},

volume = {27},

number = {1},

abstract = {BACKGROUND: Millions of people have taken Direct-to-Consumer (DTC) DNA ancestry tests to learn more about their ethnic ancestry and family history. A small but growing body of research has noted that these DTC DNA ancestry tests raise challenging ethical, psychosocial, and resource-related issues that have not been adequately considered nor discussed. One key issue concerns a "Not Parent Expected" (NPE) discovery, in which a user suddenly and unexpectedly learns from these tests that an assumed parent (typically the father) is not a biological parent. Such news can negatively affect mental health, self-identity, and family relationships. Given the limited research on this topic, we aimed to explore experts' views on the ethical, psychosocial and support-related aspects of DTC DNA ancestry testing, particularly for individuals who receive NPE news.nnMETHODS: We conducted a qualitative study. This involved semi-structured interviews with ten experts on DTC DNA ancestry testing, who had written about or actively researched these issues. The interviews were analysed using codebook thematic analysis.nnRESULTS: The analysis resulted in three overlapping themes. The first concerned insufficient support for the NPE population, despite the emergence of some relevant resources. The supports discussed included formal resources, such as genetic counselling and therapy, as well as informal resources, including online peer support. Both formal and informal resources were seen as having advantages and disadvantages. The second theme concerned the need for better consideration of informed consent before taking these tests. Many experts reported that standard consent procedures do not fully prepare consumers for the possibility of making an unexpected discovery such as an NPE event. They suggested that this information could be communicated more effectively, including using creative measures before consent is obtained. The third theme related to the testing companies' role and responsibility in relation to support for individuals learning NPE news. A few experts suggested that these companies bear some moral responsibility, even in the absence of a legal obligation, to provide or direct individuals to supportive resources.nnCONCLUSIONS: Together, these findings contribute to ongoing debates regarding DTC DNA ancestry testing by highlighting the need for greater support for those affected by NPE discoveries and clearer consideration of the responsibilities of testing companies.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41765195,

title = {Serotonergic psychedelics as epigenetic modulators: A paradigm shift in Alzheimer's disease therapeutics},

author = {Esmaeel G Gojani and Houman Farzin and Robert J Sutherland and Majid H Mohajerani},

doi = {10.1016/j.neubiorev.2026.106619},

issn = {1873-7528},

year  = {2026},

date = {2026-05-01},

journal = {Neurosci Biobehav Rev},

volume = {184},

pages = {106619},

abstract = {Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by amyloid-β (Aβ) accumulation, tau pathology, synaptic dysfunction, and neuroinflammation, which collectively drive progressive memory loss, cognitive decline, and behavioral changes. Increasing evidence implicates epigenetic dysregulation as a key contributor to these pathological processes by altering gene expression programs. Serotonergic psychedelics, which primarily act as agonists of the serotonin 2 A receptor (5-HT₂AR), have recently attracted attention for their ability to robustly promote neuroplasticity and induce sustained transcriptional changes in the brain. Preclinical studies indicate that these compounds can modulate epigenetic mechanisms, including histone modifications and DNA methylation (DNAm). This review examines the emerging intersection between psychedelic-induced epigenetic modulation and AD pathology, and proposes that targeted engagement of 5-HT₂Ars may help counteract epigenetic abnormalities that contribute to AD pathogenesis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42187272,

title = {The functional relevance of a short assessment of formal thought disorder in psychosis},

author = {Fatme Abboud and Jessica Ahrens and Estèe Ballès and Valentina Bambini and Bill Deakin and Neil A Harrison and Tilo Kircher and Gina Kuperberg and Peter F Liddle and Rohit Lodhi and Michael Mackinley and Susan L Rossell and Krish D Singh and Iris E Sommer and Alban Voppel and Farida Zaher and Nadia Zeramdini and Lena Palaniyappan},

doi = {10.1192/bjp.2026.10650},

issn = {1472-1465},

year  = {2026},

date = {2026-05-01},

journal = {Br J Psychiatry},

pages = {1--9},

abstract = {BACKGROUND: Formal thought disorder (FTD) is a highly disabling transdiagnostic feature that impedes communication and social ties. Progress in understanding and treating FTD has been hampered by the uncertainties in its assessment.nnAIMS: We examined if a short 3-5min assessment of transcribed speech can capture the latent dimensions and network structure of FTD and predict functional outcomes.nnMETHOD: In a transdiagnostic sample ( = 666) with a single longitudinal follow-up over 3-12 months ( = 244), we administered the short form of the Thought and Language Index to measure eight individual features of FTD. We determined the baseline factor structure of FTD, its temporal invariance at follow-up, and the predictive validity of FTD dimensions on the global single-item Social and Occupational Functioning Assessment Scale scores at baseline and follow-up. We identified the most influential and putative primary phenomena within the FTD syndrome, using network analysis.nnRESULTS: Factor analyses revealed a stable three-factor model of FTD: impoverishment (poverty of speech, weakening of goal), loosening (looseness, illogicality) and peculiarities (peculiar words, peculiar sentences), with excellent fit (Comparative Fit Index: 0.997, root mean square error of approximation: 0.040) and metric invariance over time. Impoverishment and peculiarities predicted functioning at baseline and 3-12 months later (cross-sectional:  = -0.196,  < 0.001 and  = -0.298,  = 0.001, respectively; longitudinal:  = -0.201,  = 0.037 and  = -0.336,  = 0.042, respectively). Looseness and poverty of speech were putative primary features influencing other FTD phenomena. Weakening of goal and peculiar sentences were the most connected phenomena.nnCONCLUSIONS: By integrating latent variable and network approaches, we provide a unified, empirically grounded framework to interpret FTD assessed using a brief speech task. We report a replicable three-dimensional structure, identify central symptoms that may maintain the FTD syndrome, and the specific dimensions that influence functional disability. These findings clarify the prognostically valuable features of FTD for future mechanistic and interventional research.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42201755,

title = {Guidelines for the prevention of psychosis from the World Federation of Societies of Biological Psychiatry (WFSBP) and EPI Canada},

author = {Marco Solmi and Christoph U Correll and Tommaso Boldrini and Jean M Addington and Edgar Barbezat and Stella Bassetto and Andreas Bechdolf and Dan Devoe and Joseph Firth and Paolo Fusar-Poli and Ary Gadelha and Renan Göksal and Matcheri Keshavan and Eoin Killackey and Nikolaos Koutsouleris and Gabriele Lo Buglio and Mirko Manchia and Patrick McGorry and Jai Shah and Helen J Stain and Philip G Tibbo and Thomas Hastings and Howard C Margolese and Nicola Otter and Eduard Vieta and Liang-Jen Wang and Scott W Woods and Lakshmi N Yatham and Alison R Yung and Muhammad Omair Husain and Peter Falkai and Michael Berk and Andre F Carvalho},

doi = {10.1080/15622975.2026.2651738},

issn = {1814-1412},

year  = {2026},

date = {2026-05-01},

journal = {World J Biol Psychiatry},

pages = {1--44},

abstract = {OBJECTIVE: To prepare evidence-based guidelines on psychosis prevention.nnMETHODS: We reviewed evidence on risk factors for/age at onset of psychosis, tools to assess clinical high-risk of psychosis (CHR-P), transition rates, risk calculation/ethical considerations around risk communication, CHR-P biological/clinical correlates, efficacy/cost-effectiveness of interventions/psychosis prevention services. The World Federation of Societies of Biological Psychiatry framework was used to grade evidence regarding interventions/services, elaborating guidelines with evidence-/consensus-based clinical recommendations to prevent psychosis in CHR-P subjects.nnRESULTS: At the service organisation level, (i) psychosis indicated prevention services might be implemented in close collaboration with early intervention services for psychosis to minimise duration of untreated illness, (ii) intake age criteria should be between 14 to 35, (iii) services should allow access to persons with cannabis use disorder. At the assessment and risk communication level, in clinical settings: (iv) staff in mental health services should be trained in administering/rating CHR-P assessment tools, (v) administer them, (vi) be trained in using/interpreting risk calculators, and (vii) in communicating risk, (viii) only use validated risk calculators, keeping a human-to-human interaction. Also, (ix) prevention services should assess comorbid mental disorders. At the intervention level: (x) staff should offer treatment for abstinence from cannabis, (xi) offer evidence-based treatment for comorbid mental disorders, and (xii) offer treatment for CHR-P based on patient preference, following the 'first do no harm' principle.nnCONCLUSIONS: Prevention services should be implemented, including interventions for cannabis use, reducing the duration of untreated psychosis, and treating comorbid mental disorders.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41978994,

title = {Elevation in network dynamics amplifies amyloid-dependent tau pathology},

author = {Jieying Li and Yang Yi and Lin Gan and Gleb Bezgin and Tevy Chan and Nesrine Rahmouni and Yi-Ting Wang and Etienne Aumont and Seyyed Ali Hosseini and Brandon J Hall and Lydia Trudel and Joseph Therriault and Arthur C Macedo and Kely Monica Quispialaya Socualaya and Jaime Fernandez Arias and Yansheng Zheng and Delphine Olivia-Lopez and Robert Hopewell and Chris Hung-Hsin Hsiao and Ting Zou and Jean-Paul Soucy and Serge Gauthier and Paolo Vitali and Tharick A Pascoal and Qolamreza R Razlighi and Maxime Montembeault and Rong Li and Pedro Rosa-Neto},

doi = {10.1002/alz.71354},

issn = {1552-5279},

year  = {2026},

date = {2026-04-01},

journal = {Alzheimers Dement},

volume = {22},

number = {4},

pages = {e71354},

abstract = {INTRODUCTION: The role of brain network dynamics in relation to amyloid beta (Aβ) and tau pathology across Braak stages remains unclear.nnMETHODS: In this cross-sectional study of 216 participants from Translational Biomarkers of Aging and Dementia (TRIAD) cohort, we analyzed resting-state functional magnetic resonance imaging using a multilayer modularity algorithm to assess brain network dynamics across 10 predefined functional networks, stratified by amyloid and tau positron emission tomography biomarkers and Braak stages.nnRESULTS: Switching rates were significantly elevated in Aβ-positive/tau-positive individuals relative to Aβ-negative/tau-negative individuals, and increased progressively with advancing Braak stages. Elevated switching rates were strongly correlated with Aβ and tau burden in dorsal attention network and sensorimotor network, as well as with cognitive severity. Importantly, the interaction between network switching rate and Aβ burden synergistically contributed to accelerated tau accumulation in Braak stage III to V regions.nnDISCUSSION: These findings support the framework that increased network switching may amplify Aβ-related tau load and cognitive deterioration in Alzheimer's disease.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41916947,

title = {Understanding depression through an intersectional framework: the joint impact of childhood adversities and social determinants using Canadian longitudinal study on aging (CLSA) data},

author = {Yingying Su and Muzi Li and Marie-Josée Fleury and G Camelia Adams and Xiangfei Meng},

doi = {10.1038/s41398-026-03973-z},

issn = {2158-3188},

year  = {2026},

date = {2026-04-01},

journal = {Transl Psychiatry},

volume = {16},

number = {1},

abstract = {While previous research has focused on individual risk factors, few studies have utilized an intersectionality-informed framework to examine how multiple social factors collectively impact depression risk, particularly in the context of childhood adversities. This study investigates the association between adverse childhood experiences (ACEs) and depression while considering the intersecting roles of sex, socioeconomic status (SES), and ethnicity in identifying high-risk population subgroups. Data were drawn from the Canadian Longitudinal Study on Aging (CLSA), a nationally representative prospective cohort comprising over 50,000 adults aged 45 and older. We included 20,559 participants from the Comprehensive cohort who completed both baseline and first follow-up assessments. Depression was measured using a validated scale (CES-D-10). Key variables included ACE exposure, sex, SES, ethnicity, and other sociodemographic covariates. Latent class analysis was conducted to explore latent ACEs groups. Multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA) was employed to investigate whether ACE patterns and intersectional social groups predicted differential risks of depression. Three distinct patterns of ACEs were identified. The high ACE group was associated with an elevated risk of depression, especially among females, individuals with low SES, and non-White groups. This risk was compounded among those with multiple marginalized identities, such as females with low SES and exposure to high ACE, highlighting the cumulative nature of depression vulnerability. In contrast, male sex and high SES were protective, particularly in the absence of ACE exposure. Integrating ACEs with an intersectional framework reveals the complex etiology of depression and underscores the need for targeted, equity-oriented prevention strategies considering cumulative disadvantage.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41981379,

title = {Analytical and clinical validation of the Lumipulse G plasma p-tau217 assay for clinical implementation},

author = {Burak Arslan and Johan Gobom and Ulf Andreasson and Laia Montoliu-Gaya and Andrea L Benedet and Anna Dittrich and Silke Kern and Ingmar Skoog and Nicholas J Ashton and Tevy Chan and Nesrine Rahmouni and Pedro Rosa-Neto and Kaj Blennow and Henrik Zetterberg and Hlin Kvartsberg},

doi = {10.1002/alz.71374},

issn = {1552-5279},

year  = {2026},

date = {2026-04-01},

journal = {Alzheimers Dement},

volume = {22},

number = {4},

pages = {e71374},

abstract = {INTRODUCTION: Although several plasma tau phosphorylated at threonine 217 (p-tau217) immunoassays are now available, comprehensive analytical validation remains limited. We therefore evaluated the Lumipulse G plasma p-tau217 assay and verified established cutoffs for clinical implementation.nnMETHODS: This study was conducted in two phases: (1) analytical validation of the Lumipulse G plasma p-tau217 assay, assessing precision, lower limit of quantification (LLoQ), selectivity, stability, and interference; and (2) verification of previously established cutoffs using a two-threshold approach in 37 samples with confirmed cerebrospinal fluid (CSF) Aβ42/Aβ40 status.nnRESULTS: The assay demonstrated strong analytical performance, with repeatability and intermediate precision (%CV < 7%) and an LLoQ of 0.12 pg/mL. The p-tau217 was stable across freeze-thaw cycles but less so at 4°C, and hemolysis > 2% introduced variability. Cutoff verification showed 97% reproducibility with excellent agreement (ρ = 0.99, p < 0.0001).nnDISCUSSION: The Lumipulse assay showed robust analytical performance and reproducibility, supporting clinical use, though certified reference materials are still needed for standardization.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41928498,

title = {Interpersonal Capitalization and Unmet Interpersonal Needs Among Adolescents at Varying Risk for Suicidal Ideation: A Daily Diary Study},

author = {Ignacio Perezmontemayor Cruz and Sasha MacNeil and Johanne Renaud and Jean-Philippe Gouin},

doi = {10.1111/sltb.70096},

issn = {1943-278X},

year  = {2026},

date = {2026-04-01},

journal = {Suicide Life Threat Behav},

volume = {56},

number = {2},

pages = {e70096},

abstract = {INTRODUCTION: Adolescents at risk for suicidal ideation tend to report more unmet interpersonal needs, namely perceived burdensomeness and thwarted belongingness. Interpersonal capitalization-an interpersonal process involving disclosing a positive personal event to others and evaluating others' responsiveness to such disclosure-can promote positive affect and social connectedness. This study examined whether daily capitalization attempts and perceived active-constructive responses to the capitalization attempts were associated with fluctuations in positive affect and unmet interpersonal needs among adolescents at varying risk of suicidal ideation.nnMETHODS: Adolescents (M = 15.55; range = 12-18) with and without major depression, at respectively higher risk (n = 23) and lower risk (n = 32) for suicidal ideation, completed 10 consecutive daily diaries reporting on interpersonal capitalization, positive affect, perceived burdensomeness, and loneliness (as a proxy for thwarted belongingness).nnRESULTS: Within-person hierarchical linear modeling analyses showed that daily capitalization attempts and perceived active-constructive responses were associated with higher same-day positive affect in both groups. In the higher-risk group, daily capitalization attempts were associated with lower same-day perceived burdensomeness (b = -0.102, p < 0.05) and perceived active-constructive responses were related to lower daily loneliness (b = -0.279, p < 0.001).nnCONCLUSION: Daily interpersonal capitalization processes may represent a protective interpersonal pathway linked to reduced suicidal ideation over time, particularly among higher-risk adolescents.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41983935,

title = {Developmental Trajectories of Suicidality in Sexually Diverse and Heterosexual Adolescents: Findings From the Quebec Longitudinal Study of Child Development: Trajectoires développementales de suicidalité chez les adolescents hétérosexuels et de la diversité sexuelle : Résultats de l'Étude longitudinale sur le développement des enfants du Québec},

author = {Sasha MacNeil and Roxanne Sicotte and Camille Davisse-Paturet and Elise Chartrand and Em Alexander and Myriam Lecousy and Alain Girard and Massimiliano Orri and Nicholas Chadi and Isabelle Ouellet-Morin and Annie Pullen Sansfaçon and Srividya N Iyer and Natalie Castellanos-Ryan and Ian Colman and Robert-Paul Juster and Marie-Claude Geoffroy},

doi = {10.1177/07067437261442420},

issn = {1497-0015},

year  = {2026},

date = {2026-04-01},

journal = {Can J Psychiatry},

pages = {7067437261442420},

abstract = {IntroductionSexually diverse adolescents report higher suicidality (ideation and attempts) than their heterosexual peers, but information on the onset and course of suicidality from early adolescence to young adulthood among contemporary sexually diverse individuals remains limited. This study traces suicidality trajectories across this critical developmental period, comparing sexually diverse and heterosexual adolescents both overall and by sex assigned at birth.MethodsData was drawn from the Quebec Longitudinal Study of Child Development, an ongoing population-based prospective birth cohort. This study included 1,505 participants who self-reported their sexual attraction at ages 15-17 (2013-2015) and past-year suicidal ideation and attempts using 3-items at ages 13, 15, 17 and 23 (2011-2021) from which a suicidality severity score was derived.Results11.5% of the sample (n = 173, 60.5% female) reported sexually diverse attraction. Growth curve modelling tested the random effect of sexually diverse (vs. heterosexual) attraction on suicidality severity intercept, linear and quadratic latent growth factors. Age-specific contrasts in suicidality severity between sexually diverse and heterosexual adolescents were also examined. Compared to heterosexual adolescents, sexually diverse adolescents showed a steeper increase in suicidality severity from ages 13 to 17, and declining yet persisting disparities from ages 17 to 23. Although developmental trajectories differed across sexually diverse males and females, both experienced greater suicidality severity during adolescence compared with heterosexual peers.DiscussionOur findings point to a developmental trajectory in which sexually diverse adolescents, particularly females assigned at birth, experience elevated suicidality that persists into young adulthood. Targeted and timely interventions during this critical developmental period are essential for suicide prevention.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41986308,

title = {Stress and synaptic density in psychosis and clinical high risk: evidence from [F]SynVesT-1 PET},

author = {M Belen Blasco and Kankana Nisha Aji and Christian Ramos-Jiménez and Daniel Chartrand and Chris Hung-Hsin Hsiao and Robert Hopewell and Gassan Massarweh and Johan Cohen and Pablo M Rusjan and Romina Mizrahi},

doi = {10.1038/s41398-026-03993-9},

issn = {2158-3188},

year  = {2026},

date = {2026-04-01},

journal = {Transl Psychiatry},

volume = {16},

number = {1},

abstract = {Synaptic dysfunction is implicated in the pathophysiology of schizophrenia, and positron emission tomography (PET) studies demonstrate in vivo reductions in synaptic density across illness stages. Stress is a key modifiable risk factor, and while animal studies show it disrupts synaptic function, its effects on humans remain unclear. We examined the relationship between stress and synaptic density in individuals with first-episode psychosis (FEP) and those at clinical high risk (CHR). Seventy-eight participants, including 25 FEP, 32 CHR, and 21 healthy controls (HC), underwent 90-min [F]SynVesT-1 PET scans to quantify synaptic density measured as SV2A binding across prioritized brain regions. Stress-related measures included the Hassles and Uplifts Scale and the Trier Inventory for Chronic Stress (TICS). Depressive symptoms were evaluated using the Hamilton Depression Rating Scale (HDRS). Across all participants, greater acute stress was associated with lower [F]SynVesT-1 binding (F = 12.0, p < 0.001), with no significant group interaction (F = 2.44, p = 0.09). Group differences emerged for chronic stress and depressive symptoms (TICS × Group: F = 3.87, p = 0.02; sqHDRS × Group: F = 4.47, p = 0.01). Post hoc analyses revealed that higher chronic stress was associated with lower synaptic density in HC (F = 7.07, p = 0.009) but not in clinical groups. Lower mood symptoms were associated with lower synaptic density in FEP (F = 5.19, p = 0.02) only. These findings indicate that the relationship between stress and synaptic density differs between clinical and healthy groups. The changes in the relationship between stress and synaptic density in FEP may reflect impaired adaptive neuroplasticity, providing a potential mechanism by which stress contributes to psychosis vulnerability.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41992106,

title = {Satisfaction With Youth Mental Health Services in Diverse Settings: Results From a Pan-Canadian Initiative},

author = {John Bedirian and Tovah Cowan and Valérie Noël and Shalini Lal and Ridha Joober and Jai Shah and Amal Abdel-Baki and Rebecca Fuhrer and Patricia Boksa and Neil Andersson and Kathleen MacDonald and Charles-Albert Morin and Mary-Anne Levasseur and Helen Vallianatos and Lacey Augustine and Kevin Friese and Isabelle Godin and Liana Urichuk and Daphne Hutt-MacLeod and Vickie Plourde and Norma Rabbitskin and Paula Reaume-Zimmer and Cécile Rousseau and Ashok Malla and Srividya N Iyer},

doi = {10.1176/appi.ps.20250441},

issn = {1557-9700},

year  = {2026},

date = {2026-04-01},

journal = {Psychiatr Serv},

pages = {appips20250441},

abstract = {OBJECTIVE: Increasing concern about youth mental health has brought interest in service reform. Given the importance of positive care experiences, the authors aimed to study rates of satisfaction, as well as characteristics associated with satisfaction, in ACCESS Open Minds, a cocreated network of enhanced primary and community youth mental health services across Canada.nnMETHODS: A total of 482 youths receiving services at 10 ACCESS Open Minds sites (urban, rural, and Indigenous) completed the Client Satisfaction Questionnaire-4 and responded to additional demographic and service use questions.nnRESULTS: Ninety-one percent of youths were satisfied with their mental health services, substantially higher than the predefined goal of 75%. Youths who preferred virtual services (23%) were less satisfied than those who preferred in-person services.nnCONCLUSIONS: The findings are comparable with those from similar initiatives, highlighting the value of youth-friendly, holistic primary mental health care. High satisfaction across sociodemographic groups and sites suggests that such services are acceptable in diverse communities.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42003427,

title = {A Comprehensive Characterization of the Phospholipid and Cholesterol Composition of the Uncinate Fasciculus in the Human Brain: Evidence of Age-Related Alterations},

author = {Kelly Perlman and Chuck T Chen and Mackenzie E Smith and John Kim and Gustavo Turecki and Richard P Bazinet and Naguib Mechawar},

doi = {10.1111/jnc.70428},

issn = {1471-4159},

year  = {2026},

date = {2026-04-01},

journal = {J Neurochem},

volume = {170},

number = {4},

pages = {e70428},

abstract = {The uncinate fasciculus (UF) is a long-range association fiber tract connecting the anterior temporal lobe with the orbitofrontal cortex and has been linked to a multitude of physiological and pathophysiological conditions such as aging, epilepsy, and the vulnerability to psychopathology posed by a history of childhood abuse (CA). Since the myelin sheath is highly enriched in lipids, changes in white matter (WM) microstructure observed via neuroimaging may reflect alterations in the myelin lipid profile. Given that the UF does not exist in rodents, its molecular properties are highly understudied. Therefore, we sought to quantify the phospholipid FA and cholesterol quantities of the human postmortem UF and evaluate any lipid-related or myelin-constituent gene/protein changes associated with age and history of CA. UF samples were analyzed from individuals with depression who died by suicide with (DS-CA) or without (DS) severe CA, and control individuals (CTRL), with an age span of 15 to 85 years. Phospholipids were separated by thin-layer chromatography; FAs and nonderivatized cholesterol were quantified by gas chromatography-flame ionization detection. The relative expression of myelin-constituent genes and proteins was measured by RT-qPCR and immunoblotting, respectively. We found no robust relationships between CA or depression and lipid measures or myelin-constituent gene/protein levels. In contrast, phospholipids showed pronounced age effects that differed by fraction, with an overall trend of monounsaturated FAs increasing and long-chain omega-6 polyunsaturated FAs decreasing with age. The expression of most myelin-constituent genes and proteins declined with age; PLP1 and MAG showed significant decreases. Therefore, changes in lipid composition and lipid-protein interactions likely contribute to age-related myelin deficits and may in part underlie age-associated cognitive decline.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41938234,

title = {Distinct Roles of Positive and Negative Maternal Mental Health in Parenting Styles and Child Development},

author = {Michelle Z L Kee and Desiree Y Phua and Helen Y Chen and Yap Seng Chong and Lourdes Mary Daniel and Peter D Gluckman and Birit F P Broekman and Michael J Meaney},

doi = {10.1016/j.jaacop.2025.11.007},

issn = {2949-7329},

year  = {2026},

date = {2026-04-01},

journal = {JAACAP Open},

volume = {4},

number = {2},

pages = {241--253},

abstract = {OBJECTIVE: Maternal mental health significantly impacts child development, yet the role of positive maternal mental health in shaping parenting and child outcomes remains unclear. This study examined how parenting styles mediate the relation between maternal mental health and developmental outcomes in 4- to 4.5-year-old children.nnMETHOD: This study used data from the multiethnic Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. A total of 328 mothers, who were recruited from Singapore hospital maternity units between 2009 and 2010, had completed longitudinal postnatal assessments of their mental health and parenting and child measures in English. Maternal mental health and parenting styles were assessed using the Beck Depression Inventory-II, State-Trait Anxiety Inventory, and Parenting Styles and Dimensions Questionnaire. Behavioral problems, school readiness, executive function, and IQ were assessed in children at 4 to 4.5 years old using validated behavioral and cognitive assessments.nnRESULTS: Bifactor modeling revealed 2 distinct maternal mental health factors, general affective symptoms and positive mental health. The general affective symptoms factor was positively associated with permissive and authoritarian parenting ( = 0.27 and 0.29, s < .001), which mediated the relation to child behavioral problems. Positive mental health correlated only with authoritative parenting ( = 0.19,  < .001), which mediated improvements in child executive function, verbal and numeracy abilities, and IQ.nnCONCLUSION: These findings highlight the distinct role of positive maternal mental health in fostering authoritative parenting, which in turn supports child cognitive development. Public health initiatives should prioritize promoting positive maternal mental health to enhance effective parenting and optimize child cognitive outcomes. Future research should consider paternal influences.nnDIVERSITY & INCLUSION STATEMENT: We worked to ensure sex and gender balance in the recruitment of human participants. We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. We worked to ensure that the study questionnaires were prepared in an inclusive way. Diverse cell lines and/or genomic datasets were not available. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. We actively worked to promote sex and gender balance in our author group.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41969055,

title = {What is being measured by formal thought disorder scales? An item-level content analysis},

author = {Vanteemar S Sreeraj and Alban Voppel and Ganesan Venkatasubramanian and Lena Palaniyappan},

doi = {10.1017/S0033291726104152},

issn = {1469-8978},

year  = {2026},

date = {2026-04-01},

journal = {Psychol Med},

volume = {56},

pages = {e106},

abstract = {BACKGROUND: Formal thought disorder (FTD), characterized by disruptions in the flow and form of thought, is a core feature of psychosis. But its measurement is fragmented across numerous rating scales, leading to its continued neglect in both research and clinical practice. To determine if different FTD scales measure the same underlying construct, we need to assess the degree to which the content of commonly used FTD scales overlaps with each other.nnMETHODS: We conducted a systematic review to identify all standardized, clinician-rated scales used to measure FTD in psychotic disorders. From this set, we extracted individual items and derived a consensus list of 56 discrete FTD phenomena. Two independent clinical experts conducted item-to-item mapping for every scale item onto these FTD phenomena. Content overlap between scales was quantified using Jaccard Similarity Index (JSI). We determined the overall coverage achieved via several combinations of FTD scales.nnRESULTS: The 15 scales, comprising 207 items, showed weak content overlap. The mean JSI across all scale pairs was low, and no single phenomenon featured across all scales. While some core FTD phenomena (e.g. 'incoherence', 'poor speech content', 'drifting-off') were represented in many scales, 20% of all identified features were idiosyncratic, appearing in only one scale.nnCONCLUSIONS: Existing FTD rating scales capture a wide but heterogeneous array of symptoms with poor content overlap. This lack of harmonization challenges the comparability of mechanistic and interventional studies. We highlight the need for a consensus-based, standardized measurement of FTD and provide a comprehensive checklist to advance the research and clinical practice.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41942773,

title = {Characterization of the chromosome 7 locus associated with suicidal behavior},

author = {Laura M Fiori and Anjali Chawla and Vikram Nathan and Malosree Maitra and Corina Nagy and Gustavo Turecki},

doi = {10.1038/s41380-026-03600-9},

issn = {1476-5578},

year  = {2026},

date = {2026-04-01},

journal = {Mol Psychiatry},

abstract = {Suicide is one of the leading causes of death worldwide. Although suicidal behaviors demonstrate high heritability, identifying the underlying genetic factors has been challenging. Recent genome-wide association studies for suicidal behavior identified a SNP on chromosome 7, rs62474683, which was the most significantly associated SNP. As this SNP is intergenic, the mechanism by which it may be related to suicidal behaviors is unclear. In order to determine the potential functional effects of the rs62474683 genotype, and how it may be related to suicidal behavior, we ascertained expression of genes within a 1.8Mbp region surrounding this SNP in two brain regions in individuals with depression who died by suicide, and investigated the relationship between genetic variation and gene expression. Additionally, we explored, at the single cell level, the effect of the variant on gene expression and chromatin accessibility. While we found several genes displaying differential expression, Forkhead box P2 (FOXP2) was the most consistently altered in brains of individuals who died by suicide and its expression was related to rs62474683 genotype. Furthermore, the association between FOXP2 expression and suicide appeared to be both brain region- and cell type-specific. Finally, we found evidence for an association between the region containing rs62474683 and FOXP2, and identified Homeobox family transcription factors as potential mediators of this relationship. In conclusion, our study provides evidence suggesting a potential functional association between the most significant suicide attempt-associated locus to date and genes displaying differential expression in individuals with depression who died by suicide.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42061696,

title = {Reading between the lines: Combining pause dynamics and semantic coherence for automated assessment of thought disorder},

author = {Feng Chen and Weizhe Xu and Changye Li and Serguei Pakhomov and Alex Cohen and Simran Bhola and Sandy Yin and Sunny X Tang and Michael Mackinley and Lena Palaniyappan and Dror Ben-Zeev and Trevor Cohen},

doi = {10.1016/j.neuropsychologia.2026.109473},

issn = {1873-3514},

year  = {2026},

date = {2026-04-01},

journal = {Neuropsychologia},

volume = {228},

pages = {109473},

abstract = {Formal thought disorder (FTD), a hallmark of schizophrenia spectrum disorders, manifests as incoherent speech and poses challenges for clinical assessment. Traditional clinical rating scales, though validated, are resource-intensive and lack scalability. Automated speech recognition (ASR) allows for objective quantification of linguistic and temporal features of speech, offering scalable alternatives. Furthermore, ASR-derived utterance timestamps provide access to pause dynamics, which are thought to reflect the cognitive processes underlying speech production. Yet, their added value beyond semantic measures remains insufficiently explored. In this study, we evaluated a scalable multimodal framework that integrates pause features with semantic coherence metrics across three datasets: naturalistic self-recorded diaries (AVH, n = 140 participants), structured picture descriptions (TOPSY, n = 72 participants), and dream narratives (PsyCL, n = 43 participants). Pause-related features were evaluated alongside established coherence measures using support vector regression (SVR) to predict clinical FTD scores. Models using pause features alone robustly predict manually rated FTD severity consistently across datasets. Integrating pause features with semantic coherence metrics enhanced predictive performance compared to coherence-only models, with late fusion yielding the most robust and consistent gains in all three datasets. On average across datasets, Spearman correlation increased from ρ = 0.413 for semantic-only models to ρ = 0.455 with late fusion. The performance gains from semantic and pause features integration held consistently across all contexts, though the nature of the most informative pause patterns was dataset-dependent. These findings suggest that both pause dynamics and semantic coherence reflect complementary aspects of thought disorganization. Our integration framework provides a scalable approach for refining the assessment of disorganized speech to advance automated speech analysis in psychosis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42027716,

title = {Ultrastructural analysis of human uncinate fasciculus with coherent anti-Stokes Raman spectroscopy},

author = {Kelly Perlman and Valérie Pineau Noël and Armand Collin and Justine Major and Murielle Mardenli and Sébastien Jerczynski and Maria Antonietta Davoli and Julien Cohen-Adad and Daniel Côté and Naguib Mechawar},

doi = {10.1117/1.BIOS.3.2.025002},

issn = {3005-4745},

year  = {2026},

date = {2026-04-01},

journal = {Biophotonics Discov},

volume = {3},

number = {2},

pages = {025002},

abstract = {SIGNIFICANCE: Characterizing the ultrastructure of myelin in the human brain is key to understanding the neurobiology of both health and disease. In postmortem human brain tissue, electron microscopy is often technically unfeasible due to poorer tissue quality.nnAIM: The uncinate fasciculus (UF) is a long-range white matter association tract that connects the anterior temporal lobe with the orbitofrontal cortex. The UF is not present in rodents yet is highly expanded in humans and nonhuman primates. As such, its molecular and ultrastructural properties are virtually unknown.nnAPPROACH: Here, we develop and validate a spectral-focusing coherent anti-Stokes Raman spectroscopy (sf-CARS) system coupled with a custom AxonDeepSeg segmentation model to characterize UF ultrastructure in the human postmortem brain (  ).nnRESULTS: We provide a proof of concept of this new methodological pipeline in the UF temporal segment and observe that the mean axon diameter detected is  and the mean myelin thickness is  . We also observe that the UF axons are thicker than those in the anterior cingulate cortex white matter.nnCONCLUSIONS: We detail and validate the full methodology, including tissue fixation and sectioning, sf-CARS acquisition settings, as well as the AxonDeepSeg deep learning model parameters, such that this pipeline can be utilized by others in the field.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42029407,

title = {Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease},

author = {Alfie Wearn and Kate M Onuska and Hayley R C Shanks and Rahul Gaurav and Stéphane Lehéricy and Giulia Baracchini and Colleen Hughes and Jennifer Tremblay-Mercier and Sridar Narayanan and John Breitner and Judes Poirier and Taylor W Schmitz and Gary R Turner and R Nathan Spreng and },

doi = {10.1002/alz.71427},

issn = {1552-5279},

year  = {2026},

date = {2026-04-01},

journal = {Alzheimers Dement},

volume = {22},

number = {4},

pages = {e71427},

abstract = {INTRODUCTION: The locus coeruleus (LC) is among the first sites of tau pathology in Alzheimer's disease (AD) and may seed neocortical tau.nnMETHODS: We used longitudinal neuromelanin-sensitive MRI to assess LC integrity in vivo in a cohort of cognitively unimpaired older adults with familial risk of AD in relation to tau and amyloid positron emission tomography (PET) and long-term cognitive trajectories.nnRESULTS: We showed that both LC integrity at baseline and its rate of degeneration over time independently predicted a neocortical pattern of tau deposition. In keeping with the known function of the LC, neuropsychological tests showed that LC integrity at baseline predicted changes in attention. Finally, we found that longitudinal LC degeneration correlated with memory decline in people with elevated neocortical amyloid burden.nnDISCUSSION: Our findings underscore the importance of LC in AD pathogenesis. Longitudinal measurement of LC degeneration may help distinguish trajectories of age-related cognitive decline and early AD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42033337,

title = {High-Risk Human-AI Engagement: Clinical Assessment and Management Considerations},

author = {Lena Palaniyappan and Vincent Paquin and Etienne Barou-Laforie},

doi = {10.1177/07067437261445770},

issn = {1497-0015},

year  = {2026},

date = {2026-04-01},

journal = {Can J Psychiatry},

pages = {7067437261445770},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42037310,

title = {Increasing Participation of People with Thought Disorder in Clinical Research},

author = {Lena Palaniyappan and Sylvain Baillet and Valentina Bambini and Etienne Barou-Laforie and Marta Bosia and Oli Delgaram-Nejad and Hashwin Ganesh and Ranjini Garani and Neil Harrison and Vegas Hodgins and Ridha Joober and Gina Kuperberg and Tilo Kircher and Chantal Murthy and Susan Rossell and Krish D Singh and Iris E Sommer and Sunny X Tang and Debra Titone and Alban Voppel and Tosh Watson and Irnes Zeljkovic},

doi = {10.1192/j.eurpsy.2026.12211},

issn = {1778-3585},

year  = {2026},

date = {2026-04-01},

journal = {Eur Psychiatry},

pages = {1--36},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42054343,

title = {The Readability of Patient-Reported Measures in Early Psychosis},

author = {Maria Abou Farhat and Negin Zamani and Simran Bajaj and Nicole Pawliuk and Navdeep Kaur and Jai Shah and Manuela Ferrari and Srividya N Iyer},

doi = {10.1093/schbul/sbag018},

issn = {1745-1701},

year  = {2026},

date = {2026-04-01},

journal = {Schizophr Bull},

volume = {52},

number = {3},

abstract = {BACKGROUND: Patient-reported measures are increasingly central to early intervention in psychosis. Many persons with psychosis have lower educational attainment than the general population and cognitive difficulties, making the readability of measures salient for this population. However, the readability of patient-reported measures in psychosis has never been investigated. This study assessed the readability levels of patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) in early intervention in psychosis.nnSTUDY DESIGN: PROMs and PREMs were identified from a scoping review of measures used in early intervention services for psychosis (January 2000-January 2024). Of 111 measures identified, 104 (89 PROMs; 15 PREMs) were assessed using mean grade levels derived from 3 established readability formulas (Flesch-Kincaid Grade Level, Simple Measure of Gobbledygook index, FORCAST formula), applied to instructions, items, and total scales.nnSTUDY RESULTS: Overall, 82.7% of patient-reported measures exceeded the recommended 6th-grade reading level. Instructions were harder to read than items (mean readability: 9.44 vs. 7.95; t(90) = 6.54, P < .001). PREMs demanded higher readability levels than PROMs. Readability scores were different across formulas, with Flesch-Kincaid consistently producing lower scores. Except for one, the strikingly few measures co-developed with patients (n = 14) also exceeded 6th-grade reading level.nnCONCLUSIONS: Most patient-reported measures in early psychosis exceed recommended readability levels, raising concerns about accessibility, validity, and whose experiences are represented in patient-reported data. This creates impetus for integrating readability assessments into measures development. More fundamentally, centering the participation of persons with lived experience can support readable, relevant, and patient-centered assessments reflecting the language, priorities, and realities of people with psychosis, and advance epistemic justice.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42014609,

title = {Factors Associated with the Frequency of Treatment Admissions Over A 13-year Period Among Patients with Gambling Disorder},

author = {Marie-Josée Fleury and Ovidiu Tatar and Guy Grenier and Sharmin Sharker and Francine Ferland and Nadine Banchette-Martin},

doi = {10.1007/s10899-026-10490-7},

issn = {1573-3602},

year  = {2026},

date = {2026-04-01},

journal = {J Gambl Stud},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41965343,

title = {Advancing translational research in binge-eating: Integrating insights from clinical practice into animal models},

author = {Rachel Dufour and Uri Shalev and Linda Booij},

doi = {10.1038/s41398-026-04035-0},

issn = {2158-3188},

year  = {2026},

date = {2026-04-01},

journal = {Transl Psychiatry},

volume = {16},

number = {1},

abstract = {Binge-eating behaviors are key components of several types of eating disorders, yet their etiology remains unclear. Animal models have provided valuable insights by enabling experimentally controlled investigations of biological, behavioral, and environmental factors contributing to eating disorders. This narrative review examines the clinical relevance of animal models in advancing our understanding of binge-eating-related disorders. We propose five translational priorities focused on clinically-meaningful features of binge eating and their relevance for improving animal-model development: (1) loss of control and compulsivity, (2) negative affect and stress responsivity, (3) developmental timing and sex differences, (4) individual differences and variability, and (5) treatment responsiveness. Various animal models, including food restriction, stress-induced, and addiction-based paradigms, have been developed to study binge eating. Limitations include the inability of animal models to fully capture the psychological and sociocultural dimensions of binge eating, such as the sense of loss of control, stigma, distress, and body-image concerns. While existing models capture key biological and behavioral components of binge eating, closer alignment with clinically defining features, for example, through the inclusion of emotional stressors and varied outcome measures, could improve translational impact. By refining current models to match clinical reality, animal research may continue to enhance our understanding of eating disorders and inform the development of novel treatment approaches.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41963707,

title = {Peripheral microRNA signature in genetic frontotemporal dementia-findings from the GENFI initiative},

author = {Chiara Fenoglio and Maria Serpente and Marina Arcaro and Tiziana Carandini and Luca Sacchi and Manuela Pintus and Vittoria Borracci and Giulia Giudici and Marta Rigoni and Paola Muti and Laura Ghezzi and Arabella Bouzigues and Lucy L Rusell and Phoebe H Foster and Eve Ferry-Bolder and John C van Swieten and Lize C Jiskoot and Harro Seelaar and Raquel Sánchez Valle and Robert Laforce and Caroline Graff and Rik Vandenberghe and Alexandre de Mendonça and Pietro Tiraboschi and Isabel Santana and Alexander Gerhard and Johannes Levin and Florence Pasquier and Simon Ducharme and Isabelle Le Ber and Elizabeth Finger and Maria Carmela Tartaglia and Mario Masellis and James B Rowe and Matthis Synofzik and Fermin Moreno and Barbara Borroni and Andrea Sacconi and Jonathan D Rohrer and Andrea Arighi and Daniela Galimberti and },

doi = {10.1007/s11357-026-02214-x},

issn = {2509-2723},

year  = {2026},

date = {2026-04-01},

journal = {Geroscience},

abstract = {Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT, GRN, and C9ORF72. Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stages remains poorly understood. We conducted a miRNA expression analysis using TaqMan OpenArray® panels on blood samples collected from 171 individuals, including symptomatic mutation carriers (SMC), presymptomatic carriers (PMC), and healthy non-carriers (NC). Dysregulated miRNAs were validated and bioinformatic tools were used to identify potential associated molecular pathways. In C9ORF72, miR-20b-5p and miR-223-5p were significantly upregulated in SMC (fold regulation over NC: 2.418 p = 0.0336 and 7.829 p < 0.0264 respectively) and PMC (5.518, p < 0.0001 and 3.941, p < 0.0001 respectively). In GRN mutation carriers, miR-28-3p was altered in both SMC and PMC (fold regulation over NC: 1.484 p < 0.050 and 3.287, p < 0.050). In MAPT mutation carriers, miR-28-5p, miR-192-3p, miR-25-3p, and miR-532-3p were altered only in SMC (fold regulation over NC: 1.496 p < 0.050, 1.911 p = 0.006, 1.468 p < 0.05, and 0.728 p < 0.05). Bioinformatic analysis revealed enrichment of pathways related to neurodegeneration and synapse impairment. These results suggest that miRNA expression levels are deregulated in mutated SMC, in C9ORF72 and GRN PMC. Notably, miR-20b-5p, miR-223-5p, and miR-28-3p were increased in preclinical stages of the disease, supporting their role as early biomarkers for C9ORF72-FTD and GRN-FTD. Conversely, alterations in MAPT carriers appeared only in symptomatic stages, suggesting a different involvement in disease progression.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41951638,

title = {Astrocyte fatty acid metabolism as a driver of risk for major depressive disorder},

author = {Eamon Fitzgerald and Nicholas O'Toole and Irina Pokhvisneva and Eric J Nestler and Gustavo Turecki and Corina Nagy and Michael J Meaney},

doi = {10.1038/s41467-026-71542-5},

issn = {2041-1723},

year  = {2026},

date = {2026-04-01},

journal = {Nat Commun},

abstract = {Genome-wide association studies (GWAS) have successfully identified genetic loci associated with major depressive disorder (MDD), yet the complex gene networks underpinning this polygenic risk remain largely uncharacterised. Here, we elucidate the neurobiological mechanisms of MDD by analyzing co-expression networks of 94 risk genes in the human prefrontal cortex. By linking these networks to individual symptoms, we identify the FADS1 (fatty acid desaturase 1) network as a central integrator across symptom clusters. We find that the FADS1 network functions primarily in astrocytes to regulate fatty acid metabolism and influence oligodendrocyte-related cell states. Furthermore, we identify FGF2 as a synaptic effector of this pathway and highlight PPARα (peroxisome proliferator-activated receptor alpha) as a putative therapeutic target. These results establish astrocyte fatty acid metabolism as a critical mechanistic contributor to MDD and a promising avenue for treatment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41950274,

title = {Cultural Adaptation of a Digital Mobile App for Bipolar Disorder (PolarUs): Protocol for a Qualitative Co-Design Study},

author = {Leena W Chau and Jill K Murphy and Emma Morton and Martin D Provencher and Delphine Raucher-Chene and Steven J Barnes and Erin E Michalak},

doi = {10.2196/92600},

issn = {1929-0748},

year  = {2026},

date = {2026-04-01},

journal = {JMIR Res Protoc},

volume = {15},

pages = {e92600},

abstract = {BACKGROUND: Bipolar disorder (BD) affects approximately 40 million people worldwide and is a chronic, potentially disabling mood disorder. Although effective treatments exist, access to evidence-informed psychosocial care remains limited, particularly for culturally and linguistically diverse populations, contributing to persistent global treatment gaps. Digital mental health interventions (DMHIs), such as smartphone apps, offer a promising means to improve access to self-management support and quality of life (QoL), an outcome prioritized by people with BD and in clinical guidelines. However, most apps for BD lack quality and are not culturally adapted or co-designed with people with BD, limiting relevance and engagement. PolarUs (mobile app) is an evidence-informed DMHI developed using co-design with people with BD. The app is structured on the core 14 domains from the Quality of Life in BD scale, the only BD-tailored scale, combined with psychoeducation on self-management strategies and QoL. A recent pilot study demonstrated promising QoL, clinical, and feasibility outcomes.nnOBJECTIVE: This study aims to culturally and linguistically adapt the PolarUs app into French, Chinese, and Spanish for the North American context using qualitative and co-design methods.nnMETHODS: Guided by community-based participatory research principles, whereby end users are engaged throughout the research process, and the Ecological Validity Framework of Bernal et al, we will engage advisory groups of people with lived experience from each linguistic community throughout the cultural adaptation process. Semimonthly virtual meetings will support systematic cultural adaptation of the self-management strategies, affirmations, and resources while maintaining fidelity to core evidence-based components. This will include cultural tailoring of app content and the identification of culturally appropriate resources. Advisory groups will also contribute to the cointerpretation of findings and the co-design of culturally appropriate recruitment and implementation strategies of PolarUs for a future clinical trial. Meetings will be recorded and coanalyzed as research data with advisory groups using qualitative reflexive thematic analysis to capture advisory group perspectives and experiences.nnRESULTS: This study was funded in October 2024. As of January 31, 2026, we enrolled 7 participants, and the results are expected to be published in the fall of 2026.nnCONCLUSIONS: The findings will support the development of a culturally appropriate DMHI for BD for additional linguistic communities, advance cultural adaptation methodologies, and inform preparation for a future clinical trial. This study will produce the first culturally adapted, BD-specific DMHI developed through co-design using a community-based participatory research approach with multilingual end users from traditionally underserved communities, advancing equitable access, engagement, and scalability of DMHIs for BD and digital health care more broadly.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}