Publications

@article{pmid37293440,

title = {Interaction between Peripheral and Central immune markers in Clinical High Risk for Psychosis},

author = {Kankana Nisha Aji and Sina Hafizi and Tania Da Silva and Michael Kiang and Pablo M Rusjan and Cynthia S Weickert and Romina Mizrahi},

doi = {10.1016/j.bbih.2023.100636},

issn = {2666-3546},

year  = {2023},

date = {2023-07-01},

journal = {Brain Behav Immun Health},

volume = {30},

pages = {100636},

abstract = {•Serum IL-8 levels are elevated in individuals at CHR for psychosis.•Positive association between elevated IL-8 and prodromal general symptom severity.•Inflammatory clusters (IL-1β, IL-2, IFN-γ) are identified (entire cohort and CHR).•TSPO levels did not differ between inflammatory clusters (entire cohort or CHR).•CRP, IL-1β, TNF-α and IFN-γ levels are the independent predictors of brain TSPO.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34591530,

title = {Exploring the factor structure of the PTSD checklist for DSM-5 in psychotic disorders},

author = {Danielle Penney and Ghassan El-Baalbaki and Martin Lepage},

doi = {10.1037/tra0001146},

issn = {1942-969X},

year  = {2023},

date = {2023-07-01},

journal = {Psychol Trauma},

volume = {15},

number = {5},

pages = {767--771},

abstract = {OBJECTIVE: The PTSD Checklist for DSM (PCL) is the most widely used screener to assess posttraumatic stress disorder (PTSD) in those with psychotic disorders (psychosis), though previous research has questioned its validity in psychosis. Considerable symptom overlap between the 2 disorders (e.g., concentration difficulties, avoidance, etc.) along with the general underdiagnosing of PTSD in psychosis speaks to the need for consensus regarding brief screeners. This hypothesis-generating study is the first to explore the PCL-5 (its most recent iteration) factor structure in psychosis to assess if a more valid underlying structure may exist.nnMETHOD: Sixty-5 individuals who met the - PTSD criterion A traumatic event following an interview subsequently completed the PCL-5. Exploratory factor analysis was conducted to explore the latent structure of the PCL-5 in psychotic disorders.nnRESULTS: A 4-factor solution differing from the - 4-factor model emerged as the best fitting model. Resulting PCL-5 dimensions in psychosis were identified as (1) Reexperiencing/Negative Affect; (2) Depressive; (3) Externalizing Anxious Behaviors; and (4) Avoidance/Physiological Reactivity.nnCONCLUSIONS: Results guide the hypothesis that the latent structure of the PCL-5 may be unique in psychosis, which will have important clinical implications. Research is now needed to confirm the proposed model in larger samples of individuals with psychosis. (PsycInfo Database Record (c) 2023 APA, all rights reserved).},

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pubstate = {published},

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}

@article{pmid37276816,

title = {Subjective quality of life among first-episode psychosis patients in Chennai, India and Montreal, Canada},

author = {Sally Mustafa and Ashok Malla and Greeshma Mohan and Ramachandran Padmavati and Thara Rangaswamy and Ridha Joober and Norbert Schmitz and Howard Margolese and Srividya N Iyer},

doi = {10.1016/j.schres.2023.05.008},

issn = {1573-2509},

year  = {2023},

date = {2023-07-01},

journal = {Schizophr Res},

volume = {257},

pages = {41--49},

abstract = {Differences in subjective quality of life among persons receiving early intervention for psychosis in varying geo-sociocultural contexts have rarely been examined. Our prospective longitudinal study compared the quality of life of persons with first-episode psychosis receiving two years of similar early intervention in Chennai, India and Montreal, Canada. We hypothesized that general life satisfaction would be higher in Chennai compared to Montreal, and that social relations (a specific quality of life component) would also be higher in Chennai and positively contribute to general life satisfaction. Participants completed the general satisfaction and social relations domains of the Wisconsin Quality of Life Index at baseline, months 12 and 24. Baseline weighted mean general satisfaction and social relations scores were in the low to moderate range. Generalized estimating equation analyses showed that general satisfaction scores increased with time [Wald χ (1) = 125.28, p < 0.001] and were higher in Chennai than in Montreal [Wald χ (1) = 7.50, p = 0.006]. Social relations scores showed the highest association with general satisfaction scores (B = 0.52), followed by positive symptom remission (B = 0.24) and gender (B = 0.18) with Chennai males having the highest general satisfaction scores. Social relations weighted mean scores increased with time [Wald χ (1) = 87.30, p < 0.001] and were positively associated with years of education [Wald χ (1) = 4.76, p = 0.029] and early negative symptom remission [Wald χ (1) = 7.38, p = 0.007]. Our results suggest that subjective quality of life may improve following early intervention for psychosis across contexts. Our findings advance knowledge about the role of sociocultural (e.g., gender) and clinical factors in influencing subjective outcomes in psychosis, and point to social support networks and symptom remission as avenues to boost quality of life.},

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pubstate = {published},

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@article{pmid36681895,

title = {ABCB1 Gene Variants and Antidepressant Treatment Outcomes: A Systematic Review and Meta-Analysis Including Results from the CAN-BIND-1 Study},

author = {Leen Magarbeh and Claudia Hassel and Maximilian Choi and Farhana Islam and Victoria S Marshe and Clement C Zai and Rayyan Zuberi and Roseann S Gammal and Xiaoyu Men and Maike Scherf-Clavel and Dietmar Enko and Benicio N Frey and Roumen Milev and Claudio N Soares and Sagar V Parikh and Franca Placenza and Stephen C Strother and Stefanie Hassel and Valerie H Taylor and Francesco Leri and Pierre Blier and Faranak Farzan and Raymond W Lam and Gustavo Turecki and Jane A Foster and Susan Rotzinger and Stefan Kloiber and James L Kennedy and Sidney H Kennedy and Chad A Bousman and Daniel J Müller},

doi = {10.1002/cpt.2854},

issn = {1532-6535},

year  = {2023},

date = {2023-07-01},

journal = {Clin Pharmacol Ther},

volume = {114},

number = {1},

pages = {88--117},

abstract = {The P-glycoprotein efflux pump, encoded by the ABCB1 gene, has been shown to alter concentrations of various antidepressants in the brain. In this study, we conducted a systematic review and meta-analysis to investigate the association between six ABCB1 single-nucleotide polymorphisms (SNPs; rs1045642, rs2032582, rs1128503, rs2032583, rs2235015, and rs2235040) and antidepressant treatment outcomes in individuals with major depressive disorder (MDD), including new data from the Canadian Biomarker and Integration Network for Depression (CAN-BIND-1) cohort. For the CAN-BIND-1 sample, we applied regression models to investigate the association between ABCB1 SNPs and antidepressant treatment response, remission, tolerability, and antidepressant serum levels. For the meta-analysis, we systematically summarized pharmacogenetic evidence of the association between ABCB1 SNPs and antidepressant treatment outcomes. Studies were included in the meta-analysis if they investigated at least one ABCB1 SNP in individuals with MDD treated with at least one antidepressant. We did not find a significant association between ABCB1 SNPs and antidepressant treatment outcomes in the CAN-BIND-1 sample. A total of 39 studies were included in the systematic review. In the meta-analysis, we observed a significant association between rs1128503 and treatment response (T vs. C-allele, odds ratio = 1.30, 95% confidence interval = 1.15-1.48, P value (adjusted) = 0.024, n = 2,526). We did not find associations among the six SNPs and treatment remission nor tolerability. Our findings provide limited evidence for an association between common ABCB1 SNPs and antidepressant outcomes, which do not support the implementation of ABCB1 genotyping to inform antidepressant treatment at this time. Future research, especially on rs1128503, is recommended.},

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pubstate = {published},

tppubtype = {article}

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@article{pmid37002151,

title = {New Research Perspectives on the Interplay Between Genes and Environment on Executive Function Development},

author = {Patrícia Maidana Miguel and Michael J Meaney and Patrícia Pelufo Silveira},

doi = {10.1016/j.biopsych.2023.01.008},

issn = {1873-2402},

year  = {2023},

date = {2023-07-01},

journal = {Biol Psychiatry},

volume = {94},

number = {2},

pages = {131--141},

abstract = {Executive functions (EFs) are a set of skills responsible for the cognitive control of emotional states and behavior as well as for information processing required for learning and memory. Impairments in these abilities, such as focused attention, working memory, cognitive flexibility, and self-regulation, are implicated in a variety of psychopathologies across the lifespan. EF development shows a protracted course that begins in early childhood and continues throughout adolescence and into early adulthood. Maturation of EFs is subject to environmental influences such that adversity during development can affect multiple EF-mediated processes and outcomes. In this review, we describe sensitive periods for the development of EFs and the effects of adverse environmental exposures, with consideration of the underlying neurobiological mechanisms. However, there is considerable interindividual variation in the impact of adversity, with some individuals more vulnerable and some more resilient to its effects. We explore the evidence for the genetic contribution to interindividual variation in EFs, providing an overview of classic studies, followed by the results of recent genome-wide association studies and innovative genomic methods. Finally, we review studies investigating the interdependence between early-life adversities and genetic factors on EFs. We discuss the importance of novel functional genomics approaches, multilevel analyses, and big data to elucidate the complexity of the relationships between genes, environment, and the development of EFs.},

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@article{pmid37017737,

title = {Longitudinal head-to-head comparison of C-PiB and F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly inherited Alzheimer's disease},

author = {Charles D Chen and Austin McCullough and Brian Gordon and Nelly Joseph-Mathurin and Shaney Flores and Nicole S McKay and Diana A Hobbs and Russ Hornbeck and Anne M Fagan and Carlos Cruchaga and Alison M Goate and Richard J Perrin and Guoqiao Wang and Yan Li and Xinyu Shi and Chengjie Xiong and Michael J Pontecorvo and Gregory Klein and Yi Su and William E Klunk and Clifford Jack and Robert Koeppe and B Joy Snider and Sarah B Berman and Erik D Roberson and Jared Brosch and Ghulam Surti and Ivonne Z Jiménez-Velázquez and Douglas Galasko and Lawrence S Honig and William S Brooks and Roger Clarnette and David Wallon and Bruno Dubois and Jérémie Pariente and Florence Pasquier and Raquel Sanchez-Valle and Sergey Shcherbinin and Ixavier Higgins and Ilke Tunali and Colin L Masters and Christopher H van Dyck and Mario Masellis and Robin Hsiung and Serge Gauthier and Steve Salloway and David B Clifford and Susan Mills and Charlene Supnet-Bell and Eric McDade and Randall J Bateman and Tammie L S Benzinger and },

doi = {10.1007/s00259-023-06209-0},

issn = {1619-7089},

year  = {2023},

date = {2023-07-01},

journal = {Eur J Nucl Med Mol Imaging},

volume = {50},

number = {9},

pages = {2669--2682},

abstract = {PURPOSE: Pittsburgh Compound-B (C-PiB) and F-florbetapir are amyloid-β (Aβ) positron emission tomography (PET) radiotracers that have been used as endpoints in Alzheimer's disease (AD) clinical trials to evaluate the efficacy of anti-Aβ monoclonal antibodies. However, comparing drug effects between and within trials may become complicated if different Aβ radiotracers were used. To study the consequences of using different Aβ radiotracers to measure Aβ clearance, we performed a head-to-head comparison of C-PiB and F-florbetapir in a Phase 2/3 clinical trial of anti-Aβ monoclonal antibodies.nnMETHODS: Sixty-six mutation-positive participants enrolled in the gantenerumab and placebo arms of the first Dominantly Inherited Alzheimer Network Trials Unit clinical trial (DIAN-TU-001) underwent both C-PiB and F-florbetapir PET imaging at baseline and during at least one follow-up visit. For each PET scan, regional standardized uptake value ratios (SUVRs), regional Centiloids, a global cortical SUVR, and a global cortical Centiloid value were calculated. Longitudinal changes in SUVRs and Centiloids were estimated using linear mixed models. Differences in longitudinal change between PET radiotracers and between drug arms were estimated using paired and Welch two sample t-tests, respectively. Simulated clinical trials were conducted to evaluate the consequences of some research sites using C-PiB while other sites use F-florbetapir for Aβ PET imaging.nnRESULTS: In the placebo arm, the absolute rate of longitudinal change measured by global cortical C-PiB SUVRs did not differ from that of global cortical F-florbetapir SUVRs. In the gantenerumab arm, global cortical C-PiB SUVRs decreased more rapidly than global cortical F-florbetapir SUVRs. Drug effects were statistically significant across both Aβ radiotracers. In contrast, the rates of longitudinal change measured in global cortical Centiloids did not differ between Aβ radiotracers in either the placebo or gantenerumab arms, and drug effects remained statistically significant. Regional analyses largely recapitulated these global cortical analyses. Across simulated clinical trials, type I error was higher in trials where both Aβ radiotracers were used versus trials where only one Aβ radiotracer was used. Power was lower in trials where F-florbetapir was primarily used versus trials where C-PiB was primarily used.nnCONCLUSION: Gantenerumab treatment induces longitudinal changes in Aβ PET, and the absolute rates of these longitudinal changes differ significantly between Aβ radiotracers. These differences were not seen in the placebo arm, suggesting that Aβ-clearing treatments may pose unique challenges when attempting to compare longitudinal results across different Aβ radiotracers. Our results suggest converting Aβ PET SUVR measurements to Centiloids (both globally and regionally) can harmonize these differences without losing sensitivity to drug effects. Nonetheless, until consensus is achieved on how to harmonize drug effects across radiotracers, and since using multiple radiotracers in the same trial may increase type I error, multisite studies should consider potential variability due to different radiotracers when interpreting Aβ PET biomarker data and, if feasible, use a single radiotracer for the best results.nnTRIAL REGISTRATION: ClinicalTrials.gov NCT01760005. Registered 31 December 2012. Retrospectively registered.},

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@article{pmid36200407,

title = {Show me you care: A patient- and family-reported measure of care experiences in early psychosis services},

author = {Srividya N Iyer and Aarati Taksal and Ashok Malla and Helen Martin and Mary Anne Levasseur and Megan A Pope and Thara Rangaswamy and Padmavati Ramachandran and Greeshma Mohan},

doi = {10.1111/eip.13360},

issn = {1751-7893},

year  = {2023},

date = {2023-07-01},

journal = {Early Interv Psychiatry},

volume = {17},

number = {7},

pages = {662--669},

abstract = {AIM: Despite their emphasis on engagement, there has been little research on patients' and families' experiences of care in early intervention services for psychosis. We sought to compare patients' and families' experiences of care in two similar early psychosis services in Montreal, Canada and Chennai, India. Because no patient- or family-reported experience measures had been used in a low- and middle-income context, we created a new measure, Show me you care. Here we present its development and psychometric properties.nnMETHODS: Show me you care was created based on the literature and stakeholder inputs. Its patient and family versions contain the same nine items (rated on a 7-point scale) about various supportive behaviours of treatment providers towards patients and families. Patients (N = 293) and families (N = 237) completed the measure in French/English in Montreal and Tamil/English in Chennai. Test-retest reliability, internal consistency, convergent validity, and ease of use were evaluated.nnRESULTS: Test-retest reliability (intra-class correlation coefficients) ranged from excellent (0.95) to good (0.66) across the patient and family versions, in Montreal and Chennai, and in English, French, and Tamil. Internal consistency estimates (Cronbach's alphas) were excellent (≥0.87). The measure was reported to be easy to understand and complete.nnCONCLUSION: Show me you care fills a gap between principles and practice by making engagement and collaboration as central to measurement in early intervention as it is to its philosophy. Having been co-designed and developed in three languages and tested in a low-and-middle-income and a high-income context, our tool has the potential for global application.},

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pubstate = {published},

tppubtype = {article}

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@article{pmid37121089,

title = {Non-linear variations in glutamate dynamics during a cognitive task engagement in schizophrenia},

author = {James W C Graham and Peter Jeon and Jean Théberge and Lena Palaniyappan},

doi = {10.1016/j.pscychresns.2023.111640},

issn = {1872-7506},

year  = {2023},

date = {2023-07-01},

journal = {Psychiatry Res Neuroimaging},

volume = {332},

pages = {111640},

abstract = {To investigate the role of glutamate in psychosis, we employ functional magnetic resonance spectroscopy at an ultra-high magnetic field (7T) and employ fuzzy-approximate entropy (F-ApEn) and Hurst Exponent (HE) to capture time-varying nature of glutamate signaling during a cognitive task. We recruited thirty first-episode psychosis patients (FEP) with age- and gender-matched healthy controls (HC) and administered the Color-Word Stroop paradigm, providing 128 raw MRS time-points per subject over a period of 16 min. We then performed metabolite quantification of glutamate in the dorsal anterior cingulate cortex, a region reliably activated during the Stroop task. Symptoms/cognitive functioning was measured using Positive and Negative Syndrome Scale-8 score, Social and Occupational Functioning (SOFAS) score, digit symbol) coding score, and Stroop accuracy. These scores were related to the Entropy/HE data from the overall glutamate time-series. Patients with FEP had significantly higher HE compared to HC, with individuals displaying significantly higher HE having lower functional performance (SOFAS) in both HC and FEP groups. Among healthy individuals, higher HE also indicated significantly lower cognitive function through Stroop accuracy and DSST scores. F-ApEn had an inverse Pearson correlation with HE, and tracked diagnosis, cognition and function as expected, but with lower effect sizes not reaching statistical significance. We demonstrate notable diagnostic differences in the temporal course of glutamate signaling during a cognitive task in psychosis.},

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tppubtype = {article}

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@article{pmid37400244b,

title = {Expressive Prosody in Patients With Focal Anterior Temporal Neurodegeneration},

author = {Amandine Geraudie and Peter S Pressman and Jeremie Pariente and Carly Millanski and Eleanor R Palser and Buddhika M Ratnasiri and Giovanni Battistella and Maria Luisa Mandelli and Zachary A Miller and Bruce L Miller and Virginia Sturm and Katherine P Rankin and Maria Luisa Gorno-Tempini and Maxime Montembeault},

doi = {10.1212/WNL.0000000000207516},

issn = {1526-632X},

year  = {2023},

date = {2023-07-01},

journal = {Neurology},

abstract = {INTRODUCTION: Progressive focal anterior temporal lobe (ATL) neurodegeneration has been historically called semantic dementia. More recently, semantic variant primary progressive aphasia (svPPA) and semantic behavioral variant frontotemporal dementia (sbvFTD) have been linked with predominant left or right ATL neurodegeneration, respectively. Nonetheless, clinical tools for accurate diagnosis of sbvFTD are still lacking. Expressive prosody refers to the modulation of pitch, loudness, tempo, and quality of voice used to convey emotional and linguistic information and has been linked to bilateral but right-predominant frontotemporal functioning. Changes in expressive prosody can be detected with semi-automated methods and could represent a useful diagnostic marker of socio-emotional functioning in sbvFTD.nnMETHODS: Participants underwent a comprehensive neuropsychological and language evaluation and a 3T MRI at UCSF. Each participant provided a verbal description of the picnic scene from the Western Aphasia Battery. The fundamental frequency (f0) range, an acoustic measure of pitch variability, was extracted for each participant. We compared the f0 range between groups and investigated associations with an informant-rated measure of empathy, a facial emotion labelling task, and gray matter volumes using voxel-based morphometry.nnRESULTS: Twenty-eight patients with svPPA, 18 with sbvFTD, and 18 healthy controls (HC) were included. f0 range was significantly different across groups: sbvFTD patients showed reduced f0 in comparison to both patients with svPPA (mean difference of -1.4±2.4 semitones; 95% CI [-2.4, -0.4];  < .005), and HC (mean difference of -1.9±3.0 semitones; 95% CI [-3.0, -0.7];  < .001). f0 range was significantly positively correlated with informant-rated empathy ( = .355;  ≤ .05), but not facial emotion labelling. Finally, the f0 range was significantly correlated with gray matter volume in the right superior temporal gyrus, encompassing anterior and posterior portions ( < .05 FWE cluster corrected).nnCONCLUSION: Expressive prosody may be a useful clinical marker of sbvFTD. Reduced empathy is a core symptom in sbvFTD; the present results extend this to prosody, a core component of social interaction, at the intersection of speech and emotion. They also inform the long-standing debate on the lateralization of expressive prosody in the brain, highlighting the critical role of the right superior temporal lobe.},

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pubstate = {published},

tppubtype = {article}

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@article{pmid37150400b,

title = {Predictors of dropout from treatment among patients using specialized addiction treatment centers},

author = {Marie-Josée Fleury and Zhirong Cao and Guy Grenier and Christophe Huỳnh},

doi = {10.1016/j.josat.2023.209062},

issn = {2949-8759},

year  = {2023},

date = {2023-07-01},

journal = {J Subst Use Addict Treat},

volume = {150},

pages = {209062},

abstract = {OBJECTIVES: This study investigated the use of outpatient care, and sociodemographic and clinical characteristics of patients with substance-related disorders (SRD) to predict treatment dropout from specialized addiction treatment centers. The study also explored risks of adverse outcomes, frequent emergency department (ED) use (3+ visits/year), and death, associated with treatment dropout within the subsequent 12 months.nnMETHODS: The study examined a cohort of 16,179 patients who completed their last treatment episode for SRD between 2012-13 and 2014-15 (financial years: April 1 to March 31) in 14 specialized addiction treatment centers using Quebec (Canada) health administrative databases. We used multivariable logistic regressions to measure risk of treatment dropout (1996-96 to 2014-15), while we used survival analysis controlling for sex and age to assess the odds of frequent ED use and death in 2015-16.nnRESULTS: Of the 55 % of patients reporting dropout from SRD treatment over the 3-year period, 17 % were frequent ED users, and 1 % died in the subsequent 12 months. Patients residing in the most socially deprived areas, having polysubstance-related disorders or personality disorders, and having previously dropped out from specialized addiction treatment centers had increased odds of current treatment dropout. Older patients, those with a history of homelessness, past SRD treatment, or more concurrent outpatient care outside specialized addiction treatment centers had decreased odds of treatment dropout. Patients who dropped out were subsequently at higher risk of frequent ED use and death.nnCONCLUSIONS: This study highlighted that patients with more severe problems and previous dropout may need more sustained and adequate help to prevent subsequent treatment dropout. Specialized addiction treatment centers may consider enhancing their follow-up care of patients over a longer duration and better integrating their treatment with other outpatient care resources to meet the multiple needs of the more vulnerable patients using their services.},

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pubstate = {published},

tppubtype = {article}

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@article{pmid37406925,

title = {A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes},

author = {Danusa Mar Arcego and Jan-Paul Buschdorf and Nicholas O'Toole and Zihan Wang and Barbara Barth and Irina Pokhvisneva and Nirmala Arul Rayan and Sachin Patel and Euclides José de Mendonça Filho and Patrick Lee and Jennifer Tan and Ming Xuan Koh and Chu Ming Sim and Carine Parent and Randriely Merscher Sobreira de Lima and Andrew Clappison and Kieran J O'Donnell and Carla Dalmaz and Janine Arloth and Nadine Provençal and Elisabeth B Binder and Josie Diorio and Patrícia Pelufo Silveira and Michael J Meaney},

doi = {10.1016/j.biopsych.2023.06.028},

issn = {1873-2402},

year  = {2023},

date = {2023-07-01},

journal = {Biol Psychiatry},

abstract = {BACKGROUND: Early stress increases the risk for psychiatric disorders. Glucocorticoids are stress mediators that regulate transcriptional activity and morphology in the hippocampus, which is implicated in the pathophysiology of multiple psychiatric conditions. We aimed to establish the relevance of hippocampal, glucocorticoid-induced transcriptional activity as a mediator of the effects of early life on later psychopathology in humans.nnMETHODS: RNA sequencing was performed with anterior and posterior hippocampal dentate gyrus from adult female macaques (n = 12/group) that were chronically treated with betamethasone (glucocorticoid receptor agonist) or vehicle. Coexpression network analysis identified a preserved gene network in the posterior hippocampal dentate gyrus that was strongly associated with glucocorticoid exposure. The single nucleotide polymorphisms in the genes in this network were used to create an expression-based polygenic score in humans.nnRESULTS: The expression-based polygenic score significantly moderated the association between early adversity and psychotic disorders in adulthood (UK Biobank, women, n = 44,519) and on child peer relations (ALSPAC [Avon Longitudinal Study of Parents and Children], girls, n = 1666 for 9-year-olds and n = 1594 for 11-year-olds), an endophenotype for later psychosis. Analyses revealed that this network was enriched for glucocorticoid-induced epigenetic remodeling in human hippocampal cells. We also found a significant association between single nucleotide polymorphisms from the expression-based polygenic score and adult brain gray matter density.nnCONCLUSIONS: We provide an approach for the use of transcriptomic data from animal models together with human data to study the impact of environmental influences on mental health. The results are consistent with the hypothesis that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.},

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tppubtype = {article}

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@article{pmid37414359,

title = {Differential Expression of Anomalous Self-Experiences in Spontaneous Speech in Clinical High-Risk and Early-Course Psychosis Quantified by Natural Language Processing},

author = {Agrima Srivastava and Alexandria Selloni and Zarina R Bilgrami and Cansu Sarac and Alessia McGowan and Matthew Cotter and Johanna Bayer and Jessica Spark and Marija Krcmar and Melanie Formica and Kate Gwyther and Jessica Hartmann and Ezra Ellenberg and Andrea Polari and Patrick McGorry and Jai L Shah and Alison R Yung and Romina Mizrahi and Cheryl M Corcoran and Guillermo A Cecchi and Barnaby Nelson},

doi = {10.1016/j.bpsc.2023.06.007},

issn = {2451-9030},

year  = {2023},

date = {2023-07-01},

journal = {Biol Psychiatry Cogn Neurosci Neuroimaging},

abstract = {BACKGROUND: Basic self-disturbance, or anomalous self-experiences (ASEs), is a core feature of the schizophrenia spectrum. We propose a novel method of natural language processing to quantify ASEs in spoken language by direct comparison to an inventory of self-disturbance, the Inventory of Psychotic-Like Anomalous Self-Experiences (IPASE). We hypothesized that there would be increased similarity in open-ended speech to the IPASE items in individuals with early-course psychosis (PSY) compared with healthy individuals, with clinical high-risk (CHR) individuals intermediate in similarity.nnMETHODS: Open-ended interviews were obtained from 170 healthy control participants, 167 CHR participants, and 89 PSY participants. We calculated the semantic similarity between IPASE items and "I" sentences from transcribed speech samples using S-BERT (Sentence Bidirectional Encoder Representation from Text). Kolmogorov-Smirnov tests were used to compare distributions across groups. A nonnegative matrix factorization of cosine similarity was performed to rank IPASE items.nnRESULTS: Spoken language of CHR individuals had the greatest semantic similarity to IPASE items when compared to both healthy control (s = 0.44, p < 10) and PSY (s = 0.36, p < 10) individuals, while IPASE scores were higher among PSY than CHR group participants. In addition, the nonnegative matrix factorization approach produced a data-driven domain that differentiated the CHR group from the others.nnCONCLUSIONS: We found that open-ended interviews elicited language with increased semantic similarity to the IPASE by participants in the CHR group compared with patients with psychosis. This demonstrates the utility of these methods for differentiating patients from healthy control participants. This complementary approach has the capacity to scale to large studies investigating phenomenological features of schizophrenia and potentially other clinical populations.},

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tppubtype = {article}

}

@article{pmid37414898,

title = {A prognostic risk score for development and spread of chronic pain},

author = {Christophe Tanguay-Sabourin and Matt Fillingim and Gianluca V Guglietti and Azin Zare and Marc Parisien and Jax Norman and Hilary Sweatman and Ronrick Da-Ano and Eveliina Heikkala and  and Jordi Perez and Jaro Karppinen and Sylvia Villeneuve and Scott J Thompson and Marc O Martel and Mathieu Roy and Luda Diatchenko and Etienne Vachon-Presseau},

doi = {10.1038/s41591-023-02430-4},

issn = {1546-170X},

year  = {2023},

date = {2023-07-01},

journal = {Nat Med},

volume = {29},

number = {7},

pages = {1821--1831},

abstract = {Chronic pain is a complex condition influenced by a combination of biological, psychological and social factors. Using data from the UK Biobank (n = 493,211), we showed that pain spreads from proximal to distal sites and developed a biopsychosocial model that predicted the number of coexisting pain sites. This data-driven model was used to identify a risk score that classified various chronic pain conditions (area under the curve (AUC) 0.70-0.88) and pain-related medical conditions (AUC 0.67-0.86). In longitudinal analyses, the risk score predicted the development of widespread chronic pain, the spreading of chronic pain across body sites and high-impact pain about 9 years later (AUC 0.68-0.78). Key risk factors included sleeplessness, feeling 'fed-up', tiredness, stressful life events and a body mass index >30. A simplified version of this score, named the risk of pain spreading, obtained similar predictive performance based on six simple questions with binarized answers. The risk of pain spreading was then validated in the Northern Finland Birth Cohort (n = 5,525) and the PREVENT-AD cohort (n = 178), obtaining comparable predictive performance. Our findings show that chronic pain conditions can be predicted from a common set of biopsychosocial factors, which can aid in tailoring research protocols, optimizing patient randomization in clinical trials and improving pain management.},

keywords = {},

pubstate = {published},

tppubtype = {article}

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@article{pmid37419977,

title = {Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice},

author = {Lauren M Reynolds and Giovanni Hernandez and Del MacGowan and Christina Popescu and Dominique Nouel and Santiago Cuesta and Samuel Burke and Katherine E Savell and Janet Zhao and Jose Maria Restrepo-Lozano and Michel Giroux and Sonia Israel and Taylor Orsini and Susan He and Michael Wodzinski and Radu G Avramescu and Matthew Pokinko and Julia G Epelbaum and Zhipeng Niu and Andrea Harée Pantoja-Urbán and Louis-Éric Trudeau and Bryan Kolb and Jeremy J Day and Cecilia Flores},

doi = {10.1038/s41467-023-39665-1},

issn = {2041-1723},

year  = {2023},

date = {2023-07-01},

journal = {Nat Commun},

volume = {14},

number = {1},

pages = {4035},

abstract = {Initiating drug use during adolescence increases the risk of developing addiction or other psychopathologies later in life, with long-term outcomes varying according to sex and exact timing of use. The cellular and molecular underpinnings explaining this differential sensitivity to detrimental drug effects remain unexplained. The Netrin-1/DCC guidance cue system segregates cortical and limbic dopamine pathways in adolescence. Here we show that amphetamine, by dysregulating Netrin-1/DCC signaling, triggers ectopic growth of mesolimbic dopamine axons to the prefrontal cortex, only in early-adolescent male mice, underlying a male-specific vulnerability to enduring cognitive deficits. In adolescent females, compensatory changes in Netrin-1 protect against the deleterious consequences of amphetamine on dopamine connectivity and cognitive outcomes. Netrin-1/DCC signaling functions as a molecular switch which can be differentially regulated by the same drug experience as function of an individual's sex and adolescent age, and lead to divergent long-term outcomes associated with vulnerable or resilient phenotypes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37431265,

title = {Relationship between insulin and Netrin-1/DCC guidance cue pathway regulation in the prefrontal cortex of rodents exposed to prenatal dietary restriction},

author = {Aashita Batra and Santiago Cuesta and Marcio Bonesso Alves and Jose Maria Restrepo and Michel Giroux and Daniela Pereira Laureano and Amanda Brondani Mucellini Lovato and Patrícia Maidana Miguel and Tania Diniz Machado and Roberta Dalle Molle and Cecilia Flores and Patricia Pelufo Silveira},

doi = {10.1017/S204017442300017X},

issn = {2040-1752},

year  = {2023},

date = {2023-07-01},

journal = {J Dev Orig Health Dis},

pages = {1--7},

abstract = {Fetal restriction (FR) alters insulin sensitivity, but it is unknown how the metabolic profile associated with restriction affects development of the dopamine (DA) system and DA-related behaviors. The Netrin-1/DCC guidance cue system participates in maturation of the mesocorticolimbic DA circuitry. Therefore, our objective was to identify if FR modifies Netrin-1/DCC receptor protein expression in the prefrontal cortex (PFC) at birth and mRNA in adulthood in rodent males. We used cultured HEK293 cells to assess if levels of miR-218, microRNA regulator of DCC, are sensitive to insulin. To assess this, pregnant dams were subjected to a 50% FR diet from gestational day 10 until birth. Medial PFC (mPFC) DCC/Netrin-1 protein expression was measured at P0 at baseline and /-1 mRNA levels were quantified in adults 15 min after a saline/insulin injection. miR-218 levels in HEK-293 cells were measured in response to insulin exposure. At P0, Netrin-1 levels are downregulated in FR animals in comparison to controls. In adult rodents, insulin administration results in an increase in  mRNA levels in control but not FR rats. In HEK293 cells, there is a positive correlation between insulin concentration and miR-218 levels. Since miR-218 is a  gene expression regulator and our in vitro results show that insulin regulates miR-218 levels, we suggest that FR-induced changes in insulin sensitivity could be affecting  expression via miR-218, impacting DA system maturation and organization. As fetal adversity is linked to nonadaptive behaviors later in life, this may contribute to early identification of vulnerability to chronic diseases associated with fetal adversity.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37432876,

title = { induces glutamatergic signaling following treatment with monoaminergic antidepressants},

author = {Rixing Lin and Aron Kos and Juan Pablo Lopez and Julien Dine and Laura M Fiori and Jennie Yang and Yair Ben-Efraim and Zahia Aouabed and Pascal Ibrahim and Haruka Mitsuhashi and Tak Pan Wong and El Cherif Ibrahim and Catherine Belzung and Pierre Blier and Faranak Farzan and Benicio N Frey and Raymond W Lam and Roumen Milev and Daniel J Muller and Sagar V Parikh and Claudio Soares and Rudolf Uher and Corina Nagy and Naguib Mechawar and Jane A Foster and Sidney H Kennedy and Alon Chen and Gustavo Turecki},

doi = {10.7554/eLife.85316},

issn = {2050-084X},

year  = {2023},

date = {2023-07-01},

journal = {Elife},

volume = {12},

abstract = {Pharmacotherapies for the treatment of major depressive disorder were serendipitously discovered almost seven decades ago. From this discovery, scientists pinpointed the monoaminergic system as the primary target associated with symptom alleviation. As a result, most antidepressants have been engineered to act on the monoaminergic system more selectively, primarily on serotonin, in an effort to increase treatment response and reduce unfavorable side effects. However, slow and inconsistent clinical responses continue to be observed with these available treatments. Recent findings point to the glutamatergic system as a target for rapid acting antidepressants. Investigating different cohorts of depressed individuals treated with serotonergic and other monoaminergic antidepressants, we found that the expression of a small nucleolar RNA, , was elevated following treatment response. When we increased  levels in the mouse anterior cingulate cortex (ACC), a brain region regulating mood responses, we observed antidepressive-like behaviors. We identified neuregulin 3 () as one of the targets of , which we show is regulated through the accumulation of N-methyladenosine modifications leading to YTHDF2-mediated RNA decay. We further demonstrate that a decrease in NRG3 expression resulted in increased glutamatergic release in the mouse ACC. These findings support a molecular link between monoaminergic antidepressant treatment and glutamatergic neurotransmission.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37443193,

title = {Neural variability in three major psychiatric disorders},

author = {Wei Wei and Lihong Deng and Chunxia Qiao and Yubing Yin and Yamin Zhang and Xiaojing Li and Hua Yu and Lingqi Jian and Mingli Li and Wanjun Guo and Qiang Wang and Wei Deng and Xiaohong Ma and Liansheng Zhao and Pak C Sham and Lena Palaniyappan and Tao Li},

doi = {10.1038/s41380-023-02164-2},

issn = {1476-5578},

year  = {2023},

date = {2023-07-01},

journal = {Mol Psychiatry},

abstract = {Across the major psychiatric disorders (MPDs), a shared disruption in brain physiology is suspected. Here we investigate the neural variability at rest, a well-established behavior-relevant marker of brain function, and probe its basis in gene expression and neurotransmitter receptor profiles across the MPDs. We recruited 219 healthy controls and 279 patients with schizophrenia, major depressive disorder, or bipolar disorders (manic or depressive state). The standard deviation of blood oxygenation level-dependent signal (SD) obtained from resting-state fMRI was used to characterize neural variability. Transdiagnostic disruptions in SD patterns and their relationships with clinical symptoms and cognitive functions were tested by partial least-squares correlation. Moving beyond the clinical sample, spatial correlations between the observed patterns of SD disruption and postmortem gene expressions, Neurosynth meta-analytic cognitive functions, and neurotransmitter receptor profiles were estimated. Two transdiagnostic patterns of disrupted SD were discovered. Pattern 1 is exhibited in all diagnostic groups and is most pronounced in schizophrenia, characterized by higher SD in the language/auditory networks but lower SD in the default mode/sensorimotor networks. In comparison, pattern 2 is only exhibited in unipolar and bipolar depression, characterized by higher SD in the default mode/salience networks but lower SD in the sensorimotor network. The expression of pattern 1 related to the severity of clinical symptoms and cognitive deficits across MPDs. The two disrupted patterns had distinct spatial correlations with gene expressions (e.g., neuronal projections/cellular processes), meta-analytic cognitive functions (e.g., language/memory), and neurotransmitter receptor expression profiles (e.g., D2/serotonin/opioid receptors). In conclusion, neural variability is a potential transdiagnostic biomarker of MPDs with a substantial amount of its spatial distribution explained by gene expressions and neurotransmitter receptor profiles. The pathophysiology of MPDs can be traced through the measures of neural variability at rest, with varying clinical-cognitive profiles arising from differential spatial patterns of aberrant variability.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37462796,

title = {Variables Associated with Quality of Life Among Individuals Living in Permanent Supportive Housing},

author = {Bahram Armoon and Nadia L'Espérance and Marie-Josée Fleury},

doi = {10.1007/s10597-023-01167-1},

issn = {1573-2789},

year  = {2023},

date = {2023-07-01},

journal = {Community Ment Health J},

abstract = {This study identified individual sociodemographic and clinical characteristics and service use patterns associated with quality of life (QoL) among 308 individuals living in permanent supportive housing (PSH) in Québec (Canada). Data were collected between 2020 and 2022, and linear multivariate analyses produced. Results demonstrated that better individual psychosocial conditions were positively associated with higher QoL. As well, living in PSH located in good neighborhoods for at least 5 years, higher self-esteem and community integration were positively associated with greater QoL. Met needs, satisfaction with housing support services, and no use of acute care were also linked with positive QoL. Comprehensive efforts to improve treatment for mental health disabilities responsive to the needs of PSH residents, and sustained long-term housing may reinforce QoL. Encouraging active participation in community-based activities, incorporating biophilic design into the neighborhoods around PSH, and promoting satisfaction with care may also enhance QoL.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37516683,

title = {Associations between digital media use and psychotic experiences in young adults of Quebec, Canada: a longitudinal study},

author = {Vincent Paquin and Frederick L Philippe and Holly Shannon and Synthia Guimond and Isabelle Ouellet-Morin and Marie-Claude Geoffroy},

doi = {10.1007/s00127-023-02537-6},

issn = {1433-9285},

year  = {2023},

date = {2023-07-01},

journal = {Soc Psychiatry Psychiatr Epidemiol},

abstract = {PURPOSE: Digital media use has been associated with psychotic experiences in youth from the community, but the direction of association remains unclear. We aimed to examine between- and within-person associations of digital media use and psychotic experiences in youth.nnMETHODS: The sample included 425 participants aged 18-25 years (82.5% female) from the community, followed between May 2021 and January 2022 over 3 time points-of which 263 participants (61.9%) completed at least 2. Digital media use was self-reported as time spent daily on TV and streaming platforms, social media, and video games over the past 3 months. Psychotic experiences in the past 3 months were measured with the 15-item Community Assessment of Psychic Experiences. Associations between digital media use and psychotic experiences were estimated using a random-intercept cross-lagged panel model.nnRESULTS: On average, individuals who reported greater digital media use also reported higher levels of psychotic experiences (r = 0.34, 95% CI 0.15, 0.53). However, a person's variation in digital media use, relative to their personal average, was not significantly associated with subsequent variations in their levels of psychotic experiences, or vice-versa. Results were similar across TV/streaming, social media and video game use, and after adjusting for age, sex, education, sleep, physical activity, and cannabis use.nnCONCLUSION: Individuals with a tendency for higher levels of digital media use also had a tendency for higher levels of psychotic experiences. Understanding this association may help personalize mental health interventions for people with psychotic experiences, which may be offered digitally to promote their accessibility.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37519472,

title = {Novel Functional Genomics Approaches Bridging Neuroscience and Psychiatry},

author = {Jose M Restrepo-Lozano and Cecilia Flores and Patricia P Silveira},

doi = {10.1016/j.bpsgos.2022.07.005},

issn = {2667-1743},

year  = {2023},

date = {2023-07-01},

journal = {Biol Psychiatry Glob Open Sci},

volume = {3},

number = {3},

pages = {351--361},

abstract = {The possibility of establishing a metric of individual genetic risk for a particular disease or trait has sparked the interest of the clinical and research communities, with many groups developing and validating genomic profiling methodologies for their potential application in clinical care. Current approaches for calculating genetic risk to specific psychiatric conditions consist of aggregating genome-wide association studies-derived estimates into polygenic risk scores, which broadly represent the number of inherited risk alleles for an individual. While the traditional approach for polygenic risk score calculation aggregates estimates of gene-disease associations, novel alternative approaches have started to consider functional molecular phenotypes that are closer to genetic variation and are less penalized by the multiple testing required in genome-wide association studies. Moving the focus from genotype-disease to genotype-gene regulation frameworks, these novel approaches incorporate prior knowledge regarding biological processes involved in disease and aggregate estimates for the association of genotypes and phenotypes using multi-omics data modalities. In this review, we discuss and list different functional genomics tools that can be used and integrated to inform researchers and clinicians for a better understanding and diagnosis of psychopathology. We suggest that these novel approaches can help generate biologically driven hypotheses for polygenic signals that can ultimately serve the clinical community as potential biomarkers of psychiatric disease susceptibility.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37626491,

title = {The Associations between the Homeostatic and Circadian Sleep Processes and the Neurobehavioral Functioning (NBF) of Individuals with ADHD-A Systematic Review},

author = {Reut Gruber and Gabrielle Gauthier-Gagné and Charlotte Little and Ziqi Fu},

doi = {10.3390/brainsci13081134},

issn = {2076-3425},

year  = {2023},

date = {2023-07-01},

journal = {Brain Sci},

volume = {13},

number = {8},

abstract = {The objective of the present review was to systematically examine associations between perturbations of the homeostatic or circadian sleep processes and the neurobehavioral functioning (NBF) of individuals with ADHD. Electronic databases were searched for articles published between December 2013 and March 2023. Studies were included if they used objective measures of NBF, used objective or subjective measures of sleep, and focused on individuals with ADHD. Ten studies met these inclusion criteria. Of these, eight studies found perturbations in the interplay between NBF and Process S or Process C, and three studies did not. The quality of the studies was degraded because they failed to address key factors that affect the sleep processes and by the presence of methodological weaknesses. Our review suggests that homeostatic and circadian sleep processes are associated with NBF in individuals with ADHD. However, to confirm the validity of this conclusion, future studies should examine or control for confounders and utilize experimental designs that allow causality to be inferred.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36120908,

title = {[Revue systématique des tests cognitifs validés et/ou ayant des normes de référence pour la population canadienne francophone âgée]},

author = {Thomas Carrier and Maria Belen Field Lira and Juan Andres Cortina Ortiz and Camille Duchesne and Maxime Montembeault},

doi = {10.1017/S0714980822000319},

issn = {1710-1107},

year  = {2023},

date = {2023-06-01},

journal = {Can J Aging},

volume = {42},

number = {2},

pages = {297--315},

abstract = {Il est essentiel d'utiliser des tests cognitifs ayant été validés et détenant des normes de référence auprès de la population cible, puisque les réalités culturelles et linguistiques différentes entre l'échantillon de validation ou auprès duquel les normes ont été créées et la population cible peuvent affecter les résultats. Cette revue systématique vise à recenser et décrire les tests cognitifs (incluant tests, questionnaires et grilles d'observation) validés et/ou présentant des normes sur la population âgée canadienne francophone. Au total, 46 articles ont été sélectionnés. Cette revue recense 9 tests validés, 20 tests avec normes de référence et 18 tests validés et avec normes, couvrant la majorité des domaines cognitifs (fonctions mnésiques, attentionnelles, exécutives, perceptivo-motrices et langagières), excepté la cognition sociale. La quasi-totalité des échantillons ont été recrutés au Québec. Les tests relevés présentent majoritairement des indices psychométriques satisfaisants et généralement des normes considérant l'âge, le sexe et l'éducation. Cette revue systématique permettra aux cliniciens et chercheurs canadiens en vieillissement d'orienter optimalement leurs choix de tests cognitifs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36843359,

title = {Associations Between Multidimensional Sleep Health Parameters and Adolescents' Self-reported Light Exposure in the Free-living Environment},

author = {Gabrielle Gauthier-Gagné and Sujata Saha and Jana Jensen and Gail Sommerville and Reut Gruber},

doi = {10.1177/07487304231152987},

issn = {1552-4531},

year  = {2023},

date = {2023-06-01},

journal = {J Biol Rhythms},

volume = {38},

number = {3},

pages = {305--317},

abstract = {The objective of this study was to characterize the associations between light exposure in the free-living environment and multiple dimensions of sleep health of typically developing adolescents. Fifty-six (29 girls, 27 boys) typically developing adolescents (mean age = 13.59, SD = 0.89, range = 12-17 years) participated. For six consecutive nights, sleep was assessed in the home environment using actigraphy. During the same period, participants were asked to fill out a daily sleep log and a daily light exposure log, and to complete questionnaires regarding their alertness and subjective sleep satisfaction. Longer self-reported exposure to daylight in the morning was associated with longer objectively measured sleep duration. Longer self-reported exposures to electronic devices in the evening were associated with later objectively measured sleep onset and offset times, shorter sleep duration, and greater day-to-day sleep variability. Longer morning exposure to outdoor light was associated with a longer sleep duration. Self-reported light exposure was not associated with sleep satisfaction, alertness/sleepiness, or sleep efficiency. Among the covariates, circadian preference accounted for the highest percentage of variance. Adolescents' sleep health is associated with the self-reported duration of exposure to daylight in the morning and to electronic devices in the evening.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36896711,

title = {High spatial overlap but diverging age-related trajectories of cortical magnetic resonance imaging markers aiming to represent intracortical myelin and microstructure},

author = {Olivier Parent and Emily Olafson and Aurélie Bussy and Stephanie Tullo and Nadia Blostein and Alyssa Dai and Alyssa Salaciak and Saashi A Bedford and Sarah Farzin and Marie-Lise Béland and Vanessa Valiquette and Christine L Tardif and Gabriel A Devenyi and M Mallar Chakravarty},

doi = {10.1002/hbm.26259},

issn = {1097-0193},

year  = {2023},

date = {2023-06-01},

journal = {Hum Brain Mapp},

volume = {44},

number = {8},

pages = {3023--3044},

abstract = {Statistical effects of cortical metrics derived from standard T1- and T2-weighted magnetic resonance imaging (MRI) images, such as gray-white matter contrast (GWC), boundary sharpness coefficient (BSC), T1-weighted/T2-weighted ratio (T1w/T2w), and cortical thickness (CT), are often interpreted as representing or being influenced by intracortical myelin content with little empirical evidence to justify these interpretations. We first examined spatial correspondence with more biologically specific microstructural measures, and second compared between-marker age-related trends with the underlying hypothesis that different measures primarily driven by similar changes in myelo- and microstructural underpinnings should be highly related. Cortical MRI markers were derived from MRI images of 127 healthy subjects, aged 18-81, using cortical surfaces that were generated with the CIVET 2.1.0 pipeline. Their gross spatial distributions were compared with gene expression-derived cell-type densities, histology-derived cytoarchitecture, and quantitative R1 maps acquired on a subset of participants. We then compared between-marker age-related trends in their shape, direction, and spatial distribution of the linear age effect. The gross anatomical distributions of cortical MRI markers were, in general, more related to myelin and glial cells than neuronal indicators. Comparing MRI markers, our results revealed generally high overlap in spatial distribution (i.e., group means), but mostly divergent age trajectories in the shape, direction, and spatial distribution of the linear age effect. We conclude that the microstructural properties at the source of spatial distributions of MRI cortical markers can be different from microstructural changes that affect these markers in aging.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36939138,

title = {The use of hippocampal grading as a biomarker for preclinical and prodromal Alzheimer's disease},

author = {Cassandra Morrison and Mahsa Dadar and Neda Shafiee and D Louis Collins and },

doi = {10.1002/hbm.26269},

issn = {1097-0193},

year  = {2023},

date = {2023-06-01},

journal = {Hum Brain Mapp},

volume = {44},

number = {8},

pages = {3147--3157},

abstract = {Hippocampal changes are associated with increased age and cognitive decline due to mild cognitive impairment (MCI) and Alzheimer's disease (AD). These associations are often observed only in the later stages of decline. This study examined if hippocampal grading, a method measuring local morphological similarity of the hippocampus to cognitively normal controls (NCs) and AD participants, is associated with cognition in NCs, subjective cognitive decline (SCD), early (eMCI), late (lMCI), and AD. A total of 1620 Alzheimer's Disease Neuroimaging Initiative participants were examined (495 NC, 262 eMCI, 545 lMCI, and 318 AD) because they had baseline MRIs and Alzheimer's disease Assessment Scale (ADAS-13) and Clinical Dementia Rating-Sum of Boxes (CDR-SB) scores. In a sub-analysis, NCs with episodic memory scores (as measured by Rey Auditory Verbal Learning Test, RAVLT) were divided into those with subjective cognitive decline (SCD+; 103) and those without (SCD-; 390). Linear regressions evaluated the influence of hippocampal grading on cognition in preclinical and prodromal AD. Lower global cognition, as measured by increased ADAS-13, was associated with hippocampal grading: NC (p < .001), eMCI (p < .05), lMCI (p < .05), and AD (p = .01). Lower global cognition as measured increased CDR-SB was associated with hippocampal grading in lMCI (p < .05) and AD (p < .001). Lower RAVLT performance was associated with hippocampal grading in SCD- (p < .05) and SCD+ (p < .05). These findings suggest that hippocampal grading is associated with global cognition in NC, eMCI, lMCI, and AD. Early changes in episodic memory during pre-clinical AD are associated with changes in hippocampal grading. Hippocampal grading may be sensitive to progressive changes early in the disease course.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36948466,

title = {Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study},

author = {Melissa Henry and Raphaële Harvey and Lawrence M Chen and Michael Meaney and Thi Thu Thao Nguyen and Han-Tin Kao and Zeev Rosberger and Saul Frenkiel and Michael Hier and Anthony Zeitouni and Karen Kost and Alex Mlynarek and Keith Richardson and Celia M T Greenwood and David Melnychuk and Phil Gold and Gabrielle Chartier and Martin Black and Marco Mascarella and Christina MacDonald and Nader Sadeghi and Khalil Sultanem and Georges Shenouda and Fabio Cury and Kieran John O'Donnell},

doi = {10.1016/j.jad.2023.03.007},

issn = {1573-2517},

year  = {2023},

date = {2023-06-01},

journal = {J Affect Disord},

volume = {331},

pages = {149--157},

abstract = {OBJECTIVE: The primary purpose of this study was to investigate the contribution of genetic predispositions to depression and inflammation, as measured through polygenic risk scores, on symptom burden (physical and psychological) in patients with head and neck cancer in the immediate post-treatment period (i.e., at three months post-diagnosis), as well as on 3-, 6-, 12-, 24- and 36-month survival.nnMETHODS: Prospective longitudinal study of 223 adults (72 % participation) newly diagnosed with a first occurrence of primary head and neck cancer, paired with genetic data (Illumina PsychArray), validated psychometric measures, Structured Clinical Interviews for DSM Disorders (SCID-I), and medical chart reviews.nnRESULTS: Symptom burden at 3 months was predicted by (R adj. = 0.38, p < 0.001): a baseline SCID-I Anxiety Disorder (b = 1.69, B = 0.23, 95%CI = 0.43-2.94; p = 0.009), baseline levels of HADS anxiety (b = 0.20, B = 0.29, 95%CI = 0.07-0.34; p = 0.003), the polygenic risk score (PRS) for depression (b = 0.66, B = 0.18, 95%CI = 0.003-1.32; p = 0.049), and cumulated dose of radiotherapy (b = 0.002, B = 0.46, 95%CI = 0.001-0.003; p < 0.001). When controlling for factors known to be associated with cancer survival, patients with a higher PRS associated with depression and inflammation, respectively, presented higher risk of death within 36 months (b = 1.75, Exp(B) = 5.75, 95%CI = 1.55-21.27, p = 0.009 and b = 0.14, Exp(B) = 1.15, 95%CI = 1.01-1.30, p = 0.03).nnCONCLUSIONS: Our results outline three potential pathways of symptom burden in patients with head and neck cancer: a genetic predisposition towards depression; an initial anxiety disorder upon being diagnosed with cancer or high levels of anxiety upon diagnosis; and a dose-related response to radiotherapy. One may want to investigate early interventions in these areas to alleviate symptom burden in patients faced with a life-threatening disease, as well as consider targeting genetic predisposition towards depression and inflammation implicated in survival. The high prevalence of distress in patients with head and neck cancer is an opportunity to study genetic predispositions, which could potentially be broadly generalized to other cancers and diseases.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36958999,

title = {Disruption of Astrocyte-Dependent Dopamine Control in the Developing Medial Prefrontal Cortex Leads to Excessive Grooming in Mice},

author = {Francesco Petrelli and Tamara Zehnder and Anthony Laugeray and Sarah Mondoloni and Corrado Calì and Luca Pucci and Alicia Molinero Perez and Bianca Maria Bondiolotti and Eva De Oliveira Figueiredo and Glenn Dallerac and Nicole Déglon and Bruno Giros and Lorenzo Magrassi and Jean-Pierre Mothet and Manuel Mameli and Linda D Simmler and Paola Bezzi},

doi = {10.1016/j.biopsych.2022.11.018},

issn = {1873-2402},

year  = {2023},

date = {2023-06-01},

journal = {Biol Psychiatry},

volume = {93},

number = {11},

pages = {966--975},

abstract = {BACKGROUND: Astrocytes control synaptic activity by modulating perisynaptic concentrations of ions and neurotransmitters including dopamine (DA) and, as such, could be involved in the modulating aspects of mammalian behavior.nnMETHODS: We produced a conditional deletion of the vesicular monoamine transporter 2 (VMAT2) specifically in astrocytes (aVMTA2cKO mice) and studied the effects of the lack of VMAT2 in prefrontal cortex (PFC) astrocytes on the regulation of DA levels, PFC circuit functions, and behavioral processes.nnRESULTS: We found a significant reduction of medial PFC (mPFC) DA levels and excessive grooming and compulsive repetitive behaviors in aVMAT2cKO mice. The mice also developed a synaptic pathology, expressed through increased relative AMPA versus NMDA receptor currents in synapses of the dorsal striatum receiving inputs from the mPFC. Importantly, behavioral and synaptic phenotypes were rescued by re-expression of mPFC VMAT2 and L-DOPA treatment, showing that the deficits were driven by mPFC astrocytes that are critically involved in developmental DA homeostasis. By analyzing human tissue samples, we found that VMAT2 is expressed in human PFC astrocytes, corroborating the potential translational relevance of our observations in mice.nnCONCLUSIONS: Our study shows that impairment of the astrocytic control of DA in the mPFC leads to symptoms resembling obsessive-compulsive spectrum disorders such as trichotillomania and has a profound impact on circuit function and behaviors.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35485835,

title = {Manualized group cognitive behavioral therapy for social anxiety in first-episode psychosis: a randomized controlled trial},

author = {Martin Lepage and Christopher R Bowie and Tina Montreuil and Larry Baer and Olivier Percie du Sert and Tania Lecomte and Ridha Joober and Amal Abdel-Baki and G Eric Jarvis and Howard C Margolese and Luigi De Benedictis and Norbert Schmitz and Ashok K Malla},

doi = {10.1017/S0033291721005328},

issn = {1469-8978},

year  = {2023},

date = {2023-06-01},

journal = {Psychol Med},

volume = {53},

number = {8},

pages = {3335--3344},

abstract = {BACKGROUND: Social anxiety (SA), a prevalent comorbid condition in psychotic disorders with a negative impact on functioning, requires adequate intervention relatively early. Using a randomized controlled trial, we tested the efficacy of a group cognitive-behavioral therapy intervention for SA (CBT-SA) that we developed for youth who experienced the first episode of psychosis (FEP). For our primary outcome, we hypothesized that compared to the active control of group cognitive remediation (CR), the CBT-SA group would show a reduction in SA that would be maintained at 3- and 6-month follow-ups. For secondary outcomes, it was hypothesized that the CBT-SA group would show a reduction of positive and negative symptoms and improvements in recovery and functioning.nnMETHOD: Ninety-six patients with an FEP and SA, recruited from five different FEP programs in the Montreal area, were randomized to 13 weekly group sessions of either CBT-SA or CR intervention.nnRESULTS: Linear mixed models revealed that multiple measures of SA significantly reduced over time, but with no significant group differences. Positive and negative symptoms, as well as functioning improved over time, with negative symptoms and functioning exhibiting a greater reduction in the CBT-SA group.nnCONCLUSIONS: While SA decreased over time with both interventions, a positive effect of the CBT-SA intervention on measures of negative symptoms, functioning, and self-reported recovery at follow-up suggests that our intervention had a positive effect that extended beyond symptoms specific to SA.ClinicalTrials.gov identifier: NCT02294409.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37055181,

title = {VGLUT3 Deletion Rescues Motor Deficits and Neuronal Loss in the zQ175 Mouse Model of Huntington's Disease},

author = {Karim S Ibrahim and Salah El Mestikawy and Khaled S Abd-Elrahman and Stephen S G Ferguson},

doi = {10.1523/JNEUROSCI.0014-23.2023},

issn = {1529-2401},

year  = {2023},

date = {2023-06-01},

journal = {J Neurosci},

volume = {43},

number = {23},

pages = {4365--4377},

abstract = {Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by progressive motor and cognitive impairments, with no disease-modifying therapies yet available. HD pathophysiology involves evident impairment in glutamatergic neurotransmission leading to severe striatal neurodegeneration. The vesicular glutamate transporter-3 (VGLUT3) regulates the striatal network that is centrally affected by HD. Nevertheless, current evidence on the role of VGLUT3 in HD pathophysiology is lacking. Here, we crossed mice lacking  gene ( ) with heterozygous  knock-in mouse model of HD ( ). Longitudinal assessment of motor and cognitive functions from 6 to 15 months of age reveals that VGLUT3 deletion rescues motor coordination and short-term memory deficits in both male and female  mice. VGLUT3 deletion also rescues neuronal loss likely via the activation of Akt and ERK1/2 in the striatum of  mice of both sexes. Interestingly, the rescue in neuronal survival in   mice is accompanied by a reduction in the number of nuclear mutant huntingtin (mHTT) aggregates with no change in the total aggregate levels or microgliosis. Collectively, these findings provide novel evidence that VGLUT3, despite its limited expression, can be a vital contributor to HD pathophysiology and a viable target for HD therapeutics. Dysregulation of the striatal network centrally contributes to the pathophysiology of Huntington's disease (HD). The atypical vesicular glutamate transporter-3 (VGLUT3) has been shown to regulate several major striatal pathologies, such as addiction, eating disorders, or L-DOPA-induced dyskinesia. Yet, our understanding of VGLUT3's role in HD remains unclear. We report here that deletion of the  () gene rescues the deficits in both motor and cognitive functions in HD mice of both sexes. We also find that VGLUT3 deletion activates neuronal survival signaling and reduces nuclear aggregation of abnormal huntingtin proteins and striatal neuron loss in HD mice. Our novel findings highlight the vital contribution of VGLUT3 in HD pathophysiology that can be exploited for HD therapeutic management.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37095250,

title = {Tau-targeting antisense oligonucleotide MAPT in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial},

author = {Catherine J Mummery and Anne Börjesson-Hanson and Daniel J Blackburn and Everard G B Vijverberg and Peter Paul De Deyn and Simon Ducharme and Michael Jonsson and Anja Schneider and Juha O Rinne and Albert C Ludolph and Ralf Bodenschatz and Holly Kordasiewicz and Eric E Swayze and Bethany Fitzsimmons and Laurence Mignon and Katrina M Moore and Chris Yun and Tiffany Baumann and Dan Li and Daniel A Norris and Rebecca Crean and Danielle L Graham and Ellen Huang and Elena Ratti and C Frank Bennett and Candice Junge and Roger M Lane},

doi = {10.1038/s41591-023-02326-3},

issn = {1546-170X},

year  = {2023},

date = {2023-06-01},

journal = {Nat Med},

volume = {29},

number = {6},

pages = {1437--1447},

abstract = {Tau plays a key role in Alzheimer's disease (AD) pathophysiology, and accumulating evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT expression with a tau-targeting antisense oligonucleotide (MAPT) and reduce tau levels in patients with mild AD. A randomized, double-blind, placebo-controlled, multiple-ascending dose phase 1b trial evaluated the safety, pharmacokinetics and target engagement of MAPT. Four ascending dose cohorts were enrolled sequentially and randomized 3:1 to intrathecal bolus administrations of MAPT or placebo every 4 or 12 weeks during the 13-week treatment period, followed by a 23 week post-treatment period. The primary endpoint was safety. The secondary endpoint was MAPT pharmacokinetics in cerebrospinal fluid (CSF). The prespecified key exploratory outcome was CSF total-tau protein concentration. Forty-six patients enrolled in the trial, of whom 34 were randomized to MAPT and 12 to placebo. Adverse events were reported in 94% of MAPT-treated patients and 75% of placebo-treated patients; all were mild or moderate. No serious adverse events were reported in MAPT-treated patients. Dose-dependent reduction in the CSF total-tau concentration was observed with greater than 50% mean reduction from baseline at 24 weeks post-last dose in the 60 mg (four doses) and 115 mg (two doses) MAPT groups. Clinicaltrials.gov registration number: NCT03186989 .},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36453876,

title = {Feasibility of a standard cognitive assessment in European academic memory clinics},

author = {Alice Grazia and Daniele Altomare and Lukas Preis and Andreas U Monsch and Stefano F Cappa and Serge Gauthier and Lutz Frölich and Bengt Winblad and Kathleen A Welsh-Bohmer and Stefan J Teipel and Marina Boccardi},

doi = {10.1002/alz.12830},

issn = {1552-5279},

year  = {2023},

date = {2023-06-01},

journal = {Alzheimers Dement},

volume = {19},

number = {6},

pages = {2276--2286},

abstract = {INTRODUCTION: Standardized cognitive assessment would enhance diagnostic reliability across memory clinics. An expert consensus adapted the Uniform Dataset (UDS)-3 for European centers, the clinician's UDS (cUDS). This study assessed its implementation acceptability and feasibility.nnMETHODS: We developed a survey investigating barriers, facilitators, and willingness to implement the cUDS. With a mixed-methods design, we analyzed data from academic memory clinics.nnRESULTS: Seventy-eight percent of responding clinicians were experienced neuropsychologists/psychologists and 22% were medical specialists coming from 18 European countries. Sixty-five percent clinicians were willing to implement cUDS. General barriers related to implementation (43%) and clinical-methodological domains (21%). Favorable clinicians reported finances (15%) and digitalization (9%) as facilitating, but unavailability of local norms (23%) as hindering. Unfavorable clinicians reported logistical (23%) and time issues (18%).nnDISCUSSION: Despite challenges, data showed moderate clinicians' acceptability and requirements to improve feasibility. Nonetheless, these results come from academic clinicians. The next steps will require feasibility evaluation in non-academic contexts.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37126580,

title = {Characterization of an automated method to segment the human locus coeruleus},

author = {Ahmad Sibahi and Rushali Gandhi and Rami Al-Haddad and Joseph Therriault and Tharick Pascoal and Mira Chamoun and Krysta Boutin-Miller and Christine Tardif and Pedro Rosa-Neto and Clifford M Cassidy},

doi = {10.1002/hbm.26324},

issn = {1097-0193},

year  = {2023},

date = {2023-06-01},

journal = {Hum Brain Mapp},

volume = {44},

number = {9},

pages = {3913--3925},

abstract = {Following the development of magnetic resonance imaging (MRI) methods to assay the integrity of catecholamine nuclei, including the locus coeruleus (LC), there has been an effort to develop automated methods that can accurately segment this small structure in an automated manner to promote its widespread use and overcome limitations of manual segmentation. Here we characterize an automated LC segmentation approach (referred to as the funnel-tip [FT] method) in healthy individuals and individuals with LC degeneration in the context of Alzheimer's disease (AD, confirmed with tau-PET imaging using [18F]MK6240). The first sample included n = 190 individuals across the AD spectrum from cognitively normal to moderate AD. LC signal assayed with FT segmentation showed excellent agreement with manual segmentation (intraclass correlation coefficient [ICC] = 0.91). Compared to other methods, the FT method showed numerically higher correlation to AD status (defined by presence of tau: Cohen's d = 0.64) and AD severity (Braak stage: Pearson R = -.35, cognitive function: R = .25). In a separate sample of n = 12 control participants, the FT method showed excellent scan-rescan reliability (ICC = 0.82). In another sample of n = 30 control participants, we found that the structure of the LC defined by FT segmentation approximated its expected shape as a contiguous line: <5% of LC voxels strayed >1 voxel (0.69 mm) from this line. The FT LC segmentation shows high agreement with manual segmentation and captures LC degeneration in AD. This practical method may facilitate larger research studies of the human LC-norepinephrine system and has potential to support future use of neuromelanin-sensitive MRI as a clinical biomarker.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35962919,

title = {Current Potential for Clinical Optimization of Social Cognition Assessment for Frontotemporal Dementia and Primary Psychiatric Disorders},

author = {Jan Van den Stock and Maxime Bertoux and Janine Diehl-Schmid and Olivier Piguet and Katherine P Rankin and Florence Pasquier and Simon Ducharme and Yolande Pijnenburg and Fiona Kumfor},

doi = {10.1007/s11065-022-09554-3},

issn = {1573-6660},

year  = {2023},

date = {2023-06-01},

journal = {Neuropsychol Rev},

volume = {33},

number = {2},

pages = {544--550},

abstract = {Dodich and colleagues recently reviewed the evidence supporting clinical use of social cognition assessment in behavioral variant frontotemporal dementia (Dodich et al., 2021). Here, we comment on their methods and present an initiative to address some of the limitations that emerged from their study. In particular, we established the social cognition workgroup within the Neuropsychiatric International Consortium Frontotemporal dementia (scNIC-FTD), aiming to validate social cognition assessment for diagnostic purposes and tracking of change across clinical situations.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37198279,

title = {Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies},

author = {Laia Montoliu-Gaya and Andréa L Benedet and Cécile Tissot and Agathe Vrillon and Nicholas J Ashton and Wagner S Brum and Juan Lantero-Rodriguez and Jenna Stevenson and Johanna Nilsson and Mathias Sauer and Nesrine Rahmouni and Gunnar Brinkmalm and Firoza Z Lussier and Tharick A Pascoal and Ingmar Skoog and Silke Kern and Henrik Zetterberg and Claire Paquet and Johan Gobom and Pedro Rosa-Neto and Kaj Blennow},

doi = {10.1038/s43587-023-00405-1},

issn = {2662-8465},

year  = {2023},

date = {2023-06-01},

journal = {Nat Aging},

volume = {3},

number = {6},

pages = {661--669},

abstract = {Blood phosphorylated tau (p-tau) biomarkers, at differing sites, demonstrate high accuracy to detect Alzheimer's disease (AD). However, knowledge on the optimal marker for disease identification across the AD continuum and the link to pathology is limited. This is partly due to heterogeneity in analytical methods. In this study, we employed an immunoprecipitation mass spectrometry method to simultaneously quantify six phosphorylated (p-tau181, p-tau199, p-tau202, p-tau205, p-tau217 and p-tau231) and two non-phosphorylated plasma tau peptides in a total of 214 participants from the Paris Lariboisière and Translational Biomarkers of Aging and Dementia cohorts. Our results indicate that p-tau217, p-tau231 and p-tau205 are the plasma tau forms that best reflect AD-related brain changes, although with distinct emergences along the disease course and correlations with AD features-amyloid and tau. These findings support the differential association of blood p-tau variants with AD pathology, and our method offers a potential tool for disease staging in clinical trials.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37220744,

title = {Grid cell disruption in a mouse model of early Alzheimer's disease reflects reduced integration of self-motion cues},

author = {Johnson Ying and Antonio Reboreda and Motoharu Yoshida and Mark P Brandon},

doi = {10.1016/j.cub.2023.04.065},

issn = {1879-0445},

year  = {2023},

date = {2023-06-01},

journal = {Curr Biol},

volume = {33},

number = {12},

pages = {2425--2437.e5},

abstract = {Converging evidence from human and rodent studies suggests that disrupted grid cell coding in the medial entorhinal cortex (MEC) underlies path integration behavioral deficits during early Alzheimer's disease (AD). However, grid cell firing relies on both self-motion cues and environmental features, and it remains unclear whether disrupted grid coding can account for specific path integration deficits reported during early AD. Here, we report in the J20 transgenic amyloid beta (Aβ) mouse model of early AD that grid cells were spatially unstable toward the center of the arena, had qualitatively different spatial components that aligned parallel to the borders of the environment, and exhibited impaired integration of distance traveled via reduced theta phase precession. Our results suggest that disrupted early AD grid coding reflects reduced integration of self-motion cues but not environmental information via geometric boundaries, providing evidence that grid cell impairments underlie path integration deficits during early AD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37394176,

title = {Variations in Cortical Functional Gradients Relate to Dimensions of Psychopathology in Preschool Children},

author = {Thuan Tinh Nguyen and Xing Qian and Eric Kwun Kei Ng and Marcus Qin Wen Ong and Zhen Ming Ngoh and Shayne S P Yeo and Jia Ming Lau and Ai Peng Tan and Birit F P Broekman and Evelyn C Law and Peter D Gluckman and Yap-Seng Chong and Samuele Cortese and Michael J Meaney and Juan Helen Zhou},

doi = {10.1016/j.jaac.2023.05.029},

issn = {1527-5418},

year  = {2023},

date = {2023-06-01},

journal = {J Am Acad Child Adolesc Psychiatry},

abstract = {OBJECTIVE: It is unclear how the functional brain hierarchy is organized in preschool-aged children, and whether alterations in the brain organization are linked to mental health in this age group. Here, we assessed whether preschool-aged children exhibit a brain organizational structure similar to that of older children, how this structure might change over time, and whether it might reflect mental health.nnMETHOD: This study derived functional gradients using diffusion embedding from resting state functional magnetic resonance imaging data of 4.5-year-old children (N = 100, 42 male participants) and 6.0-year-old children (N = 133, 62 male participants) from the longitudinal Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. We then conducted partial least-squares correlation analyses to identify the association between the impairment ratings of different mental disorders and network gradient values.nnRESULTS: The main organizing axis of functional connectivity (ie, principal gradient) separated the visual and somatomotor regions (ie, unimodal) in preschool-aged children, whereas the second axis delineated the unimodal-transmodal gradient. This pattern of organization was stable from 4.5 to 6 years of age. The second gradient separating the high- and low-order networks exhibited a diverging pattern across mental health severity, differentiating dimensions related to attention-deficit/hyperactivity disorder and phobic disorders.nnCONCLUSION: This study characterized, for the first time, the functional brain hierarchy in preschool-aged children. A divergence in functional gradient pattern across different disease dimensions was found, highlighting how perturbations in functional brain organization can relate to the severity of different mental health disorders.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37244653,

title = {Study Preregistration: Measuring What Matters: Development and Dissemination of a Core Outcome Set for Pediatric Anxiety Disorders Clinical Trials},

author = {Suneeta Monga and Riddhi Desai and Samantha J Anthony and Paul D Arnold and Alexa Bagnell and Boris Birmaher and Leslie Anne Campbell and Rachel Churchill and Kristin Cleverley and Darren B Courtney and Gina Dimitropoulos and Sarah E Hetrick and Karolin R Krause and Lidwine B Mokkink and Scott B Patten and Megan C Patton and Matthew J Prebeg and Beth K Potter and Erin Romanchych and Jai L Shah and Maureen Smith and S Evelyn Stewart and Peter Szatmari and Andrea C Tricco and Peter Tugwell and John T Walkup and Vivian A Welch and Bonnie T Zima and Nancy J Butcher and Martin Offringa},

doi = {10.1016/j.jaac.2023.01.016},

issn = {1527-5418},

year  = {2023},

date = {2023-06-01},

journal = {J Am Acad Child Adolesc Psychiatry},

volume = {62},

number = {6},

pages = {696--698},

abstract = {Pediatric anxiety disorders (AD) are prevalent disorders with an impact on all aspects of a child's life and functioning. Although evidence supports commonly used treatments, there are notable concerns with the research to date. Heterogeneity in outcome selection, measurement, analysis, and reporting is a contributing factor to the hinderance of the translation of research into clinical practice. Recognition for outcome standardization in pediatric mental health disorders is evolving and there are several initiatives of importance, including the International Consortium for Health Outcomes Measurement (ICHOM), which has developed standardized outcome sets for use in the routine clinical mental health treatment of children and adolescents. Similarly, the International Alliance of Mental Health Research Funders advocate for use of 1 specific outcome measurement instrument (OMI) in the youth mental health research that they fund. Development of a Core Outcome Set (COS), a minimal set of outcomes that should be measured and reported in clinical trials, has been a solution in other areas of medicine to address heterogeneity in outcome selection and measurement across trials. The Core Outcomes and Measures in Pediatric Anxiety Clinical Trials (COMPACT) Initiative will develop a harmonized, evidence- and consensus-based COS that is meaningful to youth and families for use in future trials in pediatric AD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37386570,

title = {Physical discipline as a normative childhood experience in Singapore},

author = {Mioko Sudo and Ying Qing Won and Winnie W Y Chau and Michael J Meaney and Michelle Z L Kee and Helen Chen and Johan Gunnar Eriksson and Fabian Yap and Anne Rifkin-Graboi and Henning Tiemeier and Peipei Setoh},

doi = {10.1186/s13034-023-00632-9},

issn = {1753-2000},

year  = {2023},

date = {2023-06-01},

journal = {Child Adolesc Psychiatry Ment Health},

volume = {17},

number = {1},

pages = {81},

abstract = {BACKGROUND: The cultural normativeness theory posits that specific parenting behaviors can be interpreted as displays of appropriate parenting in contexts where they are deemed normative. Previous studies suggest high acceptance of physical discipline in Singapore, where strict parenting could be interpreted as care for the child. However, there is a lack of studies on the local prevalence and implications of physical discipline. This study aimed to investigate the prevalence of Singaporean children experiencing parental physical discipline, longitudinal changes in this prevalence, and how exposure to physical discipline relates to children's evaluation of their parents' parenting.nnMETHODS: Participants were 710 children with parental reports of physical discipline at one or more assessments at ages 4.5, 6, 9, and 11 years in the Growing Up in Singapore Towards healthy Outcomes birth cohort study. Parental reports of physical discipline were obtained using the Parenting Styles and Dimensions Questionnaire or the Alabama Parenting Questionnaire across the four assessments. Child reports of their parents' care and control were obtained using the Parental Bonding Instrument for Children at the age 9 assessment. Prevalence was specified as being exposed to at least one physical discipline at any frequency. A generalized linear mixed model was performed to examine whether children's age predicted their exposure to physical discipline. Linear regression analyses were conducted to investigate whether children's exposure to physical discipline predicted their evaluation of their parents' parenting.nnRESULTS: The prevalence of children experiencing at least one physical discipline was above 80% at all ages. There was a decrease in this prevalence from age 4.5 to 11 years (B = - 0.14, SE = 0.01, OR = 0.87, p < 0.001). The more frequent the paternal physical discipline children were exposed to, the more likely they were to report lower levels of care (B = - 1.74, SE = 0.66, p = 0.03) and higher levels of denial of psychological autonomy by fathers (B = 1.05, SE = 0.45, p = 0.04). Maternal physical discipline was not significantly associated with children's evaluation of their mothers' parenting (ps ≥ 0.53).nnCONCLUSIONS: Physical discipline was a common experience among our Singaporean sample, consistent with the notion that strict parenting could be regarded as a form of care. However, exposure to physical discipline did not translate to children reporting their parents as caring, with paternal physical discipline being negatively associated with children's evaluations of paternal care.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37371441,

title = {Cortical Structure Differences in Relation to Age, Sexual Attractions, and Gender Dysphoria in Adolescents: An Examination of Mean Diffusivity and T1 Relaxation Time},

author = {Malvina N Skorska and Lindsey T Thurston and Jessica M Biasin and Gabriel A Devenyi and Kenneth J Zucker and M Mallar Chakravarty and Meng-Chuan Lai and Doug P VanderLaan},

doi = {10.3390/brainsci13060963},

issn = {2076-3425},

year  = {2023},

date = {2023-06-01},

journal = {Brain Sci},

volume = {13},

number = {6},

abstract = {Recent research found that the combination of masculine gender identity and gynephilia was associated with cortical T1 relaxation time, which is considered to reflect gray matter density. We hypothesized that mean diffusivity (MD), a diffusion tensor imaging metric that reflects the degree to which water movement is free versus constrained, in combination with T1 relaxation time would provide further insight regarding cortical tissue characteristics. MD and T1 relaxation time were measured in 76 cortical regions in 15 adolescents assigned female at birth who experience gender dysphoria (GD AFAB) and were not receiving hormone therapy, 17 cisgender girls, and 14 cisgender boys (ages 12-17 years). Sexual orientation was represented by the degree of androphilia-gynephilia and the strength of sexual attraction. In multivariate analyses, cortical T1 relaxation time showed a weak but statistically significant positive association with MD across the cortex, suggesting that macromolecule-rich cortical tissue also tends to show water movement that is somewhat more constrained. In further multivariate analyses, in several left frontal, parietal, and temporal regions, the combination of shorter T1 relaxation time and faster MD was associated with older age and greater gynephilia in GD AFAB individuals and cisgender boys and with stronger attractions in cisgender boys only. Thus, for these cortical regions in these groups, older age, gynephilia, and stronger attractions (cisgender boys only) were associated with macromolecule-rich tissue in which water movement was freer-a pattern that some prior research suggests is associated with greater cell density and size. Overall, this study indicates that investigating T1 relaxation time and MD together can further inform how cortical gray matter tissue characteristics relate to age and psychosexuality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37357714,

title = {Predictors of Physician Follow-Up Care Among Patients Affected by an Incident Mental Disorder Episode in Quebec (Canada)},

author = {Marie-Josée Fleury and Louis Rochette and Lia Gentil and Guy Grenier and Alain Lesage},

doi = {10.1177/07067437231182570},

issn = {1497-0015},

year  = {2023},

date = {2023-06-01},

journal = {Can J Psychiatry},

pages = {7067437231182570},

abstract = {OBJECTIVES: This study identified predictors of prompt (1+ outpatient physician consultations/within 30 days), adequate (3+/90 days) and continuous (5+/365 days) follow-up care from general practitioners (GPs) or psychiatrists among patients with an incident mental disorder (MD) episode.nnMETHODS: Study data were extracted from the Quebec Integrated Chronic Disease Surveillance System (QICDSS), which covers 98% of the population eligible for health-care services under the Quebec (Canada) Health Insurance Plan. This observational epidemiological study investigating the QICDSS from 1 April 1997 to 31 March 2020, is based on a 23-year patient cohort including 12+ years old patients with an incident MD episode ( = 2,670,133). Risk ratios were calculated using Robust Poisson regressions to measure patient sociodemographic and clinical characteristics, and prior service use, which predicted patients being more or less likely to receive prompt, adequate, or continuous follow-up care after their last incident MD episode, controlling for previous MD episodes, co-occurring disorders, and years of entry into the cohort.nnRESULTS: A minority of patients, and fewer over time, received physician follow-up care after an incident MD episode. Women; patients aged 18-64; with depressive or bipolar disorders, co-occurring MDs-substance-related disorders (SRDs) or physical illnesses; those receiving previous GP follow-up care, especially in family medicine groups; patients with higher prior continuity of GP care; and previous high users of emergency departments were more likely to receive follow-up care. Patients living outside the Montreal metropolitan area; those without prior MDs; patients with anxiety, attention deficit hyperactivity, personality, schizophrenia and other psychotic disorders, or SRDs were less likely to receive follow-up care.nnCONCLUSION: This study shows that vulnerable patients with complex clinical characteristics and those with better previous GP care were more likely to receive prompt, adequate or continuous follow-up care after an incident MD episode. Overall, physician follow-up care should be greatly improved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37355003,

title = {Gains and Losses: Resilience to Social Defeat Stress in Adolescent Female Mice},

author = {Andrea Harée Pantoja-Urbán and Samuel Richer and Amelie Mittermaier and Michel Giroux and Dominique Nouel and Giovanni Hernandez and Cecilia Flores},

doi = {10.1016/j.biopsych.2023.06.014},

issn = {1873-2402},

year  = {2023},

date = {2023-06-01},

journal = {Biol Psychiatry},

abstract = {BACKGROUND: Adolescence is a unique period of psychosocial growth during which social adversity can negatively influence mental health trajectories. Understanding how adolescent social stress impacts males and females and why some individuals are particularly affected is becoming increasingly urgent. Social defeat stress models for adolescent male mice have been effective in reproducing some physical/psychological aspects of bullying. Designing a model suitable for females has proven challenging.nnMETHODS: We report a version of the adolescent male accelerated social defeat stress (AcSD) paradigm adapted for females. Early adolescent C57BL/6J female mice (N = 107) were exposed to our modified AcSD procedure twice a day for 4 days and categorized as resilient or susceptible based on a social interaction test 24 hours later. Mice were then assessed for changes in Netrin-1/DCC guidance cue expression in dopamine systems, for inhibitory control in adulthood using the Go/No-Go task, or for alterations in dopamine connectivity organization in the matured prefrontal cortex.nnRESULTS: Most adolescent females showed protection against stress-induced social avoidance, but in adulthood, these resilient females developed inhibitory control deficits and showed diminution of prefrontal cortex presynaptic dopamine sites. Female mice classified as susceptible were protected against cognitive and dopaminergic alterations. AcSD did not alter Netrin-1/DCC in early adolescent females, contrary to previous findings with males.nnCONCLUSIONS: Preserving prosocial behavior in adolescent females may be important for survival advantage but seems to come at the price of developing persistent cognitive and dopamine deficiencies. The female AcSD paradigm produced findings comparable to those found in males, allowing mechanistic investigation in both sexes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37294682,

title = {Longitudinal blood biomarker trajectories in preclinical Alzheimer's disease},

author = {Yara Yakoub and Nicholas J Ashton and Cherie Strikwerda-Brown and Laia Montoliu-Gaya and Thomas K Karikari and Przemysław R Kac and Fernando Gonzalez-Ortiz and Jonathan Gallego-Rudolf and Pierre-François Meyer and Frédéric St-Onge and Michael Schöll and Jean-Paul Soucy and John C S Breitner and Henrik Zetterberg and Kaj Blennow and Judes Poirier and Sylvia Villeneuve and },

doi = {10.1002/alz.13318},

issn = {1552-5279},

year  = {2023},

date = {2023-06-01},

journal = {Alzheimers Dement},

abstract = {INTRODUCTION: Plasma biomarkers are altered years prior to Alzheimer's disease (AD) clinical onset.nnMETHODS: We measured longitudinal changes in plasma amyloid-beta (Aβ) ratio, pTau181, pTau231, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) in a cohort of older adults at risk of AD (n = 373 total, n = 229 with Aβ and tau positron emission tomography [PET] scans) considering genetic and demographic factors as possible modifiers of these markers' progression.nnRESULTS: Aβ ratio concentrations decreased, while NfL and GFAP values increased over the 4-year follow-up. Apolipoprotein E (APOE) ε4 carriers showed faster increase in plasma pTau181 than non-carriers. Older individuals showed a faster increase in plasma NfL, and females showed a faster increase in plasma GFAP values. In the PET subsample, individuals both Aβ-PET and tau-PET positive showed faster plasma pTau181 and GFAP increase compared to PET-negative individuals.nnDISCUSSION: Plasma markers can track biological change over time, with plasma pTau181 and GFAP markers showing longitudinal change in individuals with preclinical AD.nnHIGHLIGHTS: Longitudinal increase of plasma pTau181 and glial fibrillary acidic protein (GFAP) can be measured in the preclinical phase of AD. Apolipoprotein E ε4 carriers experience faster increase in plasma pTau181 over time than non-carriers. Female sex showed accelerated increase in plasma GFAP over time compared to males. Aβ and pTau231 values are already abnormal at baseline in individuals with both amyloid and tau PET burden.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37290121,

title = {Psychological interventions for loneliness and social isolation among older adults during medical pandemics: a systematic review and meta-analysis},

author = {Muzi Li and Wenwang Rao and Yingying Su and Youngjoo Sul and Gabriel Caron and Carl D'Arcy and Marie-Josee Fleury and Xiangfei Meng},

doi = {10.1093/ageing/afad076},

issn = {1468-2834},

year  = {2023},

date = {2023-06-01},

journal = {Age Ageing},

volume = {52},

number = {6},

abstract = {OBJECTIVES: There is little research conducted to systematically synthesize the evidence on psychological interventions for social isolation and loneliness among older adults during medical pandemics. This systematic review aims to address this information gap and provides guidance for planning and implementing interventions to prevent and reduce loneliness and social isolation for older adults, especially during medical pandemics.nnMETHODS: Four electronic databases (EMBASE, PsychoInfo, Medline and Web of Science) and grey literature from 1 January 2000 to 13 September 2022 were searched for eligible studies on loneliness and social isolation. Data extraction and methodological quality assessment on key study characteristics were conducted independently by two researchers. Both qualitative synthesis and meta-analysis were used.nnRESULTS: The initial search yielded 3,116 titles. Of the 215 full texts reviewed, 12 intervention articles targeting loneliness during the COVID-19 pandemic met the inclusion criteria. No studies were found concerning intervention with respect to social isolation. Overall, interventions targeting social skills and the elimination of negativities effectively alleviated the feelings of loneliness in the older population. However, they had only short-term effects.nnCONCLUSION: This review systematically summarised the key characteristics and the effectiveness of existing interventions addressing loneliness in older adults during the COVID-19 pandemic. Future interventions should focus on social skills and eliminating negativities and be tailored to the needs and characteristics of older people. Repeated larger-scale randomized controlled trials and long-term effectiveness evaluations on this topic are warranted.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37282623,

title = {Preconception and prenatal maternal stress are associated with broad autism phenotype in young adults: Project Ice Storm},

author = {Xinyuan Li and David P Laplante and Guillaume Elgbeili and Suzanne King},

doi = {10.1017/S2040174423000156},

issn = {2040-1752},

year  = {2023},

date = {2023-06-01},

journal = {J Dev Orig Health Dis},

pages = {1--9},

abstract = {Studies show associations between prenatal maternal stress (PNMS) and child autism, with little attention paid to PNMS and autism in young adulthood. The broad autism phenotype (BAP), encompassing sub-clinical levels of autism, includes aloof personality, pragmatic language impairment and rigid personality. It remains unclear whether different aspects of PNMS explain variance in different BAP domains in young adult offspring. We recruited women who were pregnant during, or within 3 months of, the 1998 Quebec ice storm crisis, and assessed three aspects of their stress (i.e., objective hardship, subjective distress and cognitive appraisal). At age 19, the young adult offspring ( = 33, 22F / 11M) completed a BAP self-report. Linear and logistic regressions were implemented to examine associations between PNMS and BAP traits. Up to 21.4% of the variance in BAP total score and in BAP three domains tended to be explained by at least one aspect of maternal stress, For example, 16.8% of the variance in aloof personality tended to be explained by maternal objective hardship; 15.1% of the variance in pragmatic language impairment tended to be explained by maternal subjective distress; 20.0% of the variance in rigid personality tended to be explained by maternal objective hardship and 14.3% by maternal cognitive appraisal. Given the small sample size, the results should be interpreted with caution. In conclusion, this small prospective study suggests that different aspects of maternal stress could have differential effects on different components of BAP traits in young adults.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37266694,

title = {Sex differences in the clinical presentation of early psychosis in a primary care setting},

author = {Brooke Carter and Rebecca Rodrigues and Jennifer Reid and Suzanne Archie and Amanda L Terry and Lena Palaniyappan and Arlene G MacDougall and Aristotle Voineskos and Saadia Hameed Jan and Liisa Jaakkimainen and Branson Chen and Neo Sawh and Kelly K Anderson},

doi = {10.1007/s00737-023-01329-w},

issn = {1435-1102},

year  = {2023},

date = {2023-06-01},

journal = {Arch Womens Ment Health},

abstract = {Primary care is an important part of the help-seeking pathway for young people experiencing early psychosis, but sex differences in clinical presentation in these settings are unexplored. We aimed to identify sex differences in clinical presentation to primary care services in the 1-year period prior to a first diagnosis of psychotic disorder. We identified first-onset cases of non-affective psychotic disorder over a 10-year period (2005-2015) using health administrative data linked with electronic medical records (EMRs) from primary care (n = 465). Detailed information on encounters in the year prior to first diagnosis was abstracted, including psychiatric symptoms, other relevant behaviours, and diagnoses recorded by the family physician (FP). We used modified Poisson regression models to examine sex differences in the signs, symptoms, and diagnoses recorded by the FP, adjusting for various clinical and sociodemographic factors. Positive symptoms (PR = 0.76, 95%CI: 0.58, 0.98) and substance use (PR = 0.54, 95%CI: 0.40, 0.72) were less prevalent in the medical records of women. Visits by women were more likely to be assigned a diagnosis of depression or anxiety (PR = 1.18, 95%CI: 1.00, 1.38), personality disorder (PR = 5.49, 95%CI: 1.22, 24.62), psychological distress (PR = 11.29, 95%CI: 1.23, 103.91), and other mental or behavioral disorders (PR = 3.49, 95%CI: 1.14, 10.66) and less likely to be assigned a diagnosis of addiction (PR = 0.33, 95%CI: 0.13, 0.87). We identified evidence of sex differences in the clinical presentation of early psychosis and recorded diagnoses in the primary care EMR. Further research is needed to better understand sex differences in clinical presentation in the primary care context, which can facilitate better understanding, detection, and intervention for first-episode psychotic disorders.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37276658,

title = {Derivation of probable child maltreatment indicators using prospectively recorded information between 5 months and 17 years in a longitudinal cohort of Canadian children},

author = {Sara Scardera and Rachel Langevin and Delphine Collin-Vézina and Maude Comtois Cabana and Snehal M Pinto Pereira and Sylvana Côté and Isabelle Ouellet-Morin and Marie-Claude Geoffroy},

doi = {10.1016/j.chiabu.2023.106247},

issn = {1873-7757},

year  = {2023},

date = {2023-06-01},

journal = {Child Abuse Negl},

volume = {143},

pages = {106247},

abstract = {BACKGROUND: Both prospective and retrospective measures of child maltreatment predict mental and physical health problems, despite their weak concordance. Research remains largely based on retrospective reports spanning the entire childhood due to a scarcity of prospectively completed measures targeting maltreatment specifically.nnOBJECTIVE: We developed a prospective index of child maltreatment in the Québec Longitudinal Study of Child Development (QLSCD) using prospective information collected from ages 5 months to 17 years and examined its concordance with retrospective maltreatment.nnPARTICIPANTS AND SETTING: The QLSCD is an ongoing population-based cohort that includes 2,120 participants born from 1997-1998 in the Canadian Province of Quebec.nnMETHODS: As the QLSCD did not have maltreatment as a focal variable, we screened 29,600 items completed by multiple informants (mothers, children, teachers, home observations) across 14 measurement points (5 months-17 years). Items that could reflect maltreatment were first extracted. Indicators were derived across preschool, school-age and adolescence periods and by the end of childhood and adolescence, including presence (yes/no), chronicity (re-occurrence), extent of exposure and cumulative maltreatment. Two maltreatment experts reviewed these items for inclusion and determined cut-offs for possible child maltreatment (n=251 items). Retrospective maltreatment was self-reported at 23 years.nnRESULTS: Across all developmental periods, the presence of maltreatment was as follows: physical abuse (16.3-21.8%), psychological abuse (3.3-21.9%), emotional neglect (20.4-21.6%), physical neglect (15.0-22.3%), supervisory neglect (25.8-44.9%), family violence (4.1-11.2%) and sexual abuse (9.5% in adolescence only). The degree of concordance between prospective and retrospective reports for each type of maltreatment was weak (.038-.110), yet significant (p<.01), except for emotional neglect (p=.148).nnCONCLUSIONS: In addition to the many future research opportunities offered by these prospective indicators of maltreatment, this study offers a roadmap to researchers wishing to undertake a similar task.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37268433,

title = {Association of Cortical Gyrification With Imaging and Serum Biomarkers in Patients With Parkinson Disease},

author = {Yuanchao Zhang and Yu Zhang and Chengjie Mao and Zhen Jiang and Guohua Fan and Erlei Wang and Yifan Chen and Lena Palaniyappan},

doi = {10.1212/WNL.0000000000207410},

issn = {1526-632X},

year  = {2023},

date = {2023-06-01},

journal = {Neurology},

abstract = {BACKGROUND AND OBJECTIVES: Pathological progression across the cortex is a key feature of Parkinson disease (PD). Cortical gyrification is a morphologic feature of human cerebral cortex that is tightly linked to the integrity of underlying axonal connectivity. Monitoring cortical gyrification reductions may provide a sensitive marker of progression via structural connectivity, preceding the progressive stages of PD pathology. We aimed to examine the progressive cortical gyrification reductions and their associations with overlying cortical thickness, white matter (WM) integrity, striatum dopamine availability, serum neurofilament light (NfL) chain and cerebrospinal fluid (CSF) α-synuclein levels in PD.nnMETHODS: This study included a longitudinal dataset with baseline (T0), 1-year (T1) and 4-year (T4) follow-ups, and two cross-sectional datasets. Local gyrification index (LGI) was computed from T1-weighted MRI data to measure cortical gyrification. Fractional anisotropy (FA) was computed from diffusion-weighted MRI data to measure WM integrity. Striatal binding ratio (SBR) was measured from Ioflupane SPECT scans. Serum NfL and CSF α-synuclein levels were also measured.nnRESULTS: The longitudinal dataset included 113 de novo PD patients and 55 healthy controls (HC). The cross-sectional datasets included 116 patients with relatively more advanced PD and 85 HC. Compared with HC, de novo PD patients showed accelerated LGI and FA reductions over 1-year period and further decline at 4-year follow-up. Across the three time points, the LGI paralleled and correlated with FA (p=0.002 at T0, p=0.0214 at T1, p=0.0037 at T4) and SBR (p=0.0095 at T0, p=0.0035 at T1, p=0.0096 at T4) but not with overlying cortical thickness in PD patients. Both LGI and FA correlated with serum NfL level (LGI: p<0.0001 at T0, p=0.0043 at T1; FA: p<0.0001 at T0, p=0.0001 at T1) but not with CSF α-synuclein level in PD patients. In the two cross-sectional datasets, we revealed similar patterns of LGI and FA reductions and associations between LGI and FA in patients with more advanced PD.nnDISCUSSION: We demonstrated progressive reductions in cortical gyrification that were robustly associated with WM microstructure, striatum dopamine availability and serum NfL level in PD. Our findings may contribute biomarkers for PD progression and potential pathways for early interventions of PD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37271424,

title = {Methods and results of studies on reporting guideline adherence are poorly reported: a meta-research study},

author = {Tiffany Dal Santo and Danielle B Rice and Lara S N Amiri and Amina Tasleem and Kexin Li and Jill T Boruff and Marie-Claude Geoffroy and Andrea Benedetti and Brett D Thombs},

doi = {10.1016/j.jclinepi.2023.05.017},

issn = {1878-5921},

year  = {2023},

date = {2023-06-01},

journal = {J Clin Epidemiol},

abstract = {OBJECTIVES: We investigated recent meta-research studies on adherence to 4 reporting guidelines to determine the proportion that provided (1) an explanation for how adherence to guideline items was rated and (2) results from all included individual studies. We examined conclusions of each meta-research study to evaluate possible repetitive and similar findings.nnSTUDY DESIGN AND SETTING: Cross-sectional meta-research study. MEDLINE (Ovid) was searched on July 5, 2022 for studies that used any version of the CONSORT, PRISMA, STARD, or STROBE reporting guidelines or their extensions to evaluate reporting.nnRESULTS: Of 148 included meta-research studies published between August 2020 and June 2022, 14 (10%, 95% confidence interval [CI] 6% to 15%) provided a fully replicable explanation of how they coded the adherence ratings and 49 (33%, 95% CI 26% to 41%) completely reported individual study results. Of 90 studies that classified reporting as adequate or inadequate in the study abstract, 6 (7%, 95% CI 3% to 14%) concluded that reporting was adequate, but none of those 6 studies provided information on how items were coded or provided item-level results for included studies.nnCONCLUSIONS: Almost all included meta-research studies found that reporting in health research is suboptimal. However, few of these reported enough information for verification or replication.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37208985,

title = {Respiratory sinus arrhythmia, negative social interactions, and fluctuations in unmet interpersonal needs: A daily diary study},

author = {Sasha MacNeil and Johanne Renaud and Jean-Philippe Gouin},

doi = {10.1111/sltb.12967},

issn = {1943-278X},

year  = {2023},

date = {2023-05-01},

journal = {Suicide Life Threat Behav},

abstract = {INTRODUCTION: This study examined daily fluctuations in the unmet interpersonal needs of thwarted belongingness and perceived burdensomeness in response to daily negative social interactions, as well as the moderating role of respiratory sinus arrhythmia (RSA) across adolescents at lower and higher risk for suicidal ideation.nnMETHODS: Fifty five adolescents with major depressive disorder (MDD, i.e., higher-risk group) and without MDD (i.e., lower-risk group) completed measures of resting RSA, and daily measures of negative social interactions, perceived burdensomeness, and loneliness, as a proxy for thwarted belongingness, for 10 consecutive days. Within-person analyses examined the association between daily negative social interactions and unmet interpersonal needs, and the moderating roles of RSA and higher-risk group status. Between-person analyses also examined the association between RSA and unmet interpersonal needs across groups.nnRESULTS: At the within-person level, participants reported more unmet interpersonal needs on days when they reported more negative social interactions. At the between-person level, higher RSA was associated with decreased loneliness in both groups, and decreased burdensomeness among the higher-risk group.nnCONCLUSIONS: Negative social interactions are associated with daily unmet interpersonal needs. Higher RSA may serve as a protective factor mitigating risk for unmet interpersonal needs, particularly burdensomeness, among adolescents at higher risk for suicidal ideation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}