Publications

@article{pmid39428944,

title = {A longitudinal study of adolescent pathways differentiating suicide ideation and attempt in early adulthood},

author = {Geneviève Morneau-Vaillancourt and Massimiliano Orri and Isabelle Ouellet-Morin and Marie-Claude Geoffroy and Michel Boivin},

doi = {10.1002/jad.12427},

issn = {1095-9254},

year  = {2025},

date = {2025-02-01},

journal = {J Adolesc},

volume = {97},

number = {2},

pages = {395--408},

abstract = {OBJECTIVE: Suicide ideation and attempt are leading risk factors for mortality in young adults. However, the adolescent risk factors distinguishing suicide ideation from attempt in young adults remain unclear. The present study aimed to examine the extent to which within-person stability and change in depressive symptoms, school difficulties, and peer victimization from ages 12 to 17 were differentially associated with later suicide ideation and attempt from ages 20 to 23.nnMETHOD: The study included 1647 participants from the Quebec Longitudinal Study of Child Development (QLSCD; 52% female). Participants reported on their depressive symptoms, school difficulties, and peer victimization at ages 12, 13, 15, and 17, and on suicide ideation and attempt at ages 20 and 23. Data were collected in the Province of Quebec, Canada, between 2010 and 2021.nnRESULTS: Results indicated that 11% (N = 121) and 8% (N = 86) reported suicide ideation and attempt, respectively, between ages 20 and 23. A random-intercept cross-lagged panel model showed that within-person increases in depressive symptoms during adolescence were related to both suicide ideation and attempt, whereas within-person increases in school difficulties and peer victimization were for the most part related to suicide attempt only. Within-person stability in depressive symptoms from ages 12 to 17 years were also related to suicide attempt, and not ideation. However, this association was only marginally significant.nnCONCLUSION: Findings suggest that experiencing unusual rises in school difficulties and peer victimization during adolescence, as well as depressive symptoms persisting over time, may distinguish young adults who think about suicide from those who attempt suicide.},

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pubstate = {published},

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}

@article{pmid39334334,

title = {Reasons Explaining High Emergency Department Use in Patients With Mental Illnesses: Different Staff Perspectives},

author = {Marie-Josée Fleury and Francine Ferland and Lambert Farand and Guy Grenier and Armelle Imboua and Firas Gaida},

doi = {10.1111/inm.13442},

issn = {1447-0349},

year  = {2025},

date = {2025-02-01},

journal = {Int J Ment Health Nurs},

volume = {34},

number = {1},

pages = {e13442},

abstract = {For patients with mental illnesses (MIs), emergency departments (EDs) are often the entry point into the healthcare system, or their only resort for quickly accessing mental health treatment. A better understanding of the various barriers justifying high ED use among patients with MIs may help recommend targeted interventions that better meet their needs. This explorative qualitative study aimed to identify such barriers and the solutions brought forth to reduce ED use based on the perspectives of clinicians and managers working in EDs, other hospital departments or the community sector. Interviews were conducted between April 2021 and February 2022; 86 mental health professionals (22% were nurses) from four large urban ED sites in Quebec (Canada) were interviewed. Barriers were identified in relation to patient profiles, healthcare system and organisational features and professional characteristics. The key barriers that were found to explain high ED use were patients having serious MIs (e.g., psychotic disorders) or social issues (e.g., poverty), lack of coordination and patient referrals between EDs and other health services, insufficient access to mental health and addiction services and inadequacy of care. Very few solutions were implemented to improve care for high ED users. Better deployment of ED interventions in collaboration with outpatient care may be prioritised to reduce high ED use for patients with MIs. Improvements to the referral and transfer processes to outpatient care, particularly through care plans and case management programs, may be implemented to reduce high ED use and improve outpatient care among patients with multiple health and social needs.},

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@article{pmid39255831,

title = {The interplay of maternal and paternal postpartum depressive symptoms with children's internalizing and externalizing symptoms from childhood to adolescence: does socioeconomic status matter? A longitudinal cohort study},

author = {Myriam Clément and Marilyn N Ahun and Massimiliano Orri and Tina C Montreuil and Martin St-André and Catherine M Herba and Gregory Moullec and Sylvana M Côté},

doi = {10.1111/jcpp.14051},

issn = {1469-7610},

year  = {2025},

date = {2025-02-01},

journal = {J Child Psychol Psychiatry},

volume = {66},

number = {2},

pages = {225--240},

abstract = {BACKGROUND: Maternal postpartum depression is an important risk factor for internalizing and externalizing problems in children. The role of concurrent paternal depression remains unclear, especially by socioeconomic status. This study examined independent and interactive associations of postpartum maternal and paternal depression with children's internalizing/externalizing symptoms throughout childhood and adolescence (ages 3.5-17 years).nnMETHODS: We used data from the Québec Longitudinal Study of Child Development, a representative birth cohort (1997-1998) in Canada. Data included self-reported maternal and paternal depressive symptoms at 5 months' postpartum using the Center for Epidemiologic Studies Depression Scale. Internalizing and externalizing symptoms in children were reported by parents, teachers and children/adolescents using the Social Behaviour Questionnaire (ages 3.5-13 years) and the Mental Health and Social Inadaptation Assessment for Adolescents (ages 15-17 years). We used three-level mixed effects modelling to test associations after adjusting for confounding factors.nnRESULTS: With 168 single-parent families excluded, our sample consisted of 1,700 families with useable data. Of these, 275 (16.2%) families reported maternal depression (clinically elevated symptoms), 135 (7.9%) paternal depression and 39 (2.3%) both. In families with high socioeconomic status, maternal depression was associated with greater child internalizing (β = .34; p < .001) and externalizing symptoms (β = .22; p = .002), regardless of the presence/absence of paternal depression. In families with low socioeconomic status, associations with symptoms were stronger with concurrent paternal depression (internalizing, β = .84, p < .001; externalizing, β = .71, p = .003) than without (internalizing, β = .30, p < .001; externalizing, β = .24, p = .002).nnCONCLUSIONS: Maternal depression increases the risk for children's internalizing/externalizing problems in all socioeconomic contexts. In families with low socioeconomic status, risks were exacerbated by concurrent paternal depression. Postpartum depression, especially in low socioeconomic environments, should be a primary focus to optimize mental health across generations.},

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pubstate = {published},

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}

@article{pmid39887549,

title = {The higher benefit of lecanemab in males compared to females in CLARITY AD is probably due to a real sex effect},

author = {Daniel Andrews and Simon Ducharme and Howard Chertkow and Maria Pia Sormani and D Louis Collins and },

doi = {10.1002/alz.14467},

issn = {1552-5279},

year  = {2025},

date = {2025-01-01},

journal = {Alzheimers Dement},

volume = {21},

number = {1},

pages = {e14467},

abstract = {INTRODUCTION: The phase 3 trial CLARITY AD found lecanemab slowed cognitive decline by 27%. However, subgroup analyses indicated a significant 31% sex difference in the effect and suggested no or limited effectiveness in females. We used simulations constrained by the trial design to determine whether that difference reflects a pre-existing sex difference in Alzheimer's disease progression or was a random event.nnMETHODS: Simulations were generated using linear mixed models of cognitive decline fit to data from Alzheimer's Disease Neuroimaging Initiative participants satisfying CLARITY AD inclusion criteria.nnRESULTS: The statistically non-significant 7.9% smaller cognitive decline rate in our cohort's males versus females does not explain CLARITY AD's 31% sex difference in lecanemab's effect. A ≥ 31% difference occurred randomly in only 12 of our 10,000 simulations (0.0012 probability).nnDISCUSSION: CLARITY AD's sex difference was probably not random. Lecanemab is likely less effective in females than males, but we cannot conclude the drug is ineffective in females.nnHIGHLIGHTS: Lecanemab is more clinically effective in males than in females. Forest plots should only report subgroup-specific effects in well-powered subgroups. Trial simulations based on real data enable investigation of subgroup drug effects. We cannot conclude that lecanemab is clinically ineffective in females. A sex difference in lecanemab's efficacy could be linked to its action mechanism.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38679357,

title = {Immune Alterations in the Intrauterine Environment Shape Offspring Brain Development in a Sex-Specific Manner},

author = {Elisa Guma and M Mallar Chakravarty},

doi = {10.1016/j.biopsych.2024.04.012},

issn = {1873-2402},

year  = {2025},

date = {2025-01-01},

journal = {Biol Psychiatry},

volume = {97},

number = {1},

pages = {12--27},

abstract = {Exposure to immune dysregulation in utero or in early life has been shown to increase risk for neuropsychiatric illness. The sources of inflammation can be varied, including acute exposures due to maternal infection or acute stress, or persistent exposures due to chronic stress, obesity, malnutrition, or autoimmune diseases. These exposures may cause subtle alteration in brain development, structure, and function that can become progressively magnified across the lifespan, potentially increasing the likelihood of developing a neuropsychiatric conditions. There is some evidence that males are more susceptible to early-life inflammatory challenges than females. In this review, we discuss the various sources of in utero or early-life immune alteration and the known effects on fetal development with a sex-specific lens. To do so, we leveraged neuroimaging, behavioral, cellular, and neurochemical findings. Gaining clarity about how the intrauterine environment affects offspring development is critically important for informing preventive and early intervention measures that may buffer against the effects of these early-life risk factors.},

keywords = {},

pubstate = {published},

tppubtype = {article}

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@article{pmid39879633,

title = {Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer's disease spectrum},

author = {Jaime Fernández Arias and Wagner S Brum and Gemma Salvadó and Joseph Therriault and Stijn Servaes and Yi-Ting Wang and Etienne Aumont and Nesrine Rahmouni and Arthur Macedo and Kely Quispialaya and Seyyed Ali Hosseini and Peter Kunach and Wan Lu Jia and Tevy Chan and Lydia Trudel and Brandon Hall and Yanseng Zheng and Sejal Mohapatra and Sulantha S Mathotaarachchi and Paolo Vitali and Cécile Tissot and Gleb Bezgin and Yasser Iturria-Medina and Nicholas J Ashton and Andréa Lessa Benedet and Thomas K Karikari and Gallen Triana-Baltzer and Jesse Klostranec and Hartmuth C Kolb and Eduardo R Zimmer and Shorena Janelidze and Niklas Mattson-Carlgren and Erik Stomrud and Sebastian Palmqvist and Henrik Zetterberg and Kaj Blennow and Tharick Pascoal and Maxime Montembeault and Oskar Hansson and Pedro Rosa-Neto},

doi = {10.1093/brain/awaf033},

issn = {1460-2156},

year  = {2025},

date = {2025-01-01},

journal = {Brain},

abstract = {Plasma phosphorylated tau biomarkers open unprecedented opportunities for identifying carriers of Alzheimer's disease pathophysiology in early disease stages using minimally invasive techniques. Plasma p-tau biomarkers are believed to reflect tau phosphorylation and secretion. However, it remains unclear to what extent the magnitude of plasma p-tau abnormalities reflects neuronal network disturbance in the form of cognitive impairment. To address this question, we included 103 cognitively unimpaired elderly and 40 cognitively impaired, amyloid-β positive individuals from the TRIAD cohort, as well as 336 cognitively unimpaired and 216 cognitively impaired, amyloid-β positive older adults from the BioFINDER-2 cohort. Participants had tau PET scans, amyloid PET scans or amyloid CSF, p-tau217, p-tau181 and p-tau231 blood measures, structural T1-MRI and cognitive assessments. In this cross-sectional study, we used regression models and correlation analyses to assess the relationship between plasma biomarkers and cognitive scores. Furthermore, we applied receiver operating characteristic curves to assess cognitive impairment across plasma biomarkers. Finally, we categorized participants into amyloid (A), p-tau (T1), and tau PET (T2) positive (+) or negative (-) profiles and ran nonparametric comparisons to assess differences across cognitive domains. We found that plasma p-tau217 was more associated with cognitive performance than p-tau181 and p-tau231, and that this relationship was particularly strong for memory scores (TRIAD: βp-tau217=-0.53; βp-tau181=-0.35; βp-tau231=-0.24; BioFINDER-2: βp-tau217=-0.52; βp-tau181=-0.24; βp-tau231=-0.29). Associations in amyloid-β positive participants resembled these results, but other cognitive scores also showed strong associations in cognitively impaired individuals. Moreover, plasma p-tau217 outperformed plasma p-tau181 and plasma p-tau231 in identifying memory impairment (Area Under the Curve values for TRIAD: p-tau217=0.86, p-tau181=0.77, p-tau231=0.75; Area Under the Curve values for BioFINDER-2: p-tau217=0.86, p-tau181=0.76, p-tau231=0.81), and in identifying executive function impairment only in the BioFINDER-2 cohort (p-tau217=0.82, p-tau181=0.76, p-tau231=0.76). Lastly, we showed that subtle memory deficits were present in A+T1+T2- participants for plasma p-tau217 (p=0.007) and plasma p-tau181 (p=0.01) in the TRIAD cohort, and for all biomarkers across cognitive domains in A+T1-T2- and A+T1+T2- individuals (p<0.001 in all) in the BioFINDER-2 cohort. A+T1+T2+ individuals showed cognitive deficits in both cohorts (p<0.001 in all). Together, our results suggest that plasma p-tau217 stands out as a biomarker capable of identifying memory deficits due to Alzheimer's disease and that memory impairment certainly occurs in amyloid and plasma p-tau positive individuals that have no significant amounts of tau in the neocortex.},

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@article{pmid39875591,

title = {fMRI data acquisition and analysis for task-free, anesthetized rats},

author = {Roël M Vrooman and Monica van den Berg and Gabriel Desrosiers-Gregoire and Wessel A van Engelenburg and Marie E Galteau and Sung-Ho Lee and Andor Veltien and David A Barrière and Diana Cash and M Mallar Chakravarty and Gabriel A Devenyi and Alessandro Gozzi and Olli Gröhn and Andreas Hess and Judith R Homberg and Ileana O Jelescu and Georgios A Keliris and Tom Scheenen and Yen-Yu Ian Shih and Marleen Verhoye and Claire Wary and Marcel Zwiers and Joanes Grandjean},

doi = {10.1038/s41596-024-01110-y},

issn = {1750-2799},

year  = {2025},

date = {2025-01-01},

journal = {Nat Protoc},

abstract = {Templates for the acquisition of large datasets such as the Human Connectome Project guide the neuroimaging community to reproducible data acquisition and scientific rigor. By contrast, small animal neuroimaging often relies on laboratory-specific protocols, which limit cross-study comparisons. The establishment of broadly validated protocols may facilitate the acquisition of large datasets, which are essential for uncovering potentially small effects often seen in functional MRI (fMRI) studies. Here, we outline a procedure for the acquisition of fMRI datasets in rats and describe animal handling, MRI sequence parameters, data conversion, preprocessing, quality control and data analysis. The procedure is designed to be generalizable across laboratories, has been validated by using datasets across 20 research centers with different scanners and field strengths ranging from 4.7 to 17.2 T and can be used in studies in which it is useful to compare functional connectivity measures across an extensive range of datasets. The MRI procedure requires 1 h per rat to complete and can be carried out by users with limited expertise in rat handling, MRI and data processing.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39874727,

title = {A specific GPR56/ADGRG1 splicing isoform is associated with antidepressant response in major depressive disorder},

author = {Montaine Lion and El Chérif Ibrahim and Elodie Caccomo-Garcia and Julie Bourret and Guillaume Cinquanta and Olfa Khalfallah and Nicolas Glaichenhaus and Laetitia Davidovic and Philippe Courtet and Gustavo Turecki and Eleni Tzavara and Raoul Belzeaux},

doi = {10.1016/j.euroneuro.2025.01.001},

issn = {1873-7862},

year  = {2025},

date = {2025-01-01},

journal = {Eur Neuropsychopharmacol},

volume = {93},

pages = {5--14},

abstract = {Major Depressive Episode (MDE) is one of the most common psychiatric disorders. Often difficult to treat, this disease is one of the leading causes of suicide. A recent study showed an association between GPR56/ADGRG1 mRNA, MDE and response to antidepressant treatment in blood and in brain. Among GPR56 splicing variant, the S4 isoform has recently been associated with microglial synaptic pruning, while microglia are already known as a central player in MDE. Therefore, we hypothesized that S4 is the specific isoform associated to MDE and antidepressant response. To test our hypothesis, an in silico analysis was first performed to identify the different proteins and transcript isoforms of GPR56. This analysis allowed to design PCR and qPCR primers. GPR56 total, S4 and S3 were assessed by RT-qPCR in leukocytes from a cohort of 46 MDE patients including non-responders (NR, n = 31) and responders-remitters (R, n = 17) to antidepressant treatment. We replicated the result of one of our previous studies, which described an increase in total GPR56 mRNA in Rs. Additionally, we observed that this variation differs among mRNA splicing variants, with S4 exhibiting a similar pattern of variation while S3 shows no significant change. The differences observed withstood statistical correction for covariates of interest such as smoking, gender and suicidal ideation, demonstrating the robustness of the model. These findings confirm our hypothesis that certain mRNA splicing variants of GPR56 may play a more significant role in depression. This study highlighted a link between the GPR56-S4 and response to antidepressant treatment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38767000,

title = {Psychotic-like experiences and associated factors in resident physicians: A Canadian cross-sectional study},

author = {Vincent Paquin and Emilie Guay and Christophe Moderie and Camille Paradis and Nima Nahiddi and Frederick L Philippe and Marie-Claude Geoffroy},

doi = {10.1111/eip.13564},

issn = {1751-7893},

year  = {2025},

date = {2025-01-01},

journal = {Early Interv Psychiatry},

volume = {19},

number = {1},

pages = {e13564},

abstract = {AIM: Medical residency training is associated with a range of sociodemographic, lifestyle and mental health factors that may confer higher risk for psychotic-like experiences (PLEs) in residents, yet little research has examined this question. Thus, we aimed to document the prevalence and associated factors of PLEs among resident physicians.nnMETHODS: Physicians enrolled in residency programmes in the Province of Québec, Canada (four universities) were recruited in Fall 2022 via their programme coordinators and social media. They completed an online questionnaire assessing PLEs in the past 3 months (the 15-item Community Assessment of Psychic Experiences), as well as sociodemographic characteristics, lifestyle and mental health. Analyses included survey weights and gamma regressions.nnRESULTS: The sample included 502 residents (mean age, 27.6 years; 65.9% women). Only 1.3% (95% CI: 0.5%, 4.0%) of residents met the screening cut-off for psychotic disorder. Factors associated with higher scores for PLEs included racialised minority status (relative difference: +7.5%; 95% CI: +2.2%, +13.2%) and English versus French as preferred language (relative difference: +7.9% 95% CI: +3.1%, +12.9%), as well as each additional point on scales of depression (relative difference: +0.8%; 95% CI: +0.3%, +1.3%) and anxiety (relative difference: +1.3%; 95% CI: +0.8%, +1.7%). In secondary analyses, racialised minority status was associated with persecutory items, but not with other PLEs. Gender, residency programmes and lifestyle variables were not associated with PLEs.nnCONCLUSIONS: This study found low reports of PLEs in a sample of resident physicians. Associations of PLEs with minoritised status may reflect experiences of discrimination.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39843416,

title = {Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia},

author = {Xiaoqian Ma and Nana Feng and Lena Palaniyappan and Luolong Cao and Zixin Gu and Jujiao Kang and Liu Yuan and Lijun Ouyang and Yujue Wang and Chunwang Li and Ke Jin and Xiaogang Chen and Jianfeng Feng and Ying He and Qiang Luo},

doi = {10.1038/s41398-025-03237-2},

issn = {2158-3188},

year  = {2025},

date = {2025-01-01},

journal = {Transl Psychiatry},

volume = {15},

number = {1},

pages = {18},

abstract = {The striatum, a core brain structure relevant for schizophrenia, exhibits heterogeneous volumetric changes in this illness. Due to this heterogeneity, its role in the risk of developing schizophrenia following exposure to environmental stress remains poorly understood. Using the putamen (a subnucleus of the striatum) as an indicator for convergent genetic risk of schizophrenia, 63 unaffected first-degree relatives of patients (22.08 ± 4.80 years) with schizophrenia (UFR-SZ) were stratified into two groups. Compared with healthy controls (HC; n = 59), voxel-based and brain-wide volumetric changes and their associations with stressful life events (SLE) were tested. These stratified associations were validated using two large population-based cohorts (the ABCD study; n = 1680, 11.92 ± 0.62 years; and UK Biobank, n = 20547, 55.38 ± 7.43 years). Transcriptomic analysis of brain tissues was used to identify the biological processes associated with the brain mediation effects on the SLE-psychosis relationship. The stratified UFR-SZ subgroup with smaller right putamen had a smaller volume in the left caudate when compared to HC; this caudate volume was associated with both a higher level of SLE and more psychotic symptoms. This caudate-SLE association was replicated in two independent large-scale cohorts, when individuals were stratified by both a higher polygenic burden for schizophrenia and smaller right putamen. In UFR-SZ, the caudate cluster mediated the relationship between SLE and more psychotic symptoms. This mediation was associated with the genes enriched in both glutamatergic synapses and response to oxidative stress. The stratified association between the striatum and stress highlights the differential vulnerability to stress, contributing to the complexity of the gene-by-environment etiology of schizophrenia.},

keywords = {},

pubstate = {published},

tppubtype = {article}

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@article{pmid39841452,

title = {Depressive Symptoms and Amyloid Pathology},

author = {Wietse A Wiels and Julie E Oomens and Sebastiaan Engelborghs and Chris Baeken and Christine A F von Arnim and Mercè Boada and Mira Didic and Bruno Dubois and Tormod Fladby and Wiesje M van der Flier and Giovanni B Frisoni and Lutz Fröhlich and Kiran Dip Gill and Timo Grimmer and Helmut Hildebrandt and Jakub Hort and Yoshiaki Itoh and Takeshi Iwatsubo and Aleksandra Klimkowicz-Mrowiec and Dong Young Lee and Alberto Lleó and Pablo Martinez-Lage and Alexandre de Mendonça and Philipp T Meyer and Elisabeth N Kapaki and Piero Parchi and Matteo Pardini and Lucilla Parnetti and Julius Popp and Lorena Rami and Eric M Reiman and Juha O Rinne and Karen M Rodrigue and Pascual Sánchez-Juan and Isabel Santana and Marie Sarazin and Nikolaos Scarmeas and Ingmar Skoog and Peter J Snyder and Reisa A Sperling and Sylvia Villeneuve and Anders Wallin and Jens Wiltfang and Henrik Zetterberg and Rik Ossenkoppele and Frans R J Verhey and Stephanie J B Vos and Pieter Jelle Visser and Willemijn J Jansen and  and  and Daniel Alcolea and Daniele Altomare and Simone Baiardi and Ines Baldeiras and Randall J Bateman and Kaj Blennow and Michel Bottlaender and Anouk den Braber and Mark A van Buchem and Min Soo Byun and Jirí Cerman and Kewei Chen and Elena Chipi and Gregory S Day and Alexander Drzezga and Marie Eckerström and Laura L Ekblad and Stéphane Epelbaum and Stefan Förster and Juan Fortea and Yvonne Freund-Levi and Lars Frings and Eric Guedj and Lucrezia Hausner and Sabine Hellwig and Edward D Huey and Julio F Jiménez-Bonilla and Keith A Johnson and Ane Iriondo Juaristi and Ramesh Kandimalla and George Paraskevas and Silke Kern and Bjørn-Eivind S Kirsebom and Johannes Kornhuber and Julien Lagarde and Susan M Landau and Nienke Legdeur and Jorge J Llibre Guerra and Nancy N Maserejian and Marta Marquié and Shinobu Minatani and Silvia Daniela Morbelli and Barbara Mroczko and Eva Ntanasi and Catarina Resende de Oliveira and Pauline Olivieri and Adelina Orellana and Richard J Perrin and Oliver Peters and Sudesh Prabhakar and Inez H Ramakers and Eloy Rodríguez-Rodriguez and Agustín Ruiz and Eckart Rüther and Per Selnes and Dina Silva and Hilkka Soininen and Luiza Spiru and Akitoshi Takeda and Marc Teichmann and Betty M Tijms and Charlotte E Teunissen and Loisa I Thompson and Jonathan Vogelgsangs and Jonathan Vöglein and Gunhild Waldemar and Åsa K Wallin and Mary Yannakoulia and Dahyun Yi and Anna Zettergren},

doi = {10.1001/jamapsychiatry.2024.4305},

issn = {2168-6238},

year  = {2025},

date = {2025-01-01},

journal = {JAMA Psychiatry},

abstract = {IMPORTANCE: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology.nnOBJECTIVE: To examine the association between depressive symptoms and amyloid pathology and its dependency on age, sex, education, and APOE genotype in older individuals without dementia.nnDESIGN, SETTING, AND PARTICIPANTS: Cross-sectional analyses were performed using data from the Amyloid Biomarker Study data pooling initiative. Data from 49 research, population-based, and memory clinic studies were pooled and harmonized. The Amyloid Biomarker Study has been collecting data since 2012 and data collection is ongoing. At the time of analysis, 95 centers were included in the Amyloid Biomarker Study. The study included 9746 individuals with normal cognition (NC) and 3023 participants with mild cognitive impairment (MCI) aged between 34 and 100 years for whom data on amyloid biomarkers, presence of depressive symptoms, and age were available. Data were analyzed from December 2022 to February 2024.nnMAIN OUTCOMES AND MEASURES: Amyloid-β1-42 levels in cerebrospinal fluid or amyloid positron emission tomography scans were used to determine presence or absence of amyloid pathology. Presence of depressive symptoms was determined on the basis of validated depression rating scale scores, evidence of a current clinical diagnosis of depression, or self-reported depressive symptoms.nnRESULTS: In individuals with NC (mean [SD] age, 68.6 [8.9] years; 5664 [58.2%] female; 3002 [34.0%] APOE ε4 carriers; 937 [9.6%] had depressive symptoms; 2648 [27.2%] had amyloid pathology), the presence of depressive symptoms was not associated with amyloid pathology (odds ratio [OR], 1.13; 95% CI, 0.90-1.40; P = .29). In individuals with MCI (mean [SD] age, 70.2 [8.7] years; 1481 [49.0%] female; 1046 [44.8%] APOE ε4 carriers; 824 [27.3%] had depressive symptoms; 1668 [55.8%] had amyloid pathology), the presence of depressive symptoms was associated with a lower likelihood of amyloid pathology (OR, 0.73; 95% CI 0.61-0.89; P = .001). When considering subgroup effects, in individuals with NC, the presence of depressive symptoms was associated with a higher frequency of amyloid pathology in APOE ε4 noncarriers (mean difference, 5.0%; 95% CI 1.0-9.0; P = .02) but not in APOE ε4 carriers. This was not the case in individuals with MCI.nnCONCLUSIONS AND RELEVANCE: Depressive symptoms were not consistently associated with a higher frequency of amyloid pathology in participants with NC and were associated with a lower likelihood of amyloid pathology in participants with MCI. These findings were not influenced by age, sex, or education level. Mechanisms other than amyloid accumulation may commonly underlie depressive symptoms in late life.},

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pubstate = {published},

tppubtype = {article}

}

@article{pmid39827219,

title = {Novel synaptic markers predict early tau pathology and cognitive deficit in an asymptomatic population at risk of Alzheimer's disease},

author = {Jiarui Ao and Cynthia Picard and Daniel Auld and Henrik Zetterberg and Ann Brinkmalm and Kaj Blennow and Sylvia Villeneuve and John C S Breitner and Judes Poirier and },

doi = {10.1038/s41380-024-02884-z},

issn = {1476-5578},

year  = {2025},

date = {2025-01-01},

journal = {Mol Psychiatry},

abstract = {Cognitive dysfunction in Alzheimer's disease (AD) correlates closely with pathology in the neuronal microtubule-associated protein tau. Tau pathology may spread via neural synapses. In a population of cognitively unimpaired elderly at elevated risk of AD, we investigated four cerebrospinal (CSF) markers of synaptic dysfunction and degeneration. Three of these (SYT1, SNAP25, and ADAM23) are derived from pre-synaptic structures, while ADAM22 reflects post-synaptic changes. All four markers correlated strongly with tau protein measures. In statistical models, SYT1 accounted for more than half the total variance in both total- and P(181)-tau levels. Observed correlations with CSF levels of Alzheimer amyloid-β (Aβ42) were somewhat weaker. In longitudinal data, baseline levels of ADAM22 and ADAM23 robustly predicted increase over time in both total- and P-tau. CSF SYT1 levels also correlated with PET image uptake of tau and (at a trend level) Aβ in areas of interest for early AD pathology. CSF SYT1 and SNAP25 levels correlated inversely with a global psychometric score and several of its domain subscales. In quantitative trait loci analyses, all four synaptic markers were associated with at least one AD genetic risk locus. Upon "staging" participants by their evidence of amyloid and tau pathology (A/T/N framework), the CSF synaptic markers were unexpectedly reduced in participants with CSF evidence of amyloid but not tau pathology. They were clearly elevated, however, in the CSF of persons with indications of both tau and amyloid pathology. These observations provide evidence for clear pre-synaptic degeneration in cognitively unimpaired persons with biomarker evidence of early AD pathology.},

keywords = {},

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tppubtype = {article}

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@article{pmid39810425,

title = {Synaptic Targets and Cellular Sources of CB1 Cannabinoid Receptor and Vesicular Glutamate Transporter-3 Expressing Nerve Terminals in Relation to GABAergic Neurons in the Human Cerebral Cortex},

author = {Peter Somogyi and Sawa Horie and Istvan Lukacs and Emily Hunter and Barbara Sarkany and Tim James Viney and James Livermore and Puneet Plaha and Richard Stacey and Olaf Ansorge and Salah El Mestikawy and Qianru Zhao},

doi = {10.1111/ejn.16652},

issn = {1460-9568},

year  = {2025},

date = {2025-01-01},

journal = {Eur J Neurosci},

volume = {61},

number = {1},

pages = {e16652},

abstract = {Cannabinoid receptor 1 (CB1) regulates synaptic transmission through presynaptic receptors in nerve terminals, and its physiological roles are of clinical relevance. The cellular sources and synaptic targets of CB1-expressing terminals in the human cerebral cortex are undefined. We demonstrate a variable laminar pattern of CB1-immunoreactive axons and electron microscopically show that CB1-positive GABAergic terminals make type-2 synapses innervating dendritic shafts (69%), dendritic spines (20%) and somata (11%) in neocortical layers 2-3. Of the CB1-immunopositive GABAergic terminals, 25% were vesicular-glutamate-transporter-3 (VGLUT3)-immunoreactive, suggesting GABAergic/glutamatergic co-transmission on dendritic shafts. In vitro recorded and labelled VGLUT3 or CB1-positive GABAergic interneurons expressed cholecystokinin, vasoactive-intestinal-polypeptide and calretinin, had diverse firing, axons and dendrites, and included rosehip, neurogliaform and basket cells, but not double bouquet or axo-axonic cells. CB1-positive interneurons innervated pyramidal cells and GABAergic interneurons. Glutamatergic synaptic terminals formed type-1 synapses and some were positive for CB1 receptor with a distribution that appeared different from that in GABAergic terminals. From the sampled VGLUT3-positive terminals, 60% formed type-1 synapses with dendritic spines (80%) or shafts (20%) and 52% were also positive for VGLUT1, suggesting intracortical origin. Some VGLUT3-positive terminals were immunopositive for vesicular-monoamine-transporter-2, suggesting 5-HT/glutamate co-transmission. Overall, the results show that CB1 regulates GABA release mainly to dendritic shafts of both pyramidal cells and interneurons and predict CB1-regulated co-release of GABA and glutamate from single cortical interneurons. We also demonstrate the co-existence of multiple vesicular glutamate transporters in a select population of terminals probably originating from cortical neurons and innervating dendritic spines in the human cerebral cortex.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39800776,

title = {Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research},

author = {Sarah M Merrill and Chaini Konwar and Fizza Fatima and Kristy Dever and Julia L MacIsaac and Nicole Letourneau and Gerald F Giesbrecht and Deborah Dewey and Gillian England-Mason and Candace R Lewis and Dennis Wang and Ai Ling Teh and Michael J Meaney and Andrea Gonzalez and Jennie G Noll and Carolina De Weerth and Nicole R Bush and Kieran J O'Donnell and S Evelyn Stewart and Michael S Kobor},

doi = {10.1038/s41467-025-55909-8},

issn = {2041-1723},

year  = {2025},

date = {2025-01-01},

journal = {Nat Commun},

volume = {16},

number = {1},

pages = {609},

abstract = {Cheek swabs, heterogeneous samples consisting primarily of buccal epithelial cells, are widely used in pediatric DNA methylation studies and biomarker creation. However, the decrease in buccal proportion with age in adults remains unexamined in childhood. We analyzed cheek swabs from 4626 typically developing children 2-months to 20-years-old. Estimated buccal proportion declined throughout childhood with both increasing chronological and predicted epigenetic age. However, buccal proportion did not associate with age throughout adolescence. Variability in buccal proportion increased with age through the entire developmental range. These trends held inversely true for neutrophil proportions. Correcting for buccal proportion attenuated the weak association with PedBE age acceleration to non-significance during initial estimation. Notably, correcting for buccal proportion attenuated the association of PedBE age acceleration with obsessive-compulsive disorder and strengthened the association with diurnal cortisol slope. Thus, the age-related change in children's oral cells is a crucial consideration for cell type-sensitive research.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39799284,

title = {Profiles of physician follow-up care, correlates and outcomes among patients affected by an incident mental disorder},

author = {Marie-Josée Fleury and Louis Rochette and Zhirong Cao and Guy Grenier and Victoria Massamba and Alain Lesage},

doi = {10.1186/s12875-024-02674-0},

issn = {2731-4553},

year  = {2025},

date = {2025-01-01},

journal = {BMC Prim Care},

volume = {26},

number = {1},

pages = {7},

abstract = {OBJECTIVES: This study identified profiles of outpatient physician follow-up care and other practice features, mostly after detection of incident mental disorders (MD), and associated these profiles with patient characteristics and subsequent adverse outcomes.nnMETHODS: A cohort of 170,957 patients age 12 + with a new or recurrent MD detected in 2019-20 was investigated based on data from the Quebec Integrated Chronic Disease Surveillance System. Latent class analysis was performed to identify follow-up care profiles, mostly within one year of MD detection. Bivariate analyses tested associations between profiles and patient characteristics; logistic regressions examined relationships between profiles and adverse outcomes after one year.nnRESULTS: Five profiles were identified: Profiles 2 and 5 (64%) offered low mental health (MH) outpatient follow-up care, while the others dispensed higher MH follow-up care. Profiles differed in patient characteristics and related outcomes. Labelled "Follow-up care by usual psychiatrist", Profile 1 (1% of sample) included younger patients with the most health and social issues. Profile 2 (50%), "Low MH follow-up care but high prior consultations for physical reasons", mostly integrated older patients with chronic physical illnesses. Profile 3 (11%), "Follow-up care by general practitioners (GP) and psychiatrists", referred to physicians other than the usual ones (e.g., walk-in practice) and encompassed patients with severe MD conditions. Profile 4 (23%), "High follow-up care by usual GP and prior consultations for physical reasons", showed the typical characteristics of patients treated in primary care (more common MD, women, less materially and socially deprived). Profile 5 (15%), "Low MH follow-up care and prior consultations for physical reasons", integrated more younger men, materially deprived patients, and with substance-related disorders (SRD) or co-occurring MD-SRD. More Profile 1 and 3 patients lived in university regions - those of Profile 4 were the least numerous in such regions. More Profile 5 patients lived in metropolitan and rural areas. Risk of death was higher in Profiles 5, 2, 3, and risk of frequent ED use and hospitalization higher in Profiles 1, 3, and 5 - patients with severe health and social issues.nnCONCLUSION: The study confirmed the need to improve prompt, adequate and continuous follow-up care for patients with incident MD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39791308,

title = {Patterns of Cerebellar-Cortical Structural Covariance Mirror Anatomical Connectivity of Sensorimotor and Cognitive Networks},

author = {Zaki Alasmar and M Mallar Chakravarty and Virginia B Penhune and Christopher J Steele},

doi = {10.1002/hbm.70079},

issn = {1097-0193},

year  = {2025},

date = {2025-01-01},

journal = {Hum Brain Mapp},

volume = {46},

number = {1},

pages = {e70079},

abstract = {The cortex and cerebellum are densely connected through reciprocal input/output projections that form segregated circuits. These circuits are shown to differentially connect anterior lobules of the cerebellum to sensorimotor regions, and lobules Crus I and II to prefrontal regions. This differential connectivity pattern leads to the hypothesis that individual differences in structure should be related, especially for connected regions. To test this hypothesis, we examined covariation between the volumes of anterior sensorimotor and lateral cognitive lobules of the cerebellum and measures of cortical thickness (CT) and surface area (SA) across the whole brain in a sample of 270 young adults drawn from the HCP dataset. We observed that patterns of cerebellar-cortical covariance differed between sensorimotor and cognitive networks. Anterior motor lobules of the cerebellum showed greater covariance with sensorimotor regions of the cortex, while lobules Crus I and Crus II showed greater covariance with frontal and temporal regions. Interestingly, cerebellar volume showed predominantly negative relationships with CT and predominantly positive relationships with SA. Individual differences in SA are thought to be largely under genetic control while CT is thought to be more malleable by experience. This suggests that cerebellar-cortical covariation for SA may be a more stable feature, whereas covariation for CT may be more affected by development. Additionally, similarity metrics revealed that the pattern of covariance showed a gradual transition between sensorimotor and cognitive lobules, consistent with evidence of functional gradients within the cerebellum. Taken together, these findings are consistent with known patterns of structural and functional connectivity between the cerebellum and cortex. They also shed new light on possibly differing relationships between cerebellar volume and cortical thickness and surface area. Finally, our findings are consistent with the interactive specialization framework which proposes that structurally and functionally connected brain regions develop in concert.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39781337,

title = {Early intervention in psychosis programs in Africa, Asia and Latin America; challenges and recommendations},

author = {Els van der Ven and Xinyu Yang and Franco Mascayano and Karl J Weinreich and Eric Yh Chen and Charmaine Yz Tang and Sung-Wan Kim and Jonathan K Burns and Bonginkosi Chiliza and Greeshma Mohan and Srividya N Iyer and Thara Rangawsamy and Ralph de Vries and Ezra S Susser},

doi = {10.1017/gmh.2024.78},

issn = {2054-4251},

year  = {2025},

date = {2025-01-01},

journal = {Glob Ment Health (Camb)},

volume = {12},

pages = {e3},

abstract = {BACKGROUND: While early intervention in psychosis (EIP) programs have been increasingly implemented across the globe, many initiatives from Africa, Asia and Latin America are not widely known. The aims of the current review are (a) to describe population-based and small-scale, single-site EIP programs in Africa, Asia and Latin America, (b) to examine the variability between programs located in low-and-middle income (LMIC) and high-income countries in similar regions and (c) to outline some of the challenges and provide recommendations to overcome existing obstacles.nnMETHODS: EIP programs in Africa, Asia and Latin America were identified through experts from the different target regions. We performed a systematic search in Medline, Embase, APA PsycInfo, Web of Science and Scopus up to February 6, 2024.nnRESULTS: Most EIP programs in these continents are small-scale, single-site programs that serve a limited section of the population. Population-based programs with widespread coverage and programs integrated into primary health care are rare. In Africa, EIP programs are virtually absent. Mainland China is one of the only LMICs that has begun to take steps toward developing a population-based EIP program. High-income Asian countries (e.g. Hong Kong and Singapore) have well-developed, comprehensive programs for individuals with early psychosis, while others with similar economies (e.g. South Korea and Japan) do not. In Latin America, Chile is the only country in the process of providing population-based EIP care.nnCONCLUSIONS: Financial resources and integration in mental health care, as well as the availability of epidemiological data on psychosis, impact the implementation of EIP programs. Given the major treatment gap of early psychosis in Africa, Latin America and large parts of Asia, publicly funded, locally-led and accessible community-based EIP care provision is urgently needed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39773678,

title = {Promoting Digital Health Data Literacy: The Datum Project},

author = {Daniel Powell and Laiba Asad and Elissa Zavaglia and Manuela Ferrari},

doi = {10.2196/60832},

issn = {2561-326X},

year  = {2025},

date = {2025-01-01},

journal = {JMIR Form Res},

volume = {9},

pages = {e60832},

abstract = {With the increased use of digital health innovations in Canadian health care, educating health care users, professionals, and researchers on the ethical challenges and privacy implications of these tools is essential. The Datum project, funded by the Fondation Barreau du Quebec, was created to help these actors better understand legal and ethical issues regarding the collection, use, and disclosure of digital health data for the purposes of scientific research, thereby enhancing literacy around data privacy. The project consists of a multimedia website divided into legislation and policy documents and narrative-based video content. Users can access the core legislation and policies governing the collection and use of health care data geared toward researchers and health practitioners. Users can also view the narrative-based video content explaining key concepts related to digital health data. The Datum project makes an original contribution to the field of law and ethics in health science research by using novel approaches, such as learning health systems and data banks, to improve equity in health care delivery and by generating multimedia content aimed at encouraging health care users to become better consumers and supporting the collective use of their data. The Datum project also promotes digital literacy as a digital communication tool, which has the significant potential to improve health outcomes, bridge the digital divide, and reduce health inequities.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39763421,

title = {Aberrant controllability of functional connectome during working memory tasks in patients with schizophrenia and unaffected siblings},

author = {Feiwen Wang and Zhening Liu and Ju Wang and Xiao Li and Yunzhi Pan and Jun Yang and Peng Cheng and Fuping Sun and Wenjian Tan and Danqing Huang and Jiamei Zhang and Xiawei Liu and Maoxing Zhong and Guowei Wu and Jie Yang and Lena Palaniyappan},

doi = {10.1192/bjp.2024.225},

issn = {1472-1465},

year  = {2025},

date = {2025-01-01},

journal = {Br J Psychiatry},

pages = {1--10},

abstract = {BACKGROUND: Working memory deficit, a key feature of schizophrenia, is a heritable trait shared with unaffected siblings. It can be attributed to dysregulation in transitions from one brain state to another.nnAIMS: Using network control theory, we evaluate if defective brain state transitions underlie working memory deficits in schizophrenia.nnMETHOD: We examined average and modal controllability of the brain's functional connectome in 161 patients with schizophrenia, 37 unaffected siblings and 96 healthy controls during a two-back task. We use one-way analysis of variance to detect the regions with group differences, and correlated aberrant controllability to task performance and clinical characteristics. Regions affected in both unaffected siblings and patients were selected for gene and functional annotation analysis.nnRESULTS: Both average and modal controllability during the two-back task are reduced in patients compared to healthy controls and siblings, indicating a disruption in both proximal and distal state transitions. Among patients, reduced average controllability was prominent in auditory, visual and sensorimotor networks. Reduced modal controllability was prominent in default mode, frontoparietal and salience networks. Lower modal controllability in the affected networks correlated with worse task performance and higher antipsychotic dose in schizophrenia (uncorrected). Both siblings and patients had reduced average controllability in the paracentral lobule and Rolandic operculum. Subsequent out-of-sample gene analysis revealed that these two regions had preferential expression of genes relevant to bioenergetic pathways (calmodulin binding and insulin secretion).nnCONCLUSIONS: Aberrant control of brain state transitions during task execution marks working memory deficits in patients and their siblings.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39757164,

title = {"I'm trying to figure out who the hell I am": Examining the psychosocial and mental health experience of individuals learning "Not Parent Expected" news from a direct-to-consumer DNA ancestry test},

author = {Juliette Careau and Maarten H D Larmuseau and Rebekah Drumsta and Rob Whitley},

doi = {10.1186/s12888-024-06380-0},

issn = {1471-244X},

year  = {2025},

date = {2025-01-01},

journal = {BMC Psychiatry},

volume = {25},

number = {1},

pages = {9},

abstract = {BACKGROUND: According to recent estimates, around 30 million people have taken Direct-to-Consumer DNA ancestry tests, typically marketed as a fun, harmless and exciting process of discovery. These tests estimate a user's ethnic ancestry, also matching users with biological relations on their database. This matching can produce a surprising 'not parent expected' discovery, where a user learns that an assumed parent (typically the father) is not a biological parent. Such news may negatively affect mental health, self-identity and familial relationships, while prompting the utilization of putatively helpful resources by affected individuals. However, there is a lack of research on this topic. Thus, this study aimed to document the psychosocial experience of adults who have learnt that an assumed parent is not a biological parent via a Direct-to-Consumer DNA ancestry test. Specific objectives include investigating and understanding impact on mental health, familial relationships and subsequent resources mobilized.nnMETHODS: To meet these objectives, we conducted an inductive qualitative study, allowing for the documentation of common experiences and perspectives. This involved 52 semi-structured interviews with affected individuals, analyzed using thematic analysis.nnRESULTS: This resulted in five overlapping themes, namely (i) participants typically described their experience as an extraordinary shock that had a negative impact on their mental health, with some exceptions; (ii) the experience typically led to a severe and troubling disruption of their self-identity, with some exceptions; (iii) the news often ruptured extant familial relationships, especially with the mother, and any experiences with the new biological family were mixed; (iv) participants sought support from a variety of resources including spouses, siblings, and online peer support groups, which were generally considered helpful, with some exceptions; and (v) many participants consulted mental health professionals, who were sometimes considered supportive, but some participants noted that they were ill-equipped to help. Common across these themes were issues of grief, loss and trauma.nnCONCLUSIONS: This study reveals an expanding, vulnerable, and under-researched population facing unique stressors, that may be at high risk of developing a psychiatric disorder. There is a need for new services and supports for this population including tailored clinical interventions and specific self-care resources.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39755156,

title = {Classes of outpatient quality of care among individuals with substance-related disorders, based on a survey and health insurance registry},

author = {Marie-Josée Fleury and Zhirong Cao and Guy Grenier and Christophe Huỳnh and Xianghei Meng},

doi = {10.1016/j.josat.2024.209619},

issn = {2949-8759},

year  = {2025},

date = {2025-01-01},

journal = {J Subst Use Addict Treat},

volume = {170},

pages = {209619},

abstract = {OBJECTIVES: Improving quality of care for individuals with substance-related disorders (SRD) should be a priority considering SRD are associated with high morbidity. This study aimed to identify classes of individuals with SRD based on their clinical characteristics and the quality of outpatient care they received, and to verify whether better quality of care was associated with other respondent characteristics and more favorable subsequent outcomes.nnMETHODS: Data came from the 2013-14 and 2015-16 Canadian Community Health Survey (N = 42,099), merged with administrative data from Quebec's health insurance registry. Investigating a cohort of 1473 individuals with SRD, we conducted Latent class analysis based on the respondents' diagnoses and outpatient quality of care indicators such as access, diversity, continuity and regularity of care received in the 12 months preceding interview. Chi-Square, Fisher's exact tests or t-tests, and logistic regression associate classes with sociodemographic and health behavior (e.g., suicidal behaviors) correlates, and outcomes (repeated emergency department use, hospitalization, quality of life) over the three months following interview, respectively.nnRESULTS: The study identified four classes: (1) Individuals with polysubstance-related disorders and other health disorders, receiving high diversity and moderate regularity of care (6 % of sample); (2) Individuals with alcohol-related disorders, receiving low quality of care (41 %); (3) Individuals with drug-related disorders, receiving high overall quality of care (9 %); and (4) Individuals with alcohol-related disorders, receiving high continuity of family doctor care (44 %). Classes 2 and 4 showed better social conditions (e.g., higher education), health behaviors, and subsequent outcomes than Classes 1 and 3, despite receiving lower quality of care - especially mental healthcare.nnCONCLUSION: Study outcomes related more to health and social conditions than to the quality of outpatient care received, especially as outpatient care alone might not meet needs of Classes 1 and 3 individuals having important health and social issues, unmet care needs and worse outcomes. Results suggest that interventions like assertive community treatment or intensive case management with integrated SRD-mental health disorders treatment could better respond to the needs of Classes 1 and 3. Overall, enhanced care, including peer support, might benefit all individuals with SRD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39742489,

title = {Mesolimbic dopamine neurons drive infradian rhythms in sleep-wake and heightened activity state},

author = {Pratap S Markam and Clément Bourguignon and Lei Zhu and Bridget Ward and Martin Darvas and Paul V Sabatini and Maia V Kokoeva and Bruno Giros and Kai-Florian Storch},

doi = {10.1126/sciadv.ado9965},

issn = {2375-2548},

year  = {2025},

date = {2025-01-01},

journal = {Sci Adv},

volume = {11},

number = {1},

pages = {eado9965},

abstract = {Infradian mood and sleep-wake rhythms with periods of 48 hours and beyond have been observed in patients with bipolar disorder (BD), which even persist in the absence of exogenous timing cues, indicating an endogenous origin. Here, we show that mice exposed to methamphetamine in drinking water develop infradian locomotor rhythms with periods of 48 hours and beyond which extend to sleep length and manic state-associated behaviors in support of a model for cycling in BD. The cycling capacity is abrogated upon genetic disruption of dopamine (DA) production in DA neurons of the ventral tegmental area (VTA) or ablation of nucleus accumbens projecting DA neurons. Furthermore, chemogenetic activation of DA neurons including those that project to the nucleus accumbens led to locomotor period lengthening in circadian clock-deficient mice, which was counteracted by antipsychotic treatment. Together, our findings argue that BD cycling relies on infradian rhythm generation that depends on mesolimbic DA neurons.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39675227,

title = {Does metacognitive training for psychosis (MCT) improve neurocognitive performance? A systematic review and meta-analysis},

author = {Clayton Jeffrey and Danielle Penney and Geneviève Sauvé and Daniel Mendelson and Élisabeth Thibaudeau and Steffen Moritz and Adèle Hotte-Meunier and Martin Lepage},

doi = {10.1016/j.schres.2024.12.004},

issn = {1573-2509},

year  = {2025},

date = {2025-01-01},

journal = {Schizophr Res},

volume = {275},

pages = {79--86},

abstract = {BACKGROUND: Metacognitive training for psychosis (MCT) offers benefits for addressing hallmark deficits/symptoms in schizophrenia spectrum disorders including reductions in cognitive biases and positive/negative symptoms as well as improvements in social cognition and functioning. However, differing results exist regarding the relationship between MCT and neurocognition. A comprehensive understanding of the nature of this relationship would significantly contribute to the existing literature and our understanding of the potential added value of MCT as a cognitive intervention for psychosis.nnMETHODS: Across eleven electronic databases, 1312 sources were identified, and 14 studies examining MCT and neurocognition in psychosis were included in this review. Measures of estimated effect sizes were calculated with Hedge's g, moderator analyses used Cochrane's Q statistic and significance tests to measure group differences according to control conditions.nnRESULTS: Twelve studies, 11 randomized controlled trials (RCTs) and 1 non-RCT, were included in the main meta-analyses, consisting of 673 participants (n = 345, n = 328). When comparing MCT against control interventions, non-significant differences in estimated effect sizes were observed across all neurocognitive domains when evaluating pre-post changes (g ≤ 0.1, p > .05). Two additional studies corroborated these results in a narrative review.nnCONCLUSION: These findings suggest that when compared against control conditions, MCT does not pose a statistically meaningful benefit to neurocognitive performance. General practice/learning effects are likely the main contributor that explains improvement in neurocognitive performance, and not a difference of intervention allocation when considering MCT against the included control comparators. These findings help establish the specificity of the effects of MCT.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39607834,

title = {Expert opinions on pharmacological symptomatic treatment of behavioral symptoms in frontotemporal dementia: A survey of the Neuropsychiatric International Consortium on Frontotemporal Dementia (NIC-FTD)},

author = {Dirk van Paassen and Luc Hartog and Sterre de Boer and Everard Vijverberg and Simon Ducharme and Yolande Pijnenburg and Alexander Santillo},

doi = {10.1111/ene.16537},

issn = {1468-1331},

year  = {2025},

date = {2025-01-01},

journal = {Eur J Neurol},

volume = {32},

number = {1},

pages = {e16537},

abstract = {BACKGROUND AND PURPOSE: Behavioral variant frontotemporal dementia (bvFTD) is essentially characterized by progressive changes in personality and cognition. Clinically, bvFTD presents with often profound behavioral symptomatology. Despite the high burden of these symptoms for both patients and caregivers, there is no general consensus on an effective pharmacological symptomatic treatment. Interestingly, for multiple similar symptoms in primary psychiatric disorders, there is consensus on an effective pharmacological treatment. The aim of this study is to explore currently preferred clinical practices in the pharmacological treatment of specific core behavioral symptoms in bvFTD by world-leading clinical experts.nnMETHODS: A digital survey was conducted among members of the Neuropsychiatric International Consortium on Frontotemporal Dementia, comprising neurologists, psychiatrists, and neuropsychiatrists. Respondents recommended pharmacological treatments targeting symptoms including disinhibition, apathy, loss of empathy, hyperorality, perseverative/compulsive behaviors, and positive psychotic symptoms.nnRESULTS: Of 48 respondents with a median experience of 11.5 years in treating bvFTD, disinhibition was most frequently targeted (58.4%), followed by perseverative/compulsive behaviors (46.5%). Recommended drug classes included atypical antipsychotics (35.1%), selective serotonin reuptake inhibitors (31.2%), antiepileptics (10.0%), serotonin antagonist and reuptake inhibitors (8.4%), benzodiazepines (4.0%), and others (11.4%).nnCONCLUSIONS: Our survey revealed diverse pharmacological treatment practices for behavioral symptoms in bvFTD, reflecting the expected radical heterogeneity in pharmacological treatment strategies. Notwithstanding this, results from this explorative survey could further inform future research directions, and thus in turn potentially aid in establishing more consensus on effective pharmacological management of bvFTD, while the field awaits the development of highly anticipated disease-modifying treatment(s).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39579961,

title = {Increased structural covariance of cortical measures in individuals with an at-risk mental state},

author = {Daiki Sasabayashi and Sakiko Tsugawa and Shinichiro Nakajima and Tsutomu Takahashi and Yoichiro Takayanagi and Shinsuke Koike and Naoyuki Katagiri and Masahiro Katsura and Atsushi Furuichi and Yuko Mizukami and Shimako Nishiyama and Haruko Kobayashi and Yusuke Yuasa and Naohisa Tsujino and Atsushi Sakuma and Noriyuki Ohmuro and Yutaro Sato and Kazuho Tomimoto and Naohiro Okada and Mariko Tada and Motomu Suga and Norihide Maikusa and Eric Plitman and Cassandra M J Wannan and Andrew Zalesky and Mallar Chakravarty and Kyo Noguchi and Hidenori Yamasue and Kazunori Matsumoto and Takahiro Nemoto and Hiroaki Tomita and Masafumi Mizuno and Kiyoto Kasai and Michio Suzuki},

doi = {10.1016/j.pnpbp.2024.111197},

issn = {1878-4216},

year  = {2025},

date = {2025-01-01},

journal = {Prog Neuropsychopharmacol Biol Psychiatry},

volume = {136},

pages = {111197},

abstract = {An anomalous pattern of structural covariance has been reported in schizophrenia, which has been suggested to represent connectome changes during brain maturation and neuroprogressive processes. It remains unclear whether similar differences exist in a clinical high-risk state for psychosis, and if they are associated with a prodromal phenotype and/or later psychosis onset. This multicenter magnetic resonance imaging study cross-sectionally examined structural covariance in a large at-risk mental state (ARMS) sample with different outcomes. The whole-brain structural covariance of four cortical measures (thickness, area, volume, and gyrification) was assessed in 155 individuals with ARMS, who were subclassified into 26 (16.8 %) with a later psychosis onset (ARMS-P), 44 with persistent subthreshold psychotic symptoms, and 53 with the remission of psychotic symptoms (ARMS-R) during the clinical follow-up, and 191 healthy controls. The relationships of changes in structural covariance with clinical symptoms and cognitive impairments were also investigated in the ARMS subsample. Structural covariance was significantly higher in widespread cortical regions in the ARMS group than in the controls, with each cortical measure having a different pattern in affected cortical regions. The higher structural covariance of the cortical area was partly related to severe suspiciousness-persecutory ideation. Structural covariance was significantly higher, mainly in fronto-parietal gyrification, in the ARMS-P group than in the ARMS-R group. The present results suggest that changes in structural covariance result in psychosis vulnerability and the excessive structural covariance of brain gyrification in ARMS subjects may contribute to their later clinical course.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39579760,

title = {Identifying representational structure in CA1 to benchmark theoretical models of cognitive mapping},

author = {J Quinn Lee and Alexandra T Keinath and Erica Cianfarano and Mark P Brandon},

doi = {10.1016/j.neuron.2024.10.027},

issn = {1097-4199},

year  = {2025},

date = {2025-01-01},

journal = {Neuron},

volume = {113},

number = {2},

pages = {307--320.e5},

abstract = {Decades of theoretical and empirical work have suggested the hippocampus instantiates some form of a cognitive map. Yet, tests of competing theories have been limited in scope and largely qualitative in nature. Here, we develop a novel framework to benchmark model predictions against observed neuronal population dynamics as animals navigate a series of geometrically distinct environments. In this task space, we show a representational structure in the dynamics of hippocampal remapping that generalizes across brains, discriminates between competing theoretical models, and effectively constrains biologically viable model parameters. With this approach, we find that accurate models capture the correspondence in spatial coding of a changing environment. The present dataset and framework thus serve to empirically evaluate and advance theories of cognitive mapping in the brain.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39527069,

title = {School Readiness and Early Childhood Education and Care Services Among Dual Language Learners},

author = {Ophélie A Collet and Pascale M Domond and Cédric Galéra and Thuy Mai Luu and Tianna Loose and Alejandro Vásquez-Echeverría and Massimiliano Orri and Sylvana M Côté},

doi = {10.1001/jamapediatrics.2024.4489},

issn = {2168-6211},

year  = {2025},

date = {2025-01-01},

journal = {JAMA Pediatr},

volume = {179},

number = {1},

pages = {73--82},

abstract = {IMPORTANCE: Dual language learners (DLL) (ie, children learning 2 or more languages) present lower school readiness than non-DLL children, putting DLL children at risk of later school difficulties and adverse outcomes. However, it is unclear whether participation in early childhood education and care (ECEC) services may reduce this gap.nnOBJECTIVE: To assess whether ECEC exposure may reduce the school readiness gap between DLL and non-DLL children in a population-based sample.nnDESIGN, SETTING, AND PARTICIPANTS: This census survey study was performed from February to May 2022 in the Canadian province of Quebec using data from the Quebec Survey of Child Development in Kindergarten, which includes all children who attended kindergarten in the 2021 to 2022 school year in public and private schools in Quebec (n = 80 587), except for Cree and Inuit territories.nnEXPOSURE: Children's ECEC arrangement before kindergarten was retrieved from register-based data and teachers and arrangements were categorized as exclusive parental care, childcare, pre-kindergarten only, or childcare and pre-kindergarten. Based on their mother tongue and language of instruction, children were classified as French speaking, English speaking, bilingual French-English speaking, or neither French nor English speaking (allophone) children, the last 2 groups of which represented the DLL category.nnMAIN OUTCOMES AND MEASURES: Vulnerability in school readiness was defined as a score below the 10th percentile in any of the 5 domains of the validated Early Development Instrument (EDI): (1) physical health and well-being; (2) social competence; (3) emotional maturity; (4) language and cognitive development; and (5) communication skills and general knowledge.nnRESULTS: In total, 80 587 children were surveyed, and 71 585 children were included in analyses. Mean (SD) child age was 6.0 (0.3) years, 34 911 children (48.8%) were female, and 18 341 children (25.6%) were DLL. English-speaking, bilingual French-English-speaking, and allophone children were more likely to be vulnerable in the EDI (769 of 2355 children [32.7%], 4814 of 13 981 children [34.4%], and 1622 of 4360 children [37.2%], respectively) than French-speaking children (13 664 of 50 890 children [26.9%]). In logistic regression analyses adjusted for social selection bias in ECEC arrangement, attending ECEC services was associated with a lower risk of being vulnerable among all language groups compared to parental care, with odds ratios ranging from 0.26 (95% CI, 0.25-0.27) to 0.96 (95% CI, 0.80-1.14), except in the emotional maturity domain. ECEC exposure was associated with reduction in vulnerabilities disparities between DLL and non-DLL children after adjusting for confounding factors, including socioeconomic status.nnCONCLUSIONS AND RELEVANCE: ECEC services may foster school readiness for all children, especially DLL, and should be considered to reduce school inequalities.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39521350,

title = {A mesocorticolimbic insulin receptor gene co-expression network moderates the association between early life adversity and food approach eating behaviour style in childhood},

author = {Angela Marcela Jaramillo-Ospina and Roberta Dalle Molle and Sachin Patel and Shona Kelly and Irina Pokhvisneva and Carolina de Weerth and Patrícia Pelufo Silveira},

doi = {10.1016/j.appet.2024.107762},

issn = {1095-8304},

year  = {2025},

date = {2025-01-01},

journal = {Appetite},

volume = {204},

pages = {107762},

abstract = {Insulin receptors, located in brain regions associated with reward sensitivity and decision-making, facilitate insulin action in the brain, modulating intracellular signaling cascades, gene expression, and neural activity. Here, we tested if variations in the expression of the insulin receptor gene network in the prefrontal cortex (PFC) and striatum (STR) moderate the association between early life adversity and eating behaviour in childhood and if this moderation is sex-specific. Participants from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) and Basal Influences on the Baby's Development (BIBO) were included as two independent cohorts. A biologically-informed polygenic score reflecting functional variation of the mesocorticolimbic insulin receptor gene network was created by using insulin receptor co-expression data from the PFC and STR in mice, and validated in humans through filtering by homologous expression in PFC using well-known databases. Early life adversity exposure was measured as a composite score. Eating behaviour was characterized using the Child Eating Behaviour Questionnaire administered to mothers of children aged 4 and 6 years in MAVAN, and 6 years in BIBO. We found that only in those with high expression of the mesocorticolimbic insulin receptor gene network a higher early adversity score associated with a higher desire to drink in 4-year boys and 6-year girls, as well as a higher food approach score and food approach/food avoidance ratio in 4-year girls. Also, a higher early life adversity was associated with higher food responsiveness, food approach score and food approach/food avoidance ratio at 6 years in the MAVAN full sample. The moderation observed on desire to drink was partially replicated in BIBO children aged 6 years. Identifying individual differences in response to early adversity may help to prioritize individuals at high risk for long-term disease and design suitable interventions.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39488991,

title = {The prospective associations between problematic gaming and phubbing among Chinese adolescents: Insights from a cross-lagged panel network model},

author = {Yingying Su and Yan Chen and Qian Gai and Xiangfei Meng and Tingting Gao},

doi = {10.1016/j.comppsych.2024.152542},

issn = {1532-8384},

year  = {2025},

date = {2025-01-01},

journal = {Compr Psychiatry},

volume = {136},

pages = {152542},

abstract = {BACKGROUND AND AIMS: Previous studies are limited in addressing the directionality of temporal relationships between problematic gaming and phubbing symptoms by exploring cross-sectional studies. Therefore, we estimated the longitudinal relationships between individual behavioral addictive symptoms including problematic gaming and phubbing in adolescence, and explored potential sex differences in these relationships.nnMETHODS: This study included 3296 participants in Shandong Province, China. Data were collected from November 2021 (mean [SD] age: 15.17 [1.44] years) to May 2023 (mean [SD] age: 17.50 [1.18] years), with females comprising 54.5 % of the sample. Problematic gaming and phubbing were assessed using validated scales at each wave. We construct cross-sectional networks and cross-lagged panel networks (CLPN) to explore the contemptuous and temporal relationships between problematic gaming and phubbing.nnRESULTS: Contemporaneous networks revealed significant differences in problematic gaming and phubbing networks between males and females. Additionally, temporal network analyses indicated that among male adolescents, feeling anxious when unable to play games was the most influential predictor of subsequent behavioral addictive symptoms. For female adolescents, fantasizing about gaming had the most significant associations with future addictive behaviors. The strongest bridge symptom linking problematic gaming and phubbing for both sexes was focusing on phones rather than engaging in conversation.nnDISCUSSION AND CONCLUSIONS: The study applied network modeling to panel data from a large, population-based cohort of adolescents, identifying unique longitudinal relationships between problematic gaming and phubbing across symptom domains. It provides valuable insights into the characterization of behavioral addictive symptoms among adolescents and the potential predictive relationships among these symptoms among different sexes, guiding sex-specific targeted interventions for adolescents.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39477493,

title = {Comparison Between Brain and Cerebellar Autoradiography Using [F]Flortaucipir, [F]MK6240, and [F]PI2620 in Postmortem Human Brain Tissue},

author = {Antonio Aliaga and Joseph Therriault and Kely Monica Quispialaya and Arturo Aliaga and Robert Hopewell and Nesrine Rahmouni and Arthur C Macedo and Peter Kunach and Jean-Paul Soucy and Gassan Massarweh and Aida Abreu Diaz and Tharick A Pascoal and Andreia Rocha and Marie-Christine Guiot and Luiza S Machado and Marco Antônio De Bastiani and Débora Guerini de Souza and Diogo O Souza and Serge Gauthier and Eduardo R Zimmer and Pedro Rosa-Neto},

doi = {10.2967/jnumed.124.267539},

issn = {1535-5667},

year  = {2025},

date = {2025-01-01},

journal = {J Nucl Med},

volume = {66},

number = {1},

pages = {123--129},

abstract = {Our objective was to evaluate the in vitro binding properties of [F]flortaucipir, 6-(fluoro-F)-3-(1-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([F]MK6240), and 2-(2-([F]fluoro)pyridin-4-yl)-9-pyrrolo[2,3-b:4,5c']dipyridine ([F]PI2620) head-to-head in postmortem human brain tissue.  Autoradiography was used to assess uptake of [F]flortaucipir, [F]MK6240, and [F]PI2620 in control and Alzheimer disease (AD) autopsy-confirmed brain tissues. The study focused on the analysis of the prefrontal cortex, hippocampus, and cerebellum sections in 12 controls and 12 AD cases, as well as whole-brain hemisphere in 1 control and 1 AD sample, for each radiotracer. The binding values of [F]flortaucipir, [F]MK6240, and [F]PI2620 were calculated from regions of interest manually drawn in the prefrontal, hippocampal, and cerebellar cortices.  For all 3 radioligands investigated, we observed significant tracer binding differences between control and AD tissues in the whole-brain hemisphere, prefrontal cortex, and hippocampus but not in the cerebellar cortex. [F]MK6240 and [F]PI2620 had higher effect sizes to differentiate control and AD cases than did [F]flortaucipir. Bland-Altman analyses revealed strong correlations between [F]MK6240, [F]PI2620, and [F]flortaucipir, with the highest agreement found for [F]MK6240 versus [F]PI2620.  The 3 radioligands showed comparable diagnostic properties to assess tau aggregates in vitro. Binding to AD brain tissues was higher for [F]MK6240 and [F]PI2620 than for [F]flortaucipir. Additionally, [F]MK6240 and [F]PI2620 had greater selectivity, displaying decreased uptake in control brain tissue compared with [F]flortaucipir. These results might provide insights on ongoing initiatives to create a universal scale for tau imaging studies.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39367209,

title = {Body mass index across development and adolescent hair cortisol: the role of persistence, variability, and timing of exposure},

author = {Christina Y Cantave and Paula L Ruttle and Sylvana M Coté and Sonia J Lupien and Marie-Claude Geoffroy and Frank Vitaro and Mara Brendgen and Richard Tremblay and Michel Boivin and Isabelle Ouellet-Morin},

doi = {10.1038/s41366-024-01640-1},

issn = {1476-5497},

year  = {2025},

date = {2025-01-01},

journal = {Int J Obes (Lond)},

volume = {49},

number = {1},

pages = {125--132},

abstract = {BACKGROUND: Research suggests a putative role of the glucocorticoid stress hormone cortisol in the accumulation of adiposity. However, obesity and weight fluctuations may also wear and tear physiological systems promoting adaptation, affecting cortisol secretion. This possibility remains scarcely investigated in longitudinal research. This study tests whether trajectories of body mass index (BMI) across the first 15 years of life are associated with hair cortisol concentration (HCC) measured two years later and whether variability in BMI and timing matter.nnMETHODS: BMI (kg/m) was prospectively measured at twelve occasions between age 5 months and 15 years. Hair was sampled at age 17 in 565 participants. Sex, family socioeconomic status, and BMI measured concurrently to HCC were considered as control variables.nnRESULTS: Latent class analyses identified three BMI trajectories: "low-stable" (59.2%, n = 946), "moderate" (32.6%, n = 507), and "high-rising" (8.2%, n = 128). BMI variability was computed by dividing the standard deviation of an individual's BMI measurements by the mean of these measurements. Findings revealed linear effects, such that higher HCC was noted for participants with moderate BMI trajectories in comparison to low-stable youth (β = 0.10, p = 0.03, 95% confidence interval (CI) = [0.02-0.40]); however, this association was not detected in the high-rising BMI youth (β = -0.02, p = 0.71, 95% CI = [-0.47-0.32]). Higher BMI variability across development predicted higher cortisol (β = 0.17, p = 0.003, 95% CI = [0.10-4.91]), additively to the contribution of BMI trajectories. BMI variability in childhood was responsible for that finding, possibly suggesting a timing effect.nnCONCLUSIONS: This study strengthens empirical support for BMI-HCC association and suggests that more attention should be devoted to BMI fluctuations in addition to persistent trajectories of BMI.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39140868,

title = {Prenatal Cannabis and Tobacco Co-Exposure and Its Association with Behavioural Outcomes in Middle Childhood: Co-exposition prénatale au cannabis et au tabac et son association avec les résultats comportementaux au cours de l'enfance intermédiaire},

author = {Emma Nadler and Joanna Jacobus and Rachel A Rabin},

doi = {10.1177/07067437241271696},

issn = {1497-0015},

year  = {2025},

date = {2025-01-01},

journal = {Can J Psychiatry},

volume = {70},

number = {1},

pages = {41--53},

abstract = {OBJECTIVES: Cannabis legalization has triggered an increase in prenatal cannabis use. Given that tobacco is commonly co-used with cannabis, determining outcomes associated with prenatal cannabis and tobacco co-exposure is crucial. While literature exists regarding the individual effects of prenatal cannabis and tobacco exposure on childhood behaviour, there is a gap regarding their combined use, which may have interactive effects. Therefore, we investigated whether prenatal cannabis and tobacco co-exposure was associated with greater externalizing and internalizing problems in middle childhood compared to prenatal exposure to either substance alone or no exposure.nnMETHODS: Baseline data from the Adolescent Brain Cognitive Development (ABCD) Study (collected in children ages 9-11) were used to explore differences in externalizing and internalizing scores derived from the Childhood Behavior Checklist across four groups: children with prenatal cannabis and tobacco co-exposure (CT,  = 290), children with prenatal cannabis-only exposure (CAN,  = 225), children with prenatal tobacco-only exposure (TOB,  = 966), and unexposed children (CTL,  = 8,311). We also examined if the daily quantity of tobacco exposure modulated the effect of cannabis exposure on outcomes.nnRESULTS: Adjusting for covariates, a 2 × 2 ANCOVA revealed significant main effects for prenatal cannabis ( = 0.03) and tobacco exposure ( < 0.001), and a significant interaction effect on externalizing scores ( = 0.032); no significant main effects or interactions were found for internalizing scores. However, interactions between daily quantity of cannabis and tobacco exposure significantly predicted both externalizing and internalizing scores ( < 0.01).nnCONCLUSIONS: These findings indicate that co-exposure is associated with greater externalizing problems than exposure to either substance alone, which did not differ from each other. Further, greater tobacco exposure may amplify the negative effect of cannabis exposure on both externalizing and internalizing behaviours in children. These findings underscore the need for interventions that target cannabis and tobacco co-use in pregnant women to circumvent their adverse impact on middle childhood behaviour.nnPLAIN LANGUAGE SUMMARY TITLE: Prenatal Cannabis and Tobacco Co-exposure and its Association with Middle Childhood Behaviours.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40017733,

title = {Assessing cognitive flexibility in mice using a custom-built touchscreen chamber},

author = {Rui C Pais and Ali Goldani and Jayden Hutchison and Amirhossein Mazrouei and Mostafa Khavaninzadeh and Leonardo A Molina and Robert J Sutherland and Majid H Mohajerani},

doi = {10.3389/fnbeh.2025.1536458},

issn = {1662-5153},

year  = {2025},

date = {2025-01-01},

journal = {Front Behav Neurosci},

volume = {19},

pages = {1536458},

abstract = {Automated touchscreen systems have become increasingly prevalent in rodent model screening. This technology has significantly enhanced cognitive and behavioral assessments in mice and has bridged the translational gap between basic research using rodent models and human clinical research. Our study introduces a custom-built touchscreen operant conditioning chamber powered by a Raspberry Pi and a commercially available computer tablet, which effectively addresses the significant cost barriers traditionally associated with this technology. In order to test our prototype, we decided to train C57BL/6 mice on a visual discrimination serial-reversal task, and both C57BL/6 and Appstrain - an Alzheimer's Disease (AD) mouse model - on a new location discrimination serial-reversal task. The results demonstrated a clear progression toward asymptotic performance, particularly in the location discrimination task, which also revealed potential genotype-specific deficits, with App mice displaying an increase in the average number of errors in the first reversal as well as in perseverative errors, compared to wild-type mice. These results validate the practical utility of our touchscreen apparatus and underline its potential to provide insights into the behavioral and cognitive markers of neurobiological disorders.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39990273,

title = {Frontotemporal dementia subtyping using machine learning, multivariate statistics and neuroimaging},

author = {Amelie Metz and Yashar Zeighami and Simon Ducharme and Sylvia Villeneuve and Mahsa Dadar},

doi = {10.1093/braincomms/fcaf065},

issn = {2632-1297},

year  = {2025},

date = {2025-01-01},

journal = {Brain Commun},

volume = {7},

number = {1},

pages = {fcaf065},

abstract = {Frontotemporal dementia (FTD) is a prevalent form of early-onset dementia characterized by progressive neurodegeneration and encompasses a group of heterogeneous disorders. Due to overlapping symptoms, diagnosis of FTD and its subtypes still poses a challenge. Magnetic resonance imaging (MRI) is commonly used to support the diagnosis of FTD. Using machine learning and multivariate statistics, we tested whether brain atrophy patterns are associated with severity of cognitive impairment, whether this relationship differs between the phenotypic subtypes and whether we could use these brain patterns to classify patients according to their FTD variant. A total of 136 patients (70 behavioural variant FTD, 36 semantic variant primary progressive aphasia and 30 non-fluent variant primary progressive aphasia) from the frontotemporal lobar degeneration neuroimaging initiative (FTLDNI) database underwent brain MRI and clinical and neuropsychological examination. Deformation-based morphometry, which offers increased sensitivity to subtle local differences in structural image contrasts, was used to estimate regional cortical and subcortical atrophy. Atlas-based associations between atrophy values and performance across different cognitive tests were assessed using partial least squares. We then applied linear regression models to discern the group differences regarding the relationship between atrophy and cognitive decline in the three FTD phenotypes. Lastly, we assessed whether the combination of atrophy and cognition patterns in the latent variables identified in the partial least squares analysis could be used as features in a machine learning model to predict FTD subtypes in patients. Results revealed four significant latent variables that combined accounted for 86% of the shared covariance between cognitive and brain atrophy measures. Partial least squares-based atrophy and cognitive patterns predicted the FTD phenotypes with a cross-validated accuracy of 89.12%, with high specificity (91.46-97.15%) and sensitivity (84.19-93.56%). When using only MRI measures and two behavioural tests in the partial least squares and classification algorithms, ensuring clinical feasibility, our model was equally precise in the same participant sample (87.18%, specificity 76.14-92.00%, sensitivity 86.93-98.26%). Here, including only atrophy or behaviour patterns in the analysis led to prediction accuracies of 69.76% and 76.54%, respectively, highlighting the increased value of combining MRI and clinical measures in subtype classification. We demonstrate that the combination of brain atrophy and clinical characteristics and multivariate statistical methods can serve as a biomarker for disease phenotyping in FTD, whereby the inclusion of deformation-based morphometry measures adds to the classification accuracy in the absence of extensive clinical testing.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39029777,

title = {Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience},

author = {Gregor Stein and Janine S Aly and Annamaria Manzolillo and Lisa Lange and Konstantin Riege and Iqra Hussain and Elisabeth A Heller and Susana Cubillos and Thomas Ernst and Christian A Hübner and Gustavo Turecki and Steve Hoffmann and Olivia Engmann},

doi = {10.1016/j.biopsych.2024.07.009},

issn = {1873-2402},

year  = {2025},

date = {2025-01-01},

journal = {Biol Psychiatry},

volume = {97},

number = {1},

pages = {54--63},

abstract = {BACKGROUND: Chronic stress significantly contributes to mood and anxiety disorders. Previous data suggest a correlative connection between vitamin B12 supplementation, depression, and stress resilience. However, the underlying mechanisms are still poorly understood.nnMETHODS: Using the chronic variable stress mouse model coupled with RNA sequencing, we identified vitamin B12-induced transcriptional changes related to stress resilience. Using viral-mediated gene transfer and in vivo epigenome editing, we revealed a functional pathway linking vitamin B12, DNA methylation (DNAme), and depression-like symptoms.nnRESULTS: We identified Ttr (transthyretin) as a key sex-specific target of vitamin B12 in chronic stress. Accordingly, TTR expression was increased postmortem in the prefrontal cortex of male but not female patients with depression. Virally altered Ttr in the prefrontal cortex functionally contributed to stress- and depression-related behaviors, changes in dendritic spine morphology, and gene expression. In stressed mice, vitamin B12 reduced DNAme in the Ttr promoter region. Importantly, using in vivo epigenome editing to alter DNAme in the brains of living mice for the first time, we established a direct causal link between DNAme and Ttr and stress-associated behaviors.nnCONCLUSIONS: Using state-of-the-art techniques, this study uncovered a mechanistic link between vitamin B12 supplementation, Ttr, and markers of chronic stress and depression, encouraging further studies into dietary interventions for mood disorders.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39326302,

title = {Modeling the progression of neuropsychiatric symptoms in Alzheimer's disease with PET-based Braak staging},

author = {Arthur C Macedo and Joseph Therriault and Cécile Tissot and Étienne Aumont and Stijn Servaes and Nesrine Rahmouni and Jaime Fernandez-Arias and Firoza Z Lussier and Yi-Ting Wang and Kok Pin Ng and Marie Vermeiren and Gleb Bezgin and Kely Quispialaya Socualaya and Jenna Stevenson and Seyyed Ali Hosseini and Mira Chamoun and João Pedro Ferrari-Souza and Pâmela C L Ferreira and Bruna Bellaver and Douglas Teixeira Leffa and Paolo Vitali and Eduardo R Zimmer and Zahinoor Ismail and Tharick A Pascoal and Serge Gauthier and Pedro Rosa-Neto},

doi = {10.1016/j.neurobiolaging.2024.09.009},

issn = {1558-1497},

year  = {2024},

date = {2024-12-01},

journal = {Neurobiol Aging},

volume = {144},

pages = {127--137},

abstract = {In Alzheimer's disease (AD), neuropsychiatric symptoms (NPS) correlate with tau deposition in the brain. Here, we investigated the association of PET-based Braak stages with NPS and assessed whether they predict annual changes in NPS. We evaluated 231 individuals in the aging and AD continuum. Participants were assigned a Braak stage at baseline and followed for 1.97 (s.d. 0.62) years. NPS were investigated using the Mild Behavioral Impairment Checklist (MBI-C) and the Neuropsychiatric Inventory Questionnaire severity (NPI-Q-S) and distress (NPI-Q-D) scales. Multiple linear regressions (MLR) assessed the association of Braak stages with baseline NPS and the annual change in NPS scores. At baseline, stages I-II, III-IV, and V-VI were associated with higher MBI-C, NPI-Q-S, and NPI-Q-D scores. Stages V-VI were associated with a significant annual increase in MBI-C scores. These findings suggest that tau accumulation may manifest clinically with an increase in NPS, which seems to be an early event in AD pathophysiology. Moreover, PET-based Braak staging appears to be a good predictor of NPS severity progression.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39650737,

title = {Altered m6A RNA methylation profiles in depression implicate the dysregulation of discrete cellular functions in males and females},

author = {Haruka Mitsuhashi and Rixing Lin and Anjali Chawla and Naguib Mechawar and Corina Nagy and Gustavo Turecki},

doi = {10.1016/j.isci.2024.111316},

issn = {2589-0042},

year  = {2024},

date = {2024-12-01},

journal = {iScience},

volume = {27},

number = {12},

pages = {111316},

abstract = {Adverse environmental stress represents a significant risk factor for major depressive disorder (MDD), often resulting in disrupted synaptic connectivity which is known to be partly regulated by epigenetic mechanisms. N-methyladenosine (m6A), an epitranscriptomic modification, has emerged as a crucial regulator of activity-dependent gene regulation. In this study, we characterized m6A profiles in the ventromedial prefrontal cortex (vmPFC) of individuals with MDD. Using m6A sequencing, we identified a total of 30,279 high-confidence m6A peaks, exhibiting significant enrichment in genes related to neuronal and synaptic function. The m6A peaks between males and females with MDD that passed the significance threshold showed opposite m6A patterns, while the threshold-free m6A patterns were concordant. Distinct m6A profiles were found in MDD for each sex, with dysregulation associated with microtubule movement in males and neuronal projection in females. Our results suggest the potential roles of m6A as part of the dysregulated molecular network in MDD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39636028,

title = {Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)},

author = {Howard Chertkow and Natalie Phillips and Kenneth Rockwood and Nicole Anderson and Melissa K Andrew and Robert Bartha and Camille Beaudoin and Nathalie Bélanger and Pierre Bellec and Sylvie Belleville and Howard Bergman and Sarah Best and Jennifer Bethell and Louis Bherer and Sandra Black and Michael Borrie and Richard Camicioli and Julie Carrier and Neil Cashman and Senny Chan and Lynden Crowshoe and Claudio Cuello and Max Cynader and Thanh Dang-Vu and Samir Das and Roger A Dixon and Simon Ducharme and Gillian Einstein and Alan C Evans and Margaret Fahnestock and Howard Feldman and Guylaine Ferland and Elizabeth Finger and John D Fisk and Jennifer Fogarty and Edward Fon and Ziv Gan-Or and Serge Gauthier and Carol Greenwood and Charlie Henri-Bellemare and Nathan Herrmann and David B Hogan and Robin Hsiung and Inbal Itzhak and Kristen Jacklin and Krista Lanctôt and Andrew Lim and Ian MacKenzie and Mario Masellis and Colleen Maxwell and Carrie McAiney and Katherine McGilton and JoAnne McLaurin and Alex Mihailidis and Zia Mohades and Manuel Montero-Odasso and Debra Morgan and Gary Naglie and Haakon Nygaard and Megan O'Connell and Ron Petersen and Randi Pilon and Maria Natasha Rajah and Mark Rapoport and Pamela Roach and Julie M Robillard and Ekaterina Rogaeva and Pedro Rosa-Neto and Jane Rylett and Joel Sadavoy and Peter St George-Hyslop and Dallas Seitz and Eric Smith and Bojana Stefanovic and Isabelle Vedel and Jennifer D Walker and Cheryl Wellington and Victor Whitehead and Walter Wittich},

doi = {10.1177/13872877241290990},

issn = {1875-8908},

year  = {2024},

date = {2024-12-01},

journal = {J Alzheimers Dis},

volume = {102},

number = {3},

pages = {535--561},

abstract = {The Canadian Consortium on Neurodegeneration in Aging (CCNA) was created by the Canadian federal government through its health research funding agency, the Canadian Institutes for Health Research (CIHR), in 2014, as a response to the G7 initiative to fight dementia. Two five-year funding cycles (2014-2019; 2019-2024) have occurred following peer review, and a third cycle (Phase 3) has just begun. A unique construct was mandated, consisting of 20 national teams in Phase I and 19 teams in Phase II (with research topics spanning from basic to clinical science to health resource systems) along with cross-cutting programs to support them. Responding to the needs of researchers within the CCNA teams, a unique sample of 1173 deeply phenotyped patients with various forms of dementia was accrued and studied over eight years (COMPASS-ND). In the second phase of funding (2019-2024), a national dementia prevention program (CAN-THUMBS UP) was set up. In a short time, this prevention program became a member of the World Wide FINGERS prevention consortium. In this article, the challenges, successes, and impacts of CCNA in Canada and internationally are discussed. Short-term deliverables have occurred, along with considerable promise of impacts in the longer term. The creation of synergy, networking, capacity building, engagement of people with lived experience, and economies of scale have contributed to the considerable success of CCNA by all measures. CCNA is evidence that an organized "centrally-organized" approach to dementia research can catalyze important progress nationally and yield significant and measurable results.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39293281,

title = {Joint-trajectories of clinical severity, social functioning and cannabis use in first-episode psychosis: A 5-year longitudinal study in 2 urban early intervention services},

author = {Giuseppe D'Andrea and Clairélaine Ouellet-Plamondon and Marie Villeneuve and Jai L Shah and Srividya N Iyer and Amal Abdel-Baki},

doi = {10.1016/j.psychres.2024.116184},

issn = {1872-7123},

year  = {2024},

date = {2024-12-01},

journal = {Psychiatry Res},

volume = {342},

pages = {116184},

abstract = {Cannabis use is associated with increased psychosis incidence alongside worse outcomes. The role of cannabis may be complex, vary across patients and over time. Yet, few have examined the longer-term trajectories of cannabis use, symptoms and functioning and their inter-relationships. We conducted a 5-year longitudinal study to estimate joint-trajectories of clinical severity, social functioning, and cannabis use via group-based multi-trajectory modelling on a sample of 395 incident FEP cases. Associations of trajectories with socio-demographic and clinical factors were tested using multinomial regression. The best-fitting model identified 5 joint-trajectories. A first group (N = 93,23.7 %) presented only marginal improvement despite not using cannabis, while a second with no cannabis use and a third group with low-decreasing use showed clinical amelioration. Among those with baseline harmful cannabis use, a fourth group progressively discontinued use and improved clinically (N = 78,19.9 %). A fifth group with continued use did not significantly improve over follow-up (N = 74,18.8 %), and also had the highest odds of homelessness (OR = 22.5,95 %CI = 6.25-81.1) and childhood adversities (OR = 2.25,95 %CI = 1.71-2.97). There is substantial heterogeneity in the joint-trajectories of cannabis use and FEP outcomes. Our findings support the need for intervention aimed at cannabis reduction among heavy users. Multi-disciplinary, trauma-informed interventions may benefit those with persistent cannabis use, given its associations with childhood and social adversity.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39620472,

title = {Childhood conduct problems and adolescent medical service use: serial mediating effects of peer victimization and internalizing problems},

author = {Olivia Crescenzi and Alexa Martin-Storey and Martine Poirier and Stéphanie Boutin and Annie Lemieux and Michèle Déry and Eric Latimer and Caroline E Temcheff},

doi = {10.1017/S0033291724002241},

issn = {1469-8978},

year  = {2024},

date = {2024-12-01},

journal = {Psychol Med},

volume = {54},

number = {15},

pages = {1--10},

abstract = {BACKGROUND: Adolescents with a history of conduct problems (CP) are at heightened risk of increased service utilization as they develop. While the mechanisms underlying this association are unclear, early CP have also been linked with peer victimization and internalizing problems. The goals of the current study were: (1) to examine peer victimization and internalizing problems as potential serial mediators explaining increased medical and psychiatric service use in adolescents with a history of childhood CP, and; (2) to explore whether the proposed mediation models vary by sex.nnMETHODS: Participants ( = 744; 53% boys, Mage = 8.39 years) from an ongoing longitudinal study that began in 2008 in Québec, Canada were recruited and assessed for CP, service use, and other behaviours via self-, parent- and teacher-reported questionnaires. Serial mediation analyses were conducted to examine the effects of peer victimization and internalizing problems on the association between childhood CP and adolescent medical and psychiatric service use, controlling for sex and household income.nnRESULTS: Adolescents with childhood CP reported higher medical and psychiatric service use than non-CP peers. Peer victimization and internalizing problems significantly mediated this association in both general medical and psychiatric service use models. The models did not vary by sex.nnCONCLUSIONS: Findings support higher levels of service use in adolescents with a history of CP, mediated by peer victimization and internalizing problems. Specifically, results highlight the importance of examining peer and socioemotional factors that may explain the increased service usage observed among youth with CP, to support better health outcomes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39430603,

title = {Prenatal cannabis exposure in the clinic and laboratory: What do we know and where do we need to go?},

author = {Lani Cupo and Karen A Dominguez-Cancino and José Ignacio Nazif-Munoz and M Mallar Chakravarty},

doi = {10.1016/j.dadr.2024.100282},

issn = {2772-7246},

year  = {2024},

date = {2024-12-01},

journal = {Drug Alcohol Depend Rep},

volume = {13},

pages = {100282},

abstract = {Coincident with the legalisation of cannabis in many nations, rates of cannabis use during pregnancy have increased. Like prior investigations on smoking and alcohol, understanding how prenatal cannabis exposure (PCE) impacts offspring outcomes across the lifespan will be critical for informing choices for pregnant people, clinicians, and policy makers alike. A thorough characterization of the life-long impacts is especially urgent for supporting all of these stakeholders in the decision-making process. While studies in humans bring forth the most direct information, it can be difficult to parse the impact of PCE from confounding variables. Laboratory studies in animal models can provide experimental designs that allow for causal inferences to be drawn, however there can be challenges in designing experiments with external validity in mirroring real-world exposure, as well as challenges translating results from the laboratory back to the clinic. In this literature review, we first highlight what is known about patterns of cannabis use during pregnancy. We then seek to lay out updates to the current understanding of the impact of PCE on offspring development informed by both human and nonhuman animal experiments. Finally we highlight opportunities for information exchange among the laboratory, clinic, and policy, identifying gaps to be filled by future research.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39306959,

title = {Sleep problems in preschool mediate the association between chronotype and socioemotional problems at school-age},

author = {Derric Z H Eng and Elaine K H Tham and Nur K Jafar and Jael S Y Tan and Daniel Y T Goh and Yung Seng Lee and Lynette P Shek and Oon-Hoe Teoh and Fabian Yap and Kok Hian Tan and Johan G Eriksson and Yap Seng Chong and Michael J Meaney and Shirong Cai and Birit F P Broekman},

doi = {10.1016/j.sleep.2024.09.003},

issn = {1878-5506},

year  = {2024},

date = {2024-12-01},

journal = {Sleep Med},

volume = {124},

pages = {174--186},

abstract = {OBJECTIVES: Evening-chronotype is associated with increased socioemotional problems among school-aged children. Inadequate sleep and increased sleep problems are also prevalent among evening-chronotype children and may underlie the relationship between chronotype and socioemotional problems. However, it is unclear whether the association between chronotype and socioemotional problems at school-age may be mediated by poorer sleep during late preschool.nnMETHODS: Our study utilized cross-sectional data to examine the relations between chronotype, sleep duration, sleep problems and socioemotional problems in preschoolers. We subsequently performed longitudinal mediation analyses to examine how the association between chronotype at preschool-age and later socioemotional problems at school-age may be mediated by sleep problems and sleep duration during late preschool. 399 children from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study were included for analyses. Children's chronotype were identified with the Children's Chronotype Questionnaire at 4.5 years old. Sleep duration and problems were measured with the Children's Sleep Habits Questionnaire at 4.5 and 6 years old. Socioemotional problems were evaluated using the Child Behavioral Checklist at 4 and 7 years of age. All questionnaires were caregiver-reported.nnRESULTS: Linear regressions demonstrated that eveningness was associated with concurrent sleep problems and internalizing, externalizing and total behavioral problems at 4-4.5 years old, but not sleep duration. Mediation analyses supported that sleep problems (and not sleep duration) at 6 years old mediated the relationship between chronotype and socioemotional problems at 7 years old.nnCONCLUSIONS: Our findings suggest addressing sleep problems during early development may reduce socioemotional problems at school-age, especially among evening-chronotype children.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39423674,

title = {Diagnosing and treating hypersomnolence in depression},

author = {Christophe Moderie and Diane B Boivin},

doi = {10.1016/j.sleep.2024.10.008},

issn = {1878-5506},

year  = {2024},

date = {2024-12-01},

journal = {Sleep Med},

volume = {124},

pages = {462--470},

abstract = {Hypersomnolence, a broad presentation encompassing excessive daytime sleepiness, hypersomnia and sleep inertia, affects around 25 % of patients with a major depressive disorder. Yet, hypersomnolence is often overlook in clinical settings - which can prevent remission of the mood disorder in addition to significantly interfering with quality of life. Clinical guidelines are lacking to support clinicians in the diagnosis and treatment of hypersomnolence in depression. Pharmacological treatment with selective serotonin reuptake inhibitors is insufficient and noradrenaline and dopamine reuptake inhibitors or similar molecules are generally indicated. Low-sodium oxybate was recently approved for Idiopathic Hypersomnia, but studies are needed to assess its efficacy in patients with comorbid depression. In parallel, cognitive behavioral therapy for hypersomnia is being developed as adjunct non-pharmacological treatment. Light therapy might also be beneficial in these populations. This narrative review aims at proposing a diagnostic approach reconciliating psychiatry and sleep medicine nosologies, as well as offering a multimodal treatment algorithm for hypersomnolence in depression.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39069958,

title = {Sleep, chronotype, social jetlag, and mental health in resident physicians: a cross-sectional study},

author = {Christophe Moderie and Camille Paradis and Frederick L Philippe and Marie-Claude Geoffroy and Emilie Guay and Vincent Paquin},

doi = {10.5664/jcsm.11288},

issn = {1550-9397},

year  = {2024},

date = {2024-12-01},

journal = {J Clin Sleep Med},

volume = {20},

number = {12},

pages = {1915--1922},

abstract = {STUDY OBJECTIVES: Social jetlag, the difference between imposed and endogenous sleep schedules, may be detrimental to resident physicians' health. The current profiles of sleep habits, particularly the differences between workdays and free days, are unknown in that population. This cross-sectional study of Quebec resident physicians aimed at assessing sleep habits on workdays and free days and predictors of social jetlag.nnMETHODS: Residents were recruited via their residency programs and social media to complete an online questionnaire. Measures included means of sleep duration and timing, chronotype, sleep debt, sleep disturbances, and social jetlag. A range of sociodemographic variables, lifestyle characteristics, and mental health indicators were examined as predictors of severe social jet lag using logistic regressions.nnRESULTS: A total of 492 residents were included in the study (mean [standard deviation] age, 27.6 [3.6] years; 330 females [67.1%]). The mean sleep duration was 7.15 hours (95% confidence interval [CI], 7.02-7.28 hours) on workdays and 8.36 hours (95% CI, 8.18-8.54 hours) on free days. The mean sleep debt was 1.59 hours (95% CI, 1.37-1.81 hours), and mean social jetlag was 1.37 hours (95% CI, 1.28-1.47 hours), with 31.9% (95% CI, 25.0-39.6%) of residents experiencing ≥2 hours of sleep debt and 21.8% (95% CI, 16.5-28.3%) experiencing severe social jetlag. The prevalence of sleep disturbances was 51.7% (95% CI, 44.4-58.8%). Severe social jetlag was associated with earlier stage of training, later chronotype, decreased physical activity, increased sleep debt, and depressive symptoms.nnCONCLUSIONS: Many residents experience severe social jetlag, chronic sleep deprivation, and sleep disturbances. Importantly, severe social jetlag was associated with depressive symptoms, suggesting a potential intervention target for promoting residents' mental health.nnCITATION: Moderie C, Paradis C, Philippe FL, Geoffroy M-C, Guay E, Paquin V. Sleep, chronotype, social jetlag, and mental health in resident physicians: a cross-sectional study.  2024;20(12):1915-1922.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39419121,

title = {T1- and T2-weighted MRI signal and histology findings in suboptimally fixed human brains},

author = {Eve-Marie Frigon and Philippe Pharand and Amy Gérin-Lajoie and Liana Guerra Sanches and Denis Boire and Mahsa Dadar and Josefina Maranzano},

doi = {10.1016/j.jneumeth.2024.110301},

issn = {1872-678X},

year  = {2024},

date = {2024-12-01},

journal = {J Neurosci Methods},

volume = {412},

pages = {110301},

abstract = {Neuroscientific research that requires brain tissue depends on brain banks that provide very small tissue samples fixed by immersion in neutral-buffered formalin (NBF), while anatomy laboratories could provide full brain specimens. However, these brains are generally fixed by perfusion of the full body with solutions other than NBF generally used by brain banks, such as an alcohol-formaldehyde solution (AFS) that is typically used for dissection and teaching. Therefore, fixation quality of these brains needs to be assessed to determine their usefulness in post-mortem investigations through magnetic resonance imaging (MRI) and histology, two common neuroimaging modalities. Here, we report the characteristics of five brains fixed by full body perfusion of an AFS from our Anatomy Laboratory suspected of being poorly fixed, given the altered signal seen on T1w MRI scans in situ. We describe 1- the characteristics of the donors; 2- the fixation procedures applied for each case; 3- the tissue contrast characteristics of the T1w and T2w images; 4- the macroscopic tissue quality after extraction of the brains; 5- the macroscopic arterial characteristics and presence or absence of blood clots; and 6- four histological stains of the areas that we suspected were poorly fixed. We conclude that multiple factors can affect the fixation quality of the brain. Nevertheless, cases in which brain fixation is suboptimal, consequently altering the T1w signal, still have T2w of adequate gray-matter to white-matter contrast and may also be used for histology stains with sufficient quality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39426730,

title = {Early Influences on Development of Sensory Perception and Eating Habits},

author = {Kelly Guedes de Oliveira Scudine and Paula Midori Castelo and João Paulo Maires Hoppe and André Krumel Portella and Patricia Pelufo Silveira},

doi = {10.1016/j.advnut.2024.100325},

issn = {2156-5376},

year  = {2024},

date = {2024-12-01},

journal = {Adv Nutr},

volume = {15},

number = {12},

pages = {100325},

abstract = {Infancy and early childhood are important periods for the development of food choices and eating preferences that are tracked into adult life, influencing weight gain, body composition, and metabolism and ultimately affecting the balance between health and disease. In this narrative review, we discuss studies focused on the effects of fetal programming and early food experiences, highlighting recent advances in the discovery of factors that contribute to the development of food preferences and eating behavior. Food preference can be influenced by early direct contact with flavors, textures, and aromas, as well as by environmental adversities during early development. Evidence suggests that exposure to intrauterine growth restriction is associated with increased preferences for highly palatable foods, such as those rich in carbohydrates and fats, over the life course. Early flavor experiences, whether from amniotic fluid or human milk, may also shape the development of food preferences. Finally, children are more likely to accept textures that they are able to manipulate, and early exposure to a range of textures facilitates the acceptance of foods of various textures later on. Improving dietary habits during gestation (fetal) and postnatal periods is of critical importance for the establishment of positive eating habits and healthy growth in infants and should be an important focus of primary prevention efforts.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39591741,

title = {Investigating the contribution of childhood maltreatment to suicide attempt: A multivariable Mendelian randomization study},

author = {Min-Hyuk Kim and Gustavo Turecki and Massimiliano Orri},

doi = {10.1016/j.psychres.2024.116278},

issn = {1872-7123},

year  = {2024},

date = {2024-12-01},

journal = {Psychiatry Res},

volume = {342},

pages = {116278},

abstract = {Childhood maltreatment has been associated with suicidal behavior. However, whether this risk is causal and uniquely due to consequences of childhood maltreatment such as mental disorders, socioeconomic difficulties, and cognitive skills impairments needs clarification. We investigated direct and indirect contributions of childhood maltreatment to suicide attempt using a two-sample multivariable Mendelian randomization design. We used 7 single nucleotide polymorphisms from the childhood maltreatment genome-wide association study as instruments for childhood maltreatment. Multivariable Mendelian randomization was used to investigate the association of childhood maltreatment with suicide attempt accounting for risk of major psychiatric disorders (major depression, schizophrenia, attention-deficit/hyperactivity disorder), cognitive factors, and socioeconomic factors. Evidence supported a possible causal role of childhood maltreatment on suicide attempt (OR 4.36, CI 2.36-7.97). Significant associations with suicide attempt were identified for subtypes of maltreatment (physical abuse, physical neglect, emotional abuse, emotional neglect, sexual abuse), although unclear for sexual abuse. In multivariable analyses, childhood maltreatment was associated with suicidal attempt independently from selected mental disorders, socioeconomic factors, and cognitive factors although these factors accounted for most of the association (OR 1.51, CI 1.10-2.09). To prevent suicide among children exposed to maltreatment, it may be important to combine interventions to reduce mental disorders, psychosocial intervention, and suicide-specific preventive intervention.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}