PSEN1 and PSEN2 gene expression in Alzheimer's disease brain: a new approach.

TitlePSEN1 and PSEN2 gene expression in Alzheimer's disease brain: a new approach.
Publication TypeJournal Article
Year of Publication2014
AuthorsDelabio R, Rasmussen L, Mizumoto I, Viani G-A, Chen E, Villares J, Costa I-B, Turecki G, Linde SAparecido, Smith MCardoso, Payão S-L
JournalJ Alzheimers Dis
Volume42
Issue3
Pagination757-60
Date Published2014
ISSN1875-8908
KeywordsAged, Aged, 80 and over, Alzheimer Disease, Arabidopsis Proteins, Brain, Female, Gene Expression Regulation, Humans, Intramolecular Transferases, Male, Presenilin-1, Presenilin-2
Abstract

Presenilin 1 (PSEN1) and presenilin 2 (PSEN2) genes encode the major component of y-secretase, which is responsible for sequential proteolytic cleavages of amyloid precursor proteins and the subsequent formation of amyloid-β peptides. 150 RNA samples from the entorhinal cortex, auditory cortex and hippocampal regions of individuals with Alzheimer's disease (AD) and controls elderly subjects were analyzed with using real-time rtPCR. There were no differences between groups for PSEN1 expression. PSEN2 was significantly downregulated in the auditory cortex of AD patients when compared to controls and when compared to other brain regions of the patients. Alteration in PSEN2 expression may be a risk factor for AD.

DOI10.3233/JAD-140033
Alternate JournalJ. Alzheimers Dis.
PubMed ID24927704

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