Progress update from the hippocampal subfields group.

TitleProgress update from the hippocampal subfields group.
Publication TypeJournal Article
Year of Publication2019
AuthorsOlsen RK, Carr VA, Daugherty AM, La Joie R, Amaral RSC, Amunts K, Augustinack JC, Bakker A, Bender AR, Berron D, Boccardi M, Bocchetta M, Burggren AC, M Chakravarty M, Chételat G, de Flores R, DeKraker J, Ding S-L, Geerlings MI, Huang Y, Insausti R, Johnson EG, Kanel P, Kedo O, Kennedy KM, Keresztes A, Lee JK, Lindenberger U, Mueller SG, Mulligan EM, Ofen N, Palombo DJ, Pasquini L, Pluta J, Raz N, Rodrigue KM, Schlichting ML, Shing YLee, Stark CEL, Steve TA, Suthana NA, Wang L, Werkle-Bergner M, Yushkevich PA, Yu Q, Wisse LEM
Corporate AuthorsHippocampal Subfields Group
JournalAlzheimers Dement (Amst)
Volume11
Pagination439-449
Date Published2019 Dec
ISSN2352-8729
Abstract

Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence.Methods: Our international working group, funded by the EU Joint Programme-Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel data set and online consensus procedures to ensure validity and facilitate adoption.Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures.Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.

DOI10.1016/j.dadm.2019.04.001
Alternate JournalAlzheimers Dement (Amst)
PubMed ID31245529
PubMed Central IDPMC6581847