| Title | Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [(11)C]ABP688 PET. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | DuBois JM [1], Rousset OG [2], Rowley J [3], Porras-Betancourt M [4], Reader AJ [5], Labbe A [6], Massarweh G [7], Soucy J-P [8], Rosa-Neto P [9], Kobayashi E [10] |
| Journal | Eur J Nucl Med Mol Imaging |
| Volume | 43 |
| Issue | 1 |
| Pagination | 152-62 |
| Date Published | 2016 Jan |
| ISSN | 1619-7089 |
| Keywords | Adult [11], Aged [12], Aging [13], Brain [14], Carbon Radioisotopes [15], Female [16], Healthy Volunteers [17], Humans [18], Male [19], Middle Aged [20], Oximes [21], Positron-Emission Tomography [22], Pyridines [23], Receptor, Metabotropic Glutamate 5 [24], Sex Characteristics [25], Young Adult [26] |
| Abstract | PURPOSE: Metabotropic glutamate receptor type 5 (mGluR5) is a G protein-coupled receptor that has been implicated in several psychiatric and neurological diseases. The radiopharmaceutical [(11)C]ABP688 allows for in vivo quantification of mGluR5 availability using positron emission tomography (PET). In this study, we aimed to detail the regional distribution of [(11)C]ABP688 binding potential (BPND) and the existence of age/sex effects in healthy individuals.METHODS: Thirty-one healthy individuals aged 20 to 77 years (men, n = 18, 45.3 ± 18.2 years; females, n = 13, 41.5 ± 19.6 years) underwent imaging with [(11)C]ABP688 using the high-resolution research tomograph (HRRT). We developed an advanced partial volume correction (PVC) method using surface-based analysis in order to accurately estimate the regional variation of radioactivity. BPND was calculated using the simplified reference tissue model, with the cerebellum as the reference region. Surface-based and volume-based analyses were performed for 39 cortical and subcortical regions of interest per hemisphere.RESULTS: We found the highest [(11)C]ABP688 BPND in the lateral prefrontal and anterior cingulate cortices. The lowest [(11)C]ABP688 BPND was observed in the pre- and post-central gyri as well as the occipital lobes and the thalami. No sex effect was observed. Associations between age and [(11)C]ABP688 BPND without PVC were observed in the right amygdala and left putamen, but were not significant after multiple comparisons correction.CONCLUSIONS: The present results highlight complexities underlying brain adaptations during the aging process, and support the notion that certain aspects of neurotransmission remain stable during the adult life span. |
| DOI | 10.1007/s00259-015-3167-6 [27] |
| Alternate Journal | Eur. J. Nucl. Med. Mol. Imaging |
| PubMed ID | 26290423 [28] |
| Grant List | MOP-115131 / / Canadian Institutes of Health Research / Canada MOP-93614 / / Canadian Institutes of Health Research / Canada |
