| Title | Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Boccardi M [1], Bocchetta M [2], Apostolova LG [3], Barnes J [4], Bartzokis G [5], Corbetta G [6], DeCarli C [7], deToledo-Morrell L [8], Firbank M [9], Ganzola R [10], Gerritsen L [11], Henneman W [12], Killiany RJ [13], Malykhin N [14], Pasqualetti P [15], Pruessner JC [16], Redolfi A [17], Robitaille N [18], Soininen H [19], Tolomeo D [20], Wang L [21], Watson C [22], Wolf H [23], Duvernoy H [24], Duchesne S [25], Jack CR [26], Frisoni GB [27] |
| Corporate Authors | Segmentation E-AWorking Gr [28] |
| Journal | Alzheimers Dement |
| Volume | 11 |
| Issue | 2 |
| Pagination | 126-38 |
| Date Published | 2015 Feb |
| ISSN | 1552-5279 |
| Keywords | Alzheimer Disease [29], Atrophy [30], Consensus [31], Delphi Technique [32], Hippocampus [33], Humans [34], Image Processing, Computer-Assisted [35], Imaging, Three-Dimensional [36], Internationality [37], Magnetic Resonance Imaging [38], Neuroimaging [39] |
| Abstract | BACKGROUND: This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.METHODS: The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests.RESULTS: Agreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates.DISCUSSION: Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol. |
| DOI | 10.1016/j.jalz.2014.02.009 [40] |
| Alternate Journal | Alzheimers Dement |
| PubMed ID | 25130658 [41] |
| PubMed Central ID | PMC4419736 |
| Grant List | P30 AG010129 / AG / NIA NIH HHS / United States |
