Preventing synaptic deficits in Alzheimer's disease by inhibiting tumor necrosis factor alpha signaling.

TitlePreventing synaptic deficits in Alzheimer's disease by inhibiting tumor necrosis factor alpha signaling.
Publication TypeJournal Article
Year of Publication2018
AuthorsCavanagh C, Wong TPan
JournalIBRO Rep
Volume4
Pagination18-21
Date Published2018 Jun
ISSN2451-8301
Abstract

The characterization of preclinical stages of Alzheimer's disease (AD) would provide a therapeutic window for prevention. One of the challenges of developing preventive therapy for AD is to identify early biomarkers for intervention studies. We have recently shown that in the TgCRND8 transgenic AD mouse model, increased hippocampal levels of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα) and enhanced excitatory synaptic transmission were early-onset changes that occurred weeks before amyloid plaque formation. Inhibiting TNFα before plaque formation not only normalized excitatory synaptic function, but also prevented the impairment of synaptic function 4 months later. In this review paper, we will examine the potential contributions of TNFα to the alteration of brain function in preclinical AD. The prospective use of TNFα inhibitors for preventing AD will be discussed.

DOI10.1016/j.ibror.2018.01.003
Alternate JournalIBRO Rep
PubMed ID30135948
PubMed Central IDPMC6084902

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