Preprocessing, analysis and quantification in single-voxel magnetic resonance spectroscopy: experts' consensus recommendations

TitlePreprocessing, analysis and quantification in single-voxel magnetic resonance spectroscopy: experts' consensus recommendations
Publication TypeJournal Article
Year of Publication2020
AuthorsNear J, Harris AD, Juchem C, Kreis R, Marjańska M, Öz G, Slotboom J, Wilson M, Gasparovic C
JournalNMR in BiomedicineNMR in BiomedicineNMR in Biomedicine
Volumen/a
Issuen/a
Paginatione4257
Date Published2020/02/21
ISBN Number0952-3480
Keywordsanalysis, MRS, preprocessing, processing, quantification, quantitation, water referencing
Abstract

Once an MRS dataset has been acquired, several important steps must be taken to obtain the desired metabolite concentration measures. First, the data must be preprocessed to prepare them for analysis. Next, the intensity of the metabolite signal(s) of interest must be estimated. Finally, the measured metabolite signal intensities must be converted into scaled concentration units employing a quantitative reference signal to allow meaningful interpretation. In this paper, we review these three main steps in the post-acquisition workflow of a single-voxel MRS experiment (preprocessing, analysis and quantification) and provide recommendations for best practices at each step.

URLhttps://doi.org/10.1002/nbm.4257
Short TitleNMR in Biomedicine