Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.

TitlePreclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.
Publication TypeJournal Article
Year of Publication2016
AuthorsDubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, Bakardjian H, Benali H, Bertram L, Blennow K, Broich K, Cavedo E, Crutch S, Dartigues J-F, Duyckaerts C, Epelbaum S, Frisoni GB, Gauthier S, Genthon R, Gouw AA, Habert M-O, Holtzman DM, Kivipelto M, Lista S, Molinuevo J-L, O'Bryant SE, Rabinovici GD, Rowe C, Salloway S, Schneider LS, Sperling R, Teichmann M, Carrillo MC, Cummings J, Jack CR
Corporate AuthorsProceedings of the Meeting of the International Working Group(IWG) and the American Alzheimer's Association on “The Preclinical State of AD”; July 23, 2015; Washington DC, USA
JournalAlzheimers Dement
Volume12
Issue3
Pagination292-323
Date Published2016 Mar
ISSN1552-5279
KeywordsAlzheimer Disease, Animals, Brain, Disease Progression, Humans
Abstract

During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at the preclinical stage before the occurrence of the first clinical symptoms. This preclinical stage of AD has become a major research focus as the field postulates that early intervention may offer the best chance of therapeutic success. To date, very little evidence is established on this "silent" stage of the disease. A clarification is needed about the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage. This article is aimed at addressing all the different issues by providing for each of them an updated review of the literature and evidence, with practical recommendations.

DOI10.1016/j.jalz.2016.02.002
Alternate JournalAlzheimers Dement
PubMed ID27012484