The plasticity of development: how knowledge of epigenetics may advance understanding of eating disorders.

TitleThe plasticity of development: how knowledge of epigenetics may advance understanding of eating disorders.
Publication TypeJournal Article
Year of Publication2014
AuthorsStrober M, Peris T, Steiger H
JournalInt J Eat Disord
Volume47
Issue7
Pagination696-704
Date Published2014 Nov
ISSN1098-108X
KeywordsAnimals, Anxiety Disorders, Birth Weight, Disease Models, Animal, DNA Methylation, Environmental Exposure, Epigenesis, Genetic, Feeding and Eating Disorders, Female, Gene-Environment Interaction, Germ Cells, Humans, Male, Maternal Exposure, Maternal Nutritional Physiological Phenomena, Paternal Exposure, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological
Abstract

OBJECTIVE: To depict the processes through which animals and human beings engage their environment in continuously evolving states of conflict and cooperation.METHOD: Descriptive literature review.RESULTS: Life history outcomes are more relative than they are absolute. Genetic variations play a crucial role, but heavily influencing behavioral outcomes, psychopathology included, are external cues that epigenetically remodel DNA along experience-dependent signaling pathways. The result is phenotypes that either optimize adjustment, or constrain it.DISCUSSION: Knowledge of epigenetic mechanisms may help shed new light on the origin of maturational phenotypes underlying eating disorders and why adjusting treatments to these realities warrants our attention.

DOI10.1002/eat.22322
Alternate JournalInt J Eat Disord
PubMed ID24976293