The plasticity of development: how knowledge of epigenetics may advance understanding of eating disorders.
|Title||The plasticity of development: how knowledge of epigenetics may advance understanding of eating disorders.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Strober M, Peris T, Steiger H|
|Journal||Int J Eat Disord|
|Date Published||2014 Nov|
|Keywords||Animals, Anxiety Disorders, Birth Weight, Disease Models, Animal, DNA Methylation, Environmental Exposure, Epigenesis, Genetic, Feeding and Eating Disorders, Female, Gene-Environment Interaction, Germ Cells, Humans, Male, Maternal Exposure, Maternal Nutritional Physiological Phenomena, Paternal Exposure, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological|
OBJECTIVE: To depict the processes through which animals and human beings engage their environment in continuously evolving states of conflict and cooperation.METHOD: Descriptive literature review.RESULTS: Life history outcomes are more relative than they are absolute. Genetic variations play a crucial role, but heavily influencing behavioral outcomes, psychopathology included, are external cues that epigenetically remodel DNA along experience-dependent signaling pathways. The result is phenotypes that either optimize adjustment, or constrain it.DISCUSSION: Knowledge of epigenetic mechanisms may help shed new light on the origin of maturational phenotypes underlying eating disorders and why adjusting treatments to these realities warrants our attention.
|Alternate Journal||Int J Eat Disord|