Obesity, adipokines and neuroinflammation.

TitleObesity, adipokines and neuroinflammation.
Publication TypeJournal Article
Year of Publication2015
AuthorsAguilar-Valles A, Inoue W, Rummel C, Luheshi G
JournalNeuropharmacology
Volume96
IssuePt A
Pagination124-34
Date Published2015 Sep
ISSN1873-7064
Abstract

Global levels of obesity are reaching epidemic proportions, leading to a dramatic increase in incidence of secondary diseases and the significant economic burden associated with their treatment. These comorbidities include diabetes, cardiovascular disease, and some psychopathologies, which have been linked to a low-grade inflammatory state. Obese individuals exhibit an increase in circulating inflammatory mediators implicated as the underlying cause of these comorbidities. A number of these molecules are also manufactured and released by white adipose tissue (WAT), in direct proportion to tissue mass and are collectively known as adipokines. In the current review we focused on the role of two of the better-studied members of this family namely, leptin and adiponectin, with particular emphasis on their role in neuro-immune interactions, neuroinflammation and subsequent brain diseases. This article is part of a Special Issue entitled 'Neuroimmunology and Synaptic Function'.

DOI10.1016/j.neuropharm.2014.12.023
Alternate JournalNeuropharmacology
PubMed ID25582291


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