No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder.
|Title||No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Hernaus D, Collip D, Kasanova Z, Winz O, Heinzel A, van Amelsvoort T, Shali SM, Booij J, Rong Y, Piel M, Pruessner J, Mottaghy FM, Myin-Germeys I|
|Keywords||Adult, Benzamides, Brain, Case-Control Studies, Dopamine, Female, Fluorine Radioisotopes, Humans, Male, Middle Aged, Neostriatum, Positron-Emission Tomography, Prefrontal Cortex, Psychotic Disorders, Stress, Psychological, Synaptic Transmission, Temporal Lobe|
Stress is an important risk factor in the etiology of psychotic disorder. Preclinical work has shown that stress primarily increases dopamine (DA) transmission in the frontal cortex. Given that DA-mediated hypofrontality is hypothesized to be a cardinal feature of psychotic disorder, stress-related extrastriatal DA release may be altered in psychotic disorder. Here we quantified for the first time stress-induced extrastriatal DA release and the spatial extent of extrastriatal DA release in individuals with non-affective psychotic disorder (NAPD). Twelve healthy volunteers (HV) and 12 matched drug-free NAPD patients underwent a single infusion [(18)F]fallypride positron emission tomography scan during which they completed the control and stress condition of the Montreal Imaging Stress Task. HV and NAPD did not differ in stress-induced [(18)F]fallypride displacement and the spatial extent of stress-induced [(18)F]fallypride displacement in medial prefrontal cortex (mPFC) and temporal cortex (TC). In the whole sample, the spatial extent of stress-induced radioligand displacement in right ventro-mPFC, but not dorso-mPFC or TC, was positively associated with task-induced subjective stress. Psychotic symptoms during the scan or negative, positive and general subscales of the Positive and Negative Syndrome Scale were not associated with stress-induced [(18)F]fallypride displacement nor the spatial extent of stress-induced [(18)F]fallypride displacement in NAPD. Our results do not offer evidence for altered stress-induced extrastriatal DA signaling in NAPD, nor altered functional relevance. The implications of these findings for the role of the DA system in NAPD and stress processing are discussed.
|Alternate Journal||Transl Psychiatry|
|PubMed Central ID||PMC4462602|