Neural function in DCC mutation carriers with and without mirror movements.

TitleNeural function in DCC mutation carriers with and without mirror movements.
Publication TypeJournal Article
Year of Publication2019
AuthorsVosberg DE, Beaulé V, Torres-Berrío A, Cooke D, Chalupa A, Jaworska N, Cox SML, Larcher K, Zhang Y, Allard D, Durand F, Dagher A, Benkelfat C, Srour M, Tampieri D, La Piana R, Joober R, Lepore F, Rouleau G, Pascual-Leone A, Fox MD, Flores C, Leyton M, Théoret H
JournalAnn Neurol
Volume85
Issue3
Pagination433-442
Date Published2019 Mar
ISSN1531-8249
Abstract

OBJECTIVE: Recently identified mutations of the axon guidance molecule receptor gene, DCC, present an opportunity to investigate, in living human brain, mechanisms affecting neural connectivity and the basis of mirror movements, involuntary contralateral responses that mirror voluntary unilateral actions. We hypothesized that haploinsufficient DCC mutation carriers with mirror movements would exhibit decreased DCC mRNA expression, a functional ipsilateral corticospinal tract, greater "mirroring" motor representations, and reduced interhemispheric inhibition. DCC mutation carriers without mirror movements might exhibit some of these features.

METHODS: The participants (n = 52) included 13 DCC mutation carriers with mirror movements, 7 DCC mutation carriers without mirror movements, 13 relatives without the mutation or mirror movements, and 19 unrelated healthy volunteers. The multimodal approach comprised quantitative real time polymerase chain reaction, transcranial magnetic stimulation (TMS), functional magnetic resonance imaging (fMRI) under resting and task conditions, and measures of white matter integrity.

RESULTS: Mirror movements were associated with reduced DCC mRNA expression, increased ipsilateral TMS-induced motor evoked potentials, increased fMRI responses in the mirroring M1 and cerebellum, and markedly reduced interhemispheric inhibition. The DCC mutation, irrespective of mirror movements, was associated with reduced functional connectivity and white matter integrity.

INTERPRETATION: Diverse connectivity abnormalities were identified in mutation carriers with and without mirror movements, but corticospinal effects and decreased peripheral DCC mRNA appeared driven by the mirror movement phenotype. ANN NEUROL 2019;85:433-442.

DOI10.1002/ana.25418
Alternate JournalAnn. Neurol.
PubMed ID30666715
PubMed Central IDPMC6444183
Grant ListR01 DA037911 / DA / NIDA NIH HHS / United States
MOP-258547 / / Canadian Institutes of Health Research / Canada
R01DA037911 / / National Institute on Drug Abuse /