The Netrin-1/DCC Guidance Cue Pathway as a Molecular Target in Depression: Translational Evidence.

TitleThe Netrin-1/DCC Guidance Cue Pathway as a Molecular Target in Depression: Translational Evidence.
Publication TypeJournal Article
Year of Publication2020
AuthorsTorres-Berrío A, Hernandez G, Nestler EJ, Flores C
JournalBiol Psychiatry
Volume88
Issue8
Pagination611-624
Date Published2020 Oct 15
ISSN1873-2402
Abstract

The Netrin-1/DCC guidance cue pathway plays a critical role in guiding growing axons toward the prefrontal cortex during adolescence and in the maturational organization and adult plasticity of prefrontal cortex connectivity. In this review, we put forward the idea that alterations in prefrontal cortex architecture and function, which are intrinsically linked to the development of major depressive disorder, originate in part from the dysregulation of the Netrin-1/DCC pathway by a mechanism that involves microRNA-218. We discuss evidence derived from mouse models of stress and from human postmortem brain and genome-wide association studies indicating an association between the Netrin-1/DCC pathway and major depressive disorder. We propose a potential role of circulating microRNA-218 as a biomarker of stress vulnerability and major depressive disorder.

DOI10.1016/j.biopsych.2020.04.025
Alternate JournalBiol Psychiatry
PubMed ID32593422
PubMed Central IDPMC7529861
Grant ListP50 MH096890 / MH / NIMH NIH HHS / United States
R01 DA037911 / DA / NIDA NIH HHS / United States
R01 MH051399 / MH / NIMH NIH HHS / United States