Naguib Mechawar

Human Neuroscience

Naguib Mechawar, PhD

F-2101.1, Frank B. Common Pavilion

6875 Boulevard LaSalle
Montréal, QC
H4H 1R3

(514) 761-6131 x3365

Research area: 
Basic Neuroscience / Animal Research

Research Theme: 
Stress, mood and impulsivity disorders

Researcher, Douglas Research Centre 
Group Leader, Stress, Anxiety, Depression, and Suicide
Director, Douglas-Bell Canada Brain Bank, Douglas Research Centre 
Associate Professor, Department of Psychiatry, McGill University
Graduate Program Director, Department of Psychiatry, McGill University

Neuroanatomy of mood disorders and suicide

Naguib Mechawar, PhD, joined the Douglas Institute and the McGill Group for Suicide Studies in 2007. He is mainly interested in identifying the neurochemical and neuroanatomical features underlying major depression and suicide. His research is focused on limbic brain regions. Different research themes are explored in his laboratory, namely:

  • Neuroinflammation in depression and suicide;
  • The characterization of astrocytes in the human brain;
  • Astrocytic abnormalities in depression and suicide;
  • The lasting impact of child abuse on cerebral oligodendrocytes and myelination.

Dr Mechawar’s research is funded by the CFI, CIHR, FRQS, NSERC, and the AFSP.

  • Tanti A, Kim JJ, Wakid M, Davoli MA, Turecki G, Mechawar N. Child abuse associates with an imbalance of oligodendrocyte-lineage cells in ventromedial prefrontal white matter. Mol Psychiatry. 2017 Nov 21. doi: 10.1038/mp.2017.231.
  • Lutz PE, Tanti A, Gasecka A, Barnett-Burns S, Kim JJ, Zhou Y, Chen GG, Wakid M, Shaw M, Almeida D, Chay MA, Yang J, Larivière V, M’Boutchou MN, van Kempen LC, Yerko V, Prud’homme J, Davoli MA, Vaillancourt K, Théroux JF, Bramoullé A, Zhang  TY, Meaney MJ, Ernst C, Côté D, Mechawar N, Turecki G. Association of a History of Child Abuse With Impaired Myelination in the Anterior Cingulate Cortex: Convergent Epigenetic, Transcriptional, and Morphological Evidence. Am J Psychiatry. 2017 Jul 28:appiajp201716111286. doi: 10.1176/appi.ajp.2017.16111286.
  • Mahar I, Labonte B, Yogendran S, Isingrini E, Perret L, Davoli MA, Rachalski A, Giros B, Turecki G, Mechawar N. Disrupted hippocampal neuregulin-1/ErbB3 signaling and dentate gyrus granule cell alterations in suicide. Transl Psychiatry. 2017 Jul 4;7(7):e1161. doi: 10.1038/tp.2017.132. Erratum in: Transl Psychiatry. 2017 Sep 26;7(9):e1243.
  • Mechawar N, Savitz J. Neuropathology of mood disorders: do we see the stigmata of inflammation? Transl Psychiatry. 2016 Nov 8;6(11):e946. doi: 10.1038/tp.2016.212. Review.
  • Susana G. Torres-Platas, Samuel Comeau, Adeline Rachalski, Gregory Dal Bo, Cristiana Cruceanu, Gustavo Turecki, Bruno Giros and Naguib Mechawar Morphometric characterization of microglial phenotypes in human cerebral cortex Journal of Neuroinflammation 2014, 11:12 link
  • Maheu M, Davoli MA, Turecki G, Mechawar N† (2013) Amygdalar expression of proteins associated with neuroplasticity in major depression and suicide. J Psych Res 47:384-90.
  • Torres-Platas SG, Hercher C, Davoli MA, Maussion G, Labonté B, Turecki G, Mechawar N† (2011) Astrocytic hypertrophy in anterior cingulate white matter of depressed suicides.Neuropsychopharmacology 36:2650-2658.

CIHR New Investigator (2012-17)
Bell Senior Fellow in Mental Health (2012-14)

Recent publications