Multiple Running Speed Signals in Medial Entorhinal Cortex.

TitleMultiple Running Speed Signals in Medial Entorhinal Cortex.
Publication TypeJournal Article
Year of Publication2016
AuthorsHinman JR, Brandon MP, Climer JR, G Chapman W, Hasselmo ME
JournalNeuron
Volume91
Issue3
Pagination666-79
Date Published2016 Aug 03
ISSN1097-4199
Abstract

Grid cells in medial entorhinal cortex (MEC) can be modeled using oscillatory interference or attractor dynamic mechanisms that perform path integration, a computation requiring information about running direction and speed. The two classes of computational models often use either an oscillatory frequency or a firing rate that increases as a function of running speed. Yet it is currently not known whether these are two manifestations of the same speed signal or dissociable signals with potentially different anatomical substrates. We examined coding of running speed in MEC and identified these two speed signals to be independent of each other within individual neurons. The medial septum (MS) is strongly linked to locomotor behavior, and removal of MS input resulted in strengthening of the firing rate speed signal, while decreasing the strength of the oscillatory speed signal. Thus, two speed signals are present in MEC that are differentially affected by disrupted MS input.

DOI10.1016/j.neuron.2016.06.027
Alternate JournalNeuron
PubMed ID27427460
PubMed Central IDPMC4976037
Grant ListR01 MH060013 / MH / NIMH NIH HHS / United States
R01 MH061492 / MH / NIMH NIH HHS / United States