The molecular bases of the suicidal brain.

TitleThe molecular bases of the suicidal brain.
Publication TypeJournal Article
Year of Publication2014
AuthorsTurecki G
JournalNat Rev Neurosci
Volume15
Issue12
Pagination802-16
Date Published2014 Dec
ISSN1471-0048
KeywordsBrain, Humans, Mental Disorders, Risk Factors, Suicide
Abstract

Suicide ranks among the leading causes of death around the world and takes a heavy emotional and public health toll on most societies. Both distal and proximal factors contribute to suicidal behaviour. Distal factors - such as familial and genetic predisposition, as well as early-life adversity - increase the lifetime risk of suicide. They alter responses to stress and other processes through epigenetic modification of genes and associated changes in gene expression, and through the regulation of emotional and behavioural traits. Proximal factors are associated with the precipitation of a suicidal event and include alterations in key neurotransmitter systems, inflammatory changes and glial dysfunction in the brain. This Review explores the key molecular changes that are associated with suicidality and discusses some promising avenues for future research.

DOI10.1038/nrn3839
Alternate JournalNat. Rev. Neurosci.
PubMed ID25354482
Grant ListMOP119429 / / Canadian Institutes of Health Research / Canada
MOP119430 / / Canadian Institutes of Health Research / Canada