MicroRNA regulation of prefrontal cortex development and psychiatric risk in adolescence.

TitleMicroRNA regulation of prefrontal cortex development and psychiatric risk in adolescence.
Publication TypeJournal Article
Year of Publication2021
AuthorsMorgunova A, Flores C
JournalSemin Cell Dev Biol
Volume118
Pagination83-91
Date Published2021 10
ISSN1096-3634
Abstract

In this review, we examine the role of microRNAs in the development of the prefrontal cortex (PFC) in adolescence and in individual differences in vulnerability to mental illness. We describe results from clinical and preclinical research indicating that adolescence coincides with drastic changes in local microRNA expression, including microRNAs that control gene networks involved in PFC and cognitive refinement. We highlight that altered levels of microRNAs in the PFC are associated with psychopathologies of adolescent onset, notably depression and schizophrenia. We show that microRNAs can be measured non-invasively in peripheral samples and could serve as longitudinal physiological readouts of brain expression and psychiatric risk in youth.

DOI10.1016/j.semcdb.2021.04.011
Alternate JournalSemin Cell Dev Biol
PubMed ID33933350
PubMed Central IDPMC8435008
Grant ListR01 DA037911 / DA / NIDA NIH HHS / United States
MOP-74709 / / CIHR / Canada
FRN 170130 / / CIHR / Canada