MicroRNA regulation of prefrontal cortex development and psychiatric risk in adolescence.
|Title||MicroRNA regulation of prefrontal cortex development and psychiatric risk in adolescence.|
|Publication Type||Journal Article|
|Year of Publication||2021|
|Authors||Morgunova A, Flores C|
|Journal||Semin Cell Dev Biol|
|Date Published||2021 10|
In this review, we examine the role of microRNAs in the development of the prefrontal cortex (PFC) in adolescence and in individual differences in vulnerability to mental illness. We describe results from clinical and preclinical research indicating that adolescence coincides with drastic changes in local microRNA expression, including microRNAs that control gene networks involved in PFC and cognitive refinement. We highlight that altered levels of microRNAs in the PFC are associated with psychopathologies of adolescent onset, notably depression and schizophrenia. We show that microRNAs can be measured non-invasively in peripheral samples and could serve as longitudinal physiological readouts of brain expression and psychiatric risk in youth.
|Alternate Journal||Semin Cell Dev Biol|
|PubMed Central ID||PMC8435008|
|Grant List||R01 DA037911 / DA / NIDA NIH HHS / United States |
MOP-74709 / / CIHR / Canada
FRN 170130 / / CIHR / Canada