Methylation of the OXTR gene in women with anorexia nervosa: Relationship to social behavior.

TitleMethylation of the OXTR gene in women with anorexia nervosa: Relationship to social behavior.
Publication TypeJournal Article
Year of Publication2019
AuthorsThaler L, Brassard S, Booij L, Kahan E, McGregor K, Labbe A, Israel M, Steiger H
JournalEur Eat Disord Rev
Date Published2019 Dec 10
ISSN1099-0968
Abstract

DNA methylation allows for the environmental regulation of gene expression and is believed to link environmental stressors to psychiatric disorder phenotypes, such as anorexia nervosa (AN). The oxytocin receptor (OXTR) gene is epigenetically regulated, and studies have shown associations between OXTR and social behaviours in various samples, including women with AN. The present study examined differential levels of methylation at various CG sites of the OXTR gene in 69 women with active AN (AN-Active), 21 in whom AN was in remission (AN-Rem) and 35 with no eating disorder (NED). Within each group, we explored the correlation between methylation and measures of social behaviour such as insecure attachment and social avoidance. Hypermethylation of a number of CG sites was seen in AN-Active participants as compared with AN-Rem and NED participants. In the AN-Rem sample, methylation at CG27501759 was significantly positively correlated with insecure attachment (r = .614, p = .003, permutation Q = 0.008) and social avoidance (r = .588, p = .005, permutation Q = 0.0184). Our results highlight differential methylation of the OXTR gene among women with AN, those in remission from AN, and those who never had AN and provide some evidence of associations between OXTR methylation and social behaviour in women remitted from AN.

DOI10.1002/erv.2703
Alternate JournalEur Eat Disord Rev
PubMed ID31823473
Grant List / / Canadian Institutes for Health Research /