Metabolic and cardiovascular consequences of shift work: The role of circadian disruption and sleep disturbances.

TitleMetabolic and cardiovascular consequences of shift work: The role of circadian disruption and sleep disturbances.
Publication TypeJournal Article
Year of Publication2018
AuthorsKervezee L, Kosmadopoulos A, Boivin DB
JournalEur J Neurosci
Date Published2018 Oct 25
ISSN1460-9568
Abstract

Shift work, defined as work occurring outside typical daytime working hours, is associated with an increased risk of various non-communicable diseases, including diabetes and cardiovascular disease. Disruption of the internal circadian timing system and concomitant sleep disturbances is thought to play a critical role in the development of these health problems. Indeed, controlled laboratory studies have shown that short-term circadian misalignment and sleep restriction independently impair physiological processes, including insulin sensitivity, energy expenditure, immune function, blood pressure and cardiac modulation by the autonomous nervous system. If allowed to persist, these acute effects may lead to the development of cardiometabolic diseases in the long term. Here, we discuss the evidence for the contributions of circadian disruption and associated sleep disturbances to the risk of metabolic and cardiovascular health problems in shift workers. Improving the understanding of the physiological mechanisms affected by circadian misalignment and sleep disturbance will contribute to the development and implementation of strategies that prevent or mitigate the cardiometabolic impact of shift work.

DOI10.1111/ejn.14216
Alternate JournalEur. J. Neurosci.
PubMed ID30357975
Grant ListMOP-137052 / / Canadian Institutes of Health Research / Canada
/ / Fonds de Recherche du Québec - Santé /
2013-0046 / / Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail /


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