Measuring the impact of cognitive and psychosocial interventions in persons with mild cognitive impairment with a randomized single-blind controlled trial: rationale and design of the MEMO+ study.

TitleMeasuring the impact of cognitive and psychosocial interventions in persons with mild cognitive impairment with a randomized single-blind controlled trial: rationale and design of the MEMO+ study.
Publication TypeJournal Article
Year of Publication2015
AuthorsBier N, Grenier S, Brodeur C, Gauthier S, Gilbert B, Hudon C, Lepage E, Ouellet M-C, Viscogliosi C, Belleville S
JournalInt Psychogeriatr
Volume27
Issue3
Pagination511-25
Date Published2015 Mar
ISSN1741-203X
KeywordsActivities of Daily Living, Aged, Aged, 80 and over, Canada, Cognition, Dementia, Education, Female, Humans, Male, Memory, Middle Aged, Mild Cognitive Impairment, Neuropsychological Tests, Patient Outcome Assessment, Research Design, Self Efficacy, Single-Blind Method
Abstract

BACKGROUND: Several studies have suggested that cognitive training is a potentially effective way to improve cognition and postpone cognitive decline in older adults with mild cognitive impairment (MCI). The MEMO+ study is a randomized, controlled, single-blind trial designed to test the efficacy, specificity, and long-term effect of a cognitive training intervention and a psychosocial intervention in persons with MCI.METHODS: One hundred and sixty-two participants with MCI will be recruited. They will be randomized into three groups: cognitive training, psychosocial intervention, and no-contact. Each intervention will last for eight weeks (one session per week) and a booster training session will be provided three months after the end of the intervention. Various proximal and distal outcomes will be measured at pre-intervention as well as at one week, three months, and six months post-training. Proximal outcomes include memory and psychological health measures. Distal outcomes focus on self-rated functioning in complex daily activities and strategies used in daily life to enhance function. Socio-demographic factors (age, gender, and education), general cognition, personality traits, engagement in activities, and self-efficacy will be used as moderators. Enrolment began in April 2012 and will be completed by December 2014.CONCLUSIONS: This study is likely to have a significant impact on the well-being of persons with MCI by contributing to the development of adapted and scientifically supported cognitive and psychosocial interventions.

DOI10.1017/S1041610214001902
Alternate JournalInt Psychogeriatr
PubMed ID25268968
Grant List / / Canadian Institutes of Health Research / Canada