Maturational trajectories of pericortical contrast in typical brain development.

TitleMaturational trajectories of pericortical contrast in typical brain development.
Publication TypeJournal Article
Year of Publication2021
AuthorsDrakulich S, Thiffault A-C, Olafson E, Parent O, Labbe A, Albaugh MD, Khundrakpam B, Ducharme S, Evans A, Chakravarty MM, Karama S
JournalNeuroimage
Volume235
Pagination117974
Date Published2021 07 15
ISSN1095-9572
KeywordsAdolescent, Adult, Cerebral Cortex, Child, Child, Preschool, Female, Gray Matter, Human Development, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Sex Factors, White Matter, Young Adult
Abstract

In the last few years, a significant amount of work has aimed to characterize maturational trajectories of cortical development. The role of pericortical microstructure putatively characterized as the gray-white matter contrast (GWC) at the pericortical gray-white matter boundary and its relationship to more traditional morphological measures of cortical morphometry has emerged as a means to examine finer grained neuroanatomical underpinnings of cortical changes. In this work, we characterize the GWC developmental trajectories in a representative sample (n = 394) of children and adolescents (~4 to ~22 years of age), with repeated scans (1-3 scans per subject, total scans n = 819). We tested whether linear, quadratic, or cubic trajectories of contrast development best described changes in GWC. A best-fit model was identified vertex-wise across the whole cortex via the Akaike Information Criterion (AIC). GWC across nearly the whole brain was found to significantly change with age. Cubic trajectories were likeliest for 63% of vertices, quadratic trajectories were likeliest for 20% of vertices, and linear trajectories were likeliest for 16% of vertices. A main effect of sex was observed in some regions, where males had a higher GWC than females. However, no sex by age interactions were found on GWC. In summary, our results suggest a progressive decrease in GWC at the pericortical boundary throughout childhood and adolescence. This work contributes to efforts seeking to characterize typical, healthy brain development and, by extension, can help elucidate aberrant developmental trajectories.

DOI10.1016/j.neuroimage.2021.117974
Alternate JournalNeuroimage
PubMed ID33766753
PubMed Central IDPMC8278832
Grant ListN01NS92315 / NS / NINDS NIH HHS / United States
K08 MH121654 / MH / NIMH NIH HHS / United States
N01HD23343 / HD / NICHD NIH HHS / United States
N01NS92316 / NS / NINDS NIH HHS / United States
N01 HD023343 / HD / NICHD NIH HHS / United States
/ / CIHR / Canada
N01NS92320 / NS / NINDS NIH HHS / United States
N01NS92314 / NS / NINDS NIH HHS / United States
N01NS92319 / NS / NINDS NIH HHS / United States
N01NS92317 / NS / NINDS NIH HHS / United States
N01MH90002 / MH / NIMH NIH HHS / United States